Effective and Affordable Flu Vaccines for the World

Informazioni relative al progetto

INDIGO

ID dell’accordo di sovvenzione: 874653

DOI

10.3030/874653

Progetto chiuso

Data della firma CE 13 Dicembre 2019

Data di avvio 1 Aprile 2020

Data di completamento 31 Marzo 2026

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 16 000 968,00

Contributo UE

€ 9 975 979,00

Coordinato da

STICHTING AMSTERDAM UMC
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (10)

Report on status of posting results in the study registry TETRA-LITE Phase I (EU)

Report on the status of the results posting including timelines when final posting of results is scheduled after end of funding period of Phase I trial TETRA-LITE (EU).

Publication Treg/Teffector cell immune-profiling donor PBMC
Publication LVA and MDPA adjuvants on human PBMCs

Publication LVA and MDPA adjuvants on human PBMCs and DCs

Report/Publication effect LVA & MDPA, Treg/effector-balance, immunosuppression

Report/Publication effect and mode of action of LVA & MDPA, Treg/effector-balance, immunosuppression

Publication(s) data of Phase I and Ib studies (EU)

Pubilcation(s) of the obtained data of the clinical Phase I and Ib studies (EU)

Regulatory recommendations global pandemic responses and vaccine approval
Report/Publication PANDEMIC-PLUS ID patches

Report/Publication manufacturing, safety, immunogenicity, physio-chemical characteristics of PANDEMIC-PLUS ID patches

Report/Publication protective immunity TETRA-LITE in ferrets

ReportPublication protective immunity TETRALITE in ferrets

Report on status of posting results in the study registry TETRA-LITE Phase Ib (EU)

Report on the status of the results posting including timelines when final posting of results is scheduled after end of funding period of TETRA-LITE Phase Ib (EU).

Report/Publication mode of action LVA for CTA

ReportPublication mode of action LVA for CTA

Open Research Data Pilot (1)

Publications regulation and legal aspects pandemic flu

Websites, patent fillings, videos etc. (1)

Website, Facebook, etc.

Website Facebook etc

Pubblicazioni

Peer reviewed articles (15)

A Novel Carbohydrate Fatty-Acid Monosulphate Ester, Squalane-in-Water Adjuvant Is Safe and Enhances Inactivated Influenza Vaccine Immunogenicity in Older Adults

Autori: Valentino D’Onofrio, Bart Jacobs, Azhar Alhatemi, Simon De Gussem, Marjolein Verstraete, Sharon Porrez, Anthony Willems, Fien De Boever, Gwenn Waerlop, Geert Leroux-Roels, Els Michels, Francesca Van
Pubblicato in: Vaccines, Numero 13, 2025, Pagina/e 922, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines13090922

Influenza vaccination uptake of health care workers in a tertiary hospital: Findings from qualitative research in Mysuru, India

Autori: Jantine Marly van Wijlick, K. S. Sahana, P. A. Mahesh, B. S. Jayaraj, Gangadhar Mysore Rajagopal, Christopher Pell
Pubblicato in: Global Public Health, Numero 20, 2025, ISSN 1744-1692
Editore: Routledge
DOI: 10.1080/17441692.2025.2541228

TRIPS at thirty: The evolving interactional law of public health exceptions to intellectual property protection

Autori: Geraldo Vidigal; Pramiti Parwani
Pubblicato in: VANDERBILT JOURNAL OF TRANSNATIONAL LAW, Numero 57, 2024, Pagina/e 1493–1494, ISSN 0090-2594
Editore: University of Vanderbilt Law School
DOI: 10.3316/informit.t2025020500004891207935195

Influenza vaccination post-COVID-19 expands vaccine-specific effector CD4 T-cells and Tregs under positive influence of host trained innate immunity

Autori: Hima Bindhu, Srabanti Rakshit, Vasista Adiga, Asma Ahmed, Nirutha Chetan Kumar, Maria Macrina, Himanshu Tripathi, Francesca Vanni, Emanuele Montomoli, Sweety Samal, Sneha Raj, Preeti Vishwakarma, Geor
Pubblicato in: npj Vaccines, Numero 11, 2026, ISSN 2059-0105
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41541-025-01331-6

Retrospective analysis on the immunopotentiating mechanism of an emulsion-based vaccine adjuvant on human antigen presenting cells

Autori: Srinivasa Reddy Bonam, Peter Paul Platenburg and Jagadeesh Bayry
Pubblicato in: Frontiers Immunology, Numero 9 January 2023, 2023, ISSN 1664-3224
Editore: Frontiers in immunology

Perceptions of respiratory tract infections and their implications for disease prevention practices among older adults in Mysuru, India

Autori: Jantine Marly van Wijlick, K.S. Sahana, B.S. Jayaraj, Christopher Pell, Gangadhar Mysore Rajagopal, P. A. Mahesh
Pubblicato in: PLOS Global Public Health, Numero 5, 2025, Pagina/e e0004982, ISSN 2767-3375
Editore: Public Library of Science (PLoS)
DOI: 10.1371/journal.pgph.0004982

