Development of “smart” amplifiers of reactive oxygen species specific to aberrant polymorphonuclear neutrophils for treatment of inflammatory and autoimmune diseases, cancer and myeloablation.

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

NeutroCure newsletter No.3
Set-up of NeutroCure web page/ design of consortium's Logo

Design of consortium’s Logo; set-up of NeutroCure web page that should include consortium’s Logo

NeutroCure newsletter No.2
NeutroCure newsletter No.1

A symposium with participation of the supervisory board

A symposium with participation of the supervisory board (Prof. Dr. C. Hackenberger, Leibniz Research Institute for Molecular Pharmacology and Prof. Dr. R. Voll, University Medical Center Freiburg): report with agenda, list of participants, and executive summary of the meeting.

Setup of in vitro assays to assess ROS production, NET formation and killing of cancerous cells mediated by neutrophils

Pubblicazioni

The Potential of Developing Pan-Coronaviral Antibodies to Spike Peptides in Convalescent COVID-19 Patients.

Autori: Andrii Rabets; Galyna Bila; Roman Grytsko; Markian Samborskyy; Yuriy Rebets; Sandor G. Vari; Quentin Pagneux; Alexandre Barras; Rabah Boukherroub; Sabine Szunerits; Rostyslav Bilyy
Pubblicato in: Springer Nature, Numero 2, 2021, ISSN 1661-4917
Editore: Springer
DOI: 10.1007/s00005-021-00607-8

3D-Shaped Binders of Unfolded Proteins Inducing Cancer Cell-Specific Endoplasmic Reticulum Stress In Vitro and In Vivo

Autori: Insa Klemt, Oleg Varzatskii, Roman Selin, Serhii Vakarov, Vladyslava Kovalska, Galyna Bila, Rostyslav Bilyy, Yan Voloshin, Itziar Cossío Cuartero, Andrés Hidalgo, Benjamin Frey, Ina Becker, Bernhard Friedrich, Rainer Tietze, Ralf P. Friedrich, Christoph Alexiou, Elena-Laura Ursu, Alexandru Rotaru, Iris Solymosi, M. Eugenia Pérez-Ojeda, and Andriy Mokhir
Pubblicato in: Journal of the American Chemical Society, Numero 2, 2023, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.3c08827

Targeted opening of the blood–brain barrier facilitates doxorubicin/anti-PD-1-based chemoimmunotherapy of glioblastoma

Autori: Jonathan G. Pol, Manuela Lizarralde-Guerrero, Andrea Checcoli, Guido Kroemer
Pubblicato in: OncoImmunology, Numero 13, 2024, ISSN 2162-402X
Editore: Informa UK Limited
DOI: 10.1080/2162402x.2024.2385124

Neutrophils as Main Players of Immune Response towards Nondegradable Nanoparticles

Autori: Rostyslav Bilyy, Galyna Bila, Oleg Vishchur, Volodymyr Vovk, Martin Herrmann
Pubblicato in: Nanomaterials, Numero 10/7, 2020, Pagina/e 1273, ISSN 2079-4991
Editore: MDPI
DOI: 10.3390/nano10071273

Potent immune-dependent anticancer effects of the non-cardiotoxic anthracycline aclarubicin

Autori: Giulia Cerrato, Allan Sauvat, Mahmoud Abdellatif, Guido Kroemer
Pubblicato in: OncoImmunology, Numero 14, 2025, ISSN 2162-402X
Editore: Informa UK Limited
DOI: 10.1080/2162402x.2025.2515176

Mitochondrial DNA transfer between malignant cells and T lymphocytes shapes the cancer-immunity dialogue

Autori: Liwei Zhao, Peng Liu, Oliver Kepp, Guido Kroemer
Pubblicato in: OncoImmunology, Numero 14, 2025, ISSN 2162-402X
Editore: Informa UK Limited
DOI: 10.1080/2162402x.2025.2512109

Neutrophil Depletion Changes the N-Glycosylation Pattern of IgG in Experimental Murine Sepsis

Autori: Kursat O. Yaykasli, Karin A. van Schie, René E. M. Toes, Manfred Wuhrer, Carolien A. M. Koeleman, Galyna Bila, Nazar Negrych, Georg Schett, Jasmin Knopf, Martin Herrmann, Rostyslav Bilyy
Pubblicato in: International Journal of Molecular Sciences, Numero 25, 2025, Pagina/e 6478, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25126478

Intracellular Amplifiers of Reactive Oxygen Species Affecting Mitochondria as Radiosensitizers

