A smart, hybrid neural-computo device for drug discovery

Project Information

NEUREKA

Grant agreement ID: 863245

DOI 10.3030/863245

Project closed

EC signature date 24 September 2019

Start date 1 December 2019

End date 31 May 2024

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost € 2 776 705,00

EU contribution € 2 776 704,00

Coordinated by

IDRYMA TECHNOLOGIAS KAI EREVNAS
Greece

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Demonstrators, pilots, prototypes (4)

NEUREKA website

By month 2 we will establish the project website

1st generation 60-channels NWA

We will demonstrate the completion/operation of the 1st generation of the 60-channels NWA.

Bioengineered Synaptor: first prototype

The first prototype of the Synaptor will be ready by month 18.

Biophysical model of Synaptor

We will establish a biophysical model of the synaptor that will be used to connect the computational modelling stimulation with the NWA

Documents, reports (8)

State-of-the-art review on human iPSC-derived neurons modeling brain disease

State-of-the-art review on human iPSC-derived neurons modeling brain disease in preclinical drug discovery

Outreach activity plan

Report on our plans for outreach activities

State of the art review of micro-electrodes for neuron recording and stimulation.

State of the art review of microelectrodes used for neuron recording and stimulation

Data Management Plan

We will provide a detailed plan on how we will manage all data generated during the project. UNIPD and FORTH will work together for this deliverable, with UNIPD assuming a substantial portion of the preparatory work.

First controlled dendritic stimulation via Synaptors

First demonstration of dendritic stimulation via activation of the Synaptors

Characterization of ALD high-k dielectrics on 1D nanostructures.

The characterization of ALD highk dielectrics on 1D nanostructures will be completed and reported

Research and Implementation Plan

Formulation of the Research and Implementation Plans.

Conductive oxides / polymer characterization on 1D nanostructures.

Conductive oxides and polymer characterization on 1D nanostructures will be completed and reported

Open Research Data Pilot (1)

ORDP: Open Research Data Pilot

In this deliverable we will report on our activities for 1) Deposit selected (non-confidential) parts of our data in a research data repository (e.g. ModelDB for computational models).2) Ensure free access to the non-confidential parts of our data.3) Provide related information and/or tools for using the above mentioned data to validate our research.

Websites, patent fillings, videos etc. (1)

Web-based project management board

Web-based project management board with balanced and distributed workload

Publications

Peer reviewed articles (14)

Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit

Author(s): Olesia M. Bilash, Spyridon Chavlis, Cara D. Johnson, Panayiota Poirazi, Jayeeta Basu
Published in: Cell Reports, Issue 42, 2023, Page(s) 111962, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.111962

The dendritic engram

Author(s): George Kastellakis; Simone Tasciotti; Ioanna Pandi; Panayiota Poirazi
Published in: Frontiers in Behavioral Neuroscience, Issue 17, 2023, ISSN 1662-5153
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2023.1212139

Combining PEDOT:PSS Polymer Coating with Metallic 3D Nanowires Electrodes to Achieve High Electrochemical Performances for Neuronal Interfacing Applications

Author(s): Ines Muguet, Ali Maziz, Fabrice Mathieu, Laurent Mazenq, Guilhem Larrieu
Published in: Advanced Materials, Issue 35, 2023, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202302472

Plasma-Assisted Atomic Layer Deposition of IrO2 for Neuroelectronics

Author(s): Valerio Di Palma, Andrea Pianalto, Michele Perego, Graziella Tallarida, Davide Codegoni, Marco Fanciulli
Published in: Nanomaterials, Issue 13, 2023, Page(s) 976, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano13060976

Dendrites and efficiency: Optimizing performance and resource utilization

Author(s): Roman Makarov; Michalis Pagkalos; Panayiota Poirazi
Published in: Current Opinion in Neurobiology, Issue 13, 2023, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.1016/j.conb.2023.102812

Large-Scale 3D Two-Photon Imaging of Molecularly Identified CA1 Interneuron Dynamics in Behaving Mice

Author(s): Geiller, Tristan; Vancura, Bert; Terada, Satoshi; Troullinou, Eirini; Chavlis, Spyridon; Tsagkatakis, Grigorios; Tsakalides, Panagiotis; Ócsai, Katalin; Poirazi, Panayiota; Rózsa, Balázs J.; Losonczy, Attila
Published in: Neuron, Issue 7, 2020, Page(s) 968-983.e9, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2020.09.013

