Stratification of Obesity Phenotypes to Optimize Future Therapy

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Dataset profiles handbook
Online educational resource for clinicians with photographs, video, audio, and diaries representing patient perceptions and perspectives
Needs and challenges communication package

External Project Website

Publications

Patient perceptions of success in obesity treatment: An IMI2 SOPHIA study

Auteurs: E. Farrell, J. Nadglowski, E. Hollmann, C. W. le Roux, D. McGillicuddy
Publié dans: Obesity Science & Practice, Numéro 10, 2024, ISSN 2055-2238
Éditeur: Wiley
DOI: 10.1002/osp4.70001

Clinical characteristics and outcomes of children, adolescents and young adults with overweight or obesity and mental health disorders

Auteurs: Angela Galler, Angelika Thönnes, Jens Joas, Christine Joisten, Antje Körner, Thomas Reinehr, Markus Röbl, Gerd Schauerte, Wolfgang Siegfried, Daniel Weghuber, Susann Weihrauch-Blüher, Susanna Wiegand, Reinhard W. Holl, Nicole Prinz, null null
Publié dans: International Journal of Obesity, Numéro 48, 2024, Page(s) 423-432, ISSN 0307-0565
Éditeur: Nature Publishing Group
DOI: 10.1038/s41366-023-01449-4

Whole-genome sequencing analysis identifies rare, large-effect noncoding variants and regulatory regions associated with circulating protein levels

Auteurs: Gareth Hawkes, Kartik Chundru, Leigh Jackson, Kashyap A. Patel, Anna Murray, Andrew R. Wood, Caroline F. Wright, Michael N. Weedon, Timothy M. Frayling, Robin N. Beaumont
Publié dans: Nature Genetics, Numéro 57, 2025, Page(s) 626-634, ISSN 1061-4036
Éditeur: Nature Publishing Group
DOI: 10.1038/s41588-025-02095-4

Identification and analysis of individuals who deviate from their genetically-predicted phenotype

Auteurs: Gareth Hawkes, Loic Yengo, Sailaja Vedantam, Eirini Marouli, Robin N Beaumont, null null, Jessica Tyrrell, Michael N Weedon, Joel Hirschhorn, Timothy M Frayling, Andrew R Wood
Publié dans: PLOS Genetics, 2023, ISSN 1553-7390
Éditeur: Public Library of Science
DOI: 10.1101/2023.02.10.528019

Who benefits most from outpatient lifestyle intervention? An IMI‐SOPHIA study on pediatric individuals living with overweight and obesity

Auteurs: Prinz, Nicole; Pomares‐Millan, Hugo; Dannemann, Almut; Giordano, Giuseppe N.; Joisten, Christine; Körner, Antje; Weghuber, Daniel; Weihrauch‐Blüher, Susann; Wiegand, Susanna; Holl, Reinhard W.; Lanzinger, Stefanie; APV initiative; Stratification of Obesity Phenotypes to Optimize Future Therapy (SOPHIA) consortium
Publié dans: Obesity, Numéro 2, 2023, ISSN 1930-739X
Éditeur: Wiley

Whole-genome sequencing in 333,100 individuals reveals rare non-coding single variant and aggregate associations with height

Auteurs: Gareth Hawkes, Robin N. Beaumont, Zilin Li, Ravi Mandla, Xihao Li, Christine M. Albert, Donna K. Arnett, Allison E. Ashley-Koch, Aneel A. Ashrani, Kathleen C. Barnes, Eric Boerwinkle, Jennifer A. Brody, April P. Carson, Nathalie Chami, Yii-Der Ida Chen, Mina K. Chung, Joanne E. Curran, Dawood Darbar, Patrick T. Ellinor, Myrian Fornage, Victor R. Gordeuk, Xiuqing Guo, Jiang He, Chii-Min Hwu, Rita R
Publié dans: Nature Communications, Numéro 15, 2024, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-024-52579-w

Subclassification of obesity for precision prediction of cardiometabolic diseases: an IMI SOPHIA study

Auteurs: Paul Franks, Daniel Coral, Femke Smit, Ali Farzaneh, Alexander Gieswinkel, Juan Fernández-Tajes, Thomas Sparsø, Carl Delfin, Pierre Bauvin, Kan Wang, Marinella Temprosa, Diederick De Cock, Jordi Blanch, José Manuel Fernández-Real, Rafael Ramos, M. Kamran Ikram, Maria Gomez, Maryam Kavousi, Marina Panova-Noeva, Philipp WIld, Carla van der Kallen, Michiel Adriaens, Marleen van Greevenbroek, Ilja
Publié dans: Nature Medicine, 2024, ISSN 1546-170X
Éditeur: Nature Medicine
DOI: 10.21203/rs.3.rs-4048297/v1

Factors influencing patients to choose one obesity treatment over another: a qualitative study

Auteurs: H. C. Craig, D. Alsaeed, E. Al Ozairi, S. Norris, J. Holian, C. Kennedy, H. Heneghan, D. McGillicuddy, E. Farrell, E. Hollmann, W. Al-Najim, C. W. le Roux
Publié dans: International Journal of Obesity, 2025, ISSN 0307-0565
Éditeur: Nature Publishing Group
DOI: 10.1038/s41366-025-01789-3

Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood

Auteurs: Gareth Hawkes; Robin N. Beaumont; Jessica Tyrrell; Grace M. Power; Andrew Wood; Markku Laakso; Lilian Fernandes Silva; Michael Boehnke; Xianyong Yin; Tom G. Richardson; George Davey Smith; Timothy M. Frayling
Publié dans: Diabetologia, 2023, ISSN 1949-2448
Éditeur: Springer link
DOI: 10.1007/s00125-023-05923-6

Is COVID-19 to Blame? Trends of Incidence and Sex Ratio in Youth-Onset Type 2 Diabetes in Germany

Auteurs: Christian Denzer; Christian Denzer; Daniela Klose; Antje Korner; Thomas Reinehr; Christina Baechle; Carmen Schroder; Susanna Wiegand; Reinhard W. Holl; Nicole Prinz
Publié dans: Diabetes care, 2023, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/dc22-2257

Factors that determine patients considering medication for the disease of obesity: an IMI2 SOPHIA study

Auteurs: H. C. Craig, D. Alsaeed, H. Heneghan, W. Al-Najim, E. Al Ozairi, C. W. le Roux
Publié dans: International Journal of Obesity, 2024, ISSN 0307-0565
Éditeur: Nature Publishing Group
DOI: 10.1038/s41366-024-01524-4

What influences patient decisions when selecting an obesity treatment?

