RELapses prevENTion in chronic autoimmune disease: common mechanisms and co-morbidities

Risultati finali

Launch of website, Twitter, Research Gate, LinkedIn, Account and general project flyer/poster

Launch of website, Twitter, Research Gate, LinkedIn, Account and general project flyer/poster (inlcuding description of web site contencts and management)

Recruitment report update for “immune ageing in health and disease“

The report shall include an overview of recruited subjects by study site, potential recruiting problems and, if applicable, a detailed description of implemented and planned measures to compensate delays in the study subject recruitment.

Report on status of posting results in the study registry(s) for “Research into Genetic variation AND Leucocyte Altered Function in health and disease (GANDALF)“

A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period.

"Midterm recruitment report for ""RELENT bank of induced pluripotent stem cells"""

The report shall include an overview of recruited subjects by study site potential recruiting problems and if applicable a detailed description of implemented and planned measures to compensate delays in the study subject recruitment

All approvals package for “RELENT bank of induced pluripotent stem cells”

The all approvals package should include all approvals from ethics committees and national competent authorities (if applicable) of all study sites once the last approval has been received.

Recruitment report update for “AV-GWAS (Multi-Centre Genome-Wide Association Study of ANCA-associated vasculitis)”

Report on status of posting results in the study registry(s) for “CD4+ T cells and immune ageing, major players and predictors for disease activity in giant cell arteritis”

A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period.

"First study subject approvals package for ""RELENT bank of induced pluripotent stem cells"""

It will be provided a final version of study protocol as submitted to regulators ethics committees b registration number of CS in a WHO or ICMJE approved registry and c approvals ethics committees and national competent authority if applicable required for invitation enrolment of first subject in at least one clinical centre

Report on status of posting results in the study registry(s) for “RELENT bank of induced pluripotent stem cells”

A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period.

Recruitment report update for “ANCA associated vasculitis is a relapsing disease; the role of regulatory B cells”

Recruitment report update for “Cambridge Hinxton Centre for Translational Research in Autoimmune Disease 2 (CHIC TRIAD2)”

Report on status of posting results in the study registry(s) for “immune ageing in health and disease“

A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period.

Recruitment report update for “CD4+ T cells and immune ageing, major players and predictors for disease activity in giant cell arteritis”

Report on status of posting results in the study registry(s) for “AV-GWAS (Multi-Centre Genome-Wide Association Study of ANCA-associated vasculitis)”

A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period.

Report on status of posting results in the study registry(s) for “Cambridge Hinxton Centre for Translational Research in Autoimmune Disease 2 (CHIC TRIAD2)”

A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period.

Recruitment report update for “Research into Genetic variation AND Leucocyte Altered Function in health and disease (GANDALF)“

Report on status of posting results in the study registry(s) for “ANCA associated vasculitis is a relapsing disease; the role of regulatory B cells”

A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period.

Individualized press release for every partner

Individualized press release for every partner (including description of the partners, scope and expected impact of the project)

Preparation of first bi-annual newsletter

Preparation of first bi-annual newsletter (including achievements and report on impact)

Report on dissemination and communication activities

Pubblicazioni

ANCA-associated vasculitis

Autori: A. Richard Kitching, Hans-Joachim Anders, Neil Basu, Elisabeth Brouwer, Jennifer Gordon, David R. Jayne, Joyce Kullman, Paul A. Lyons, Peter A. Merkel, Caroline O. S. Savage, Ulrich Specks, Renate Kain
Pubblicato in: Nature Reviews Disease Primers, Numero 6/1, 2020, ISSN 2056-676X
Editore: NATURE REVIEWS
DOI: 10.1038/s41572-020-0204-y

Toll-like receptors in lupus nephritis

Autori: Satish Kumar Devarapu, Hans-Joachim Anders
Pubblicato in: Journal of Biomedical Science, Numero 25/1, 2018, ISSN 1423-0127
Editore: Journal of Biomedical Science
DOI: 10.1186/s12929-018-0436-2

CD27+CD38hi B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients

Autori: Anouk von Borstel, Judith Land, Wayel H. Abdulahad, Abraham Rutgers, Coen A. Stegeman, Arjan Diepstra, Peter Heeringa, Jan Stephan Sanders
Pubblicato in: Frontiers in Immunology, Numero 10, 2019, ISSN 1664-3224
Editore: Frontiers in Immunology
DOI: 10.3389/fimmu.2019.02221