Extracellular Recording of Entire Neural Networks Using a Dual- Mode Microelectrode Array With 19584 Electrodes and High SNR

Author(s): Yuan, Xinyue; Hierlemann, Andreas; Frey, Urs
Published in: IEEE Journal of Solid-State Circuits, Issue 11, 2021, Page(s) 2466 - 2475, ISSN 0018-9200
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/JSSC.2021.3066043

Hippocampal GABAergic interneurons and memory

Author(s): Alexandra Tzilivaki, John J. Tukker, Nikolaus Maier, Panayiota Poirazi, Rosanna P. Sammons, Dietmar Schmitz
Published in: Neuron, Issue 111, 2023, Page(s) 3154-3175, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2023.06.016

Large-Scale Monolithic Fabrication of III−V Vertical Nanowires on a Standard Si(100) Microelectronic Substrate

Author(s): Lecestre, Aurélie; Martin, Mickael; Cristiano, Filadelfo; Baron, Thierry; Larrieu, Guilhem
Published in: ACS Omega, Issue 4, 2022, Page(s) 5836–5843, ISSN 2470-1343
Publisher: American Chemical Society
DOI: 10.1021/acsomega.1c05876

Introducing the Dendrify framework for incorporating dendrites to spiking neural networks

Author(s): Michalis Pagkalos, Spyridon Chavlis, Panayiota Poirazi
Published in: Nature Communications, Issue 14, 2023, Page(s) 131, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-35747-8

Drawing Inspiration from Biological Dendrites to Empower Artificial Neural Networks

Author(s): Spyridon Chavlis; Panayiota Poirazi
Published in: Current Opinion in Neurobiology, Issue 1, 2021, Page(s) 1-10, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.5281/zenodo.7648693

Real‐Time and High‐Resolution Monitoring of Neuronal Electrical Activity and pH Variations Based on the Co‐Integration of Nanoelectrodes and Chem‐FinFETs

Author(s): Luca Bettamin, Fabrice Mathieu, Florent H. Marty, Marie Charline Blatche, Daniel Gonzalez‐Dunia, Elsa Suberbielle, Guilhem Larrieu
Published in: Small, Issue 20, 2024, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202309055

A Locus Coeruleus- dorsal CA1 dopaminergic circuit modulates memory linking

Author(s): Chowdhury, Ananya; Luchetti, Alessandro; Fernandes, Giselle; Filho, Daniel Almeida; Kastellakis, George; Tzilivaki, Alexandra; Ramirez, Erica M; Tran, Mary Y; Poirazi, Panayiota; Silva, Alcino J
Published in: Neuron, Issue 1, 2022, Page(s) 3374-3388.e8, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2022.08.001

Leveraging dendritic properties to advance machine learning and neuro-inspired computing

Author(s): Michalis Pagkalos, Roman Makarov, Panayiota Poirazi
Published in: Current Opinion in Neurobiology, Issue 85, 2024, Page(s) 102853, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.1016/j.conb.2024.102853

Other (2)

Synaptic turnover promotes efficient learning in bio-realistic spiking neural networks

Author(s): Nikos Malakasis; Spyridon Chavlis; Panayiota Poirazi
Published in: BioRxiv, Issue 4, 2023
Publisher: BioRxiv
DOI: 10.1101/2023.05.22.541722

Dendrites endow artificial neural networks with accurate, robust and parameter efficient learning

Author(s): Chavlis, Spyridon; Poirazi, Panayiota
Published in: arxiv, Issue 3, 2024
Publisher: arxiv
DOI: 10.48550/arxiv.2404.03708

Conference proceedings (1)

A 0.46 nV/√Hz JFET Low-Noise Amplifier for Characterization of Nanoelectrode Coating Materials

Author(s): Elia A. Vallicelli; Valerio Di Palma; Marcello De Matteis; Andrea Baschirotto; Marco Fanciulli
Published in: 29th IEEE International Conference on Electronics, Circuits and Systems (ICECS), Issue 4, 2022, Page(s) 1-4, ISBN 978-1-6654-8823-5
Publisher: IEEE
DOI: 10.1109/icecs202256217.2022.9970943

Intellectual Property Rights

Patent (1)

NANOSTRUCTURE PLATFORM FOR CELLULAR INTERFACING AND CORRESPONDING MANUFACTURING PROCESS

Application/Publication number: 18 808036
Date: 2018-12-03
Applicant(s): CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS