Addressing the dual emerging threats of African Swine Fever and Lumpy Skin Disease in Europe (DEFEND)

Informations projet

DEFEND

N° de convention de subvention: 773701

DOI

10.3030/773701

Projet clôturé

Date de signature de la CE 8 Mai 2018

Date de début 1 Juin 2018

Date de fin 30 Novembre 2023

Financé au titre de

• SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy

Coût total

€ 5 992 500,00

Contribution de l’UE

€ 5 599 999,50

Coordonné par

THE PIRBRIGHT INSTITUTE LBG
United Kingdom

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (25)

Report on the identification and characterisation of subclinical LSDV infection
Publication on literature review and risk factor analysis
Report on the phylodynamic analysis of ASFV and LSDV in Europe
Report on proposed LSDV and ASFV molecular diagnostic and genotyping protocols.
Guidelines to implement compartmentalization for ASF in the European context
Measuring the persistence of antibodies post-LSD in the Balkans
Report of fieldwork experiences, including maps, routes, types of transboundary movements, risk factors

Report of fieldwork experiences including maps routes types of transboundary movements risk factors

Report of the indirect LSDV transmission and LSDV transmission via artificial insemination
ASF vaccination and post vaccination monitoring to assess the efficiency of ASF vaccination
Risk analysis framework
Candidate genes for LSD resistance
Report on LSDV transmission using in vitro and in vivo infected vectors
Report on LSDV in meat and hides before and after treatment
Methodological report on the implementation techniques of fieldwork activities in a comparative perspective
Optimal Selection Strategy
Standards for post-LSD-vaccination monitoring
Dissemination and communications tools (poster, webpage, factsheet)
Practice abstracts

"The resulting innovative knowledge and easy accessible end-user material from this project will feed into the EIP-AGRI (The agricultural European Innovation Partnership) website for broad dissemination. The end-user material to be produced contains a substantial number of summaries for practitioners in the EIP common format (""practice abstracts""), including the characteristics of the project (e.g. contact details of partners, etc). A full package of practice abstracts will be produced by the project, containing all the outcomes/recommendations which are ready for practice.A ""practice abstract"" is a short summary of around 1000-1500 characters (word count – no spaces; see below) which describes the main information/recommendation/practice that can serve the end-users in their daily practice. A total target number of 15 practice abstracts is foreseen for the project. A third of them are expected to be delivered in the first batch."

Influence of co-incident vaccination on immune parameters associated with LSD vaccination
Methodology to estimate ASF prevalence in wild boar in endemic and epidemic areas
Candidate genes for ASF resistance
Policy brief on implications, impacts, recommendations on conflict, migration and virus spread
Report on the ASFV and LSDV complete genome sequences generated in the project
GWAS results
Report on the PCR and virus isolation analysis of field captured biting insects during LSD outbreaks

Open Research Data Pilot (1)

Data Management Plan (DMP)

Publications

Peer reviewed articles (23)

Madin-Darby bovine kidney (MDBK) cells are a suitable cell line for the propagation and study of the bovine poxvirus lumpy skin disease virus

Auteurs: Petra C. Fay, Charlotte G. Cook, Najith Wijesiriwardana, Gessica Tore, Loic Comtet, Alix Carpentier, Barbara Shih, Graham Freimanis, Ismar R. Haga, Philippa M. Beard
Publié dans: Journal of Virological Methods, Numéro 285, 2020, Page(s) 113943, ISSN 0166-0934
Éditeur: Elsevier BV
DOI: 10.1016/j.jviromet.2020.113943

Semi-quantitative risk assessment of African swine fever virus introduction in pig farms

Auteurs: Annalisa Scollo; Francesco Valentini; Giorgio Franceschini; Alessia Rusinà; Stefania Calò; Veronica Cappa; Alessandro Bellato; Alessandro Mannelli; Giovanni Loris Alborali; Silvia Bellini
Publié dans: Front. Vet. Sci., 27 January 2023, Sec. Veterinary Epidemiology and Economics, Numéro 2, 2023, ISSN 2297-1769
Éditeur: Frontiers in Veterinary Science
DOI: 10.3389/fvets.2023.1017001

Complete genome reconstruction of the global and European regional dispersal history of the lumpy skin disease virus

Auteurs: Steven Van Borm; Simon Dellicour; Darren P. Martin; Philippe Lemey; Eirini I. Agianniotaki; Eleni D. Chondrokouki; Dejan Vidanovic; Nikola Vaskovic; Tamaš Petroviċ; Sava Laziċ; Xhelil Koleci; Ani Vodica; Igor Djadjovski; Kiril Krstevski; Frank Vandenbussche; Andy Haegeman; Kris De Clercq; Elisabeth Mathijs
Publié dans: Journal of Virology, Numéro 8, 2023, ISSN 1098-5514
Éditeur: ASM
DOI: 10.1128/jvi.01394-23

