Vaccines and Infectious Diseases in the Ageing PopuLation

Informations projet

VITAL

N° de convention de subvention: 806776

DOI

10.3030/806776

Projet clôturé

Date de signature de la CE 10 Decembre 2018

Date de début 1 Janvier 2019

Date de fin 31 Decembre 2024

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 12 427 217,25

Contribution de l’UE

€ 5 499 882,25

Coordonné par

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (25)

Database on information needs and preferences of elderly regarding information provision (channel, source and template)
Identify the deficits underlying hypo-responsiveness
Report on the review of models developed on infectious diseases in elderly
Report and model access for a static model with scenario testing
Estimation of the burden of disease in the pilot regions - year 1 interim

Estimation of the burden of disease in the pilot regions year 1 interim

Report of gaps linked to solutions in collaboration with WP1 in order to well develop the models
Report on SARS-Cov2 antibody seroconversion in the vaccine study 1
Report on status of posting results
Database with information on perceptions, attitude, and intention of elderly on vaccination (including vaccination hesitancy)
Report on how the patient flow can be measured and identified in the two pilot studies of WP1 and options for a generic application of the approach
Systematic review of qualitative studies of barriers and facilitators to the uptake of educational interventions
Report on the different intervention options that could be developed in an aging population and applicable to the local circumstances against infections. Those intervention options should be considered in collaboration with the other WPs
Network analysis regarding HCW involved in the vaccination provision for elderly people, including cross-country analysis

Network analysis regarding HCW involved in the vaccination provision for elderly people including crosscountry analysis

Estimates of burden of infectious disease
Report on immune profiles associated with aging and predictive for reduced vaccine responsiveness
Report that identifies if from the gap analysis no adequate QALY data are available the way to collect that critical information from retrospective data-bases in WP1 from the two pilot projects

Report that identifies if from the gap analysis no adequate QALY data are available the way to collect that critical information from retrospective databases in WP1 from the two pilot projects

Identify vaccine (hypo) responders (individuals at risk) per age group and the level of vaccine response based on classical read-outs (antibody responses against influenza by HI assays and pneumococcal serotypes through multiplex immune-assay)

Identify vaccine hypo responders individuals at risk per age group and the level of vaccine response based on classical readouts antibody responses against influenza by HI assays and pneumococcal serotypes through multiplex immuneassay

Report and model access for a compartmental model with scenario testing as needed
Network analysis elderly including trust in HCW that are indicated by the elderly regarding vaccination
Report on exploring the fiscal impact of vaccination programs in the elderly tested in the pilot regions
Report on burden methodologies and data sources to assess potential & gaps
Report on what type of heterogeneity, levels (categorical or continuous), and measurement process are reported in elderly
Report and tool construct in MS Excel by which a country can assess its own situation/condition of implementing a strategy of prevention against infectious diseases in ageing adults with focus on immunisation relative to a reference

Report and tool construct in MS Excel by which a country can assess its own situationcondition of implementing a strategy of prevention against infectious diseases in ageing adults with focus on immunisation relative to a reference

Systematic review of highly effective educational interventions
Estimation of the burden of disease in the pilot regions - final report

Demonstrators, pilots, prototypes (8)

Retrospective Pilot study protocol

Pilot study protocol

Statistical models to predict immuno senescence
Revised protocol for extrapolation to other regions, and a report on lessons learned
Midterm recruitment report in clinical vaccine study
Report on status of posting results in clinical vaccines study
First study subject approvals package in clinical vaccine study
Workshop with representatives of HCW to select potential training and education interventions that match the different needs
Prospective Pilot study protocol synopsis

Websites, patent fillings, videos etc. (1)

Develop VITAL website

Other (1)

Mapping of existing training, learning needs and objectives

Mapping of existing training learning needs and objectives

Publications

Peer reviewed articles (23)

Pre-vaccination immunotypes reveal weak and robust antibody responders to influenza vaccination

Auteurs: Alper Cevirgel, Sudarshan A Shetty, Martijn Vos, Nening M Nanlohy, Lisa Beckers, Elske Bijvank, Nynke Rots, Josine van Beek, Anne-Marie Buisman, Debbie van Baarle
Publié dans: Aging Cell, 2023, ISSN 1474-9718
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/acel.14048

Vaccination of older adults: Influenza, pneumococcal disease, herpes zoster, COVID-19 and beyond.