Auteurs: Hilary C. Craig, David Walley, Carel W. le Roux
Publié dans: Obesity Pillars, Numéro 12, 2024, Page(s) 100123, ISSN 2667-3681
Éditeur: Elsevier BV
DOI: 10.1016/j.obpill.2024.100123

The emergence of obesity in type 1 diabetes

Auteurs: Martin T. W. Kueh, Nicholas W. S. Chew, Ebaa Al-Ozairi, Carel W. le Roux
Publié dans: International Journal of Obesity, Numéro 48, 2024, Page(s) 289-301, ISSN 0307-0565
Éditeur: Nature Publishing Group
DOI: 10.1038/s41366-023-01429-8

Cardiovascular health, genetic predisposition, and lifetime risk of type 2 diabetes

Auteurs: Kan Wang; Maryam Kavousi; Trudy Voortman; M. Arfan Ikram; Mohsen Ghanbari; Fariba Ahmadizar;
Publié dans: European Journal of Preventive Cardiology, 2021, ISSN 2047-4873
Éditeur: SAGE Publications Ltd
DOI: 10.1093/eurjpc/zwab141

A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes

Auteurs: Daniel E. Coral; Juan Fernandez-Tajes; Neli Tsereteli; Hugo Pomares-Millan; Hugo Fitipaldi; Pascal M. Mutie; Naeimeh Atabaki-Pasdar; Sebastian Kalamajski; Alaitz Poveda; Tyne W. Miller-Fleming; Xue Zhong; Giuseppe N. Giordano; Ewan R. Pearson; Nancy J. Cox; Paul W. Franks
Publié dans: Nature Metabolism, 2023, ISSN 2522-5812
Éditeur: Nature Metabolism
DOI: 10.1038/s42255-022-00731-5

Trajectories of BMI before and after diagnosis of type 2 diabetes in a real-world population

Auteurs: Louise A. Donnelly, Rory J. McCrimmon, Ewan R. Pearson
Publié dans: Diabetologia, 2024, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-024-06217-1

BMI-residualized data uncovers a cluster of people with type 2 diabetes and increased serum ferritin protected from cardiovascular disease

Auteurs: Laura Gallardo-Nuell, Jordi Blanch, Yenny Leal, Daniel E Coral, Talita Duarte-Salles, Giuseppe N. Giordano, Paul W. Franks, Ewan R. Pearson, Geltrude Mingrone, Carel W le Roux, Rafael Ramos, José Manuel Fernández-Real
Publié dans: Cardiovascular Diabetology, Numéro 24, 2025, ISSN 1475-2840
Éditeur: BioMed Central
DOI: 10.1186/s12933-025-02685-w

Insulin Clearance in Health and Disease

Auteurs: Sonia M. Najjar, Sonia Caprio, Amalia Gastaldelli
Publié dans: Annual Review of Physiology, Numéro 85, 2023, Page(s) 363-381, ISSN 0066-4278
Éditeur: Annual Reviews, Inc.
DOI: 10.1146/annurev-physiol-031622-043133

Comparison of cardiovascular risk factors between children and adolescents with classes III and IV obesity: findings from the APV cohort

Auteurs: Thomas Reinehr, Sascha R. Tittel, Rolf Holle, Susanna Wiegand, Ines Gellhaus, Johannes Hebebrand, Susanne Greber-Platzer, Christian Denzer, Sabine Linke, Wieland Kiess, Reinhard W. Holl
Publié dans: International Journal of Obesity, Numéro 45/5, 2021, Page(s) 1061-1073, ISSN 0307-0565
Éditeur: Nature Publishing Group
DOI: 10.1038/s41366-021-00773-x

Clinical characteristics and cardiovascular risk profile in children and adolescents with latent autoimmune diabetes: Results from the German/Austrian prospective diabetes follow‐up registry

Auteurs: Alena Welters, Sascha R. Tittel, Thomas Reinehr, Daniel Weghuber, Susanna Wiegand, Wolfram Karges, Clemens Freiberg, Thomas Meissner, Nanette C. Schloot, Reinhard W. Holl
Publié dans: Pediatric Diabetes, Numéro 23, 2022, Page(s) 1602-1612, ISSN 1399-543X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/pedi.13450

“You Are Always at War With Yourself” The Perceptions and Beliefs of People With Obesity Regarding Obesity as a Disease

Auteurs: Andrew Grannell; Carel W. le Roux; Deirdre McGillicuddy;
Publié dans: Qualitative Health Research, 2021, ISSN 1049-7323
Éditeur: SAGE Publications
DOI: 10.1177/10497323211040767

A Federated Database for Obesity Research: An IMI-SOPHIA Study

Auteurs: Carl Delfin, Iulian Dragan, Dmitry Kuznetsov, Juan Fernandez Tajes, Femke Smit, Daniel E. Coral, Ali Farzaneh, André Haugg, Andreas Hungele, Anne Niknejad, Christopher Hall, Daan Jacobs, Diana Marek, Diane P. Fraser, Dorothee Thuillier, Fariba Ahmadizar, Florence Mehl, Francois Pattou, Frederic Burdet, Gareth Hawkes, Ilja C. W. Arts, Jordi Blanch, Johan Van Soest, José-Manuel Fernández-Real, Ju
Publié dans: Life, Numéro 14, 2024, Page(s) 262, ISSN 2075-1729
Éditeur: MDPI AG
DOI: 10.3390/life14020262

BMI Z-Score (SDS) versus Calculated Body Fat Percentage: Association with Cardiometabolic Risk Factors in Obese Children and Adolescents

Auteurs: Christine Joisten, Stefanie Wessely, Nicole Prinz, Susanna Wiegand, Bettina Gohlke, Sabine Keiser, Paula Moliterno, Jens Nielinger, Gabriel Torbahn, Hagen Wulff, Reinhard W. Holl, null null
Publié dans: Annals of Nutrition and Metabolism, Numéro 80, 2024, Page(s) 29-36, ISSN 0250-6807
Éditeur: S. Karger AG
DOI: 10.1159/000535216

Lipid metabolism in MASLD and MASH: From mechanism to the clinic

Auteurs: Fabrizia Carli, Giuseppe Della Pepa, Silvia Sabatini, Antonio Vidal Puig, Amalia Gastaldelli
Publié dans: JHEP Reports, Numéro 6, 2025, Page(s) 101185, ISSN 2589-5559
Éditeur: Elsevier BV
DOI: 10.1016/j.jhepr.2024.101185

Bariatric–metabolic surgery versus lifestyle intervention plus best medical care in non-alcoholic steatohepatitis (BRAVES): a multicentre, open-label, randomised trial

Auteurs: Ornella Verrastro, Simona Panunzi, Lidia Castagneto-Gissey, Andrea De Gaetano, Erminia Lembo, Esmeralda Capristo, Caterina Guidone, Giulia Angelini, Francesco Pennestrì, Luca Sessa, Fabio Maria Vecchio, Laura Riccardi, Maria Assunta Zocco, Ivo Boskoski, James R Casella-Mariolo, Pierluigi Marini, Maurizio Pompili, Giovanni Casella, Enrico Fiori, Francesco Rubino, Stefan R Bornstein, Marco Raffaell
Publié dans: The Lancet, Numéro 401, 2024, Page(s) 1786-1797, ISSN 0140-6736
Éditeur: The Lancet Publishing Group
DOI: 10.1016/s0140-6736(23)00634-7

Measuring and estimating insulin resistance in clinical and research settings

Auteurs: Amalia Gastaldelli
Publié dans: Obesity, Numéro 30, 2023, Page(s) 1549-1563, ISSN 1930-7381
Éditeur: Wiley-Blackwell
DOI: 10.1002/oby.23503

The lived experience of people with obesity: study protocol for a systematic review and synthesis of qualitative studies

Auteurs: Emma Farrell, Marta Bustillo, Carel W. le Roux, Joe Nadglowski, Eva Hollmann & Deirdre McGillicuddy
Publié dans: Systematic Reviews, 2021, ISSN 2046-4053
Éditeur: BioMed Central
DOI: 10.1186/s13643-021-01706-5

The double burden: Navigating type 1 diabetes and obesity

Auteurs: Nele Steenackers, Alix Nessa Feldman, Chantal Mathieu, Jonathan Rosen, Jeannette Soderberg, Ebaa Al‐Ozairi, Carel W. le Roux, Bart Van der Schueren
Publié dans: Clinical Obesity, Numéro 14, 2024, ISSN 1758-8103
Éditeur: Wiley
DOI: 10.1111/cob.12645

Altered Insulin Clearance after Gastric Bypass and Sleeve Gastrectomy in the Fasting and Prandial Conditions

Auteurs: Marzieh Salehi, Ralph DeFronzo, and Amalia Gastaldelli
Publié dans: Molecular Sciences, 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23147667

Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits

Auteurs: Alaitz Poveda; Hugo Pomares-Millan; Yan Chen; Azra Kurbasic; Chirag J. Patel; Frida Renström; Göran Hallmans,; Ingegerd Johansson; Paul W. Franks
Publié dans: Sci Rep, 2022, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-022-08050-1

Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Auteurs: Wendy K. Chung, Karel Erion, Jose C. Florez, Andrew T. Hattersley, Marie-France Hivert, Christine G. Lee, Mark I. McCarthy, John J. Nolan, Jill M. Norris, Ewan R. Pearson, Louis Philipson, Allison T. McElvaine, William T. Cefalu, Stephen S. Rich, Paul W. Franks
Publié dans: Diabetologia, Numéro 63, 2021, Page(s) 1671-1693, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-020-05181-w

Auteurs: Marina Panova‐Noeva, Thomas Koeck, Corinna Schoelch, Andreas Schulz, Jürgen H. Prochaska, Matthias Michal, Konstantin Strauch, Alexander K. Schuster, Karl J. Lackner, Thomas Münzel, Anita M. Hennige, Philipp S. Wild
Publié dans: Obesity, Numéro 32, 2024, Page(s) 1198-1209, ISSN 1930-7381
Éditeur: Wiley-Blackwell
DOI: 10.1002/oby.24014

Fasting indices of glucose-insulin-metabolism across life span and prediction of glycemic deterioration in children with obesity from new diagnostic cut-offs

Auteurs: Maximiliane Chiara Hammel, Robert Stein, Jürgen Kratzsch, Mandy Vogel, Alexander J. Eckert, Rima Destya Triatin, Marco Colombo, Christof Meigen, Ronny Baber, Juraj Stanik, Ulrike Spielau, Anette Stoltze, Kerstin Wirkner, Anke Tönjes, Harold Snieder, Reinhard W. Holl, Michael Stumvoll, Matthias Blüher, Wieland Kiess, Antje Körner
Publié dans: The Lancet Regional Health - Europe, Numéro 30, 2023, Page(s) 100652, ISSN 2666-7762
Éditeur: Elsevier BV
DOI: 10.1016/j.lanepe.2023.100652

Not All Type-2-Diabetes Patients Increase Body Mass Index After Initiating Insulin: Results of Latent Class Analysis from the DPV Registry

Auteurs: Nicole Prinz; Anke Schwandt; Bernadette Borgert; Bettina Hartmann; Hans-Peter Kempe; Julia K. Mader; Sigrund Merger; Rosmarie Weber-Lauffer; Frank-Jürgen Wosch; Reinhard W. Holl;
Publié dans: Diabetes Technology & Therapeutics, 2021, ISSN 1520-9156
Éditeur: Mary Ann Liebert Inc.
DOI: 10.1089/dia.2021.0144

Who benefits most from outpatient lifestyle intervention? An <scp>IMI‐SOPHIA</scp> study on pediatric individuals living with overweight and obesity

Auteurs: Nicole Prinz, Hugo Pomares‐Millan, Almut Dannemann, Giuseppe N. Giordano, Christine Joisten, Antje Körner, Daniel Weghuber, Susann Weihrauch‐Blüher, Susanna Wiegand, Reinhard W. Holl, Stefanie Lanzinger, null null
Publié dans: Obesity, Numéro 31, 2024, Page(s) 2375-2385, ISSN 1930-7381
Éditeur: Wiley-Blackwell
DOI: 10.1002/oby.23844

Next-generation epidemiology: the role of high-resolution molecular phenotyping in diabetes research

Auteurs: Paul W. Franks, Hugo Pomares-Millan
Publié dans: Diabetologia, Numéro 63, 2022, Page(s) 2521-2532, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-020-05246-w

The lived experience of patients with obesity: A systematic review and qualitative synthesis

Auteurs: Emma Farrell, Eva Hollmann, Carel W. le Roux, Marta Bustillo, Joe Nadglowski, Deirdre McGillicuddy
Publié dans: Obesity Reviews, 2021, ISSN 1467-7881
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/obr.13334

“Treated as second class citizens” - the lived experience of obesity-related stigma: an IMI2 SOPHIA study

Auteurs: Eva Hollmann, Emma Farrell, Carel Le Roux, Joe Nadglowski, Deirdre McGillicuddy
Publié dans: International Journal of Qualitative Studies on Health and Well-being, Numéro 19, 2024, ISSN 1748-2631
Éditeur: Informa UK Limited
DOI: 10.1080/17482631.2024.2344232

Baseline phenotypes with preserved β-cell function and high insulin concentrations have the best improvements in glucose tolerance after weight loss: results from the prospective DEXLIFE and EGIR-RISC studies

Auteurs: Silvia Sabatini, John J. Nolan, Grainne O'Donoghue, Aileen Kennedy, John Petrie, Mark Walker, Donal J. O'Gorman, Amalia Gastaldelli
Publié dans: Metabolism, Numéro 155, 2024, Page(s) 155910, ISSN 0026-0495
Éditeur: Elsevier BV
DOI: 10.1016/j.metabol.2024.155910

Body Mass Index's influence on arterial hypertension in Type 1 diabetes – A brief report from IMI-SOPHIA study

Auteurs: Laurence D. Petty, Enrique Soto-Pedre, Rory J. McCrimmon, Ewan R. Pearson
Publié dans: Journal of Diabetes and its Complications, Numéro 38, 2024, Page(s) 108747, ISSN 1056-8727
Éditeur: Elsevier BV
DOI: 10.1016/j.jdiacomp.2024.108747

Accurate liquid biopsy for the diagnosis of non-alcoholic steatohepatitis and liver fibrosis

Auteurs: Giulia Angelini, Simona Panunzi, Lidia Castagneto-Gissey, Francesca Pellicanò, Andrea De Gaetano, Maurizio Pompili, Laura Riccardi, Matteo Garcovich, Marco Raffaelli, Luigi Ciccoritti, Ornella Verrastro, Maria Francesca Russo, Fabio Maria Vecchio, Giovanni Casella, James Casella-Mariolo, Luigi Papa, Pier Luigi Marini, Francesco Rubino, Carel W le Roux, Stefan Bornstein, Geltrude Mingrone
Publié dans: Gut, Numéro 72, 2023, Page(s) 392-403, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2022-327498

Subclassification of obesity for precision prediction of cardiometabolic diseases

Auteurs: Daniel E. Coral, Femke Smit, Ali Farzaneh, Alexander Gieswinkel, Juan Fernandez Tajes, Thomas Sparsø, Carl Delfin, Pierre Bauvin, Kan Wang, Marinella Temprosa, Diederik De Cock, Jordi Blanch, José Manuel Fernández-Real, Rafael Ramos, M. Kamran Ikram, Maria F. Gomez, Maryam Kavousi, Marina Panova-Noeva, Philipp S. Wild, Carla van der Kallen, Michiel Adriaens, Marleen van Greevenbroek, Ilja Arts,
Publié dans: Nature Medicine, Numéro 31, 2025, Page(s) 534-543, ISSN 1078-8956
Éditeur: Nature Publishing Group
DOI: 10.1038/s41591-024-03299-7

“What would be left of me?” Patient perspectives on the risks of obesity treatment: An innovative health initiative stratification of obesity phenotypes to optimise future obesity therapy (IMI2 SOPHIA) qualitative study

Auteurs: Emma Farrell, Joseph Nadglowski, Eva Hollmann, Carel W. le Roux, Deirdre McGillicuddy
Publié dans: Obesity Pillars, Numéro 12, 2024, Page(s) 100129, ISSN 2667-3681
Éditeur: Elsevier BV
DOI: 10.1016/j.obpill.2024.100129

Patient perspectives on personalised medicine for obesity: An IMI2 SOPHIA Study

Auteurs: Emma Farrell, Carel W. le Roux, Eva Hollmann, Joseph Nadglowski, Deirdre McGillicuddy
Publié dans: Obesity Research & Clinical Practice, Numéro 18, 2024, Page(s) 216-221, ISSN 1871-403X
Éditeur: Elsevier BV
DOI: 10.1016/j.orcp.2024.06.004

ForePass endoscopic bypass device for obesity and insulin resistance—metabolic treatment in a swine model