Mathematical Approach to Estimating the Main Epidemiological Parameters of African Swine Fever in Wild Boar

Auteurs: Federica Loi, Stefano Cappai, Alberto Laddomada, Francesco Feliziani, Annalisa Oggiano, Giulia Franzoni, Sandro Rolesu, Vittorio Guberti
Publié dans: Vaccines, Numéro 8/3, 2020, Page(s) 521, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8030521

Potential link of single nucleotide polymorphisms to virulence of vaccine‐associated field strains of lumpy skin disease virus in South Africa

Auteurs: Antoinette Schalkwyk, Pravesh Kara, Karen Ebersohn, Arshad Mather, Cornelius Henry Annandale, Estelle Hildegard Venter, David Brian Wallace
Publié dans: Transboundary and Emerging Diseases, Numéro 67/6, 2020, Page(s) 2946-2960, ISSN 1865-1674
Éditeur: Blackwell-Wiss.-Verl
DOI: 10.1111/tbed.13670

A Review of Environmental Risk Factors for African Swine Fever in European Wild Boar.

Auteurs: Hannes Bergmann; Katja Schulz; Franz Josef Conraths; Carola Sauter-Louis
Publié dans: Animals : an Open Access Journal from MDPI, Numéro 9, 2021, Page(s) 2692, ISSN 2076-2615
Éditeur: MDPI
DOI: 10.3390/ani11092692

A Review of Risk Factors of African Swine Fever Incursion in Pig Farming within the European Union Scenario

Auteurs: Silvia Bellini, Gabriele Casadei, Giorgia De Lorenzi, Marco Tamba
Publié dans: Pathogens, Numéro 10/1, 2021, Page(s) 84, ISSN 2076-0817
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10010084

Identification of Risk Factors for African Swine Fever: A Systematic Review

Auteurs: Hannes Bergmann; Johanna Dups-Bergmann; Katja Schulz; Carolina Probst; Laura Zani; Melina Fischer; Jörn Gethmann; Nicolai Denzin; Sandra Blome; Franz J. Conraths; Carola Sauter-Louis
Publié dans: Viruses; Volume 14; Numéro 10; Pages: 2107, Numéro 2, 2022, Page(s) 2107, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14102107

Cellular and Humoral Immune Responses after Immunisation with Low Virulent African Swine Fever Virus in the Large White Inbred Babraham Line and Outbred Domestic Pigs

Auteurs: Lynnette C. Goatley †,Rachel H. Nash †,Catherine Andrews,Zoe Hargreaves,Priscilla TngORCID,Ana Luisa ReisORCID,Simon P. GrahamORCID andChristopher L. Netherton *ORCID
Publié dans: "Special Numéro ""African Swine Fever Virus 2.0""", 2022, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14071487

Remote Sensing Provides a Rapid Epidemiological Context for the Control of African Swine Fever in Germany

Auteurs: Hannes Bergmann, Eva-Maria Czaja, Annett Frick, Ulf Klaaß, Ronny Marquart, Annett Rudovsky, Diana Holland, Patrick Wysocki, Daike Lehnau, Ronald Schröder, Lisa Rogoll, Carola Sauter-Louis, Timo Homeier-Bachmann
Publié dans: Sensors, 2023, ISSN 1424-8220
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s23198202

R0 Estimation for the African Swine Fever Epidemics in Wild Boar of Czech Republic and Belgium

Auteurs: Andrea Marcon, Annick Linden, Petr Satran, Vincenzo Gervasi, Alain Licoppe, Vittorio Guberti
Publié dans: Veterinary Sciences, Numéro 7/1, 2020, Page(s) 2, ISSN 2306-7381
Éditeur: Veterinary Sciences
DOI: 10.3390/vetsci7010002

Estimating the Directional Spread of Epidemics in Their Early Stages Using a Simple Regression Approach: A Study on African Swine Fever in Northern Italy

Auteurs: Vincenzo Gervasi; Marco Sordilli; Federica Loi; Vittorio Guberti
Publié dans: Pathogens; Volume 12; Numéro 6; Pages: 812, Numéro 3, 2023, ISSN 2076-0817
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens12060812

The diffusion metrics of African swine fever in wild boar

Auteurs: Hartmut H. K. Lentz, Hannes Bergmann, Franz J. Conraths, Jana Schulz, Carola Sauter-Louis
Publié dans: Scientific Reports, Numéro 13, 2023, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-023-42300-0

The immune response to lumpy skin disease virus in cattle is influenced by inoculation route

Auteurs: Petra C. Fay, Najith Wijesiriwardana, Henry Munyanduki, Beatriz Sanz-Bernardo, Isabel Lewis, Ismar R. Haga, Katy Moffat, Arnoud H. M. van Vliet, Jayne Hope, Simon P. Graham and Philippa M. Beard
Publié dans: Frontiers in Immunology, Numéro 2022 Volume 13, 2022, Page(s) 1051008, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2022.1051008

