Combatting the CardioRenal Syndrome: towards an integrative Analysis to reduce cardiovascular burden in chronic kidney disease

Informazioni relative al progetto

CaReSyAn

ID dell’accordo di sovvenzione: 764474

DOI

10.3030/764474

Progetto chiuso

Data della firma CE 10 Agosto 2017

Data di avvio 1 Gennaio 2018

Data di completamento 31 Dicembre 2021

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 2 795 346,00

Contributo UE

€ 2 795 346,00

Coordinato da

UNIVERSITAETSKLINIKUM AACHEN
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (2)

List of awarded doctoral degrees

A list of awarded doctoral degrees will be provided

ESR recruitment call for distribution

The MT will advertise for all ESR positions simultaneously within Europe to recruit the best possible candidates, and this through i) websites of CaReSyAn partners and Nature-jobs; ii) websites of related consortia (e.g. iMODE-CKD) and scientific foundations of which partners are members of (ERA-EDTA; EUTox); iii) active recruitment within own networks; and iv) targeting the peer-to-peer International Student Congress of (bio)Medical Sciences (ISCOMS) and its European partners in the International Federation of Medical Students Associations (IFMSA). The advertisements will give a broad description of knowledge and competencies required, but will not be so specialized to discourage suitable applicants. A transparent description of procedures of admission, supervision, awarding of doctoral degree, working conditions and career development prospects will be included.

Other (1)

Videoclips for the lay public

We will prepare an educational video clip on CRS pathology and risk factors, as well as video clip explaining each ESR project for the lay public. These video clips will become freely available on the CaReSyAn website.

Websites, patent fillings, videos etc. (2)

Frontiers Review Topics Series end eBook by CaReSyAn partners on CRS

A special Frontiers Review Topics Series and associated eBook is planned within the Open Access Journal Frontiers with contributions of the CaReSyAn partners and ESRs on the burden pathology and open research question of the CRS and with reference to the CaReSyAn Consortium

CaReSyAn website, Facebook profile and Twitter account

We will install a website, Facebook profile and Twitter account as important means of dissemination and outreach.

Pubblicazioni

Peer reviewed articles (20)

Reduction of protein-bound uraemic toxins in plasma of chronic renal failure patients: A systematic review

Autori: V. Saar-Kovrov, W. Zidek, S. Orth-Alampour, D. Fliser, V. Jankowski, E. A. L. Biessen, J. Jankowski
Pubblicato in: Journal of Internal Medicine, 2021, ISSN 1365-2796
Editore: John Wiley & Sons Ltd
DOI: 10.1111/joim.13248

Serum and urinary biomarkers of collagen type-I turnover predict prognosis in patients with heart failure

Autori: Tianlin He, Jesus D Melgarejo, Andrew L Clark, Yu-Ling Yu, Lutgarde Thijs, Javier Díez, Begoña López, Arantxa González, John G Cleland, Joost P Schanstra, Antonia Vlahou, Agnieszka Latosinska, Harald Mischak, Jan A Staessen, Zhen-Yu Zhang, Vera Jankowski
Pubblicato in: Clinical and translational medicine, 2021, ISSN 2001-1326
Editore: John Wiley & Sons Ltd
DOI: 10.1002/ctm2.267

Urine peptidome analysis in cardiorenal syndrome reflects molecular processes

Autori: Eleni Petra, Tianlin He, Vasiliki Lygirou, Agnieszka Latosinska, Harald Mischak, Antonia Vlahou, Joachim Jankowski
Pubblicato in: Scientific Reports, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-95695-z

Development of the BioHybrid Assay: Combining Primary Human Vascular Smooth Muscle Cells and Blood to Measure Vascular Calcification Propensity

Autori: Armand M G Jaminon, Asim C Akbulut, Niko Rapp, Rafael Kramann, Erik A L Biessen, Lieve Temmerman, Barend Mees, Vincent Brandenburg, Robert Dzhanaev, Willi Jahnen-Dechent, Juergen Floege, Jouni Uitto, Chris P Reutelingsperger, Leon J Schurgers
Pubblicato in: Cells, 2021, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10082097

Hepatic and Vascular Vitamin K Status in Patients with High Cardiovascular Risk

Autori: Nikolas Rapp; Vincent Brandenburg; Nadine Kaesler; Stephan J. L. Bakker; Robert Stöhr; Alexander Schuh; Pieter Evenepoel; Leon J. Schurgers; Leon J. Schurgers
Pubblicato in: Nutrients, Numero 1, 2021, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13103490

Menaquinone-7 Supplementation Improves Osteogenesis in Pluripotent Stem Cell Derived Mesenchymal Stem Cells

Autori: Asim Cengiz Akbulut, Grzegorz B. Wasilewski, Nikolas Rapp, Francesco Forin, Heike Singer, Katrin J. Czogalla-Nitsche and Leon J. Schurgers
Pubblicato in: Frontiers in Cell and Developmental Biology, 2021, ISSN 2296-634X
Editore: Frontiers Media SA
DOI: 10.3389/fcell.2020.618760

Uremic Toxins and Vascular Calcification–Missing the Forest for All the Trees

Autori: Nikolas Rapp, Pieter Evenepoel, Peter Stenvinkel, Leon Schurgers
Pubblicato in: Toxins, 2020, ISSN 2072-6651
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins12100624

The Role of Vascular Smooth Muscle Cells in Arterial Remodeling: Focus on Calcification-Related Processes.

