Vaccines and Infectious Diseases in the Ageing PopuLation

Project Information

VITAL

Grant agreement ID: 806776

DOI

10.3030/806776

Project closed

EC signature date 10 December 2018

Start date 1 January 2019

End date 31 December 2024

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 12 427 217,25

EU contribution

€ 5 499 882,25

Coordinated by

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (25)

Database on information needs and preferences of elderly regarding information provision (channel, source and template)
Identify the deficits underlying hypo-responsiveness
Report on the review of models developed on infectious diseases in elderly
Report and model access for a static model with scenario testing
Estimation of the burden of disease in the pilot regions - year 1 interim

Estimation of the burden of disease in the pilot regions year 1 interim

Report of gaps linked to solutions in collaboration with WP1 in order to well develop the models
Report on SARS-Cov2 antibody seroconversion in the vaccine study 1
Report on status of posting results
Database with information on perceptions, attitude, and intention of elderly on vaccination (including vaccination hesitancy)
Report on how the patient flow can be measured and identified in the two pilot studies of WP1 and options for a generic application of the approach
Systematic review of qualitative studies of barriers and facilitators to the uptake of educational interventions
Report on the different intervention options that could be developed in an aging population and applicable to the local circumstances against infections. Those intervention options should be considered in collaboration with the other WPs
Network analysis regarding HCW involved in the vaccination provision for elderly people, including cross-country analysis

Network analysis regarding HCW involved in the vaccination provision for elderly people including crosscountry analysis

Estimates of burden of infectious disease
Report on immune profiles associated with aging and predictive for reduced vaccine responsiveness
Report that identifies if from the gap analysis no adequate QALY data are available the way to collect that critical information from retrospective data-bases in WP1 from the two pilot projects

Report that identifies if from the gap analysis no adequate QALY data are available the way to collect that critical information from retrospective databases in WP1 from the two pilot projects

Identify vaccine (hypo) responders (individuals at risk) per age group and the level of vaccine response based on classical read-outs (antibody responses against influenza by HI assays and pneumococcal serotypes through multiplex immune-assay)

Identify vaccine hypo responders individuals at risk per age group and the level of vaccine response based on classical readouts antibody responses against influenza by HI assays and pneumococcal serotypes through multiplex immuneassay

Report and model access for a compartmental model with scenario testing as needed
Network analysis elderly including trust in HCW that are indicated by the elderly regarding vaccination
Report on exploring the fiscal impact of vaccination programs in the elderly tested in the pilot regions
Report on burden methodologies and data sources to assess potential & gaps
Report on what type of heterogeneity, levels (categorical or continuous), and measurement process are reported in elderly
Report and tool construct in MS Excel by which a country can assess its own situation/condition of implementing a strategy of prevention against infectious diseases in ageing adults with focus on immunisation relative to a reference

Report and tool construct in MS Excel by which a country can assess its own situationcondition of implementing a strategy of prevention against infectious diseases in ageing adults with focus on immunisation relative to a reference

Systematic review of highly effective educational interventions
Estimation of the burden of disease in the pilot regions - final report

Demonstrators, pilots, prototypes (8)

Retrospective Pilot study protocol

Pilot study protocol

Statistical models to predict immuno senescence
Revised protocol for extrapolation to other regions, and a report on lessons learned
Midterm recruitment report in clinical vaccine study
Report on status of posting results in clinical vaccines study
First study subject approvals package in clinical vaccine study
Workshop with representatives of HCW to select potential training and education interventions that match the different needs
Prospective Pilot study protocol synopsis

Websites, patent fillings, videos etc. (1)

Develop VITAL website

Other (1)

Mapping of existing training, learning needs and objectives

Mapping of existing training learning needs and objectives

Publications

Peer reviewed articles (23)

Pre-vaccination immunotypes reveal weak and robust antibody responders to influenza vaccination

Author(s): Alper Cevirgel, Sudarshan A Shetty, Martijn Vos, Nening M Nanlohy, Lisa Beckers, Elske Bijvank, Nynke Rots, Josine van Beek, Anne-Marie Buisman, Debbie van Baarle
Published in: Aging Cell, 2023, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.14048

Vaccination of older adults: Influenza, pneumococcal disease, herpes zoster, COVID-19 and beyond.