Autori: Hong-Gui Xu; Viktor Reshetnikov; Marit Wondrak; Lisa Eckhardt; Leoni A. Kunz-Schughart; Christina Janko; Rainer Tietze; Christoph Alexiou; Hannes Borchardt; Achim Aigner; Wenjie Gong; Michael Schmitt; Leopold Sellner; Steffen Daum; Hülya Gizem Özkan; Andriy Mokhir
Pubblicato in: Cancers, Numero 1, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14010208

Disruption of cholesterol homeostasis by antidepressants induces immunogenic cell death

Autori: Karla Alvarez-Valadez, Jonathan G. Pol, Guido Kroemer, Mojgan Djavaheri-Mergny
Pubblicato in: OncoImmunology, Numero 14, 2025, ISSN 2162-402X
Editore: Informa UK Limited
DOI: 10.1080/2162402x.2025.2531113

Anticancer Aminoferrocene Derivatives Inducing Production of Mitochondrial Reactive Oxygen Species

Autori: Hülya Gizem Özkan; Vanrajsinh Thakor; Hong‐Gui Xu; Galyna Bila; Rostyslav Bilyy; Daria Bida; Martin Böttcher; Dimitrios Mougiakakos; Rainer Tietze; Andriy Mokhir
Pubblicato in: Chemistry, Eur. J., Numero 3, 2022, ISSN 1521-3765
Editore: Wiley-VCH GmbH, Weinheim
DOI: 10.1002/chem.202104420

A surge in endogenous spermidine is essential for rapamycin-induced autophagy and longevity

Autori: Sebastian J. Hofer, Ioanna Daskalaki, Mahmoud Abdellatif, Ulrich Stelzl, Simon Sedej, Nektarios Tavernarakis, Guido Kroemer, Frank Madeo
Pubblicato in: Autophagy, Numero 20, 2024, Pagina/e 2824-2826, ISSN 1554-8627
Editore: Landes Bioscience
DOI: 10.1080/15548627.2024.2396793

Neutrophil extracellular traps characterize caseating granulomas

Autori: Leticija Zlatar, Jasmin Knopf, Jeeshan Singh, Han Wang, Marco Muñoz-Becerra, Irmgard Herrmann, Rebecca C. Chukwuanukwu, Markus Eckstein, Philip Eichhorn, Ralf J. Rieker, Elisabeth Naschberger, Andreas Burkovski, Veit Krenn, Rostyslav Bilyy, Tetiana Butova, Iryna Liskina, Ihor Kalabukha, Oleg Khmel, Michael Boettcher, Georg Schett, Dmytro Butov, Anton Tkachenko, Martin Herrmann
Pubblicato in: Cell Death & Disease, Numero 15, 2024, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-024-06892-3

An endoplasmic reticulum – specific pro‐amplifier of reactive oxygen species in cancer cells

Autori: Hong-Gui Xu, Margot Schikora, Miroslav Sisa, Steffen Daum, Insa Klemt, Christina Janko, Christoph Alexiou, Galyna Bila, Rostyslav Bilyy, Wenjie Gong, Michael Schmitt, Leopold Sellner, Andriy Mokhir
Pubblicato in: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202100054

Transcriptional Insights of Oxidative Stress and Extracellular Traps in Lung Tissues of Fatal COVID-19 Cases

Autori: Hans-Uwe Simon; Timothée Fettrelet; Aref Hosseini; Darko Stojkov; Shida Yousefi; Rostyslav Bilyy
Pubblicato in: International journal of molecular sciences, Numero 2, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24032646

Vesicular Messages from Dental Biofilms for Neutrophils

Autori: Ljubomir Vitkov, Jelena Krunić, Johanna Dudek, Madhusudhan Reddy Bobbili, Johannes Grillari, Bernhard Hausegger, Irena Mladenović, Nikola Stojanović, Wolf Dietrich Krautgartner, Hannah Oberthaler, Christine Schauer, Martin Herrmann, Jeeshan Singh, Bernd Minnich, Matthias Hannig
Pubblicato in: International Journal of Molecular Sciences, Numero 25, 2025, Pagina/e 3314, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25063314

Periodontitis-Derived Dark-NETs in Severe Covid-19

Autori: Ljubomir Vitkov, Jasmin Knopf, Jelena Krunić, Christine Schauer, Janina Schoen, Bernd Minnich, Matthias Hannig, Martin Herrmann
Pubblicato in: Frontiers in Immunology, 2022, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2022.872695

Neutralization of acyl CoA binding protein (ACBP) for the experimental treatment of osteoarthritis

