Probing safety of nano-objects by defining immune responses of environmental organisms

Información del proyecto

PANDORA

Identificador del acuerdo de subvención: 671881

DOI

10.3030/671881

Proyecto cerrado

Fecha de la firma de la CE 10 Agosto 2015

Fecha de inicio 1 Enero 2016

Fecha de finalización 31 Diciembre 2019

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 2 814 491,16

Aportación de la UE

€ 2 814 491,16

Coordinado por

CONSIGLIO NAZIONALE DELLE RICERCHE
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (15)

NP interaction with innate immune cells/receptors

Report encompassing the joint results of individual projects 1, 2, 3, 5, 10, 11.

Industrial outreach

Reports on industrial outreach activities Multiple delivery dates Months 18 30 42

Local training

Reports on local training activities. Multiple delivery dates: Months 18, 30, 42.

Secondments

Reports on secondments Multiple delivery dates Months 25 43

Setting up immuno-risk predictive cell-based in vitro assays

Report encompassing the joint results of individual projects 1, 2, 3, 9, 11.

Virtual outreach

Reports on virtual outreach activities. Multiple delivery dates: Months 18, 30, 42.

Defining biomarkers of environmental immuno-risk

Report encompassing the joint results of individual projects 1-11.

Academic outreach

Reports on academic outreach activities. Multiple delivery dates: Months 18, 30, 42.

Dissemination

Reports on dissemination activities. Multiple delivery dates: Months 12, 24, 36, 48.

Individual CDP

Preparation of individual Career Development Plans.

Modulation of immune-pathogen interaction by NP

Report encompassing the joint results of individual projects 1, 2, 3, 5, 6, 7, 8, 10.

PhD thesis

PhD thesis for all ESR.

SSC activities

Organisation of Short Scientific Courses. Multiple delivery dates: Months 10, 22, 34.

Recruitment

Report on the recruitment process, including publication of call, CV evaluation, interview outcome, final decision on the fellows.

SCT activities

Organisation of Short Courses of Transferrable training (SCT). Multiple delivery dates: Months 16, 28, 40.

Websites, patent fillings, videos etc. (1)

Website

Development of the project website.

Other (2)

Scientific meetings

Scientific meetings organisation. Multiple delivery dates: Months 10, 22, 34.

Final Workshop

Final Workshop organisation.

Publicaciones

Peer reviewed articles (20)

Probing safety of nanoparticles by outlining sea urchin sensing and signaling cascades

Autores: Andi Alijagic, Annalisa Pinsino
Publicado en: Ecotoxicology and Environmental Safety, Edición 144, 2017, Página(s) 416-421, ISSN 0147-6513
Editor: Academic Press
DOI: 10.1016/j.ecoenv.2017.06.060

Formation of the Protein Corona: The Interface between Nanoparticles and the Immune System

Autores: Francesco Barbero, Lorenzo Russo, Michele Vitali, Jordi Piella, Ignacio Salvo, Mireya L. Borrajo, Marti Busquets-Fité, Rita Grandori, Neus G. Bastús, Eudald Casals, Victor Puntes
Publicado en: Seminars in Immunology, Edición 34, 2017, Página(s) 52-60, ISSN 1044-5323
Editor: Academic Press
DOI: 10.1016/j.smim.2017.10.001

Sea Urchin Extracellular Proteins Design a Complex Protein Corona on Titanium Dioxide Nanoparticle Surface Influencing Immune Cell Behavior

Autores: Andi Alijagic, Oldřich Benada, Olga Kofroňová, Diego Cigna, Annalisa Pinsino
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: -
DOI: 10.3389/fimmu.2019.02261

Effects of nanosilver on Mytilus galloprovincialis hemocytes and early embryo development

Autores: M. Auguste, C. Ciacci, T. Balbi, A. Brunelli, V. Caratto, A. Marcomini, R. Cuppini, L. Canesi
Publicado en: Aquatic Toxicology, Edición 203, 2018, Página(s) 107-116, ISSN 0166-445X
Editor: Elsevier BV
DOI: 10.1016/j.aquatox.2018.08.005

