Stratification of Obesity Phenotypes to Optimize Future Therapy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Dataset profiles handbook
Online educational resource for clinicians with photographs, video, audio, and diaries representing patient perceptions and perspectives
Needs and challenges communication package

External Project Website

Publications

Patient perceptions of success in obesity treatment: An IMI2 SOPHIA study

Author(s): E. Farrell, J. Nadglowski, E. Hollmann, C. W. le Roux, D. McGillicuddy
Published in: Obesity Science & Practice, Issue 10, 2024, ISSN 2055-2238
Publisher: Wiley
DOI: 10.1002/osp4.70001

Clinical characteristics and outcomes of children, adolescents and young adults with overweight or obesity and mental health disorders

Author(s): Angela Galler, Angelika Thönnes, Jens Joas, Christine Joisten, Antje Körner, Thomas Reinehr, Markus Röbl, Gerd Schauerte, Wolfgang Siegfried, Daniel Weghuber, Susann Weihrauch-Blüher, Susanna Wiegand, Reinhard W. Holl, Nicole Prinz, null null
Published in: International Journal of Obesity, Issue 48, 2024, Page(s) 423-432, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/s41366-023-01449-4

Whole-genome sequencing analysis identifies rare, large-effect noncoding variants and regulatory regions associated with circulating protein levels

Author(s): Gareth Hawkes, Kartik Chundru, Leigh Jackson, Kashyap A. Patel, Anna Murray, Andrew R. Wood, Caroline F. Wright, Michael N. Weedon, Timothy M. Frayling, Robin N. Beaumont
Published in: Nature Genetics, Issue 57, 2025, Page(s) 626-634, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-025-02095-4

Identification and analysis of individuals who deviate from their genetically-predicted phenotype

Author(s): Gareth Hawkes, Loic Yengo, Sailaja Vedantam, Eirini Marouli, Robin N Beaumont, null null, Jessica Tyrrell, Michael N Weedon, Joel Hirschhorn, Timothy M Frayling, Andrew R Wood
Published in: PLOS Genetics, 2023, ISSN 1553-7390
Publisher: Public Library of Science
DOI: 10.1101/2023.02.10.528019

Who benefits most from outpatient lifestyle intervention? An IMI‐SOPHIA study on pediatric individuals living with overweight and obesity

Author(s): Prinz, Nicole; Pomares‐Millan, Hugo; Dannemann, Almut; Giordano, Giuseppe N.; Joisten, Christine; Körner, Antje; Weghuber, Daniel; Weihrauch‐Blüher, Susann; Wiegand, Susanna; Holl, Reinhard W.; Lanzinger, Stefanie; APV initiative; Stratification of Obesity Phenotypes to Optimize Future Therapy (SOPHIA) consortium
Published in: Obesity, Issue 2, 2023, ISSN 1930-739X
Publisher: Wiley

Whole-genome sequencing in 333,100 individuals reveals rare non-coding single variant and aggregate associations with height

Author(s): Gareth Hawkes, Robin N. Beaumont, Zilin Li, Ravi Mandla, Xihao Li, Christine M. Albert, Donna K. Arnett, Allison E. Ashley-Koch, Aneel A. Ashrani, Kathleen C. Barnes, Eric Boerwinkle, Jennifer A. Brody, April P. Carson, Nathalie Chami, Yii-Der Ida Chen, Mina K. Chung, Joanne E. Curran, Dawood Darbar, Patrick T. Ellinor, Myrian Fornage, Victor R. Gordeuk, Xiuqing Guo, Jiang He, Chii-Min Hwu, Rita R
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-52579-w

Subclassification of obesity for precision prediction of cardiometabolic diseases: an IMI SOPHIA study

Author(s): Paul Franks, Daniel Coral, Femke Smit, Ali Farzaneh, Alexander Gieswinkel, Juan Fernández-Tajes, Thomas Sparsø, Carl Delfin, Pierre Bauvin, Kan Wang, Marinella Temprosa, Diederick De Cock, Jordi Blanch, José Manuel Fernández-Real, Rafael Ramos, M. Kamran Ikram, Maria Gomez, Maryam Kavousi, Marina Panova-Noeva, Philipp WIld, Carla van der Kallen, Michiel Adriaens, Marleen van Greevenbroek, Ilja
Published in: Nature Medicine, 2024, ISSN 1546-170X
Publisher: Nature Medicine
DOI: 10.21203/rs.3.rs-4048297/v1