Autori: Uxía Nogueira-Recalde, Flavia Lambertucci, Léa Montégut, Omar Motiño, Hui Chen, Sylvie Lachkar, Gerasimos Anagnostopoulos, Gautier Stoll, Sijing Li, Vincent Carbonier, Ester Saavedra Díaz, Francisco J. Blanco, Geert van Tetering, Mark de Boer, Maria Chiara Maiuri, Beatriz Caramés, Isabelle Martins, Guido Kroemer
Pubblicato in: Cell Death & Differentiation, Numero 32, 2025, Pagina/e 1484-1498, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/s41418-025-01474-y

Two decades of advances in clinical oncology — lessons learned and future directions

Autori: Susana Banerjee, Christopher M. Booth, Eduardo Bruera, Markus W. Büchler, Alexander Drilon, Terry J. Fry, Irene M. Ghobrial, Luca Gianni, Rakesh K. Jain, Guido Kroemer, Josep M. Llovet, Georgina V. Long, Klaus Pantel, Kathy Pritchard-Jones, Howard I. Scher, Josep Tabernero, Ralph R. Weichselbaum, Michael Weller, Yi-Long Wu
Pubblicato in: Nature Reviews Clinical Oncology, Numero 21, 2024, Pagina/e 771-780, ISSN 1759-4774
Editore: Nature Publishing Group
DOI: 10.1038/s41571-024-00945-4

Reaction of N‐Ferrocenylcarbamates with Nitric Oxide: An Application for Detection of Inflammatory Sites In Vivo

Autori: Roman Selin, Hülya Gizem Özkan, Galyna Bila, Rostyslav Bilyy, Andriy Mokhir
Pubblicato in: ChemMedChem, Numero 20, 2025, ISSN 1860-7179
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.202500356

Immunogenic oncolysis by tigilanol tiglate

Autori: Jonathan G. Pol, Manuela Lizarralde-Guerrero, Guido Kroemer
Pubblicato in: OncoImmunology, Numero 13, 2024, ISSN 2162-402X
Editore: Informa UK Limited
DOI: 10.1080/2162402x.2024.2360230

Moonlighting chromatin: when DNA escapes nuclear control

Autori: Jeeshan Singh, Michael Boettcher, Maximilian Dölling, Annika Heuer, Bettina Hohberger, Moritz Leppkes, Elisabeth Naschberger, Mirco Schapher, Christine Schauer, Janina Schoen, Michael Stürzl, Ljubomir Vitkov, Han Wang, Leticija Zlatar, Georg A. Schett, David S. Pisetsky, Ming-Lin Liu, Martin Herrmann, Jasmin Knopf
Pubblicato in: Cell Death & Differentiation, Numero 30, 2023, Pagina/e 861-875, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/s41418-023-01124-1

A Pleomorphic Puzzle: Heterogeneous Pulmonary Vascular Occlusions in Patients with COVID-19

Autori: Jeeshan Singh; Irmgard Herrmann; Aparna Mahajan; Christine Schauer; Xiaomei Shan; Arndt Hartmann; Ralf J. Rieker; Katja Evert; Christina Falkeis; Elisabeth Naschberger; Saskia von Stillfried; Peter Boor; Luis E. Muñoz; Georg Schett; Martin Herrmann; Jasmin Knopf
Pubblicato in: International Journal of Molecular Sciences; Volume 23; Numero 23; Pages: 15126, Numero 2, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232315126

Fatty Acid Metabolism Provides an Essential Survival Signal in OxPhos and BCR DLBCL Cells

Autori: Aurélie Montagne, Konstantina Kotta, Karoline Kielbassa-Elkadi, Isabelle Martins, José Ángel Martinez-Climent, Guido Kroemer, Catherine Thieblemont, Véronique Baud
Pubblicato in: Biomedicines, Numero 13, 2025, Pagina/e 707, ISSN 2227-9059
Editore: MDPI AG
DOI: 10.3390/biomedicines13030707

Functional selective FPR1 signaling in favor of an activation of the neutrophil superoxide generating NOX2 complex

Autori: Simon Lind, Claes Dahlgren, Rikard Holmdahl, Peter Olofsson, Huamei Forsman
Pubblicato in: Journal of Leukocyte Biology, 2020, ISSN 0741-5400
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1002/jlb.2hi0520-317r

Neutrophil extracellular traps: from physiology to pathology.