In vivo immunomodulatory and antioxidant properties of nanoceria (nCeO2) in the marine mussel Mytilus galloprovincialis

Autores: M. Auguste, T. Balbi, M. Montagna, R. Fabbri, M. Sendra, J. Blasco, L. Canesi
Publicado en: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, Edición 219, 2019, Página(s) 95-102, ISSN 1532-0456
Editor: Elsevier BV
DOI: 10.1016/j.cbpc.2019.02.006

Exposure to TiO2 nanoparticles induces shifts in the microbiota composition of Mytilus galloprovincialis hemolymph

Autores: Manon Auguste, Aide Lasa, Alberto Pallavicini, Stefano Gualdi, Luigi Vezzulli, Laura Canesi
Publicado en: Science of The Total Environment, Edición 670, 2019, Página(s) 129-137, ISSN 0048-9697
Editor: Elsevier BV
DOI: 10.1016/j.scitotenv.2019.03.133

Interaction of engineered nanomaterials with the immune system: Health-related safety and possible benefits

Autores: Diana Boraschi, Benjamin J. Swartzwelter, Paola Italiani
Publicado en: Current Opinion in Toxicology, Edición 10, 2018, Página(s) 74-83, ISSN 2468-2020
Editor: -
DOI: 10.1016/j.cotox.2018.02.002

IL-1β induces expression of costimulatory molecules and cytokines but not immune feedback regulators in dendritic cells

Autores: Sara Michelini, Muamera Sarajlic, Albert Duschl, Jutta Horejs-Hoeck
Publicado en: Human Immunology, Edición 79/8, 2018, Página(s) 610-615, ISSN 0198-8859
Editor: Elsevier BV
DOI: 10.1016/j.humimm.2018.06.002

Sea urchin Paracentrotus lividus immune cells in culture: formulation of the appropriate harvesting and culture media and maintenance conditions

Autores: Annalisa Pinsino, Andi Alijagic
Publicado en: Biology Open, Edición 8/3, 2019, Página(s) bio039289, ISSN 2046-6390
Editor: -
DOI: 10.1242/bio.039289

First person – Annalisa Pinsino and Andi Alijagic

Autores: A. Pinsino, and A. Alijagic
Publicado en: Biology Open, Edición 8/3, 2019, Página(s) bio042242, ISSN 2046-6390
Editor: -
DOI: 10.1242/bio.042242

Developmental and Immune Role of a Novel Multiple Cysteine Cluster TLR From Eisenia andrei Earthworms

Autores: Petra Prochazkova, Radka Roubalova, Frantisek Skanta, Jiri Dvorak, Natividad Isabel Navarro Pacheco, Miroslav Kolarik, Martin Bilej
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: -
DOI: 10.3389/fimmu.2019.01277

Titanium dioxide nanoparticles temporarily influence the sea urchin immunological state suppressing inflammatory-relate gene transcription and boosting antioxidant metabolic activity

Autores: Andi Alijagic, Daniela Gaglio, Elisabetta Napodano, Roberta Russo, Caterina Costa, Oldřich Benada, Olga Kofroňová, Annalisa Pinsino
Publicado en: Journal of Hazardous Materials, Edición 384, 2020, Página(s) 121389, ISSN 0304-3894
Editor: Elsevier BV
DOI: 10.1016/j.jhazmat.2019.121389

Pattern recognition receptors in annelids

Autores: P. Prochazkova, R. Roubalova, J. Dvorak, N.I. Navarro Pacheco, M. Bilej
Publicado en: Developmental & Comparative Immunology, Edición 102, 2020, Página(s) 103493, ISSN 0145-305X
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.dci.2019.103493

Shift in Immune Parameters After Repeated Exposure to Nanoplastics in the Marine Bivalve Mytilus

Autores: Manon Auguste, Teresa Balbi, Caterina Ciacci, Barbara Canonico, Stefano Papa, Alessio Borello, Luigi Vezzulli, Laura Canesi
Publicado en: Frontiers in Immunology, Edición 11, 2020, Página(s) 426, ISSN 1664-3224
Editor: -
DOI: 10.3389/fimmu.2020.00426