Factors influencing patients to choose one obesity treatment over another: a qualitative study

Author(s): H. C. Craig, D. Alsaeed, E. Al Ozairi, S. Norris, J. Holian, C. Kennedy, H. Heneghan, D. McGillicuddy, E. Farrell, E. Hollmann, W. Al-Najim, C. W. le Roux
Published in: International Journal of Obesity, 2025, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/s41366-025-01789-3

Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood

Author(s): Gareth Hawkes; Robin N. Beaumont; Jessica Tyrrell; Grace M. Power; Andrew Wood; Markku Laakso; Lilian Fernandes Silva; Michael Boehnke; Xianyong Yin; Tom G. Richardson; George Davey Smith; Timothy M. Frayling
Published in: Diabetologia, 2023, ISSN 1949-2448
Publisher: Springer link
DOI: 10.1007/s00125-023-05923-6

Is COVID-19 to Blame? Trends of Incidence and Sex Ratio in Youth-Onset Type 2 Diabetes in Germany

Author(s): Christian Denzer; Christian Denzer; Daniela Klose; Antje Korner; Thomas Reinehr; Christina Baechle; Carmen Schroder; Susanna Wiegand; Reinhard W. Holl; Nicole Prinz
Published in: Diabetes care, 2023, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/dc22-2257

Factors that determine patients considering medication for the disease of obesity: an IMI2 SOPHIA study

Author(s): H. C. Craig, D. Alsaeed, H. Heneghan, W. Al-Najim, E. Al Ozairi, C. W. le Roux
Published in: International Journal of Obesity, 2024, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/s41366-024-01524-4

What influences patient decisions when selecting an obesity treatment?

Author(s): Hilary C. Craig, David Walley, Carel W. le Roux
Published in: Obesity Pillars, Issue 12, 2024, Page(s) 100123, ISSN 2667-3681
Publisher: Elsevier BV
DOI: 10.1016/j.obpill.2024.100123

The emergence of obesity in type 1 diabetes

Author(s): Martin T. W. Kueh, Nicholas W. S. Chew, Ebaa Al-Ozairi, Carel W. le Roux
Published in: International Journal of Obesity, Issue 48, 2024, Page(s) 289-301, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/s41366-023-01429-8

Cardiovascular health, genetic predisposition, and lifetime risk of type 2 diabetes

Author(s): Kan Wang; Maryam Kavousi; Trudy Voortman; M. Arfan Ikram; Mohsen Ghanbari; Fariba Ahmadizar;
Published in: European Journal of Preventive Cardiology, 2021, ISSN 2047-4873
Publisher: SAGE Publications Ltd
DOI: 10.1093/eurjpc/zwab141

A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes

Author(s): Daniel E. Coral; Juan Fernandez-Tajes; Neli Tsereteli; Hugo Pomares-Millan; Hugo Fitipaldi; Pascal M. Mutie; Naeimeh Atabaki-Pasdar; Sebastian Kalamajski; Alaitz Poveda; Tyne W. Miller-Fleming; Xue Zhong; Giuseppe N. Giordano; Ewan R. Pearson; Nancy J. Cox; Paul W. Franks
Published in: Nature Metabolism, 2023, ISSN 2522-5812
Publisher: Nature Metabolism
DOI: 10.1038/s42255-022-00731-5

Trajectories of BMI before and after diagnosis of type 2 diabetes in a real-world population

Author(s): Louise A. Donnelly, Rory J. McCrimmon, Ewan R. Pearson
Published in: Diabetologia, 2024, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-024-06217-1

BMI-residualized data uncovers a cluster of people with type 2 diabetes and increased serum ferritin protected from cardiovascular disease

