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CORDIS - EU research results
CORDIS

Evolvable platform for programmable nanoparticle-based cancer therapies

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Final report on MD simulations and XAI model (opens in new window)

Final report on performed molecular dynamics simulations developed XAI model and results of XAI predictions

Evolutionary model definition and specifications (opens in new window)

A report containing a description of the eCS approach, definition of the meta model and specification for the implementation of the meta model.

Report of the kick-off meeting (opens in new window)

Report of the decisions from the kick-off meeting, its agenda and list of participants.

Technical/scientific review meeting documents for RP2 (opens in new window)

Draft agenda presentations and other review meeting documents before the review meeting

Technical/scientific review meeting documents for RP1 (opens in new window)

Draft agenda, presentations and other review meeting documents before the review meeting.

In vivo validation (opens in new window)

Final report on the results of in vivo validation results of NP biodistribution pharmacokinetics toxicity and efficacy in human cancer xenograft animal models Validation will be performed by injecting previously prepared and synthesized NPs Task 32 into athymic mice

Dissemination and Exploitation Plan at the end of the first Reporting Period (RP1) (opens in new window)

Plan for dissemination and exploitation activities that will be updated for the subsequent Reporting Periods.

eCS vascular and CSC strategies (opens in new window)

Evolved mechanisms of NP circulation and NP-CSC interactions. The report will comprise description of experimental settings (Task 2.1), results of in silico experiments (Task 2.2) and analysis and scoring of evolved strategies (Task 2.3). The report will also provide specifications and criteria for evaluating and scoring of evolved strategies.

Web site, logo and other mass media presence (opens in new window)

A report on launched website, logo, blog, social media channels, high-quality video presentation of the project and brochure/flyer.

Mid-term MD simulations and XAI toy model (opens in new window)

Report on performed molecular dynamics simulations and developed XAI toy model based on data obtained from molecular dynamics simulations

eCS anti-cancer strategies (opens in new window)

Evolved complete DDS strategies that include NP circulation transvascular NP translocation tumour penetration and NPCSC interaction The report will comprise description of experimental settings Task 21 results of in silico experiments Task 22 and analysis and scoring of evolved strategies Task 23 Report will provide specifications and criteria for evaluating and scoring of evolved strategies

Final report on communication and dissemination activities (opens in new window)
Final in vitro validation (opens in new window)

Report on the results of in vitro validation results of NP extravasations tumour penetration cellular uptake viability and pharmacological effect of the evolved nanoparticle strategies Validation will be performed by injecting previously prepared and synthesized NPs Task 32 into all prepared microfluidic devices Task 31

eCS endothelial and tumour strategies (opens in new window)

Evolved mechanisms of NP endothelial and tumour penetration. The report will comprise description of experimental settings (Task 2.1), results of in silico experiments (Task 2.2) and analysis and scoring of evolved strategies (Task 2.3). The report will also provide specifications and criteria for evaluating and scoring of evolved strategies.

First in vitro validation (opens in new window)

Report on validation of devices 1&4. Validation will be performed by injecting previously prepared and synthesized NPs (Task 3.2) into devices 1&4 (Task 3.1).

Mid-term eCS implementation and testing (opens in new window)

Improved eCS platform tested documented and uploaded to the public repository Documentation will include a report on implemented improvements Task 12 and their operational testing results Task 13

Final eCS implementation and testing (opens in new window)

Final version of the eCS platform tested documented and uploaded to the public repository Documentation will include a report on latest improvements Task 12 and their operational testing results Task 13

Initial eCS implementation and testing (opens in new window)

eCS platform is implemented, (Task 1.2), tested (Task 1.3), documented and uploaded to the public repository.

Workshop organization (opens in new window)

Organized International Workshop: “Evolving nano-treatments of cancer”.