Auteurs: Weinberger B
Publié dans: BMC Immunity & Ageing, Numéro Vol. 18 Art. Nr 38, 2021, ISSN 1742-4933
Éditeur: BioMed Central
DOI: 10.1186/s12979-021-00249-6

European data sources for computing burden of (potential) vaccine-preventable diseases in ageing adults

Auteurs: Estelle Méroc, Janeri Fröberg, Timea Almasi, Brita Askeland Winje, Alejandro Orrico-Sánchez, Anneke Steens, Scott A. McDonald, Kaatje Bollaerts & Mirjam J. Knol
Publié dans: BMC Infectious Diseases, Numéro 21, Article number: 345, 2021, ISSN 1471-2334
Éditeur: BioMed Central
DOI: 10.1186/s12879-021-06017-7

Country Score Tool to Assess Readiness and Guide Evidence Generation of Immunization Programs in Ageing Adults in Europe

Auteurs: Pham TH, Beck E, Postma MJ, Németh B, Ágh T, de Waure C, Salisbury DM, Nutma N, van der Schans J.
Publié dans: Front Public Health., 2023, ISSN 2296-2565
Éditeur: Front Public Health.
DOI: 10.3389/fpubh.2022.1080678

Frailty prevalence in 42 European countries by age and gender: development of the SHARE Frailty Atlas for Europe

Auteurs: János G. Pitter, Antal Zemplényi, Balázs Babarczy, Bertalan Németh, Zoltán Kaló & Zoltán Vokó
Publié dans: GeroScience, 2023, ISSN 2509-2723
Éditeur: GeroScience
DOI: 10.1007/s11357-023-00975-3

Preventing infectious diseases for healthy ageing: The VITAL public-private partnership project

Auteurs: Debbie Van Baarle, Kaatje Bollaerts, Giuseppe Del Giudice, Stephen Lockhart, Christine Luxemburger, Maarten J. Postma, Aura Timen, Baudouin Standaert
Publié dans: Vaccine, Numéro 38/37, 2020, Page(s) 5896-5904, ISSN 0264-410X
Éditeur: Elsevier BV
DOI: 10.1016/j.vaccine.2020.07.005

Cost-Effectiveness of Pediatric Influenza Vaccination in The Netherlands,

Auteurs: Pieter T. de Boer, Lisa Nagy, Franklin C.K. Dolk, Jan C. Wilschut, Richard Pitman, Maarten J. Postma,
Publié dans: Value in Health, Numéro Volume 24, Numéro 1, 2021, ISSN 1098-3015
Éditeur: Blackwell Publishing Inc.
DOI: 10.1016/j.jval.2020.10.011

Precision Medicine and Vaccination of Older Adults: From Reactive to Proactive (A Mini-Review)

Auteurs: T. Mark Doherty, Alberta Di Pasquale, Jean-Pierre Michel, Giuseppe Del Giudice
Publié dans: Gerontology, Numéro 66/3, 2020, Page(s) 238-248, ISSN 0304-324X
Éditeur: S. Karger AG
DOI: 10.1159/000503141

Using qualitative research to develop an elaboration of the TIDieR checklist for interventions to enhance vaccination communication: short report

Auteurs: Claire Glenton 1 2, Benedicte Carlsen 3, Brita Askeland Winje 4 5, Renske Eilers 6, Manuela Dominique Wennekes 6 7, Tammy C Hoffmann 8, Simon Lewin 4 9; VITAL Consortium
Publié dans: BMC; Health Res Policy Syst., 2022, ISSN 1478-4505
Éditeur: BioMed Central
DOI: 10.1186/s12961-022-00833-2

Focus group study on perceptions and information needs regarding vaccines targeting the older population: a cross-country comparison in four European countries

Auteurs: "Manuela Dominique Wennekes 1 2, Renske Eilers 3, Antonella Caputo 4, Amandine Gagneux-Brunon 5 6 7 8, Riccardo Gavioli 4, Francesco Nicoli 4, Zoltán Vokó # 9 10, Aura Timen # 3 11 12; VITAL Consortium"
Publié dans: Geroscience, 2022, ISSN 2509-2715
Éditeur: Berlin Print
DOI: 10.1007/s11357-022-00682-5

Investing in the Prevention of Communicable Disease Outbreaks: Fiscal Health Modelling—The Tool of Choice for Assessing Public Finance Sustainability

Auteurs: Simon van der Schans, Marcel H. Schöttler, Jurjen van der Schans, Mark P. Connolly, Maarten J. Postma and Cornelis Boersma
Publié dans: MDPI vaccines, 2023, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11040823

Effectiveness of educational interventions for healthcare workers on vaccination dialogue with older adults: a systematic review

Auteurs: Manuela Dominique Wennekes, Tímea Almási, Renske Eilers, Fruzsina Mezei, Zsuzsanna Ida Petykó, Aura Timen, Zoltán Vokó on behalf of VITAL Consortium
Publié dans: Archives of Public Health, 2024, ISSN 2049-3258
Éditeur: BioMed Central Ltd
DOI: 10.1186/s13690-024-01260-1

Healthcare workers’ perceptions and experiences of communicating with people over 50 years of age about vaccination: a qualitative evidence synthesis

Auteurs: Claire GlentonBenedicte CarlsenSimon LewinManuela Dominique WennekesBrita Askeland WinjeRenske Eilerson behalf of the VITAL consortium
Publié dans: Cochrane Database of Systematic Reviews, Numéro Numéro 7. Art. No.: CD013706, 2021, ISSN 1465-1858
Éditeur: John Wiley & Sons,
DOI: 10.1002/14651858.cd013706.pub2