Author(s): Weinberger B
Published in: BMC Immunity & Ageing, Issue Vol. 18 Art. Nr 38, 2021, ISSN 1742-4933
Publisher: BioMed Central
DOI: 10.1186/s12979-021-00249-6

European data sources for computing burden of (potential) vaccine-preventable diseases in ageing adults

Author(s): Estelle Méroc, Janeri Fröberg, Timea Almasi, Brita Askeland Winje, Alejandro Orrico-Sánchez, Anneke Steens, Scott A. McDonald, Kaatje Bollaerts & Mirjam J. Knol
Published in: BMC Infectious Diseases, Issue 21, Article number: 345, 2021, ISSN 1471-2334
Publisher: BioMed Central
DOI: 10.1186/s12879-021-06017-7

Country Score Tool to Assess Readiness and Guide Evidence Generation of Immunization Programs in Ageing Adults in Europe

Author(s): Pham TH, Beck E, Postma MJ, Németh B, Ágh T, de Waure C, Salisbury DM, Nutma N, van der Schans J.
Published in: Front Public Health., 2023, ISSN 2296-2565
Publisher: Front Public Health.
DOI: 10.3389/fpubh.2022.1080678

Frailty prevalence in 42 European countries by age and gender: development of the SHARE Frailty Atlas for Europe

Author(s): János G. Pitter, Antal Zemplényi, Balázs Babarczy, Bertalan Németh, Zoltán Kaló & Zoltán Vokó
Published in: GeroScience, 2023, ISSN 2509-2723
Publisher: GeroScience
DOI: 10.1007/s11357-023-00975-3

Preventing infectious diseases for healthy ageing: The VITAL public-private partnership project

Author(s): Debbie Van Baarle, Kaatje Bollaerts, Giuseppe Del Giudice, Stephen Lockhart, Christine Luxemburger, Maarten J. Postma, Aura Timen, Baudouin Standaert
Published in: Vaccine, Issue 38/37, 2020, Page(s) 5896-5904, ISSN 0264-410X
Publisher: Elsevier BV
DOI: 10.1016/j.vaccine.2020.07.005

Cost-Effectiveness of Pediatric Influenza Vaccination in The Netherlands,

Author(s): Pieter T. de Boer, Lisa Nagy, Franklin C.K. Dolk, Jan C. Wilschut, Richard Pitman, Maarten J. Postma,
Published in: Value in Health, Issue Volume 24, Issue 1, 2021, ISSN 1098-3015
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.jval.2020.10.011

Precision Medicine and Vaccination of Older Adults: From Reactive to Proactive (A Mini-Review)

Author(s): T. Mark Doherty, Alberta Di Pasquale, Jean-Pierre Michel, Giuseppe Del Giudice
Published in: Gerontology, Issue 66/3, 2020, Page(s) 238-248, ISSN 0304-324X
Publisher: S. Karger AG
DOI: 10.1159/000503141

Using qualitative research to develop an elaboration of the TIDieR checklist for interventions to enhance vaccination communication: short report

Author(s): Claire Glenton 1 2, Benedicte Carlsen 3, Brita Askeland Winje 4 5, Renske Eilers 6, Manuela Dominique Wennekes 6 7, Tammy C Hoffmann 8, Simon Lewin 4 9; VITAL Consortium
Published in: BMC; Health Res Policy Syst., 2022, ISSN 1478-4505
Publisher: BioMed Central
DOI: 10.1186/s12961-022-00833-2

Focus group study on perceptions and information needs regarding vaccines targeting the older population: a cross-country comparison in four European countries

Author(s): "Manuela Dominique Wennekes 1 2, Renske Eilers 3, Antonella Caputo 4, Amandine Gagneux-Brunon 5 6 7 8, Riccardo Gavioli 4, Francesco Nicoli 4, Zoltán Vokó # 9 10, Aura Timen # 3 11 12; VITAL Consortium"
Published in: Geroscience, 2022, ISSN 2509-2715
Publisher: Berlin Print
DOI: 10.1007/s11357-022-00682-5

Investing in the Prevention of Communicable Disease Outbreaks: Fiscal Health Modelling—The Tool of Choice for Assessing Public Finance Sustainability

Author(s): Simon van der Schans, Marcel H. Schöttler, Jurjen van der Schans, Mark P. Connolly, Maarten J. Postma and Cornelis Boersma
Published in: MDPI vaccines, 2023, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11040823

Effectiveness of educational interventions for healthcare workers on vaccination dialogue with older adults: a systematic review

Author(s): Manuela Dominique Wennekes, Tímea Almási, Renske Eilers, Fruzsina Mezei, Zsuzsanna Ida Petykó, Aura Timen, Zoltán Vokó on behalf of VITAL Consortium
Published in: Archives of Public Health, 2024, ISSN 2049-3258
Publisher: BioMed Central Ltd
DOI: 10.1186/s13690-024-01260-1

Healthcare workers’ perceptions and experiences of communicating with people over 50 years of age about vaccination: a qualitative evidence synthesis