Data management plan (opens in new window)

Delivered a first version of Data Management Plan (DMP)

Publications

Editorial: Computational approaches in cancer modelling (opens in new window)

Author(s): Igor Balaz, Sabine Hauert, Andrew Adamatzky
Published in: Biosystems, Issue 204, 2021, ISSN 0303-2647
Publisher: Elsevier BV
DOI: 10.1016/j.biosystems.2021.104385

In silico optimization of cancer therapies with multiple types of nanoparticles applied at different times (opens in new window)

Author(s): Michail-AntisthenisTsompanas, LarryBull, AndrewAdamatzky, IgorBalaz
Published in: Computer Methods and Programs in Biomedicine, Issue 200, 2021, ISSN 0169-2607
Publisher: Elsevier BV
DOI: 10.1016/j.cmpb.2020.105886

In silico modelling of cancer nanomedicine, across scales and transport barriers. (opens in new window)

Author(s): Namid R. Stillman, Marina Kovacevic, Igor Balaz & Sabine Hauert
Published in: npj Computational Materials, Issue 6, 92, 2020, ISSN 2057-3960
Publisher: Nature Publishing Group
DOI: 10.1038/s41524-020-00366-8

Evolutionary computational platform for the automatic discovery of nanocarriers for cancer treatment (opens in new window)

Author(s): Namid R. Stillman; Igor Balaz; Michail-Antisthenis I. Tsompanas; Marina Kovacevic; Sepinoud Azimi; Sebastien Lafond; Andrew Adamatzky; Sabine Hauert
Published in: npj Computational Materials, Vol 7, Iss 1, Pp 1-12 (2021), Issue 2, 2021, Page(s) 1-12, ISSN 2057-3960
Publisher: Springer Nature
DOI: 10.1038/s41524-021-00614-5

The potential of nanomedicine to alter cancer stem cell dynamics: the impact of extracellular vesicles (opens in new window)

Author(s): Petra Gener , Patricia Gonzalez Callejo, Joaquín Seras-Franzoso, Fernanda Andrade, Diana Rafael, Ibane Abasolo & Simo Schwartz
Published in: Nanomedicine, Issue 15, 2020, Page(s) 2785-2800, ISSN 1743-5889
Publisher: Future Medicine Ltd.
DOI: 10.2217/nnm-2020-0099

Measuring Nanoparticle Penetration Through Bio-Mimetic Gels (opens in new window)

Author(s): Scott C McCormick, Namid Stillman, Matthew Hockley, Adam W Perriman, Sabine Hauert
Published in: International Journal of Nanomedicine, Issue 16, 2021, Page(s) 2585–2595, ISSN 1178-2013
Publisher: DovePress
DOI: 10.2147/ijn.s292131

Metameric representations on optimization of nano particle cancer treatment (opens in new window)

Author(s): Michail-Antisthenis I. Tsompanas; Larry Bull; Andrew Adamatzky; Igor Balaz
Published in: Biocybernetics and Biomedical Engineering, Issue 6, 2021, Page(s) 352-361, ISSN 0208-5216
Publisher: Polish Scientific Publishers PWN
DOI: 10.1016/j.bbe.2021.02.002

Harnessing adaptive novelty for automated generation of cancer treatments (opens in new window)

Author(s): Igor Balaz, Tara Petrić, Marina Kovacevic, Michail-Antisthenis Tsompanas, Namid Stillman
Published in: Biosystems, 2020, Page(s) 104290, ISSN 0303-2647
Publisher: Elsevier BV
DOI: 10.1016/j.biosystems.2020.104290

Toward Engineering Biosystems With Emergent Collective Functions (opens in new window)

Author(s): Thomas E. Gorochowski, Sabine Hauert, Jan-Ulrich Kreft, Lucia Marucci, Namid R. Stillman, T.-Y. Dora Tang, Lucia Bandiera, Vittorio Bartoli, Daniel O. R. Dixon, Alex J. H. Fedorec, Harold Fellermann, Alexander G. Fletcher, Tim Foster, Luca Giuggioli, Antoni Matyjaszkiewicz, Scott McCormick, Sandra Montes Olivas, Jonathan Naylor, Ana Rubio Denniss, Daniel Ward
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2020.00705

Microvessel-on-Chip Fabrication for the In Vitro Modeling of Nanomedicine Transport (opens in new window)

Author(s): Sergio Dávila, Jean Cacheux, Isabel Rodríguez
Published in: ACS Omega, Issue 6, 2021, Page(s) 25109–25115, ISSN 2470-1343
Publisher: ACSPublications
DOI: 10.1021/acsomega.1c00735

Towards an evolvable cancer treatment simulator (opens in new window)