Author(s): Laura Gallardo-Nuell, Jordi Blanch, Yenny Leal, Daniel E Coral, Talita Duarte-Salles, Giuseppe N. Giordano, Paul W. Franks, Ewan R. Pearson, Geltrude Mingrone, Carel W le Roux, Rafael Ramos, José Manuel Fernández-Real
Published in: Cardiovascular Diabetology, Issue 24, 2025, ISSN 1475-2840
Publisher: BioMed Central
DOI: 10.1186/s12933-025-02685-w

Insulin Clearance in Health and Disease

Author(s): Sonia M. Najjar, Sonia Caprio, Amalia Gastaldelli
Published in: Annual Review of Physiology, Issue 85, 2023, Page(s) 363-381, ISSN 0066-4278
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-physiol-031622-043133

Comparison of cardiovascular risk factors between children and adolescents with classes III and IV obesity: findings from the APV cohort

Author(s): Thomas Reinehr, Sascha R. Tittel, Rolf Holle, Susanna Wiegand, Ines Gellhaus, Johannes Hebebrand, Susanne Greber-Platzer, Christian Denzer, Sabine Linke, Wieland Kiess, Reinhard W. Holl
Published in: International Journal of Obesity, Issue 45/5, 2021, Page(s) 1061-1073, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/s41366-021-00773-x

Clinical characteristics and cardiovascular risk profile in children and adolescents with latent autoimmune diabetes: Results from the German/Austrian prospective diabetes follow‐up registry

Author(s): Alena Welters, Sascha R. Tittel, Thomas Reinehr, Daniel Weghuber, Susanna Wiegand, Wolfram Karges, Clemens Freiberg, Thomas Meissner, Nanette C. Schloot, Reinhard W. Holl
Published in: Pediatric Diabetes, Issue 23, 2022, Page(s) 1602-1612, ISSN 1399-543X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pedi.13450

“You Are Always at War With Yourself” The Perceptions and Beliefs of People With Obesity Regarding Obesity as a Disease

Author(s): Andrew Grannell; Carel W. le Roux; Deirdre McGillicuddy;
Published in: Qualitative Health Research, 2021, ISSN 1049-7323
Publisher: SAGE Publications
DOI: 10.1177/10497323211040767

A Federated Database for Obesity Research: An IMI-SOPHIA Study

Author(s): Carl Delfin, Iulian Dragan, Dmitry Kuznetsov, Juan Fernandez Tajes, Femke Smit, Daniel E. Coral, Ali Farzaneh, André Haugg, Andreas Hungele, Anne Niknejad, Christopher Hall, Daan Jacobs, Diana Marek, Diane P. Fraser, Dorothee Thuillier, Fariba Ahmadizar, Florence Mehl, Francois Pattou, Frederic Burdet, Gareth Hawkes, Ilja C. W. Arts, Jordi Blanch, Johan Van Soest, José-Manuel Fernández-Real, Ju
Published in: Life, Issue 14, 2024, Page(s) 262, ISSN 2075-1729
Publisher: MDPI AG
DOI: 10.3390/life14020262

BMI Z-Score (SDS) versus Calculated Body Fat Percentage: Association with Cardiometabolic Risk Factors in Obese Children and Adolescents

Author(s): Christine Joisten, Stefanie Wessely, Nicole Prinz, Susanna Wiegand, Bettina Gohlke, Sabine Keiser, Paula Moliterno, Jens Nielinger, Gabriel Torbahn, Hagen Wulff, Reinhard W. Holl, null null
Published in: Annals of Nutrition and Metabolism, Issue 80, 2024, Page(s) 29-36, ISSN 0250-6807
Publisher: S. Karger AG
DOI: 10.1159/000535216

Lipid metabolism in MASLD and MASH: From mechanism to the clinic

Author(s): Fabrizia Carli, Giuseppe Della Pepa, Silvia Sabatini, Antonio Vidal Puig, Amalia Gastaldelli
Published in: JHEP Reports, Issue 6, 2025, Page(s) 101185, ISSN 2589-5559
Publisher: Elsevier BV
DOI: 10.1016/j.jhepr.2024.101185