Author(s): Claire GlentonBenedicte CarlsenSimon LewinManuela Dominique WennekesBrita Askeland WinjeRenske Eilerson behalf of the VITAL consortium
Published in: Cochrane Database of Systematic Reviews, Issue Issue 7. Art. No.: CD013706, 2021, ISSN 1465-1858
Publisher: John Wiley & Sons,
DOI: 10.1002/14651858.cd013706.pub2

Consultations for Influenza-Like Illness in Primary Care in The Netherlands: A Regression Approach

Author(s): Dolk FCK, de Boer PT, Nagy L, Donker GA, Meijer A, Postma MJ, Pitman R.
Published in: Value in Health, Issue Volume 24, Issue 1, 2021, ISSN 1098-3015
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.jval.2020.10.013

"""Vaccines to Prevent Infectious Diseases in the Older Population: Immunological Challenges and Future Perspectives"""

Author(s): A, Wagner, B. Weinberger
Published in: Frontiers in Immunulogy, Issue Vol 18 art. 174, 2020, ISSN 1664-3224
Publisher: Frontiers in Immunulogy
DOI: 10.3389/fimmu.2020.00717

Identification of aging-associated immunotypes and immune stability as indicators of post-vaccination immune activation

Author(s): Alper Cevirgel 1 2, Sudarshan A Shetty 1 2, Martijn Vos 1, Nening M Nanlohy 1, Lisa Beckers 1, Elske Bijvank 1, Nynke Rots 1, Josine van Beek 1, Anne-Marie Buisman 1, Debbie van Baarle 1 2
Published in: Aging Cell, 2022, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.13703

Short- and long-term impact of vaccination against cytomegalovirus: a modeling study

Author(s): Ganna Rozhnova, Mirjam E. Kretzschmar, Fiona van der Klis, Debbie van Baarle, Marjolein Korndewal, Ann C. Vossen, Michiel van Boven
Published in: BMC Medicine, Issue 18/1, 2020, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-020-01629-3

Cost-Effectiveness of Quadrivalent Versus Trivalent Influenza Vaccination in the Dutch National Influenza Prevention Program

Author(s): Zeevat F, Crépey P, Dolk FCK, Postma AJ, Breeveld-Dwarkasing VNA, Postma MJ
Published in: Value in Health, Issue Vol. 24 Iss 1, 2021, ISSN 1098-3015
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.jval.2020.11.002

Incidence of Invasive and Noninvasive Pneumococcal Pneumonia Hospitalizations in People Aged ≥50 Years: Assessing Variability Across Denmark and Spain

Author(s): Mónica López-Lacort, Marzyeh Amini, Hanne-Dorthe Emborg, Jens Nielsen, Scott A McDonald, Palle Valentiner-Branth, Javier Díez-Domingo, Alejandro Orrico-Sánchez
Published in: The Journal of Infectious Diseases, Issue 230, 2024, Page(s) e559-e567, ISSN 0022-1899
Publisher: University of Chicago Press
DOI: 10.1093/infdis/jiae088

Frailty is related to serum inflammageing markers: results from the VITAL study

Author(s): Yannick van Sleen, Sudarshan A Shetty, Marieke van der Heiden, Milou C A Venema, Nicolas Gutiérrez-Melo, Erik J M Toonen, Josine van Beek, Anne-Marie Buisman, Debbie van Baarle, Delphine Sauce
Published in: Immunity and Ageing, 2023, ISSN 1742-4933
Publisher: BioMed Central
DOI: 10.1186/s12979-023-00391-3

Vaccines and Vaccination against SARS-CoV-2: Considerations for the Older Population

Author(s): Weinberger B
Published in: Vaccines, Issue 9, no. 12: 1435, 2021, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9121435

Exploratory Analysis of the Economically Justifiable Price of a Hypothetical RSV Vaccine for Older Adults in the Netherlands and the United Kingdom

Author(s): F Zeevat, J Luttjeboer, J H J Paulissen, J van der Schans, P Beutels, C Boersma, M J Postma, RESCEU Investigators
Published in: The Journal of Infectious Diseases, 2021, ISSN 0022-1899
Publisher: University of Chicago Press
DOI: 10.1093/infdis/jiab118

Effects of Influenza Vaccine on the Immune Responses to SARS-CoV-2 Vaccination

Author(s): A. Riccomi, C. M. Trombetta, M. Dorrucci, D. Di Placido, N. Sanarico, F. Farchi, R. Giuseppetti, U. Villano, C. Marcantonio, S. Marchi, A. Ciaramella, P. Pezzotti, E. Montomoli, C. Valdarchi, A. R. Ciccaglione, S. Vendetti
Published in: Vaccines, Issue 12, 2025, Page(s) 425, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines12040425