Influenza vaccine hesitancy and acceptance among healthcare workers: A qualitative study in Amsterdam, the Netherlands / Grippeimpfung: Skepsis und Akzeptanz bei Gesundheitsfachkräften. Eine qualitat

Autori: Julia M. van Beekum, Jantine M. van Wijlick, Jaap Maas, Christopher Pell
Pubblicato in: International Journal of Health Professions, Numero 12, 2025, Pagina/e 93-103, ISSN 2296-990X
Editore: Walter de Gruyter GmbH
DOI: 10.2478/ijhp-2025-0008

Intradermal Immunization of Soluble Influenza HA Derived from a Lethal Virus Induces High Magnitude and Breadth of Antibody Responses and Provides Complete Protection In Vivo

Autori: Sneha Raj, Preeti Vishwakarma, Shikha Saxena, Varun Kumar, Ritika Khatri, Amit Kumar, Mrityunjay Singh, Surbhi Mishra, Shailendra Asthana, Shubbir Ahmed, Sweety Samal
Pubblicato in: Vaccines, Numero 11, 2023, Pagina/e 780, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11040780

Safety and Immunogenicity of a Carbohydrate Fatty Acid Monosulphate Ester Adjuvant Combined with a Low-Dose Quadrivalent Split-Virion Inactivated Influenza Vaccine: A Randomised, Observer-Blind, Active-Controlled, First-in-Human, Phase 1 Study

Autori: Valentino D’Onofrio, Sharon Porrez, Bart Jacobs, Azhar Alhatemi, Fien De Boever, Gwenn Waerlop, Els Michels, Francesca Vanni, Alessandro Manenti, Geert Leroux-Roels, Peter Paul Platenburg, Luuk Hilgers, Isabel Leroux-Roels
Pubblicato in: Vaccines, Numero 12, 2024, Pagina/e 1036, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines12091036

Carbohydrate fatty acid monosulphate ester is a potent adjuvant for low-dose seasonal influenza vaccines

Autori: Peter Paul L.I. Platenburg, Frantz Deschamps, Jennifer Jung, Clément Leonard, Séverine Rusconi, S.B. Mohan Kumar, S.M. Sulaiman, Leon de Waal, Luuk A. Th. Hilgers
Pubblicato in: Vaccine, Numero 41, 2023, Pagina/e 6980-6990, ISSN 0264-410X
Editore: Elsevier BV
DOI: 10.1016/j.vaccine.2023.10.017

Factors affecting influenza vaccine uptake among healthcare providers at a tertiary hospital in Mysuru, India: a questionnaire-based survey

Autori: Naviya Kafle, Jantine van Wijlick, P. Chaithra Poonacha, P. Priyanka, Jiten Choudhury, N. Onkar Yadav, R. Nisarga, Rebecca D. Kehm, Logan Stuck, Christopher Pell, Anil S. Bilimale
Pubblicato in: Vaccine: X, Numero 25, 2025, Pagina/e 100687, ISSN 2590-1362
Editore: Elsevier BV
DOI: 10.1016/j.jvacx.2025.100687

Carbohydrate fatty acid monosulphate ester adjuvant enhances the immunogenicity of influenza antigens via TLR4/2-dependent mechanisms

Autori: Sruthi Vijaya Retnakumar, Suraj Chandrabhan Singh, Srinivasa Reddy Bonam, Camille Chauvin, Mano Joseph Mathew, Ida Busch Nielsen, Christine Boyle, Luuk Hilgers, Max Søgaard, Peter Paul Platenburg, Jagadeesh Bayry
Pubblicato in: Frontiers in Immunology, Numero 17, 2026, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2026.1787181

Trust Beyond Borders: European External Regulatory Influence on Access to Medicines

Autori: Pramiti Parwani, Katrina Perehudoff, Anniek de Ruijter
Pubblicato in: Journal of Law, Medicine & Ethics, Numero 53, 2025, Pagina/e 365-378, ISSN 1073-1105
Editore: American Society of Law, Medicine & Ethics
DOI: 10.1017/jme.2025.10140

From human rights to the pandemic agreement and beyond: reframing vaccines access through a framework of ‘States’ capabilities’

Autori: Pramiti Parwani
Pubblicato in: Journal of Global Health Law, Numero 2, 2025, Pagina/e 55-79, ISSN 2976-5951
Editore: Edward Elgar Publishing
DOI: 10.4337/jghl.2025.01.03

Decoding the Tecfidera Case: The Court of Justice of the European Union’s Verdict on the “Same Global Marketing Authorisation”

Autori: Pramiti Parwani
Pubblicato in: SSRN Electronic Journal, 2025, ISSN 1556-5068
Editore: Elsevier BV
DOI: 10.2139/ssrn.5153591

Thesis and dissertations (1)

States capabilities of least-developed countries to access pandemic vaccines. EU and India's legal and regulatory influence

Autori: P. Parwani
Pubblicato in: 2025
Editore: Library of the University of Amsterdam