Dynamic Equilibrium in the Cetyltrimethylammonium Bromide–Au Nanoparticle Bilayer, and the Consequent Impact on the Formation of the Nanoparticle Protein Corona

Autores: Francesco Barbero, Oscar H. Moriones, Neus G. Bastús, Victor Puntes
Publicado en: Bioconjugate Chemistry, Edición 30/11, 2019, Página(s) 2917-2930, ISSN 1043-1802
Editor: American Chemical Society
DOI: 10.1021/acs.bioconjchem.9b00624

Surface Exposure of PEG and Amines on Biodegradable Nanoparticles as a Strategy to Tune Their Interaction with Protein-Rich Biological Media

Autores: Claudia Conte, Giovanni Dal Poggetto, Benjamin J. Swartzwelter, Diletta Esposito, Francesca Ungaro, Paola Laurienzo, Diana Boraschi, Fabiana Quaglia
Publicado en: Nanomaterials, Edición 9/10, 2019, Página(s) 1354, ISSN 2079-4991
Editor: -
DOI: 10.3390/nano9101354

Addressing Nanomaterial Immunosafety by Evaluating Innate Immunity across Living Species

Autores: Diana Boraschi, Andi Alijagic, Manon Auguste, Francesco Barbero, Eleonora Ferrari, Szabolcs Hernadi, Craig Mayall, Sara Michelini, Natividad I. Navarro Pacheco, Alessandra Prinelli, Elmer Swart, Benjamin J. Swartzwelter, Neus G. Bastús, Laura Canesi, Damjana Drobne, Albert Duschl, Marie‐Ann Ewart, Jutta Horejs‐Hoeck, Paola Italiani, Birgit Kemmerling, Peter Kille, Petra Prochazkova, Victor F.
Publicado en: Small, Edición 16/21, 2020, Página(s) 2000598, ISSN 1613-6810
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202000598

Mechanisms of particles in sensitization, effector function and therapy of allergic disease.

Autores: A.I. Joubert, M. Geppert, L. Johnson, R. Mills-Goodlet, S. Michelini, E. Korotchenko, A. Duschl, R. Weiss, J. Horejs-Höck and M. Himly
Publicado en: Front. Immunol, Edición 11, 2020, Página(s) 1334
Editor: -
DOI: 10.3389/fimmu.2020.01334

Gold Nanoparticles Modulate BCG-Induced Innate Immune Memory in Human Monocytes by Shifting the Memory Response towards Tolerance

Autores: Benjamin J. Swartzwelter, Francesco Barbero, Alessandro Verde, Maria Mangini, Marinella Pirozzi, Anna Chiara De Luca, Victor F. Puntes, Luciana C. C. Leite, Paola Italiani, Diana Boraschi
Publicado en: Cells, Edición 9/2, 2020, Página(s) 284, ISSN 2073-4409
Editor: -
DOI: 10.3390/cells9020284

The Effects of in Vivo Exposure to Copper Oxide Nanoparticles on the Gut Microbiome, Host Immunity and Susceptibility to a Bacterial Infection in Earthworms

Autores: Elmer Swart, Jiri Dvorak, Szabolcs Hernádi, Tim Goodall, Peter Kille, David Spurgeon, Claus Svendsen and Petra Prochazkova
Publicado en: Nanomaterials, Edición 10, 2020, Página(s) 1337
Editor: -
DOI: 10.3390/nano10071337

Book chapters (1)

Annelida: Environmental Interactions and Ecotoxicity in Relation to the Earthworm Immune System

Autores: Radka Roubalová, Barbara Płytycz, Petra Procházková, Natividad Isabel Navarro Pacheco, Martin Bilej
Publicado en: Advances in Comparative Immunology, 2018, Página(s) 933-951, ISBN 978-3-319-76767-3
Editor: Springer International Publishing
DOI: 10.1007/978-3-319-76768-0_27