Author(s): Richard J. Preen, Larry Bull, Andrew Adamatzky
Published in: Biosystems, Issue 182, 2019, Page(s) 1-7, ISSN 0303-2647
Publisher: Elsevier BV
DOI: 10.1016/j.biosystems.2019.05.005

Zileuton™ loaded in polymer micelles effectively reduce breast cancer circulating tumor cells and intratumoral cancer stem cells (opens in new window)

Author(s): Petra Gener, Sara Montero, Helena Xandri-Monje, Zamira V. Díaz-Riascos, Diana Rafael, Fernanda Andrade, Francesc Martínez-Trucharte, Patricia González, Joaquin Seras-Franzoso, Albert Manzano, Diego Arango, Joan Sayós, Ibane Abasolo, Simo Schwartz
Published in: Nanomedicine: Nanotechnology, Biology and Medicine, Issue 24, 2020, Page(s) 102106, ISSN 1549-9634
Publisher: Elsevier BV
DOI: 10.1016/j.nano.2019.102106

Novelty search employed into the development of cancer treatment simulations (opens in new window)

Author(s): Michail-Antisthenis Tsompanas, Larry Bull, Andrew Adamatzky, Igor Balaz
Published in: Informatics in Medicine Unlocked, 2020, Page(s) 100347, ISSN 2352-9148
Publisher: Elsevier
DOI: 10.1016/j.imu.2020.100347

Pivotal Role of AKT2 during Dynamic Phenotypic Change of Breast Cancer Stem Cells (opens in new window)

Author(s): Gener, Rafael, Seras-Franzoso, Perez, Pindado, Casas, Arango, Fernández, Díaz-Riascos, Abasolo, Schwartz
Published in: Cancers, Issue 11/8, 2019, Page(s) 1058, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11081058

Mixed-monolayer functionalized gold nanoparticles for cancer treatment: Atomistic molecular dynamics simulations study (opens in new window)

Author(s): Marina Kovacevic, Igor Balaz, Domenico Marson, Erik Laurini, Branislav Jovic
Published in: Biosystems, Issue 202, 2021, ISSN 0303-2647
Publisher: Elsevier BV
DOI: 10.1016/j.biosystems.2021.104354

Evolutionary Algorithms Designing Nanoparticle Cancer Treatments with Multiple Particle Types [Application Notes] (opens in new window)

Author(s): Michail-Antisthenis I. Tsompanas; Larry Bull; Andrew Adamatzky; Igor Balaz
Published in: IEEE Computational Intelligence Magazine, Issue 7, 2021, ISSN 1556-603X
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/mci.2021.3108306

Towards open-ended evolutionary simulator for developing novel tumour drug delivery systems (opens in new window)

Author(s): Igor Balaz; Tara Petric; Namid R. Stillman
Published in: ALIFE 2021: The 2021 Conference on Artificial Life, 2021
Publisher: MIT Press
DOI: 10.1162/isal_a_00435

Trail Formation Using Large Swarms of Minimal Robots (opens in new window)

Author(s): Pere Molins, Namid Stillman, Sabine Hauert
Published in: Cybernetics and Systems, Issue 50, 2019, Page(s) 693-710
Publisher: Taylor & Francis
DOI: 10.1080/01969722.2019.1677336

Utilizing Differential Evolution into optimizing targeted cancer treatments (opens in new window)

Author(s): Tsompanas, Michail-Antisthenis; Bull, Larry; Adamatzky, Andrew; Balaz, Igor
Published in: Modern Trends in Controlled Stochastic Processes, Issue 1, 2021, Page(s) 328-340
Publisher: Springer
DOI: 10.1007/978-3-030-76928-4_17

Haploid-Diploid Evolution: Nature's Memetic Algorithm

Author(s): Tsompanas, Michail-Antisthenis; Bull, Larry; Adamatzky, Andrew; Balaz, Igor
Published in: Issue 4, 2019
Publisher: arXiv

Model Exploration with Cost-Aware Learning (opens in new window)

Author(s): Stillman, Namid; Balazs, Igor; Hauert, Sabine
Published in: ArXiv Machine Learning, Issue 2, 2020
Publisher: ArXiv
DOI: 10.48550/arxiv.2010.04512

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