Processing and Maturation of Cathepsin C Zymogen: A Biochemical and Molecular Modeling Analysis

Autori: Anne-Sophie Lamort, Yveline Hamon, Cezary Czaplewski, Artur Gieldon, Seda Seren, Laurent Coquet, Fabien Lecaille, Adam Lesner, Gilles Lalmanach, Francis Gauthier, Dieter Jenne, Brice Korkmaz
Pubblicato in: International Journal of Molecular Sciences, Numero 20/19, 2019, Pagina/e 4747, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20194747

Increased miR-142-3p Expression Might Explain Reduced Regulatory T Cell Function in Granulomatosis With Polyangiitis

Autori: Gerjan J. Dekkema, Theo Bijma, Pytrick G. Jellema, Anke Van Den Berg, Bart-Jan Kroesen, Coen A. Stegeman, Peter Heeringa, Wayel H. Abdulahad, Jan-Stephan Sanders
Pubblicato in: Frontiers in Immunology, Numero 10, 2019, ISSN 1664-3224
Editore: Frontiers in Immunology
DOI: 10.3389/fimmu.2019.02170

Prolonged IKKβ Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells

Autori: Christoph Heuser, Janine Gotot, Eveline Christina Piotrowski, Marie-Sophie Philipp, Christina Johanna Felicia Courrèges, Martin Sylvester Otte, Linlin Guo, Jonathan Leo Schmid-Burgk, Veit Hornung, Annkristin Heine, Percy Alexander Knolle, Natalio Garbi, Edgar Serfling, César Evaristo, Friedrich Thaiss, Christian Kurts
Pubblicato in: Cell Reports, Numero 21/3, 2017, Pagina/e 578-586, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2017.09.082

Irf4 -dependent CD103 + CD11b + dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus

Autori: Judith-Mira Pohl, Sebastian Gutweiler, Stephanie Thiebes, Julia K Volke, Ludger Klein-Hitpass, Denise Zwanziger, Matthias Gunzer, Steffen Jung, William W Agace, Christian Kurts, Daniel Robert Engel
Pubblicato in: Gut, Numero 66/12, 2017, Pagina/e 2110-2120, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2017-313856

Exploiting the S4–S5 Specificity of Human Neutrophil Proteinase 3 to Improve the Potency of Peptidyl Di(chlorophenyl)-phosphonate Ester Inhibitors: A Kinetic and Molecular Modeling Analysis

Autori: Carla Guarino, Natalia Gruba, Renata Grzywa, Edyta Dyguda-Kazimierowicz, Yveline Hamon, Monika Łȩgowska, Marcin Skoreński, Sandrine Dallet-Choisy, Sylvain Marchand-Adam, Christine Kellenberger, Dieter E. Jenne, Marcin Sieńczyk, Adam Lesner, Francis Gauthier, Brice Korkmaz
Pubblicato in: Journal of Medicinal Chemistry, Numero 61/5, 2018, Pagina/e 1858-1870, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.7b01416

Lymphatic exosomes promote dendritic cell migration along guidance cues

Autori: Markus Brown, Louise A. Johnson, Dario A. Leone, Peter Majek, Kari Vaahtomeri, Daniel Senfter, Nora Bukosza, Helga Schachner, Gabriele Asfour, Brigitte Langer, Robert Hauschild, Katja Parapatics, Young-Kwon Hong, Keiryn L. Bennett, Renate Kain, Michael Detmar, Michael Sixt, David G. Jackson, Dontscho Kerjaschki
Pubblicato in: The Journal of Cell Biology, 2018, Pagina/e jcb.201612051, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.201612051

Review: What Is the Current Evidence for Disease Subsets in Giant Cell Arteritis?