Auteurs: Giulia Angelini, Manoel Galvao Neto, Ivo Boskoski, Maria Emiliana Caristo, Sara Russo, Luca Proto, Elena Previti, Lisa Olsson, Hobby Aggarwal, Samantha Pezzica, Elisa Ferrari, Vincenzo Bove, Alfredo Genco, Stefan Bornstein, Valentina Tremaroli, Amalia Gastaldelli, Geltrude Mingrone
Publié dans: Gut, 2024, Page(s) gutjnl-2023-331335, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-331335

Treated as second class citizens” - the lived experience of obesity-related stigma: an IMI2 SOPHIA study

Auteurs: Eva Hollmann,Emma Farrell,Carel Le Roux (Prof.),Joe Nadglowski,Deirdre McGillicuddy
Publié dans: International Journal of Qualitative Studies on Health and Well-being, 2024, ISSN 1748-2623
Éditeur: Taylor & Francis

Disease heterogeneity of adult diabetes based on routine clinical variables at diagnosis: Results from the German/Austrian Diabetes Follow-up Registry

Auteurs: Julia M. Grimsmann; Sascha R. Tittel; Peter Bramlage; Benjamin Mayer; Andreas Fritsche; Jochen Seufert; Markus Laimer; Stefan Zimny; Sebastian M. Meyhoefer; Michael Hummel; Reinhard W. Holl
Publié dans: Diabetes, Obesity and Metabolism, 2022, ISSN 1463-1326
Éditeur: Diabetes, Obesity and Metabolism
DOI: 10.1111/dom.14812

Genetic Evidence of Causal Relation Between Intestinal Glucose Absorption and Early Postprandial Glucose Response: A Mendelian Randomization Study

Auteurs: Simon Peschard, Violeta Raverdy, Pierre Bauvin, Rebecca Goutchtat, Veronique Touche, Bruno Derudas, Celine Gheeraert, Julie Dubois-Chevalier, Robert Caiazzo, Gregory Baud, Camille Marciniak, Helene Verkindt, Naima Oukhouya Daoud, Carel W. Le Roux, Philippe Lefebvre, Bart Staels, Sophie Lestavel, François Pattou
Publié dans: Diabetes, Numéro 73, 2024, Page(s) 983-992, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/db23-0805

Characterisation and clinical outcomes in children and adolescents with diabetes according to newly defined subgroups: a cohort study from the DPV registry

Auteurs: Katharina Warncke, Alexander Eckert, Ezio Bonifacio, Peter Achenbach, Olga Kordonouri, Thomas Meissner, Ute Ohlenschläger, Walter Bonfig, Anette-G. Ziegler, Reinhard W. Holl
Publié dans: eClinicalMedicine, Numéro 64, 2024, Page(s) 102208, ISSN 2589-5370
Éditeur: eClinicalMedicine
DOI: 10.1016/j.eclinm.2023.102208

Access to Healthcare for Children and Adolescents with a Chronic Health Condition during the COVID-19 Pandemic: First Results from the KICK-COVID Study in Germany

Auteurs: Julia M. Göldel, Clemens Kamrath, Kirsten Minden, Susanna Wiegand, Stefanie Lanzinger, Claudia Sengler, Susann Weihrauch-Blüher, Reinhard W. Holl, Sascha R. Tittel, Petra Warschburger
Publié dans: Children, Numéro 10, 2024, Page(s) 10, ISSN 2227-9067
Éditeur: Children
DOI: 10.3390/children10010010

Special diet in type 1 diabetes: do gender and BMI-SDS differ?

Auteurs: Alena Gerlinde Thiele; Nicole Prinz; Monika Flury; Melanie Hess; Daniela Klose; Thomas Meissner; Klemens Raile; Klemens Raile; Sabine Wenzel; Sascha Tittel; Thomas Kapellen; Reinhard Holl
Publié dans: Child and Adolescent Obesity, 2021, ISSN 2227-9067
Éditeur: Taylor & Francis
DOI: 10.1080/2574254x.2021.2002061

Serum Metabolomic Profiling of Incident Type 2 Diabetes Mellitus in the Multi-ethnic Study of Atherosclerosis and Rotterdam Study

Auteurs: Xuanwei Jiang, Fang Zhu, Gonçalo Graça, Xihao Du, Jinjun Ran, Fariba Ahmadizar, Alexis C Wood, Yanqiu Zhou, Denise M Scholtens, Ali Farzaneh, M Arfan Ikram, Alan Kuang, Carel W le Roux, Meghana D Gadgil, Marilyn C Cornelis, Kent D Taylor, Xiuqing Guo, Mohsen Ghanbari, Laura J Rasmussen-Torvik, Russell P Tracy, Alain G Bertoni, Jerome I Rotter, David M Herrington, Philip Greenland, Maryam Kavousi
Publié dans: The Journal of Clinical Endocrinology & Metabolism, Numéro 110, 2025, Page(s) e2700-e2710, ISSN 0021-972X
Éditeur: The Endocrine Society
DOI: 10.1210/clinem/dgae812

Microbiota-gut-brain axis: relationships among the vagus nerve, gut microbiota, obesity, and diabetes

Auteurs: Susanna Longo, Stefano Rizza, Massimo Federici
Publié dans: Acta Diabetologica, Numéro 60, 2023, Page(s) 1007-1017, ISSN 1432-5233
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/s00592-023-02088-x

Plasma circulating microRNAs associated with obesity, body fat distribution, and fat mass: the Rotterdam Study

Auteurs: Yasir J. Abozaid; Xiaofang Zhang; Michelle M. J. Mens; Fariba Ahmadizar; Marlou Limpens; M. Arfan Ikram; Fernando Rivadeneira; Trudy Voortman; Maryam Kavousi; Mohsen Ghanbari
Publié dans: International Journal of Obesity, 2022, ISSN 1476-4687
Éditeur: Nature
DOI: 10.1038/s41366-022-01227-8