Autori: Andrés Hidalgo; Peter Libby; Oliver Soehnlein; Oliver Soehnlein; Iker Valle Aramburu; Venizelos Papayannopoulos; Carlos Silvestre-Roig
Pubblicato in: Cardiovasc Res, Numero 1, 2022, ISSN 1755-3245
Editore: Cardiovascular Research
DOI: 10.1093/cvr/cvab329

Metabolic Heterogeneity in Diffuse Large B-Cell Lymphoma Cells Reveals an Innovative Antimetabolic Combination Strategy

Autori: Leonardo Lordello, Stéphanie Nuan-Aliman, Karoline Kielbassa-Elkadi, Aurélie Montagne, Konstantina Kotta, Isabelle Martins, Eva Pinto Jurado, Cédric Caradeuc, Jacqueline Lehmann-Che, José Ángel Martínez-Climent, Véronique Meignin, Nicolas Giraud, Guido Kroemer, Gildas Bertho, Catherine Thieblemont, Véronique Baud
Pubblicato in: Cancers, Numero 17, 2025, Pagina/e 394, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers17030394

A quantitative LC-MS/MS method for analysis of mitochondrial -specific oxysterol metabolism

Autori: Khushboo Borah, Olivia J. Rickman, Nikol Voutsina, Isaac Ampong, Dan Gao, Emma L. Baple, Irundika HK. Dias, Andrew H. Crosby, Helen R. Griffiths
Pubblicato in: Redox Biology, Numero 36, 2020, Pagina/e 101595, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.1016/j.redox.2020.101595

Immunogenic cell death and bystander killing: expanding the therapeutic potential of modern antibody-drug conjugates

Autori: Oliver Kepp, Guido Kroemer
Pubblicato in: OncoImmunology, Numero 14, 2025, ISSN 2162-402X
Editore: Informa UK Limited
DOI: 10.1080/2162402x.2025.2533488

Neutrophil swarm control: what goes up must come down

Autori: Uderhardt, Stefan; Knopf, Jasmin; Herrmann, Martin
Pubblicato in: Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-2 (2021), Numero 1, 2021, ISSN 2059-3635
Editore: Springer Nature
DOI: 10.1038/s41392-021-00836-5

AI-based classification of anticancer drugs reveals nucleolar condensation as a predictor of immunogenicity

Autori: Giulia Cerrato, Peng Liu, Liwei Zhao, Adriana Petrazzuolo, Juliette Humeau, Sophie Theresa Schmid, Mahmoud Abdellatif, Allan Sauvat, Guido Kroemer
Pubblicato in: Molecular Cancer, Numero 23, 2024, ISSN 1476-4598
Editore: BioMed Central
DOI: 10.1186/s12943-024-02189-3

Obesity accelerates cardiovascular ageing

Autori: Celia Ruperez, Frank Madeo, Rafael de Cabo, Guido Kroemer, Mahmoud Abdellatif
Pubblicato in: European Heart Journal, Numero 46, 2025, Pagina/e 2161-2185, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehaf216

Patients with COVID-19: in the dark-NETs of neutrophils

Autori: Maximilian Ackermann, Hans-Joachim Anders, Rostyslav Bilyy, Gary L. Bowlin, Christoph Daniel, Rebecca De Lorenzo, Mikala Egeblad, Timo Henneck, Andrés Hidalgo, Markus Hoffmann, Bettina Hohberger, Yogendra Kanthi, Mariana J. Kaplan, Jason S. Knight, Jasmin Knopf, Elzbieta Kolaczkowska, Paul Kubes, Moritz Leppkes, Aparna Mahajan, Angelo A. Manfredi, Christian Maueröder, Norma Maugeri, Ioannis Mitr
Pubblicato in: Nature, 2021, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/s41418-021-00805-z

Rapid Generation of Coronaviral Immunity Using Recombinant Peptide Modified Nanodiamonds.

Autori: Rostyslav Bilyy; Quentin Pagneux; Nathan François; Galyna Bila; Roman Grytsko; Yuri Lebedin; Alexandre Barras; Jean Dubuisson; Sandrine Belouzard; Karin Séron; Rabah Boukherroub; Sabine Szunerits
Pubblicato in: https://hal.archives-ouvertes.fr/hal-03348197, Numero 1, 2021, ISSN 2076-0817
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10070861

Hypoxia Promotes Neutrophil Survival After Acute Myocardial Infarction

Autori: Maximilian Dölling, Markus Eckstein, Jeeshan Singh, Christine Schauer, Janina Schoen, Xiaomei Shan, Aline Bozec, Jasmin Knopf, Georg Schett, Luis E Muñoz, Martin Herrmann
Pubblicato in: Frontiers in Immunology, 2022, ISSN 1664-3224
Editore: Frontiers in Immunology
DOI: 10.3389/fimmu.2022.726153

