Addressing the dual emerging threats of African Swine Fever and Lumpy Skin Disease in Europe (DEFEND)

Informazioni relative al progetto

DEFEND

ID dell’accordo di sovvenzione: 773701

DOI

10.3030/773701

Progetto chiuso

Data della firma CE 8 Maggio 2018

Data di avvio 1 Giugno 2018

Data di completamento 30 Novembre 2023

Finanziato da

• SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy

Costo totale

€ 5 992 500,00

Contributo UE

€ 5 599 999,50

Coordinato da

THE PIRBRIGHT INSTITUTE LBG
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (25)

Report on the identification and characterisation of subclinical LSDV infection
Publication on literature review and risk factor analysis
Report on the phylodynamic analysis of ASFV and LSDV in Europe
Report on proposed LSDV and ASFV molecular diagnostic and genotyping protocols.
Guidelines to implement compartmentalization for ASF in the European context
Measuring the persistence of antibodies post-LSD in the Balkans
Report of fieldwork experiences, including maps, routes, types of transboundary movements, risk factors

Report of fieldwork experiences including maps routes types of transboundary movements risk factors

Report of the indirect LSDV transmission and LSDV transmission via artificial insemination
ASF vaccination and post vaccination monitoring to assess the efficiency of ASF vaccination
Risk analysis framework
Candidate genes for LSD resistance
Report on LSDV transmission using in vitro and in vivo infected vectors
Report on LSDV in meat and hides before and after treatment
Methodological report on the implementation techniques of fieldwork activities in a comparative perspective
Optimal Selection Strategy
Standards for post-LSD-vaccination monitoring
Dissemination and communications tools (poster, webpage, factsheet)
Practice abstracts

"The resulting innovative knowledge and easy accessible end-user material from this project will feed into the EIP-AGRI (The agricultural European Innovation Partnership) website for broad dissemination. The end-user material to be produced contains a substantial number of summaries for practitioners in the EIP common format (""practice abstracts""), including the characteristics of the project (e.g. contact details of partners, etc). A full package of practice abstracts will be produced by the project, containing all the outcomes/recommendations which are ready for practice.A ""practice abstract"" is a short summary of around 1000-1500 characters (word count – no spaces; see below) which describes the main information/recommendation/practice that can serve the end-users in their daily practice. A total target number of 15 practice abstracts is foreseen for the project. A third of them are expected to be delivered in the first batch."

Influence of co-incident vaccination on immune parameters associated with LSD vaccination
Methodology to estimate ASF prevalence in wild boar in endemic and epidemic areas
Candidate genes for ASF resistance
Policy brief on implications, impacts, recommendations on conflict, migration and virus spread
Report on the ASFV and LSDV complete genome sequences generated in the project
GWAS results
Report on the PCR and virus isolation analysis of field captured biting insects during LSD outbreaks

Open Research Data Pilot (1)

Data Management Plan (DMP)

Pubblicazioni

Peer reviewed articles (23)

Madin-Darby bovine kidney (MDBK) cells are a suitable cell line for the propagation and study of the bovine poxvirus lumpy skin disease virus

Autori: Petra C. Fay, Charlotte G. Cook, Najith Wijesiriwardana, Gessica Tore, Loic Comtet, Alix Carpentier, Barbara Shih, Graham Freimanis, Ismar R. Haga, Philippa M. Beard
Pubblicato in: Journal of Virological Methods, Numero 285, 2020, Pagina/e 113943, ISSN 0166-0934
Editore: Elsevier BV
DOI: 10.1016/j.jviromet.2020.113943

Semi-quantitative risk assessment of African swine fever virus introduction in pig farms

Autori: Annalisa Scollo; Francesco Valentini; Giorgio Franceschini; Alessia Rusinà; Stefania Calò; Veronica Cappa; Alessandro Bellato; Alessandro Mannelli; Giovanni Loris Alborali; Silvia Bellini
Pubblicato in: Front. Vet. Sci., 27 January 2023, Sec. Veterinary Epidemiology and Economics, Numero 2, 2023, ISSN 2297-1769
Editore: Frontiers in Veterinary Science
DOI: 10.3389/fvets.2023.1017001

Complete genome reconstruction of the global and European regional dispersal history of the lumpy skin disease virus

Autori: Steven Van Borm; Simon Dellicour; Darren P. Martin; Philippe Lemey; Eirini I. Agianniotaki; Eleni D. Chondrokouki; Dejan Vidanovic; Nikola Vaskovic; Tamaš Petroviċ; Sava Laziċ; Xhelil Koleci; Ani Vodica; Igor Djadjovski; Kiril Krstevski; Frank Vandenbussche; Andy Haegeman; Kris De Clercq; Elisabeth Mathijs
Pubblicato in: Journal of Virology, Numero 8, 2023, ISSN 1098-5514
Editore: ASM
DOI: 10.1128/jvi.01394-23