BMI variability and cardiovascular outcomes within clinical trial and real-world environments in type 2 diabetes: an IMI2 SOPHIA study

Auteurs: Robert J. Massey, Yu Chen, Marina Panova-Noeva, Michaela Mattheus, Moneeza K. Siddiqui, Nanette C. Schloot, Antonio Ceriello, Ewan R. Pearson, Adem Y. Dawed
Publié dans: Cardiovascular Diabetology, Numéro 23, 2024, ISSN 1475-2840
Éditeur: BioMed Central
DOI: 10.1186/s12933-024-02299-8

Investigating the causal relationships between excess adiposity and cardiometabolic health in men and women

Auteurs: Pascal M. Mutie, Hugo Pomares-Millan, Naeimeh Atabaki-Pasdar, Daniel Coral, Hugo Fitipaldi, Neli Tsereteli, Juan Fernandez Tajes, Paul W. Franks, Giuseppe N. Giordano
Publié dans: Diabetologia, Numéro 66, 2024, Page(s) 321-335, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-022-05811-5

Achieving consensus on the language of obesity: a modified Delphi study

Auteurs: Cecilie Heerdegen Jepsen, Jacqueline Bowman-Busato, Thomas Allvin, Niamh Arthurs, Gijs H. Goossens, Elisabeth Govers, Benjamin Assad Jaghutriz, Vicki Mooney, Bart Van der Schueren, Carel W. le Roux
Publié dans: eClinicalMedicine, Numéro 62, 2024, Page(s) 102061, ISSN 2589-5370
Éditeur: eClinical Medicine
DOI: 10.1016/j.eclinm.2023.102061

Anti‐obesity treatment preferences of healthcare providers and people living with obesity: A survey‐based study

Auteurs: Carel W. Le Roux, Anna Koroleva, Sara Larsen, Ellie Foot
Publié dans: Clinical Obesity, Numéro 15, 2025, ISSN 1758-8103
Éditeur: Wiley
DOI: 10.1111/cob.12704

Data-driven cluster analysis identifies distinct types of metabolic dysfunction-associated steatotic liver disease

Auteurs: Violeta Raverdy, Federica Tavaglione, Estelle Chatelain, Guillaume Lassailly, Antonio De Vincentis, Umberto Vespasiani-Gentilucci, Sami F. Qadri, Robert Caiazzo, Helene Verkindt, Chiara Saponaro, Julie Kerr-Conte, Gregory Baud, Camille Marciniak, Mikael Chetboun, Naima Oukhouya-Daoud, Samuel Blanck, Jimmy Vandel, Lisa Olsson, Rima Chakaroun, Viviane Gnemmi, Emmanuelle Leteurtre, Philippe Lefebvre,
Publié dans: Nature Medicine, Numéro 30, 2025, Page(s) 3624-3633, ISSN 1078-8956
Éditeur: Nature Publishing Group
DOI: 10.1038/s41591-024-03283-1

The Gut Microbiota and Diabetes: Research, Translation, and Clinical Applications—2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum

Auteurs: Mariana Byndloss, Suzanne Devkota, Frank Duca, Jan Hendrik Niess, Max Nieuwdorp, Marju Orho-Melander, Yolanda Sanz, Valentina Tremaroli, Liping Zhao
Publié dans: Diabetes Care, 2024, ISSN 0149-5992
Éditeur: American Diabetes Association
DOI: 10.2337/dci24-0052

Fetal alleles predisposing to metabolically favorable adiposity are associated with higher birth weight

Auteurs: William D Thompson, Robin N Beaumont, Alan Kuang, Nicole M Warrington, Yingjie Ji, Jessica Tyrrell, Andrew R Wood, Denise M Scholtens, Bridget A Knight, David M Evans, William L Lowe Jr, Gillian Santorelli, Raq Azad, Dan Mason, Andrew T Hattersley, Timothy M Frayling, Hanieh Yaghootkar, Maria Carolina Borges, Deborah A Lawlor, Rachel M Freathy
Publié dans: Human Molecular Genetics, Numéro 31, 2022, Page(s) 1762-1775, ISSN 0964-6906
Éditeur: Oxford University Press
DOI: 10.1093/hmg/ddab356

Stratification of obesity phenotypes to optimize future therapy (SOPHIA)

Auteurs: Abd A Tahrani, Marina Panova-Noeva, Nanette C Schloot, Anita M Hennige, Jeannette Soderberg, Joe Nadglowski, Lisa Tarasenko, Nadia N Ahmad, Barbara SC Sleypen, Rafael Bravo, Werd Al-Najim, Carel W le Roux
Publié dans: Expert Review of Gastroenterology & Hepatology, Numéro 17, 2024, Page(s) 1031-1039, ISSN 1747-4124
Éditeur: Future Drugs Ltd.
DOI: 10.1080/17474124.2023.2264783

Upper gut heat shock proteins HSP70 and GRP78 promote insulin resistance, hyperglycemia, and non-alcoholic steatohepatitis

Auteurs: Giulia Angelini; Lidia Castagneto-Gissey; Serenella Salinari; Alessandro Bertuzzi; Danila Anello; Meenakshi Pradhan; Marlen Zschätzsch; Paul Ritter; CarelW. Le Roux; Francesco Rubino; Nicola Basso; Giovanni Casella; Stefan R. Bornstein; Valentina Tremaroli; Geltrude Mingrone
Publié dans: Nature Communications, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-35310-5

Three‐variate trajectories of metabolic control, body mass index, and insulin dose: Heterogeneous response to initiation of pump therapy in youth with type 1 diabetes

Auteurs: Martin Tauschmann, Anke Schwandt, Nicole Prinz, Marianne Becker, Torben Biester, Melanie Hess, Martin Holder, Beate Karges, Andrea Näke, Oliver Kuss, Simone Sengbusch, Reinhard W. Holl, null null
Publié dans: Pediatric Diabetes, Numéro 23, 2022, Page(s) 330-340, ISSN 1399-543X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/pedi.13320