Matrix-producing neutrophils populate and shield the skin

Autori: Tommaso Vicanolo, Alaz Özcan, Jackson LiangYao Li, Carla Huerta-López, Iván Ballesteros, Andrea Rubio-Ponce, Andra C. Dumitru, Jose Ángel Nicolás-Ávila, Miguel Molina-Moreno, Pablo Reyes-Gutierrez, Andrew D. Johnston, Catherine Martone, Eric Greto, Antonio Quílez-Alvarez, Enrique Calvo, Elena Bonzon-Kulichenko, Rebeca Álvarez-Velez, Ming Yao Chooi, Immanuel Kwok, Blanca González-Bermúdez
Pubblicato in: Nature, Numero 641, 2025, Pagina/e 740-748, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-025-08741-5

Atlas of expression of acyl CoA binding protein/diazepam binding inhibitor (ACBP/DBI) in human and mouse

Autori: Sijing Li, Silvia Mingoia, Léa Montégut, Flavia Lambertucci, Hui Chen, Yanbing Dong, Fatima Domenica Elisa De Palma, Sarah Adriana Scuderi, Yan Rong, Vincent Carbonnier, Isabelle Martins, Maria Chiara Maiuri, Guido Kroemer
Pubblicato in: Cell Death & Disease, Numero 16, 2025, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-025-07447-w

Datasets of whole cell and mitochondrial oxysterols derived from THP-1, SH-SY5Y and human peripheral blood mononuclear cells using targeted metabolomics

Autori: Khushboo Borah; Olivia J. Rickman; Nikol Voutsina; Emma L. Baple; Irundika H.K. Dias; Andrew H. Crosby; Helen R. Griffiths
Pubblicato in: Data in Brief, Numero 2, 2020, ISSN 2352-3409
Editore: Elsevier BV
DOI: 10.1016/j.dib.2020.106382

FPR2 Shapes an Immune-Excluded Pancreatic Tumor Microenvironment and Drives T-cell Exhaustion in a Sex-Dependent Manner

Autori: Fei He; Apple H.M. Tay; Ahmed Calandigary; Enana Malki; Sayaka Suzuki; Tianjie Liu; Qi Wang; Carlos Fernández-Moro; Marina Kaisso; Peter Olofsson-Sahl; Marit Melssen; Siu Kwan Sze; Mikael Björnstedt; Matthias J. Löhr; Mikael C.I. Karlsson; Rainer Heuchel; Dhifaf Sarhan
Pubblicato in: Cancer Research, Numero 1, 2023, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-22-2932

Neutrophils as drivers of vascular injury in sickle cell disease

Autori: Lidiane S Torres, Andrés Hidalgo
Pubblicato in: Immunological Reviews, 2022, ISSN 0105-2896
Editore: Blackwell Publishing Inc.
DOI: 10.1111/imr.13146

ACBP/DBI neutralization for the experimental treatment of fatty liver disease

Autori: Omar Motiño, Flavia Lambertucci, Adrien Joseph, Sylvère Durand, Gerasimos Anagnostopoulos, Sijing Li, Vincent Carbonnier, Uxía Nogueira-Recalde, Léa Montégut, Hui Chen, Fanny Aprahamian, Nitharsshini Nirmalathasan, Maria Chiara Maiuri, Federico Pietrocola, Dominique Valla, Cédric Laouénan, Jean-François Gautier, Laurent Castera, null null, Laurent Castera, Anaïs Vallet-Pichard, Tiphaine V
Pubblicato in: Cell Death & Differentiation, Numero 32, 2025, Pagina/e 434-446, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/s41418-024-01410-6

Neutrophil Extracellular Traps Drive Dacryolithiasis

Autori: Leticija Zlatar, Thomas Timm, Günter Lochnit, Rostyslav Bilyy, Tobias Bäuerle, Marco Munoz-Becerra, Georg Schett, Jasmin Knopf, Jens Heichel, Mohammad Javed Ali, Mirco Schapher, Friedrich Paulsen, Martin Herrmann
Pubblicato in: Cells, Numero 12, 2025, Pagina/e 1857, ISSN 2073-4409
Editore: MDPI AG
DOI: 10.3390/cells12141857

Functional selective FPR1 signaling in favor of an activation of the neutrophil superoxide generating NOX2-complex

Autori: Simon Lind; Rikard Holmdahl; Peter Olofsson; Claes Dahlgren; Huamei Forsman
Pubblicato in: Journal of Leukocyte Biology, Numero 4, 2020, ISSN 0741-5400
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1101/2020.05.20.106310

Behavioural immune landscapes of inflammation

Autori: Georgiana Crainiciuc, Miguel Palomino-Segura, Miguel Molina-Moreno, Jon Sicilia, David G Aragones, Jackson Liang Yao Li, Rodrigo Madurga, José M Adrover, Alejandra Aroca-Crevillén, Sandra Martin-Salamanca, Alfonso Serrano Del Valle, Sandra D Castillo, Heidi C E Welch, Oliver Soehnlein, Mariona Graupera, Fátima Sánchez-Cabo, Alexander Zarbock, Thomas E Smithgall, Mauro Di Pila
Pubblicato in: Nature, 2022, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-04263-y

