From GWAS to functional studies: Tackling the complex nature of brain disorders

Informazioni relative al progetto

GWAS2FUNC

ID dell’accordo di sovvenzione: 834057

DOI

10.3030/834057

Progetto chiuso

Data della firma CE 25 Luglio 2019

Data di avvio 1 Settembre 2019

Data di completamento 31 Agosto 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 378 412,00

Contributo UE

€ 2 378 412,00

Coordinato da

STICHTING VU
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Data Management Plan

After 6 months the initial data management plan will be delivered and updated during the lifespan of the project.

Pubblicazioni

Peer reviewed articles (16)

An integrated framework for local genetic correlation analysis

Autori: Josefin Werme, Sophie van der Sluis, Danielle Posthuma, Christiaan de Leeuw
Pubblicato in: Nature Genetics, Numero March 14, 2022, 2022, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1101/2020.12.31.424652

Statistical testing in transcriptomic-neuroimaging studies: A how-to and evaluation of methods assessing spatial and gene specificity

Autori: Yongbin Wei, Siemon C. de Lange, Rory Pijnenburg, Lianne H. Scholtens, Dirk Jan Ardesch, Kyoko Watanabe, Danielle Posthuma, Martijn P. van den Heuvel
Pubblicato in: Human Brain Mapping, Numero Feb 15 2022, 2021, Pagina/e 885-901, ISSN 1097-0193
Editore: Wiley Online Library
DOI: 10.1002/hbm.25711

Genome-wide association study of cerebellar volume provides insights into heritable mechanisms underlying brain development and mental health

Autori: Elleke Tissink; Siemon C. de Lange; Jeanne E. Savage; Douglas P. Wightman; Christiaan A. de Leeuw; Kristen M. Kelly; Mats Nagel; Martijn P. van den Heuvel; Danielle Posthuma
Pubblicato in: Communications Biology, Numero 5(710), 2022, ISSN 2399-3642
Editore: Springer Nature
DOI: 10.1038/s42003-022-03672-7

Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers

Autori: Jansen, Iris; van der Lee, Sven J; Bellenguez, Céline; Ramakers, Inez; Rodriguez-Rodriguez, Eloy; Rujescu, Dan; Saltvedt, Ingvild; Sanchez-Juan, Pascual; Scheltens, Philip; Scherbaum, Norbert; Schmid, Matthias; Schneider, Anja; Selbæk, Geir; Kleineidam, Luca; Selnes, Per; Shadrin, Alexey; Skoog, Ingmar; Soininen, Hilkka; Tárraga, Lluís; Teipel, Stefan; group, GR@ACE study; Tijms, Betty; Tsolak
Pubblicato in: Acta Neuropathologica, Numero Volume 144, 2022, Pagina/e 821-842, ISSN 0001-6322
Editore: Springer Verlag
DOI: 10.1007/s00401-022-02454-z

The Genetic Architectures of Functional and Structural Connectivity Properties within Cerebral Resting-State Networks

Autori: Elleke Tissink; Josefin Werme; Siemon C. de Lange; Jeanne E. Savage; Yongbin Wei; Christiaan A. de Leeuw; Mats Nagel; Danielle Posthuma; Martijn P. van den Heuvel
Pubblicato in: eNeuro, Numero 10(4), 2023, ISSN 2373-2822
Editore: Society for Neuroscience
DOI: 10.1523/eneuro.0242-22.2023

Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence

Autori: Philip R. Jansen, Mats Nagel, Kyoko Watanabe, Yongbin Wei, Jeanne E. Savage, Christiaan A. de Leeuw, Martijn P. van den Heuvel, Sophie van der Sluis & Danielle Posthuma
Pubblicato in: Nature Communications, Numero November 5, 2020, 2020, Pagina/e Article Number: 5606, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-19378-5

Genome-wide association studies of polygenic risk score-derived phenotypes may lead to inflated false positive rates

Autori: Emil Uffelmann, Danielle Posthuma, Wouter J. Peyrot
Pubblicato in: Scientific Reports - Nature, Numero 4219 (2023), 2023, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-29428-9

Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways

Autori: Kyoko Watanabe; Philip R. Jansen; Jeanne E. Savage; Priyanka Nandakumar; Xin Wang; Michelle Agee; Stella Aslibekyan; Adam Auton; Robert K. Bell; Katarzyna Bryc; Sarah K. Clark; Sarah L. Elson; Kipper Fletez-Brant; Pierre Fontanillas; Nicholas A. Furlotte; Pooja M. Gandhi; Karl Heilbron; Barry Hicks; Karen E. Huber; Ethan M. Jewett; Yunxuan Jiang; Aaron Kleinman; Keng-Han Lin; Nadia K. Litterman; J
Pubblicato in: Nature Genetics, Numero 54(8), 2022, Pagina/e 1125-1132, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-022-01124-w

The genetic overlap between Alzheimer’s disease, amyotrophic lateral sclerosis, Lewy body dementia, and Parkinson’s disease

Autori: Douglas P. Wightman, Jeanne E. Savage, Elleke Tissink, Cato Romero, Iris E. Jansen, Danielle Posthuma
Pubblicato in: Neurobiology of Aging, Numero Volume 127, 2023, Pagina/e 99-112, ISSN 0197-4580
Editore: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2023.03.004

Emerging Methods and Resources for Biological Interrogation of Neuropsychiatric Polygenic Signal

Autori: Emil Uffelmann, Danielle Posthuma
Pubblicato in: Biological Psychiatry, Numero 89/1, 2021, Pagina/e 41-53, ISSN 0006-3223
Editore: Elsevier BV
DOI: 10.1016/j.biopsych.2020.05.022

Genome-wide gene-environment interactions in neuroticism: an exploratory study across 25 environments

Autori: Josefin Werme, Sophie van der Sluis, Danielle Posthuma & Christiaan A. de Leeuw
Pubblicato in: Translational Psychiatry, Numero March 22, 2021, 2021, Pagina/e Article number: 180, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-021-01334-6

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease

Autori: Douglas P. Wightman, Iris E. Jansen, Jeanne E. Savage, Alexey A. Shadrin, Shahram Bahrami, Dominic Holland, Arvid Rongve, Sigrid Børte, Bendik S. Winsvold, Ole Kristian Drange, Amy E. Martinsen, Anne Heidi Skogholt, Cristen Willer, Geir Bråthen, Ingunn Bosnes, Jonas Bille Nielsen, Lars G. Fritsche, Laurent F. Thomas, Linda M. Pedersen, Maiken E. Gabrielsen, Marianne Bakke Johnsen, Tore Wergeland
Pubblicato in: Nature Genetics, Numero September 7, 2021, 2021, Pagina/e 1276–1282, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-021-00977-x

Exploring the genetic overlap between twelve psychiatric disorders

Autori: ato Romero, Josefin Werme, Philip R. Jansen, Joel Gelernter, Murray B. Stein, Daniel Levey, Renato Polimanti, Christiaan de Leeuw, Danielle Posthuma, Mats Nagel, Sophie van der Sluis
Pubblicato in: Nature Genetics, Numero 54, 2022, Pagina/e 1795-1802, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-022-01245-2

On the interpretation of transcriptome-wide association studies

Autori: Christiaan de Leeuw, Josefin Werme, Jeanne E. Savage, Wouter J. Peyrot, Danielle Posthuma
Pubblicato in: PLOS Genetics, Numero 19(9): e101092, 2023, ISSN 1553-7390
Editore: Public Library of Science
DOI: 10.1371/journal.pgen.1010921

Genome-wide association studies

Autori: Emil Uffelmann, Qin Qin Huang, Nchangwi Syntia Munung, Jantina de Vries, Yukinori Okada, Alicia R. Martin, Hilary C. Martin, Tuuli Lappalainen & Danielle Posthuma
Pubblicato in: Nature Reviews Methods Primers, Numero August 29, 2021, 2021, Pagina/e Article number: 59, ISSN 2662-8449
Editore: Nature portfolio
DOI: 10.1038/s43586-021-00056-9

Demystifying non-coding GWAS variants: an overview of computational tools and methods

Autori: Marijn Schipper, Danielle Posthuma
Pubblicato in: Human Molecular Genetics, Numero Volume 31, Numero R1, 2022, Pagina/e R73-R83, ISSN 0964-6906
Editore: Oxford University Press
DOI: 10.1093/hmg/ddac198