Mathematical Approach to Estimating the Main Epidemiological Parameters of African Swine Fever in Wild Boar

Autori: Federica Loi, Stefano Cappai, Alberto Laddomada, Francesco Feliziani, Annalisa Oggiano, Giulia Franzoni, Sandro Rolesu, Vittorio Guberti
Pubblicato in: Vaccines, Numero 8/3, 2020, Pagina/e 521, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8030521

Potential link of single nucleotide polymorphisms to virulence of vaccine‐associated field strains of lumpy skin disease virus in South Africa

Autori: Antoinette Schalkwyk, Pravesh Kara, Karen Ebersohn, Arshad Mather, Cornelius Henry Annandale, Estelle Hildegard Venter, David Brian Wallace
Pubblicato in: Transboundary and Emerging Diseases, Numero 67/6, 2020, Pagina/e 2946-2960, ISSN 1865-1674
Editore: Blackwell-Wiss.-Verl
DOI: 10.1111/tbed.13670

A Review of Environmental Risk Factors for African Swine Fever in European Wild Boar.

Autori: Hannes Bergmann; Katja Schulz; Franz Josef Conraths; Carola Sauter-Louis
Pubblicato in: Animals : an Open Access Journal from MDPI, Numero 9, 2021, Pagina/e 2692, ISSN 2076-2615
Editore: MDPI
DOI: 10.3390/ani11092692

A Review of Risk Factors of African Swine Fever Incursion in Pig Farming within the European Union Scenario

Autori: Silvia Bellini, Gabriele Casadei, Giorgia De Lorenzi, Marco Tamba
Pubblicato in: Pathogens, Numero 10/1, 2021, Pagina/e 84, ISSN 2076-0817
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10010084

Identification of Risk Factors for African Swine Fever: A Systematic Review

Autori: Hannes Bergmann; Johanna Dups-Bergmann; Katja Schulz; Carolina Probst; Laura Zani; Melina Fischer; Jörn Gethmann; Nicolai Denzin; Sandra Blome; Franz J. Conraths; Carola Sauter-Louis
Pubblicato in: Viruses; Volume 14; Numero 10; Pages: 2107, Numero 2, 2022, Pagina/e 2107, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14102107

Cellular and Humoral Immune Responses after Immunisation with Low Virulent African Swine Fever Virus in the Large White Inbred Babraham Line and Outbred Domestic Pigs

Autori: Lynnette C. Goatley †,Rachel H. Nash †,Catherine Andrews,Zoe Hargreaves,Priscilla TngORCID,Ana Luisa ReisORCID,Simon P. GrahamORCID andChristopher L. Netherton *ORCID
Pubblicato in: "Special Numero ""African Swine Fever Virus 2.0""", 2022, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14071487

Remote Sensing Provides a Rapid Epidemiological Context for the Control of African Swine Fever in Germany

Autori: Hannes Bergmann, Eva-Maria Czaja, Annett Frick, Ulf Klaaß, Ronny Marquart, Annett Rudovsky, Diana Holland, Patrick Wysocki, Daike Lehnau, Ronald Schröder, Lisa Rogoll, Carola Sauter-Louis, Timo Homeier-Bachmann
Pubblicato in: Sensors, 2023, ISSN 1424-8220
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s23198202

R0 Estimation for the African Swine Fever Epidemics in Wild Boar of Czech Republic and Belgium

Autori: Andrea Marcon, Annick Linden, Petr Satran, Vincenzo Gervasi, Alain Licoppe, Vittorio Guberti
Pubblicato in: Veterinary Sciences, Numero 7/1, 2020, Pagina/e 2, ISSN 2306-7381
Editore: Veterinary Sciences
DOI: 10.3390/vetsci7010002

Estimating the Directional Spread of Epidemics in Their Early Stages Using a Simple Regression Approach: A Study on African Swine Fever in Northern Italy

Autori: Vincenzo Gervasi; Marco Sordilli; Federica Loi; Vittorio Guberti
Pubblicato in: Pathogens; Volume 12; Numero 6; Pages: 812, Numero 3, 2023, ISSN 2076-0817
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens12060812

The diffusion metrics of African swine fever in wild boar

Autori: Hartmut H. K. Lentz, Hannes Bergmann, Franz J. Conraths, Jana Schulz, Carola Sauter-Louis
Pubblicato in: Scientific Reports, Numero 13, 2023, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-42300-0

The immune response to lumpy skin disease virus in cattle is influenced by inoculation route

Autori: Petra C. Fay, Najith Wijesiriwardana, Henry Munyanduki, Beatriz Sanz-Bernardo, Isabel Lewis, Ismar R. Haga, Katy Moffat, Arnoud H. M. van Vliet, Jayne Hope, Simon P. Graham and Philippa M. Beard
Pubblicato in: Frontiers in Immunology, Numero 2022 Volume 13, 2022, Pagina/e 1051008, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2022.1051008