Targeting Lysosomal Thiols for Immunogenic Cancer Cell Death

Autori: Anton Arkhypov, Insa Klemt, Galyna Bila, Dina Attia, Svitlana Chernii, Rostyslav Bilyy, Andriy Mokhir
Pubblicato in: Angewandte Chemie, Numero 137, 2025, ISSN 0044-8249
Editore: Wiley
DOI: 10.1002/ange.202417509

Acyl CoA binding protein (ACBP): an autophagy checkpoint that can be targeted for improving cancer immunosurveillance

Autori: Léa Montégut, Isabelle Martins, Guido Kroemer
Pubblicato in: OncoImmunology, Numero 13, 2024, ISSN 2162-402X
Editore: Informa UK Limited
DOI: 10.1080/2162402x.2024.2413200

Mitochondria‐Catalyzed Activation of Anticancer Prodrugs

Autori: Michael Raucheisen, Dina Attia, Marlies Körber, Alejandra Aroca Crevillén, Andrés Hidalgo, Frank Beierlein, Petra Imhof, Andriy Mokhir
Pubblicato in: ChemCatChem, Numero 17, 2025, ISSN 1867-3880
Editore: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.202500054

A consensus statement

Autori: Daniela F. Quail; Borko Amulic; Monowar Aziz; Betsy J. Barnes; Evgeniy Eruslanov; Zvi G. Fridlender; Helen S. Goodridge; Zvi Granot; Andrés Hidalgo; Anna Huttenlocher; Mariana J. Kaplan; Ilaria Malanchi; Taha Merghoub; Etienne Meylan; Vivek Mittal; Mikael J. Pittet; Andrea Rubio-Ponce; Irina A. Udalova; Timo K. van den Berg; Denisa D. Wagner; Ping Wang; Arturo Zychlinsky; Karin E. de Visser; Mika
Pubblicato in: Journal of Experimental Medicine, Numero 5, 2022, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20220011

Suppression of neutrophils by sodium exacerbates oxidative stress and arthritis

Autori: Leticija Zlatar, Aparna Mahajan, Marco Muñoz-Becerra, Daniela Weidner, Galyna Bila, Rostyslav Bilyy, Jens Titze, Markus H. Hoffmann, Georg Schett, Martin Herrmann, Ulrike Steffen, Luis E. Muñoz, Jasmin Knopf
Pubblicato in: Frontiers in Immunology, Numero 14, 2023, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2023.1174537

Extracellular acyl-CoA-binding protein as an independent biomarker of COVID-19 disease severity

Autori: Stephane Isnard, Tsoarello Mabanga, Léna Royston, Carolina A. Berini, Simeng Bu, Orthy Aiyana, Hansen Feng, Bertrand Lebouché, Cecilia T. Costiniuk, Joseph Cox, Guido Kroemer, Madeleine Durand, Jean-Pierre Routy, null null
Pubblicato in: Frontiers in Immunology, Numero 15, 2025, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2024.1505752

Anti-DNA-IgM Favors the Detection of NET-Associated Extracellular DNA

Autori: Han Wang; Antonia Margarethe Stehr; Jeeshan Singh; Leticija Zlatar; Arndt Hartmann; Katja Evert; Elisabeth Naschberger; Saskia von Stillfried; Peter Boor; Luis E. Muñoz; Jasmin Knopf; Michael Stürzl; Martin Herrmann
Pubblicato in: International Journal of Molecular Sciences, Numero 2, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24044101

Neutrophils Orchestrate the Periodontal Pocket

Autori: Ljubomir Vitkov, Luis E Muñoz, Janina Schoen, Jasmin Knopf, Christine Schauer, Bernd Minnich, Martin Herrmann, Matthias Hannig
Pubblicato in: Frontiers in Immunology, 2021, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2021.788766

Synthesis of a lysosome-targeting aminoferrocene-based prodrug NCure2

Autori: Maximilian Dill, Attia Dina, Mokhir Andriy
Pubblicato in: Arkivoc, Numero 2025, 2025, ISSN 1551-7012
Editore: ARKAT USA, Inc.
DOI: 10.24820/ark.5550190.p012.322

Neutrophil Activity and Extracellular Matrix Degradation: Drivers of Lung Tissue Destruction in Fatal COVID-19 Cases and Implications for Long COVID

