IntegraSea is in line with the EU Blue Growth Agenda, in seeking to develop and evaluate new opportunities for sustainable aquaculture development. The increasing interest in the incorporation of seaweed-based extracts into ‘natural’ products has created a new market for seaweed. While strong competition for terrestrial space is a constraint, offshore cultivation is growing fast, and Portugal shows potential for expansion. Furthermore, the need to comply with environmental standards is directing fish producers to consider Integrated Multi-Trophic Aquaculture (IMTA) systems where seaweeds are integrated as a valuable crop and as waste bioprocessing means. Another potential advantage of large scale cultivation of seaweed is its integration with bivalve production. Several seaweed species have demonstrated allelopathy potential, inhibiting the growth of Harmful Microalgae which often lead to prolonged closures of bivalve production in Portugal, and across the EU. IntegraSea focuses on an innovative holistic approach to offshore cultivation of novel high value native seaweed species, together with their bioremediation and HABs’ mitigation potential in order to maximise economic and environmental benefits. IntegraSea results provide crucial understanding on the potential for seaweed cultivation in the Algarve region, and its environmental services.