Comparison of BMI and HbA1c changes before and during the COVID-19 pandemic in type 1 diabetes: a longitudinal population-based study

Auteurs: Marie Auzanneau, Dorothee M. Kieninger, Katharina Laubner, Christian Renner, Joaquina Mirza, Gerhard Däublin, Kirsten Praedicow, Holger Haberland, Claudia Steigleder-Schweiger, Bettina Gohlke, Angela Galler, Reinhard W. Holl, null null
Publié dans: Journal of Diabetes & Metabolic Disorders, Numéro 23, 2024, Page(s) 573-583, ISSN 2251-6581
Éditeur: BioMed Central
DOI: 10.1007/s40200-023-01316-z

Patient perspectives about treatment preferences for obesity with complications

Auteurs: Hilary C. Craig, Dalal Alsaeed, Suzanne Norris, John Holian, Cormac Kennedy, Alix Feldman, Carel Le Roux
Publié dans: Obesity Science & Practice, Numéro 10, 2024, ISSN 2055-2238
Éditeur: Wiley
DOI: 10.1002/osp4.720

Adipose tissue macrophage infiltration and hepatocyte stress increase GDF-15 throughout development of obesity to MASH

Auteurs: Laurent L’homme, Benan Pelin Sermikli, Joel T. Haas, Sébastien Fleury, Sandrine Quemener, Valentine Guinot, Emelie Barreby, Nathalie Esser, Robert Caiazzo, Hélène Verkindt, Benjamin Legendre, Violeta Raverdy, Lydie Cheval, Nicolas Paquot, Jacques Piette, Sylvie Legrand-Poels, Myriam Aouadi, François Pattou, Bart Staels, David Dombrowicz
Publié dans: Nature Communications, Numéro 15, 2024, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-024-51078-2

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Auteurs: Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno De
Publié dans: Hepatology, 2024, Page(s) n/a-n/a, ISSN 0270-9139
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/hep.32631

Prevalence of obesity in people with and without type 1 diabetes across Belgium, Kuwait, and Mexico: an IMI2 SOPHIA study

Auteurs: Ebaa Al Ozairi, Nele Steenackers, Sofia Pazmino, Abdulnabi T. Alattar, Jumana Al Kandari, Paloma Almeda-Valdes, Neftali Eduardo Antonio-Villa, Carl Delfin, Raquel N. Faradji, Aili García-Tuomola A, Mohammad Irshad, Joseph C. Longenecker, Jonathan Rosen, Carmen Hurtado del Pozo, Thomas Sparsø, Astrid Lavens, Chantal Mathieu, Bart Van der Schueren, Carel W. le Roux
Publié dans: eClinicalMedicine, Numéro 77, 2025, Page(s) 102869, ISSN 2589-5370
Éditeur: Elsevier BV
DOI: 10.1016/j.eclinm.2024.102869

The association between perinatal factors and cardiometabolic risk factors in children and adolescents with overweight or obesity: A retrospective two-cohort study

Auteurs: Nicole Prinz, Resthie R. Putri, Thomas Reinehr, Pernilla Danielsson, Daniel Weghuber, Mikael Norman, Niels Rochow, Claude Marcus, Reinhard W. Holl, Emilia Hagman
Publié dans: PLOS Medicine, Numéro 20, 2023, Page(s) e1004165, ISSN 1549-1676
Éditeur: PLoS Med
DOI: 10.1371/journal.pmed.1004165

Disease heterogeneity of adult diabetes based on routine clinical parameters at diagnosis: Results from the German/Austrian DPV registry.

Auteurs: Grimsmann, Julia M; Tittel, Sascha R; Bramlage, Peter; Mayer, Benjamin; Fritsche, Andreas; Seufert, Jochen; Laimer, Markus; Zimny, Stefan; Meyhoefer, Sebastian M; Hummel, Michael; Holl, Reinhard W
Publié dans: Grimsmann, Julia M; Tittel, Sascha R; Bramlage, Peter; Mayer, Benjamin; Fritsche, Andreas; Seufert, Jochen; Laimer, Markus; Zimny, Stefan; Meyhoefer, Sebastian M; Hummel, Michael; Holl, Reinhard W (2022). Disease heterogeneity of adult diabetes based on routine clinical parameters at diagnosis: Results from the German/Austrian DPV registry. Diabetes, obesity & metabolism, 24(11), pp. 2253-2262. Wi, Numéro 1, 2022, ISSN 1463-1326
Éditeur: Diabetes, obesity & metabolism
DOI: 10.48350/171154

Heterogeneity in response to GLP-1 receptor agonists in type 2 diabetes in real-world clinical practice: insights from the DPV register – an IMI-SOPHIA study

Auteurs: Martin Heni, Lisa Frühwald, Wolfram Karges, Michael Naudorf, Kathrin Niemöller, Frank Pagnia, Jörg Reindel, Jochen Seufert, Gisa Ufer, Christian Wagner, Reinhard W. Holl, Nicole Prinz
Publié dans: Diabetologia, Numéro 68, 2025, Page(s) 1666-1673, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-025-06448-w

Obesity in people living with type 1 diabetes

Auteurs: Bart Van der Schueren Darcy Ellis Raquel NFaradji Eeba Al-Ozairi Jonathan Rosen Chantal Mathieu
Publié dans: The Lancet Diabetes & Endocrinology, 2021, ISSN 2213-8587
Éditeur: Elsevier BV
DOI: 10.1016/s2213-8587(21)00246-1

Impact of the COVID-19 Pandemic on Psychosocial Distress in Adolescents with Obesity Compared to Those with Type 1 Diabetes: Results from the KICK-COVID Study in Germany