A robust, cost-effective and widely applicable whole-genome sequencing protocol for capripoxviruses

Auteurs: Elisabeth Mathijs; Andy Haegeman; Kris De Clercq; Steven Van Borm; Frank Vandenbussche
Publié dans: Journal of Virological Methods, Numéro 1, 2022, Page(s) 114464, ISSN 0166-0934
Éditeur: Elsevier BV
DOI: 10.1016/j.jviromet.2022.114464

Evaluation of the Efficiency of Active and Passive Surveillance in the Detection of African Swine Fever in Wild Boar

Auteurs: Vincenzo Gervasi, Andrea Marcon, Silvia Bellini, Vittorio Guberti
Publié dans: Veterinary Sciences, Numéro 7/1, 2020, Page(s) 5, ISSN 2306-7381
Éditeur: Veterinary Sciences
DOI: 10.3390/vetsci7010005

Evidence of Lumpy Skin Disease Virus Transmission from Subclinically Infected Cattle by Stomoxys calcitrans

Auteurs: Andy Haegeman; Charlotte Sohier; Laurent Mostin; Ilse De Leeuw; Willem Van Campe; Wannes Philips; Nick De Regge; Kris De Clercq
Publié dans: Viruses; Volume 15; Numéro 6; Pages: 1285, Numéro 7, 2023, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v15061285

Combining hunting and intensive carcass removal to eradicate African swine fever from wild boar populations

Auteurs: Vincenzo Gervasi; Vittorio Guberti
Publié dans: Crossref, Numéro 10, 2022, Page(s) 105633, ISSN 0167-5877
Éditeur: Elsevier BV
DOI: 10.1016/j.prevetmed.2022.105633

African swine fever endemic persistence in wild boar populations: Key mechanisms explored through modelling

Auteurs: Gervasi V., Guberti V.
Publié dans: Transboundary and Emerging Diseases, Numéro 2021; Volume 68, Numéro 5 p. 2812-2825, 2021, ISSN 1865-1682
Éditeur: Wiley
DOI: 10.1111/tbed.14194

Estimating the risk of environmental contamination by forest users in African Swine Fever endemic areas

Auteurs: Gervasi V., Marcon A., Guberti V.
Publié dans: Acta Veterinaria Scandinava, Numéro 64, Article number: 16 (2022) , 2022, ISSN 1751-0147
Éditeur: Pubmed
DOI: 10.1186/s13028-022-00636-z

Semi-Quantitative Risk Assessment of African Swine Fever Virus Introduction in Outdoor Pig Farms

Auteurs: Alessia Rusinà; Francesco Valentini; Annalisa Scollo; Giorgio Franceschini; Sara Salvato; Veronica Cappa; Alessandro Bellato; Alessandro Mannelli; Silvia Bellini
Publié dans: Pathogens; Volume 12; Numéro 5; Pages: 709, Numéro 5, 2023, ISSN 2076-0817
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens12050709

Review: Vaccines and Vaccination against Lumpy Skin Disease

Auteurs: Eeva Tuppurainen, Klaas Dietze, Janika Wolff, Hannes Bergmann, Daniel Beltran-Alcrudo, Anna Fahrion, Charles Euloge Lamien, Frank Busch, Carola Sauter-Louis, Franz J. Conraths, Kris De Clercq, Bernd Hoffmann and Sascha Knauf
Publié dans: Vaccines, Numéro 2021, 9(10), 1136, 2021, Page(s) 1136, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9101136

A field study evaluating the humoral immune response in Mongolian sheep vaccinated against sheeppox virus

Auteurs: Petra Fay, Georgina Limon, Gerelmaa Ulziibat, Buyantogtokh Khanui, Odonchimeg Myagmarsuren, Gessica Tore, Bodisaikhan Khishgee, John Flannery, Batkhuyag Sandag, Batchuluun Damdinjav, Philippa M. Beard
Publié dans: Transboundary and Emerging Diseases, 2021, ISSN 1865-1674
Éditeur: Blackwell-Wiss.-Verl
DOI: 10.1111/tbed.14163

Book chapters (1)

African swine fever vaccines

Auteurs: Netherton, Christopher L.
Publié dans: Viruses, 2021, Page(s) Pages: 161–182, ISBN 9789086869107
Éditeur: Wageningen Academic
DOI: 10.3920/978-90-8686-910-7_6

Conference proceedings (1)

Host variation in susceptibility to lumpy skin disease: gene expression analyses of experimentally infected cows.

Auteurs: Van Borm, S., Klingström, T., Niazi, A., De Clercq, K., Mostin, L., Haegeman, A., De Koning, D.J.
Publié dans: Proceeding of the World Conference of Genetics Applied to Livestock Production, 2023, Page(s) 668 - 671, ISBN 978-90-8686-940-4
Éditeur: Wageningen Academic
DOI: 10.3920/978-90-8686-940-4_154