Autori: Kornelis S. M. van der Geest, Maria Sandovici, Yannick van Sleen, Jan-Stephan Sanders, Nicolaas A. Bos, Wayel H. Abdulahad, Coen A. Stegeman, Peter Heeringa, Abraham Rutgers, Cees G. M. Kallenberg, Annemieke M. H. Boots, Elisabeth Brouwer
Pubblicato in: Arthritis & Rheumatology, Numero 70/9, 2018, Pagina/e 1366-1376, ISSN 2326-5191
Editore: Wiley
DOI: 10.1002/art.40520

Urinary and serum soluble CD25 complements urinary soluble CD163 to detect active renal anti-neutrophil cytoplasmic autoantibody-associated vasculitis: a cohort study

Autori: Gerjan J Dekkema, Wayel H Abdulahad, Theo Bijma, Sarah M Moran, Louise Ryan, Mark A Little, Coen A Stegeman, Peter Heeringa, Jan Stephan Sanders
Pubblicato in: Nephrology Dialysis Transplantation, Numero March 2018, 2018, ISSN 0931-0509
Editore: Oxford University Press
DOI: 10.1093/ndt/gfy018

Cellular immune regulation in the pathogenesis of ANCA-associated vasculitides

Autori: Anouk von Borstel, Jan Stephan Sanders, Abraham Rutgers, Coen A. Stegeman, Peter Heeringa, Wayel H. Abdulahad
Pubblicato in: Autoimmunity Reviews, Numero 17/4, 2018, Pagina/e 413-421, ISSN 1568-9972
Editore: Elsevier BV
DOI: 10.1016/j.autrev.2017.12.002

Checks and Balances in Autoimmune Vasculitis

Autori: Rebeca Hid Cadena, Wayel H. Abdulahad, G. A. P. Hospers, T. T. Wind, Annemieke M. H. Boots, Peter Heeringa, Elisabeth Brouwer
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, Pagina/e 315, ISSN 1664-3224
Editore: Frontiers Media
DOI: 10.3389/fimmu.2018.00315

Comprehensive Proteoform Characterization of Plasma Complement Component C8αβγ by Hybrid Mass Spectrometry Approaches

Autori: Vojtech Franc, Jing Zhu, Albert J. R. Heck
Pubblicato in: Journal of The American Society for Mass Spectrometry, Numero 29/6, 2018, Pagina/e 1099-1110, ISSN 1044-0305
Editore: Elsevier BV
DOI: 10.1007/s13361-018-1901-6

Reprint of “Dual blockade of the pro-inflammatory chemokine CCL2 and the homeostatic chemokine CXCL12 is as effective as high dose cyclophosphamide in murine proliferative lupus nephritis”

Autori: Satish Kumar Devarapu, Santhosh Kumar VR, Khader Valli Rupanagudi, Onkar P. Kulkarni, Dirk Eulberg, Sven Klussmann, Hans-Joachim Anders
Pubblicato in: Clinical Immunology, Numero 185, 2017, Pagina/e 119-127, ISSN 1521-6616
Editore: Academic Press
DOI: 10.1016/j.clim.2017.10.011

Parsimonious Charge Deconvolution for Native Mass Spectrometry

Autori: Marshall Bern, Tomislav Caval, Yong J. Kil, Wilfred Tang, Christopher Becker, Eric Carlson, Doron Kletter, K. Ilker Sen, Nicolas Galy, Dominique Hagemans, Vojtech Franc, Albert J. R. Heck
Pubblicato in: Journal of Proteome Research, Numero 17/3, 2018, Pagina/e 1216-1226, ISSN 1535-3893
Editore: American Chemical Society
DOI: 10.1021/acs.jproteome.7b00839

Direct quality control of glycoengineered erythropoietin variants

Autori: Tomislav Čaval, Weihua Tian, Zhang Yang, Henrik Clausen, Albert J. R. Heck
Pubblicato in: Nature Communications, Numero 9/1, 2018, Pagina/e 3342, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-05536-3

Therapeutic targeting of cathepsin C: from pathophysiology to treatment

Autori: Brice Korkmaz, George H. Caughey, Iain Chapple, Francis Gauthier, Josefine Hirschfeld, Dieter E. Jenne, Ralph Kettritz, Gilles Lalmanach, Anne-Sophie Lamort, Conni Lauritzen, Monika Łȩgowska, Adam Lesner, Sylvain Marchand-Adam, Sarah J. McKaig, Celia Moss, John Pedersen, Helen Roberts, Adrian Schreiber, Seda Seren, Nalin S. Thakker
Pubblicato in: Pharmacology & Therapeutics, Numero 190, 2018, Pagina/e 202-236, ISSN 0163-7258
Editore: Pergamon Press
DOI: 10.1016/j.pharmthera.2018.05.011

Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein

Autori: Melania Spadaro, Stephan Winklmeier, Eduardo Beltrán, Caterina Macrini, Romana Höftberger, Elisabeth Schuh, Franziska S. Thaler, Lisa Ann Gerdes, Sarah Laurent, Ramona Gerhards, Simone Brändle, Klaus Dornmair, Constanze Breithaupt, Markus Krumbholz, Markus Moser, Gurumoorthy Krishnamoorthy, Frits Kamp, Dieter Jenne, Reinhard Hohlfeld, Tania Kümpfel, Hans Lassmann, Naoto Kawakami, Edgar Meinl
Pubblicato in: Annals of Neurology, Numero 84/2, 2018, Pagina/e 315-328, ISSN 0364-5134
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ana.25291

Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis

Autori: Seda Seren, Maha Rashed Abouzaid, Claudia Eulenberg-Gustavus, Josefine Hirschfeld, Hala Nasr Soliman, Uwe Jerke, Koffi N'Guessan, Sandrine Dallet-Choisy, Adam Lesner, Conni Lauritzen, Beate Schacher, Peter Eickholz, Nikoletta Nagy, Marta Szell, Cécile Croix, Marie-Claude Viaud-Massuard, Abdullah Al Farraj Aldosari, Shivanna Ragunatha, Mostafa Ibrahim Mostafa, Francesca Giampieri, Maurizio Battino
Pubblicato in: Journal of Biological Chemistry, Numero 293/32, 2018, Pagina/e 12415-12428, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.RA118.001922

Extracellular traps in kidney disease

Autori: Daigo Nakazawa, Julian A. Marschner, Louise Platen, Hans-Joachim Anders
Pubblicato in: Kidney International, Numero 94/6, 2018, Pagina/e 1087-1098, ISSN 0085-2538
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2018.08.035

Dendritic cells and routing cargo into exosomes

Autori: Dario A Leone, Andrew J Rees, Renate Kain
Pubblicato in: Immunology and Cell Biology, Numero 96/7, 2018, Pagina/e 683-693, ISSN 0818-9641
Editore: Blackwell Publishing Inc.
DOI: 10.1111/imcb.12170

Circulating cathepsin-S levels correlate with GFR decline and sTNFR1 and sTNFR2 levels in mice and humans

Autori: Dominik Steubl, Santhosh V. Kumar, Maia Tato, Shrikant R. Mulay, Anders Larsson, Lars Lind, Ulf Risérus, Lutz Renders, Uwe Heemann, Axel C. Carlsson, Johan Ärnlöv, Hans-Joachim Anders
Pubblicato in: Scientific Reports, Numero 7, 2017, Pagina/e 43538, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep43538

HLA and kidney disease: from associations to mechanisms

Autori: Kate J. Robson, Joshua D. Ooi, Stephen R. Holdsworth, Jamie Rossjohn, A. Richard Kitching
Pubblicato in: Nature Reviews Nephrology, Numero 14/10, 2018, Pagina/e 636-655, ISSN 1759-5061
Editore: Nature Publishing Group
DOI: 10.1038/s41581-018-0057-8

ANCA-Associated Vasculitis: Pathogenesis, Models, and Preclinical Testing

Autori: Holly L. Hutton, Stephen R. Holdsworth, A. Richard Kitching
Pubblicato in: Seminars in Nephrology, Numero 37/5, 2017, Pagina/e 418-435, ISSN 0270-9295
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.semnephrol.2017.05.016

A Novel Role for GATA3 in Mesangial Cells in Glomerular Development and Injury

Autori: Irina V. Grigorieva, Andre Oszwald, Elena F. Grigorieva, Helga Schachner, Barbara Neudert, Tammo Ostendorf, Jürgen Floege, Maja T. Lindenmeyer, Clemens D. Cohen, Ulf Panzer, Christof Aigner, Alice Schmidt, Frank Grosveld, Rajesh V. Thakker, Andrew Jackson Rees, Renate Kain
Pubblicato in: Journal of the American Society of Nephrology, Numero 30/9, 2019, Pagina/e 1641-1658, ISSN 1046-6673
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2018111143

Decreased Expression of Negative Immune Checkpoint VISTA by CD4+ T Cells Facilitates T Helper 1, T Helper 17, and T Follicular Helper Lineage Differentiation in GCA