Auteurs: Susann Weihrauch-Blüher, Susanna Wiegand, Sascha Tittel, Susanne Greber-Platzer, Stefanie Lanzinger, Clemens Kamrath, Kirsten Minden, Claudia Sengler, Sabine Linke, Antje Büssenschütt, Felix Reschke, Julia Göldel, Petra Warschburger, Reinhard W. Holl
Publié dans: Obesity Facts, Numéro 18, 2025, Page(s) 305-318, ISSN 1662-4025
Éditeur: Karger AG
DOI: 10.1159/000542756

The effect of physical activity on glycaemic control in people with type 1 diabetes mellitus: A systematic literature review and meta‐analysis

Auteurs: Diederik De Cock, Lucas Schreurs, Nele Steenackers, Sofia Pazmino, Wilfried Cools, Lauren Eykerman, Hannah Thiels, Chantal Mathieu, Bart Van der Schueren
Publié dans: Diabetic Medicine, Numéro 41, 2024, ISSN 0742-3071
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/dme.15415

Mendelian Randomization Analyses Suggest Childhood Body Size Indirectly Influences End Points From Across the Cardiovascular Disease Spectrum Through Adult Body Size

Auteurs: Grace M. Power, Jessica Tyrrell, Timothy M. Frayling, George Davey Smith, Tom G. Richardson
Publié dans: Journal of the American Heart Association, Numéro 10, 2024, ISSN 2047-9980
Éditeur: Wiley-Blackwell
DOI: 10.1161/jaha.121.021503

Combining diabetes, sex, and menopause as meaningful clinical features associated with NASH and liver fibrosis in individuals with class II and III obesity: A retrospective cohort study

Auteurs: Violeta Raverdy, Estelle Chatelain, Guillaume Lasailly, Robert Caiazzo, Jimmy Vandel, Helene Verkindt, Camille Marciniak, Benjamin Legendre, Pierre Bauvin, Naima Oukhouya‐Daoud, Gregory Baud, Mikael Chetboun, Marie‐Christine Vantyghem, Viviane Gnemmi, Emmanuelle Leteurtre, Bart Staels, Philippe Lefebvre, Philippe Mathurin, Guillemette Marot, Francois Pattou
Publié dans: Obesity, Numéro 31, 2024, Page(s) 3066-3076, ISSN 1930-7381
Éditeur: Wiley-Blackwell
DOI: 10.1002/oby.23904

Development and validation of an interpretable machine learning-based calculator for predicting 5-year weight trajectories after bariatric surgery: a multinational retrospective cohort SOPHIA study

Auteurs: Patrick Saux, Pierre Bauvin, Violeta Raverdy, Julien Teigny, Hélène Verkindt, Tomy Soumphonphakdy, Maxence Debert, Anne Jacobs, Daan Jacobs, Valerie Monpellier, Phong Ching Lee, Chin Hong Lim, Johanna C Andersson-Assarsson, Lena Carlsson, Per-Arne Svensson, Florence Galtier, Guelareh Dezfoulian, Mihaela Moldovanu, Severine Andrieux, Julien Couster, Marie Lepage, Erminia Lembo, Ornella Verrastro,
Publié dans: The Lancet Digital Health, Numéro 5, 2023, Page(s) e692-e702, ISSN 2589-7500
Éditeur: Lancet Digital Health
DOI: 10.1016/s2589-7500(23)00135-8

Environment-wide association study (EWAS) on cardiometabolic traits: A systematic assessment of the association of lifestyle variables on a longitudinal setting

Auteurs: Alaitz Poveda, Yan Chen, Hugo Pomares-Millan, Azra Kurbasic, Chirag J Patel, Frida Renström, Göran Hallmans, Ingegerd Johansson, Paul W. Franks
Publié dans: Scientific Reports, 2024, ISSN 2070-0245
Éditeur: Scientific Reports
DOI: 10.1101/2021.03.22.21254099

At home and at risk: The experiences of Irish adults living with obesity during the COVID-19 pandemic

Auteurs: Emma Farrell; Eva Hollmann; Carel Le Roux; Joe Nadglowski; Deirdre McGillicuddy
Publié dans: EClinicalMedicine, 2022, ISSN 2589-5370
Éditeur: Elsevier
DOI: 10.1016/j.eclinm.2022.101568

Healthcare professionals perceptions of obesity management: An IMI2 SOPHIA qualitative study

Auteurs: Nele Steenackers, Seppe Willio, Anne Bruneel, Ellen Deleus, Matthias Lannoo, Christophe Matthys, Ann Mertens, Eline Van Craeyveld, Roman Vangoitsenhoven, Bart Van der Schueren
Publié dans: Clinical Obesity, 2024, ISSN 1758-8103
Éditeur: Wiley
DOI: 10.1111/cob.12686

“I am terrified of something happening to me” The lived experience of people with obesity during the COVID ‐19 pandemic

Auteurs: Andrew Grannell, Carel W. Roux, Deirdre McGillicuddy
Publié dans: Clinical Obesity, Numéro 10/6, 2020, ISSN 1758-8103
Éditeur: Clinical Obesity
DOI: 10.1111/cob.12406

Association between arterial stiffness/remodeling and new-onset type 2 diabetes mellitus in general population

Auteurs: Fariba Ahmadizar; Kan Wang; Maurits Roos; Maxime Bos; Francesco Mattace- Raso; Maryam Kavousi
Publié dans: Diabetes Research and Clinical Practice, 2023, ISSN 0168-8227
Éditeur: Elsevier BV
DOI: 10.1016/j.diabres.2023.110237

Weight development in children and adolescents with obesity during the COVID-19 pandemic

Auteurs: Angela Galler, Markus Röbl, Nicole Prinz, Almut Dannemann, Ines Gellhaus, Thomas Kapellen, Sabine Linke, Gerd Schauerte, Robert Stein, Daniel Weghuber, Susann Weihrauch-Blüher, Susanna Wiegand, Reinhard Holl
Publié dans: Deutsches Ärzteblatt international, 2022, ISSN 1866-0452
Éditeur: Deutscher Arzte-Verlag
DOI: 10.3238/arztebl.m2022.0155

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