Consultations for Influenza-Like Illness in Primary Care in The Netherlands: A Regression Approach

Auteurs: Dolk FCK, de Boer PT, Nagy L, Donker GA, Meijer A, Postma MJ, Pitman R.
Publié dans: Value in Health, Numéro Volume 24, Numéro 1, 2021, ISSN 1098-3015
Éditeur: Blackwell Publishing Inc.
DOI: 10.1016/j.jval.2020.10.013

"""Vaccines to Prevent Infectious Diseases in the Older Population: Immunological Challenges and Future Perspectives"""

Auteurs: A, Wagner, B. Weinberger
Publié dans: Frontiers in Immunulogy, Numéro Vol 18 art. 174, 2020, ISSN 1664-3224
Éditeur: Frontiers in Immunulogy
DOI: 10.3389/fimmu.2020.00717

Identification of aging-associated immunotypes and immune stability as indicators of post-vaccination immune activation

Auteurs: Alper Cevirgel 1 2, Sudarshan A Shetty 1 2, Martijn Vos 1, Nening M Nanlohy 1, Lisa Beckers 1, Elske Bijvank 1, Nynke Rots 1, Josine van Beek 1, Anne-Marie Buisman 1, Debbie van Baarle 1 2
Publié dans: Aging Cell, 2022, ISSN 1474-9718
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/acel.13703

Short- and long-term impact of vaccination against cytomegalovirus: a modeling study

Auteurs: Ganna Rozhnova, Mirjam E. Kretzschmar, Fiona van der Klis, Debbie van Baarle, Marjolein Korndewal, Ann C. Vossen, Michiel van Boven
Publié dans: BMC Medicine, Numéro 18/1, 2020, ISSN 1741-7015
Éditeur: BioMed Central
DOI: 10.1186/s12916-020-01629-3

Cost-Effectiveness of Quadrivalent Versus Trivalent Influenza Vaccination in the Dutch National Influenza Prevention Program

Auteurs: Zeevat F, Crépey P, Dolk FCK, Postma AJ, Breeveld-Dwarkasing VNA, Postma MJ
Publié dans: Value in Health, Numéro Vol. 24 Iss 1, 2021, ISSN 1098-3015
Éditeur: Blackwell Publishing Inc.
DOI: 10.1016/j.jval.2020.11.002

Incidence of Invasive and Noninvasive Pneumococcal Pneumonia Hospitalizations in People Aged ≥50 Years: Assessing Variability Across Denmark and Spain

Auteurs: Mónica López-Lacort, Marzyeh Amini, Hanne-Dorthe Emborg, Jens Nielsen, Scott A McDonald, Palle Valentiner-Branth, Javier Díez-Domingo, Alejandro Orrico-Sánchez
Publié dans: The Journal of Infectious Diseases, Numéro 230, 2024, Page(s) e559-e567, ISSN 0022-1899
Éditeur: University of Chicago Press
DOI: 10.1093/infdis/jiae088

Frailty is related to serum inflammageing markers: results from the VITAL study

Auteurs: Yannick van Sleen, Sudarshan A Shetty, Marieke van der Heiden, Milou C A Venema, Nicolas Gutiérrez-Melo, Erik J M Toonen, Josine van Beek, Anne-Marie Buisman, Debbie van Baarle, Delphine Sauce
Publié dans: Immunity and Ageing, 2023, ISSN 1742-4933
Éditeur: BioMed Central
DOI: 10.1186/s12979-023-00391-3

Vaccines and Vaccination against SARS-CoV-2: Considerations for the Older Population

Auteurs: Weinberger B
Publié dans: Vaccines, Numéro 9, no. 12: 1435, 2021, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9121435

Exploratory Analysis of the Economically Justifiable Price of a Hypothetical RSV Vaccine for Older Adults in the Netherlands and the United Kingdom

Auteurs: F Zeevat, J Luttjeboer, J H J Paulissen, J van der Schans, P Beutels, C Boersma, M J Postma, RESCEU Investigators
Publié dans: The Journal of Infectious Diseases, 2021, ISSN 0022-1899
Éditeur: University of Chicago Press
DOI: 10.1093/infdis/jiab118

Effects of Influenza Vaccine on the Immune Responses to SARS-CoV-2 Vaccination

Auteurs: A. Riccomi, C. M. Trombetta, M. Dorrucci, D. Di Placido, N. Sanarico, F. Farchi, R. Giuseppetti, U. Villano, C. Marcantonio, S. Marchi, A. Ciaramella, P. Pezzotti, E. Montomoli, C. Valdarchi, A. R. Ciccaglione, S. Vendetti
Publié dans: Vaccines, Numéro 12, 2025, Page(s) 425, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines12040425