Autori: Teluguakula Narasaraju, Indira Neeli, Sheila L. Criswell, Amita Krishnappa, Wenzhao Meng, Vasuki Silva, Galyna Bila, Volodymyr Vovk, Zolotukhin Serhiy, Gary L. Bowlin, Nuala Meyer, Eline T. Luning Prak, Marko Radic, Rostyslav Bilyy
Pubblicato in: Biomolecules, Numero 14, 2025, Pagina/e 236, ISSN 2218-273X
Editore: MDPI AG
DOI: 10.3390/biom14020236

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Autori: Jeeshan Singh, Xiaomei Shan, Aparna Mahajan, Martin Herrmann, Christine Schauer, Jasmin Knopf, Luis E. Muñoz
Pubblicato in: JoVE Journal, 2022, ISSN 2689-3649
Editore: JoVE Journal
DOI: 10.3791/63890

Neutrophil Extracellular Traps and DNases Orchestrate Formation of Peritoneal Adhesions

Autori: Julia Elrod, Annika Heuer, Jasmin Knopf, Janina Schoen, Lavinia Schönfeld, Magdalena Trochimiuk, Carolin Stiel, Birgit Appl, Laia Pagerols Raluy, Ceren Saygi, Leticija Zlatar, Sami Hosari, Dmytro Royzman, Thomas H. Winkler, Günter Lochnit, Moritz Leppkes, Robert Grützmann, Georg Schett, Christian Tomuschat, Konrad Reinshagen, Martin Herrmann, Tobias A. Fuchs, Michael Boettcher
Pubblicato in: IScience, 2023, ISSN 2589-0042
Editore: CellPress
DOI: 10.2139/ssrn.4336831

Metabolic reprogramming promotes apoptosis resistance in acute lymphoblastic leukemia through CASP3 lactylation

Autori: Zhi Lin, Fei Long, Jiao Liu, Rui Kang, Daniel J. Klionsky, Guido Kroemer, Daolin Tang, Minghua Yang
Pubblicato in: Molecular Cancer, Numero 24, 2025, ISSN 1476-4598
Editore: BioMed Central
DOI: 10.1186/s12943-025-02392-w

RIPK1 inhibition in malignant cells potentiates immunotherapy and radiotherapy outcome

Autori: Jonathan G. Pol, Andrea Checcoli, Manuela Lizarralde-Guerrero, Guido Kroemer
Pubblicato in: OncoImmunology, Numero 13, 2024, ISSN 2162-402X
Editore: Informa UK Limited
DOI: 10.1080/2162402x.2024.2425465

Breaking the Gingival Barrier in Periodontitis

Autori: Ljubomir Vitkov; Jeeshan Singh; Christine Schauer; Bernd Minnich; Jelena Krunić; Hannah Oberthaler; Sonja Gamsjaeger; Martin Herrmann; Jasmin Knopf; Matthias Hannig
Pubblicato in: International Journal of Molecular Sciences, Numero 1, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24054544

A concept of dual-responsive prodrugs based on oligomerization-controlled reactivity of ester groups: an improvement of cancer cells <i>versus</i> neutrophils selectivity of camptothecin

Autori: Insa Klemt, Viktor Reshetnikov, Subrata Dutta, Galyna Bila, Rostyslav Bilyy, Itziar Cossío Cuartero, Andrés Hidalgo, Adrian Wünsche, Maximilian Böhm, Marit Wondrak, Leoni A. Kunz-Schughart, Rainer Tietze, Frank Beierlein, Petra Imhof, Sabrina Gensberger-Reigl, Monika Pischetsrieder, Marlies Körber, Tina Jost, Andriy Mokhir
Pubblicato in: RSC Medicinal Chemistry, Numero 15, 2024, Pagina/e 1189-1197, ISSN 2632-8682
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/d3md00609c

Rapid Generation of Coronaviral Immunity Using Recombinant Peptide Modified Nanodiamonds

Autori: Rostyslav Bilyy, Quentin Pagneux, Nathan François, Galyna Bila, Roman Grytsko, Yuri Lebedin, Alexandre Barras, Jean Dubuisson, Sandrine Belouzard, Karin Séron, Rabah Boukherroub, Sabine Szunerits
Pubblicato in: Pathogens, Numero 10, 2025, Pagina/e 861, ISSN 2076-0817
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10070861

Clinically relevant GABARAP deficiency abrogates bortezomib-induced immunogenic cell death in multiple myeloma

Autori: Liwei Zhao, Zhe Shen, Guido Kroemer, Oliver Kepp
Pubblicato in: OncoImmunology, Numero 13, 2024, ISSN 2162-402X
Editore: Informa UK Limited
DOI: 10.1080/2162402x.2024.2360275

Correction: Bilyy et al. Rapid Generation of Coronaviral Immunity Using Recombinant Peptide Modified Nanodiamonds. Pathogens 2021, 10, 861