Autori: Rebeca Hid Cadena, Rosanne D. Reitsema, Minke G. Huitema, Yannick van Sleen, Kornelis S. M. van der Geest, Peter Heeringa, Annemieke M. H. Boots, Wayel H. Abdulahad, Elisabeth Brouwer
Pubblicato in: Frontiers in Immunology, Numero 10, 2019, ISSN 1664-3224
Editore: Frontiers in Immunology
DOI: 10.3389/fimmu.2019.01638

Leukocyte Dynamics Reveal a Persistent Myeloid Dominance in Giant Cell Arteritis and Polymyalgia Rheumatica

Autori: Yannick van Sleen, Jacoba C. Graver, Wayel H. Abdulahad, Kornelis S. M. van der Geest, Annemieke M. H. Boots, Maria Sandovici, Elisabeth Brouwer
Pubblicato in: Frontiers in Immunology, Numero 10, 2019, ISSN 1664-3224
Editore: Frontiers in Immunology
DOI: 10.3389/fimmu.2019.01981

The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients

Autori: Iris Marti Fernandez, Caterina Macrini, Markus Krumbholz, Paul J. Hensbergen, Agnes L. Hipgrave Ederveen, Stephan Winklmeier, Atay Vural, Asli Kurne, Dieter Jenne, Frits Kamp, Lisa Ann Gerdes, Reinhard Hohlfeld, Manfred Wuhrer, Tania Kümpfel, Edgar Meinl
Pubblicato in: Frontiers in Immunology, Numero 10, 2019, ISSN 1664-3224
Editore: Frontiers in Immunology
DOI: 10.3389/fimmu.2019.01189

Premedication with a cathepsin C inhibitor alleviates early primary graft dysfunction in mouse recipients after lung transplantation

Autori: Salome R. T. Rehm, Natalia F. Smirnova, Carmela Morrone, Jessica Götzfried, Annette Feuchtinger, John Pedersen, Brice Korkmaz, Ali Önder Yildirim, Dieter E. Jenne
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-46206-8

Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases

Autori: Carla Guarino, Yveline Hamon, C?cile Croix, Anne-Sophie Lamort, Sandrine Dallet-Choisy, Sylvain Marchand-Adam, Adam Lesner, Thomas Baranek, Marie-Claude Viaud-Massuard, Conni Lauritzen, John Pedersen, Nathalie Heuz?-Vourc'h, Mustapha Si-Tahar, Erhan F?ratl?, Dieter E. Jenne, Francis Gauthier, Marshall S. Horwitz, Niels Borregaard, Brice Korkmaz
Pubblicato in: Biochemical Pharmacology, Numero 131, 2017, Pagina/e 52-67, ISSN 0006-2952
Editore: Elsevier BV
DOI: 10.1016/j.bcp.2017.02.009

Common coding variant in SERPINA1 increases the risk for large artery stroke

Autori: Rainer Malik, Therese Dau, Maria Gonik, Anirudh Sivakumar, Daniel J. Deredge, Evgeniia V. Edeleva, Jessica G?tzfried, Sander W. van der Laan, Gerard Pasterkamp, Nathalie Beaufort, Susana Seixas, Steve Bevan, Lisa F. Lincz, Elizabeth G. Holliday, Annette I. Burgess, Kristiina Rannikm?e, Jens Minnerup, Jennifer Kriebel, Melanie Waldenberger, Martina M?ller-Nurasyid, Peter Lichtner, Danish Saleheen,
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 114/14, 2017, Pagina/e 3613-3618, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1616301114

Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis

Autori: M. Honarpisheh, J. Desai, J. A. Marschner, M. Weidenbusch, M. Lech, V. Vielhauer, H.-J. Anders, S. R. Mulay
Pubblicato in: Bioscience Reports, Numero 36/6, 2016, Pagina/e e00425-e00425, ISSN 0144-8463
Editore: Kluwer Academic Publishers
DOI: 10.1042/BSR20160336

Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases

Autori: Yveline Hamon, Monika Legowska, Virginie Hervé, Sandrine Dallet-Choisy, Sylvain Marchand-Adam, Lise Vanderlynden, Michèle Demonte, Rich Williams, Christopher J. Scott, Mustapha Si-Tahar, Nathalie Heuzé-Vourc'h, Gilles Lalmanach, Dieter E. Jenne, Adam Lesner, Francis Gauthier, Brice Korkmaz
Pubblicato in: Journal of Biological Chemistry, Numero 291/16, 2016, Pagina/e 8486-8499, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M115.707109