Autori: Jaminon, Armand; Reesink, Koen; Kroon, Abraham; Schurgers, Leon
Pubblicato in: International Journal of Molecular Sciences, Numero 1, 2019, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20225694

Associations of urinary polymeric immunoglobulin receptor peptides in the context of cardio-renal syndrome.

Autori: Tianlin He; Justyna Siwy; Jochen Metzger; William Mullen; Harald Mischak; Joost P. Schanstra; Joost P. Schanstra; Petra Zürbig; Vera Jankowski
Pubblicato in: Scientific Reports, Numero 1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-65154-2

Collagen-Derived Peptides in CKD: A Link to Fibrosis

Autori: Emmanouil Mavrogeorgis; Harald Mischak; Agnieszka Latosinska; Antonia Vlahou; Joost P. Schanstra; Justyna Siwy; Vera Jankowski; Joachim Beige; Joachim Jankowski
Pubblicato in: Toxins; Volume 14; Numero 1; Pages: 10, Numero 1, 2022, ISSN 2072-6651
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins14010010

Shedding of Klotho: Functional Implications in Chronic Kidney Disease and Associated Vascular Disease

Autori: Valeria Saar-Kovrov, Marjo M. P. C. Donners and Emiel P. C. van der Vorst
Pubblicato in: Frontiers in Cardiovascular Medicine, 2021, ISSN 2297-055X
Editore: Frontiers Media SA
DOI: 10.3389/fcvm.2020.617842

Uremic Toxins Affecting Cardiovascular Calcification: A Systematic Review

Autori: Jana Holmar, Sofia de la Puente-Secades, Jürgen Floege, Heidi Noels, Joachim Jankowski, Setareh Orth-Alampour
Pubblicato in: Cells, 2020, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells9112428

Urine peptidome in combination with transcriptomics analysis highlights MMP7, MMP14 and PCSK5 for further investigation in chronic kidney disease

Autori: Eleni Petra, Justyna Siwy, Antonia Vlahou, Joachim Jankowski
Pubblicato in: Plos One, 2022, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0262667

Senescent Cells in Early Vascular Ageing and Bone Disease of Chronic Kidney Disease—A Novel Target for Treatment

Autori: Sam Hobson, Samsul Arefin, Karolina Kublickiene, Paul Shiels, Peter Stenvinkel
Pubblicato in: Toxins, Numero 11/2, 2019, Pagina/e 82, ISSN 2072-6651
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins11020082

Urinary peptides in heart failure: a link to molecular pathophysiology

Autori: Tianlin He; Michaela Mischak; Andrew L. Clark; Ross T. Campbell; Christian Delles; Javier Díez; Gerasimos Filippatos; Alexandre Mebazaa; John J.V. McMurray; Arantxa González; Julia Raad; Rafael Stroggilos; Helle Bosselmann; Archie Campbell; Shona M. Kerr; Colette E. Jackson; Jane A. Cannon; Morten Schou; Nicolas Girerd; Patrick Rossignol; Alex McConnachie; Kasper Rossing; Joost P. Schanstra; Fai
Pubblicato in: European Journal of Heart Failure, Numero 1, 2021, ISSN 1879-0844
Editore: John Wiley & Sons Ltd
DOI: 10.1002/ejhf.2195

Editorial on the Special Issue “Comorbidities in Chronic Kidney Disease”

Autori: Heidi Noels, Joachim Jankowski
Pubblicato in: Toxins, 2020, ISSN 2072-6651
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins12060384

Peptides in Plasma, Urine, and Dialysate: Toward Unravelling Renal Peptide Handling

Autori: Tianlin He, Martin Pejchinovski, William Mullen, Joachim Beige, Harald Mischak, Vera Jankowski
Pubblicato in: Proteomics Clinical Applications, 2020, ISSN 1862-8354
Editore: John Wiley & Sons Ltd
DOI: 10.1002/prca.202000029

Development, establishment and validation of in vitro and ex vivo assays of vascular calcification

Autori: Jana Holmar, Heidi Noels, Michael Böhm, Shruti Bhargava, Joachim Jankowski, Setareh Orth-Alampour
Pubblicato in: Biochem Biophys Res Commun, 2020, ISSN 0006-291X
Editore: Academic Press
DOI: 10.1016/j.bbrc.2020.05.085

PRYNT: a tool for prioritization of disease candidates from proteomics data using a combination of shortest-path and random walk algorithms.

Autori: Franck Boizard; Bénédicte Buffin-Meyer; Bénédicte Buffin-Meyer; Julien Aligon; Olivier Teste; Joost P. Schanstra; Joost P. Schanstra; Julie Klein; Julie Klein
Pubblicato in: Scientific Reports, Numero 1, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-85135-3

Reproducibility Evaluation of Urinary Peptide Detection Using CE-MS

Autori: Emmanouil Mavrogeorgis; Harald Mischak; Agnieszka Latosinska; Justyna Siwy; Vera Jankowski; Joachim Jankowski
Pubblicato in: Molecules, Numero 1, 2021, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26237260