Other (10)

Mapping the genetic evolutionary timeline of human neural and cognitive traits

Autori: Ilan Libedinsky; Yongbin Wei; Christiaan de Leeuw; James K. Rilling; Danielle Posthuma; Martijn P. van den Heuvel
Pubblicato in: bioRxiv, Numero Sep 28, 2023, 2023
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.02.05.525539

Genome-wide association study of cerebellar volume

Autori: E.P. Tissink, S.C. de Lange, J.E. Savage, D.P. Wightman, K.M. Kelly, M. Nagel, M.P. van den Heuvel, D. Posthuma
Pubblicato in: bioRxiv, Numero November 4, 2021, 2021
Editore: bioRxiv
DOI: 10.1101/2021.11.04.467250

Patient iPSC-derived astrocytes with high polygenic risk for schizophrenia reveals a role for mitochondrial glutamate carrier SLC25A18

Autori: Stephanie Beekhuis-Hoekstra; Karen Laupman; Yongbin Wei; Kyoko Watanabe; Paulien Cornelissen-Steijger; Patrick Sullivan; Danielle Posthuma; Vivi Heine
Pubblicato in: Research Square, Numero 15 JUl, 2022, 2022, ISSN 2693-5015
Editore: Research Square
DOI: 10.21203/rs.3.rs-1811182/v1

Reconsidering the validity of transcriptome-wide association studies

Autori: Christiaan de Leeuw, Josefin Werme, Jeanne Savage, Wouter Peyrot, Danielle Posthuma
Pubblicato in: BioRxiv, Numero August 15, 2021, 2021
Editore: BioRxiv
DOI: 10.1101/2021.08.15.456414

Estimating Disorder Probability Based on Polygenic Prediction Using the BPC Approach

Autori: Emil Uffelmann, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Alkes L. Price, Danielle Posthuma, Wouter J. Peyrot
Pubblicato in: medRxiv, Numero January 14, 2024, 2024
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.01.12.24301157

Local Genetic Sex Differences in Quantitative Traits

Autori: Emil Uffelmann, Christiaan de Leeuw, Danielle Posthuma
Pubblicato in: medRxiv, Numero May 4, 2023, 2023
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.05.04.539410

Rare Variant Aggregation in 148,508 Exomes Identifies Genes Associated with Proxy Alzheimer’s Disease

Autori: Douglas P Wightman, Jeanne E Savage, Christiaan A de Leeuw, Iris E Jansen, Danielle Posthuma
Pubblicato in: medRxiv, Numero October 18, 2021, 2021
Editore: medRxiv
DOI: 10.1101/2021.10.17.21265070

Genome-wide meta-analysis of insomnia in over 2.3 million individuals implicates involvement of specific biological pathways through gene-prioritization

Autori: Kyoko Watanabe, Philip R. Jansen, Jeanne E. Savage, Priyanka Nandakumar, Xin Wang, 23andMe Research Team, David A. Hinds, Joel Gelernter, Daniel F. Levey, Renato Polimanti, Murray B. Stein, Eus J.W. Van Someren, August B. Smit, Danielle Posthuma
Pubblicato in: medRxiv, Numero December 7, 2020, 2020
Editore: bioRxiv
DOI: 10.1101/2020.12.07.20245209

Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study

Autori: E.P. Tissink; A.A. Shadrin; D. van der Meer; N. Parker; G. Hindley; D. Roelfs; O. Frei; C.C. Fan; M. Nagel; T. Nærland; M. Budisteanu; S. Djurovic; L. T. Westlye; M.P. van den Heuvel; D. Posthuma; T. Kaufmann; A.M. Dale; O.A. Andreassen
Pubblicato in: bioRxiv, Numero 20 December, 2022, 2022
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.12.20.521181

Local genetic correlation analysis links depression with molecular and brain imaging endophenotypes

Autori: J. Werme; E.P. Tissink; S.C. de Lange; M.P. van den Heuvel; D. Posthuma; C.A. de Leeuw
Pubblicato in: medRxiv, Numero March 3, 2023, 2023
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.03.01.23286613