Surface LAMP-2 Is an Endocytic Receptor That Diverts Antigen Internalized by Human Dendritic Cells into Highly Immunogenic Exosomes

Autori: Dario Armando Leone, Andrea Peschel, Markus Brown, Helga Schachner, Miriam J. Ball, Marianna Gyuraszova, Ulrike Salzer-Muhar, Minoru Fukuda, Caterina Vizzardelli, Barbara Bohle, Andrew J. Rees, Renate Kain
Pubblicato in: The Journal of Immunology, 2017, Pagina/e ji1601263, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1601263

Cellular and Molecular Mechanisms of Autoimmunity and Lupus Nephritis

Autori: S.K. Devarapu, G. Lorenz, O.P. Kulkarni, H.-J. Anders, S.R. Mulay
Pubblicato in: International Review of Cell and Molecular Biology, 2017, Pagina/e 43-154, ISSN 1937-6448
Editore: Elsevier BV
DOI: 10.1016/bs.ircmb.2016.12.001

Quantitative analysis of protease recognition by inhibitors in plasma using microscale thermophoresis

Autori: T. Dau, E. V. Edeleva, S. A. I. Seidel, R. A. Stockley, D. Braun, D. E. Jenne
Pubblicato in: Scientific Reports, Numero 6/1, 2016, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep35413

Animal Models of ANCA Associated Vasculitis

Autori: Lani Shochet, Stephen Holdsworth, A. Richard Kitching
Pubblicato in: Frontiers in Immunology, Numero 11, 2020, ISSN 1664-3224
Editore: Frontiers in Immunology
DOI: 10.3389/fimmu.2020.00525

Proteoform Profile Mapping of the Human Serum Complement Component C9 Revealing Unexpected New Features of N -, O -, and C -Glycosylation

Autori: Vojtech Franc, Yang Yang, Albert J. R. Heck
Pubblicato in: Analytical Chemistry, Numero 89/6, 2017, Pagina/e 3483-3491, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.6b04527

Resolving the micro-heterogeneity and structural integrity of monoclonal antibodies by hybrid mass spectrometric approaches

Autori: Yang Yang, Guanbo Wang, Ting Song, Carlito B. Lebrilla, Albert J. R. Heck
Pubblicato in: mAbs, Numero 9/4, 2017, Pagina/e 638-645, ISSN 1942-0870
Editore: Landes Bioscience
DOI: 10.1080/19420862.2017.1290033

Preservation with α1-antitrypsin improves primary graft function of murine lung transplants

Autori: Jessica Götzfried, Natalia F. Smirnova, Carmela Morrone, Brice Korkmaz, Ali Önder Yildirim, Oliver Eickelberg, Dieter E. Jenne
Pubblicato in: The Journal of Heart and Lung Transplantation, Numero 37/8, 2018, Pagina/e 1021-1028, ISSN 1053-2498
Editore: Elsevier BV
DOI: 10.1016/j.healun.2018.03.015

Neutrophil myeloperoxidase harbors distinct site-specific peculiarities in its glycosylation

Autori: Karli R. Reiding, Vojtech Franc, Minke G. Huitema, Elisabeth Brouwer, Peter Heeringa, Albert J.R. Heck
Pubblicato in: Journal of Biological Chemistry, Numero 294/52, 2019, Pagina/e 20233-20245, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.011098

The glomerular crescent

Autori: Lidia Anguiano, Renate Kain, Hans-Joachim Anders
Pubblicato in: Current Opinion in Nephrology and Hypertension, Numero 29/3, 2020, Pagina/e 302-309, ISSN 1062-4821
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mnh.0000000000000596

A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity

Autori: Joshua D. Ooi, Jhih-Hang Jiang, Peter J. Eggenhuizen, Ling L. Chua, Mirjan van Timmeren, Khai L. Loh, Kim M. O’Sullivan, Poh Y. Gan, Yong Zhong, Kirill Tsyganov, Lani R. Shochet, Jessica Ryan, Coen A. Stegeman, Lars Fugger, Hugh H. Reid, Jamie Rossjohn, Peter Heeringa, Stephen R. Holdsworth, Anton Y. Peleg, A. Richard Kitching
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-11255-0

Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury

Autori: Maia Tato, Santhosh V. Kumar, Yajuan Liu, Shrikant R. Mulay, Solange Moll, Bastian Popper, Jonathan N. Eberhard, Dana Thomasova, Arne Christian Rufer, Sabine Gruner, Wolfgang Haap, Guido Hartmann, Hans-Joachim Anders
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-017-01894-y

Chemokine receptor co-expression reveals aberrantly distributed TH effector memory cells in GPA patients

Autori: Lucas L. Lintermans, Abraham Rutgers, Coen A. Stegeman, Peter Heeringa, Wayel H. Abdulahad
Pubblicato in: Arthritis Research & Therapy, Numero 19/1, 2017, Pagina/e 136, ISSN 1478-6362
Editore: BioMed Central
DOI: 10.1186/s13075-017-1343-8

Towards precision medicine in ANCA-associated vasculitis

Autori: Kornelis S M van der Geest, Elisabeth Brouwer, Jan-Stephan Sanders, Maria Sandovici, Nicolaas A Bos, Annemieke M H Boots, Wayel H Abdulahad, Coen A Stegeman, Cees G M Kallenberg, Peter Heeringa, Abraham Rutgers
Pubblicato in: Rheumatology, 2017, Pagina/e 1332, ISSN 1462-0324
Editore: Oxford University Press
DOI: 10.1093/rheumatology/kex367

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Pubblicato in: Frontiers in Immunology, Numero 8, 2017, Pagina/e 1205, ISSN 1664-3224
Editore: Frontiers Research Foundation
DOI: 10.3389/fimmu.2017.01205

Remote Activation of a Latent Epitope in an Autoantigen Decoded with Simulated B-Factors

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Pubblicato in: Frontiers in Immunology, Numero 1, 2019, ISSN 1664-3224
Editore: Frontiers in Immunology
DOI: 10.1101/559963

Discovery and Quantification of Nonhuman Proteins in Human Milk

Autori: Jing Zhu, Luc Garrigues, Henk Van den Toorn, Bernd Stahl, Albert J. R. Heck
Pubblicato in: Journal of Proteome Research, 2018, ISSN 1535-3893
Editore: American Chemical Society
DOI: 10.1021/acs.jproteome.8b00550

Deviation of antigen presentation through (auto)antibodies

Autori: Kain R.
Pubblicato in: Séminaire Hospitalo-Universitaire de Strasbourg, Numero 20/09/2018, 2018
Editore: Université de Strasbourg

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Pubblicato in: 2016
Editore: Omics International

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Pubblicato in: Mitteilungen der Deutschen Gesellschaft für Nephrologie, Numero 2, 2016, Pagina/e 20-23
Editore: Deutschen Gesellschaft für Nephrologie

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Pubblicato in: Medical Tribune Online, 2016, Pagina/e 1
Editore: Medical Tribune

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Autori: Hubert V.
Pubblicato in: Numero 14/11/2017, 2017
Editore: Medical University Vienna

ISN Nexus 2016 Symposia: Translational Immunology in Kidney Disease—The Berlin Roadmap

Autori: Hans-Joachim Anders, Brad Rovin, David Jayne, Paul Brunetta, Rosanna Coppo, Anne Davidson, Satish Kumar Devarapu, Dick de Zeeuw, Jeremy Duffield, Dirk Eulberg, Alberto Fierro, Jürgen Floege, Steffen Frese, Loïc Guillevin, Stephen Holdsworth, Jeremy Hughes, Ralph Kettritz, Malte Kluger, Christian Krebs, Larissa Lapteva, Adeera Levin, Jinhua Li, Liz Lightstone, Matthias Mack, Ladan Mansouri, Steph
Pubblicato in: Kidney International Reports, Numero 1/4, 2016, Pagina/e 327-339, ISSN 2468-0249
Editore: Elsevier Inc.
DOI: 10.1016/j.ekir.2016.06.009

The Role of Macroautophagy in T Cells

Autori: Wei Jia, Ian McLeod, Ming-Xiao He, You-Wen He
Pubblicato in: Immunology, 2018, Pagina/e 23-33, ISBN 9780-128098196
Editore: Elsevier
DOI: 10.1016/b978-0-12-809819-6.00003-4

Isolation of exosomes from body fluids by differential ultracentrifugation

Autori: Schulz S, Schachner H, Rees AJ, Kain R.
Pubblicato in: Poster, 2019
Editore: 15th YSA PhD Symposium

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