A robust, cost-effective and widely applicable whole-genome sequencing protocol for capripoxviruses

Autori: Elisabeth Mathijs; Andy Haegeman; Kris De Clercq; Steven Van Borm; Frank Vandenbussche
Pubblicato in: Journal of Virological Methods, Numero 1, 2022, Pagina/e 114464, ISSN 0166-0934
Editore: Elsevier BV
DOI: 10.1016/j.jviromet.2022.114464

Evaluation of the Efficiency of Active and Passive Surveillance in the Detection of African Swine Fever in Wild Boar

Autori: Vincenzo Gervasi, Andrea Marcon, Silvia Bellini, Vittorio Guberti
Pubblicato in: Veterinary Sciences, Numero 7/1, 2020, Pagina/e 5, ISSN 2306-7381
Editore: Veterinary Sciences
DOI: 10.3390/vetsci7010005

Evidence of Lumpy Skin Disease Virus Transmission from Subclinically Infected Cattle by Stomoxys calcitrans

Autori: Andy Haegeman; Charlotte Sohier; Laurent Mostin; Ilse De Leeuw; Willem Van Campe; Wannes Philips; Nick De Regge; Kris De Clercq
Pubblicato in: Viruses; Volume 15; Numero 6; Pages: 1285, Numero 7, 2023, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v15061285

Combining hunting and intensive carcass removal to eradicate African swine fever from wild boar populations

Autori: Vincenzo Gervasi; Vittorio Guberti
Pubblicato in: Crossref, Numero 10, 2022, Pagina/e 105633, ISSN 0167-5877
Editore: Elsevier BV
DOI: 10.1016/j.prevetmed.2022.105633

African swine fever endemic persistence in wild boar populations: Key mechanisms explored through modelling

Autori: Gervasi V., Guberti V.
Pubblicato in: Transboundary and Emerging Diseases, Numero 2021; Volume 68, Numero 5 p. 2812-2825, 2021, ISSN 1865-1682
Editore: Wiley
DOI: 10.1111/tbed.14194

Estimating the risk of environmental contamination by forest users in African Swine Fever endemic areas

Autori: Gervasi V., Marcon A., Guberti V.
Pubblicato in: Acta Veterinaria Scandinava, Numero 64, Article number: 16 (2022) , 2022, ISSN 1751-0147
Editore: Pubmed
DOI: 10.1186/s13028-022-00636-z

Semi-Quantitative Risk Assessment of African Swine Fever Virus Introduction in Outdoor Pig Farms

Autori: Alessia Rusinà; Francesco Valentini; Annalisa Scollo; Giorgio Franceschini; Sara Salvato; Veronica Cappa; Alessandro Bellato; Alessandro Mannelli; Silvia Bellini
Pubblicato in: Pathogens; Volume 12; Numero 5; Pages: 709, Numero 5, 2023, ISSN 2076-0817
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens12050709

Review: Vaccines and Vaccination against Lumpy Skin Disease

Autori: Eeva Tuppurainen, Klaas Dietze, Janika Wolff, Hannes Bergmann, Daniel Beltran-Alcrudo, Anna Fahrion, Charles Euloge Lamien, Frank Busch, Carola Sauter-Louis, Franz J. Conraths, Kris De Clercq, Bernd Hoffmann and Sascha Knauf
Pubblicato in: Vaccines, Numero 2021, 9(10), 1136, 2021, Pagina/e 1136, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9101136

A field study evaluating the humoral immune response in Mongolian sheep vaccinated against sheeppox virus

Autori: Petra Fay, Georgina Limon, Gerelmaa Ulziibat, Buyantogtokh Khanui, Odonchimeg Myagmarsuren, Gessica Tore, Bodisaikhan Khishgee, John Flannery, Batkhuyag Sandag, Batchuluun Damdinjav, Philippa M. Beard
Pubblicato in: Transboundary and Emerging Diseases, 2021, ISSN 1865-1674
Editore: Blackwell-Wiss.-Verl
DOI: 10.1111/tbed.14163

Book chapters (1)

African swine fever vaccines

Autori: Netherton, Christopher L.
Pubblicato in: Viruses, 2021, Pagina/e Pages: 161–182, ISBN 9789086869107
Editore: Wageningen Academic
DOI: 10.3920/978-90-8686-910-7_6

Conference proceedings (1)

Host variation in susceptibility to lumpy skin disease: gene expression analyses of experimentally infected cows.

Autori: Van Borm, S., Klingström, T., Niazi, A., De Clercq, K., Mostin, L., Haegeman, A., De Koning, D.J.
Pubblicato in: Proceeding of the World Conference of Genetics Applied to Livestock Production, 2023, Pagina/e 668 - 671, ISBN 978-90-8686-940-4
Editore: Wageningen Academic
DOI: 10.3920/978-90-8686-940-4_154