Autori: Rostyslav Bilyy, Quentin Pagneux, Nathan François, Galyna Bila, Roman Grytsko, Yuri Lebedin, Alexandre Barras, Jean Dubuisson, Sandrine Belouzard, Karin Séron, Rabah Boukherroub, Sabine Szunerits
Pubblicato in: Pathogens, Numero 12, 2023, Pagina/e 1411, ISSN 2076-0817
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens12121411

Neutrophils' Extracellular Trap Mechanisms: From Physiology to Pathology

Autori: Janina Schoen, Maximilien Euler, Christine Schauer, Georg Schett, Martin Herrmann, Jasmin Knopf, Kursat Oguz Yaykasli
Pubblicato in: MDPI, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232112855

Calpain-1 weakens the nuclear envelope and promotes the release of neutrophil extracellular traps

Autori: Jeeshan Singh, Leticija Zlatar, Marco Muñoz-Becerra, Günter Lochnit, Irmgard Herrmann, Felix Pfister, Christina Janko, Jasmin Knopf, Moritz Leppkes, Janina Schoen, Luis E. Muñoz, Georg Schett, Martin Herrmann, Christine Schauer, Aparna Mahajan
Pubblicato in: Cell Communication and Signaling, Numero 22, 2024, ISSN 1478-811X
Editore: BioMed Central
DOI: 10.1186/s12964-024-01785-6

Formation and Clearance of NETs in Health and Disease

Autori: Jasmin Knopf, Aparna Mahajan, Luis E. Muñoz, Martin Herrmann
Pubblicato in: Cells, Numero 11, 2025, Pagina/e 4022, ISSN 2073-4409
Editore: MDPI AG
DOI: 10.3390/cells11244022

Neutrophil NADPH oxidase promotes bacterial eradication and regulates NF-κB-Mediated inflammation via NRF2 signaling during urinary tract infections

Autori: Israel Cotzomi-Ortega, Emily E. Rosowski, Xin Wang, Yuriko I. Sanchez-Zamora, Jeimy M. Lopez-Torres, Gamaliel Sanchez-Orellana, Rachel Han, Gabriela Vásquez-Martínez, Gabriel Mayoral Andrade, Gregory Ballash, Hanna Cortado, Birong Li, Yusuf Ali, Raul Rascon, Frank Robledo-Avila, Santiago Partida-Sanchez, Eduardo Pérez-Campos, Peter Olofsson-Sahl, Diana Zepeda-Orozco, John David Spencer, Brian B
Pubblicato in: Mucosal Immunology, Numero 18, 2025, Pagina/e 402-417, ISSN 1933-0219
Editore: Nature Publishing Group
DOI: 10.1016/j.mucimm.2024.12.010

NET Formation in Systemic Lupus Erythematosus: Changes during the COVID-19 Pandemic

Autori: Jasmin Knopf, Johanna Sjöwall, Martina Frodlund, Jorma Hinkula, Martin Herrmann, Christopher Sjöwall
Pubblicato in: MDPI, 2022, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells11172619

Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes

Autori: Stephan Culemann; Katharina Knab; Maximilien Euler; Anja Wegner; Hilal Garibagaoglu; Jochen Ackermann; Kim Fischer; Deborah Kienhöfer; Georgiana Crainiciuc; Jonas Hahn; Anika Grüneboom; Falk Nimmerjahn; Stefan Uderhardt; Andrés Hidalgo; Georg Schett; Markus H. Hoffmann; Gerhard Krönke
Pubblicato in: Journal of Experimental Medicine, Numero 4, 2023, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20220525

Neutrophils in Physiology and Pathology

Autori: Alejandra Aroca-Crevillén, Tommaso Vicanolo, Samuel Ovadia, Andrés Hidalgo
Pubblicato in: Annual Review of Pathology: Mechanisms of Disease, Numero 19, 2024, Pagina/e 227-259, ISSN 1553-4006
Editore: Annual Reviews, Inc.
DOI: 10.1146/annurev-pathmechdis-051222-015009

Nano- and Microparticles and Their Role in Inflammation and Immune Response: Focus on Neutrophil Extracellular Traps

Autori: Galyna Bila, Andrii Rabets, Rostyslav Bilyy
Pubblicato in: Biomedical Nanomaterials, 2021, Pagina/e 149-170, ISBN 978-3-030-76234-6
Editore: Springer International Publishing
DOI: 10.1007/978-3-030-76235-3_6

Aminoferrocene- or ferrocenylaniline-based ROS amplifiers with anticancer activity

Autori: Honggui Xu
Pubblicato in: 2022
Editore: FAU

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