Bariatric–metabolic surgery versus lifestyle intervention plus best medical care in non-alcoholic steatohepatitis (BRAVES): a multicentre, open-label, randomised trial

Author(s): Ornella Verrastro, Simona Panunzi, Lidia Castagneto-Gissey, Andrea De Gaetano, Erminia Lembo, Esmeralda Capristo, Caterina Guidone, Giulia Angelini, Francesco Pennestrì, Luca Sessa, Fabio Maria Vecchio, Laura Riccardi, Maria Assunta Zocco, Ivo Boskoski, James R Casella-Mariolo, Pierluigi Marini, Maurizio Pompili, Giovanni Casella, Enrico Fiori, Francesco Rubino, Stefan R Bornstein, Marco Raffaell
Published in: The Lancet, Issue 401, 2024, Page(s) 1786-1797, ISSN 0140-6736
Publisher: The Lancet Publishing Group
DOI: 10.1016/s0140-6736(23)00634-7

Measuring and estimating insulin resistance in clinical and research settings

Author(s): Amalia Gastaldelli
Published in: Obesity, Issue 30, 2023, Page(s) 1549-1563, ISSN 1930-7381
Publisher: Wiley-Blackwell
DOI: 10.1002/oby.23503

The lived experience of people with obesity: study protocol for a systematic review and synthesis of qualitative studies

Author(s): Emma Farrell, Marta Bustillo, Carel W. le Roux, Joe Nadglowski, Eva Hollmann & Deirdre McGillicuddy
Published in: Systematic Reviews, 2021, ISSN 2046-4053
Publisher: BioMed Central
DOI: 10.1186/s13643-021-01706-5

The double burden: Navigating type 1 diabetes and obesity

Author(s): Nele Steenackers, Alix Nessa Feldman, Chantal Mathieu, Jonathan Rosen, Jeannette Soderberg, Ebaa Al‐Ozairi, Carel W. le Roux, Bart Van der Schueren
Published in: Clinical Obesity, Issue 14, 2024, ISSN 1758-8103
Publisher: Wiley
DOI: 10.1111/cob.12645

Altered Insulin Clearance after Gastric Bypass and Sleeve Gastrectomy in the Fasting and Prandial Conditions

Author(s): Marzieh Salehi, Ralph DeFronzo, and Amalia Gastaldelli
Published in: Molecular Sciences, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23147667

Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits

Author(s): Alaitz Poveda; Hugo Pomares-Millan; Yan Chen; Azra Kurbasic; Chirag J. Patel; Frida Renström; Göran Hallmans,; Ingegerd Johansson; Paul W. Franks
Published in: Sci Rep, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-08050-1

Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Author(s): Wendy K. Chung, Karel Erion, Jose C. Florez, Andrew T. Hattersley, Marie-France Hivert, Christine G. Lee, Mark I. McCarthy, John J. Nolan, Jill M. Norris, Ewan R. Pearson, Louis Philipson, Allison T. McElvaine, William T. Cefalu, Stephen S. Rich, Paul W. Franks
Published in: Diabetologia, Issue 63, 2021, Page(s) 1671-1693, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-020-05181-w

Author(s): Marina Panova‐Noeva, Thomas Koeck, Corinna Schoelch, Andreas Schulz, Jürgen H. Prochaska, Matthias Michal, Konstantin Strauch, Alexander K. Schuster, Karl J. Lackner, Thomas Münzel, Anita M. Hennige, Philipp S. Wild
Published in: Obesity, Issue 32, 2024, Page(s) 1198-1209, ISSN 1930-7381
Publisher: Wiley-Blackwell
DOI: 10.1002/oby.24014

Fasting indices of glucose-insulin-metabolism across life span and prediction of glycemic deterioration in children with obesity from new diagnostic cut-offs

Author(s): Maximiliane Chiara Hammel, Robert Stein, Jürgen Kratzsch, Mandy Vogel, Alexander J. Eckert, Rima Destya Triatin, Marco Colombo, Christof Meigen, Ronny Baber, Juraj Stanik, Ulrike Spielau, Anette Stoltze, Kerstin Wirkner, Anke Tönjes, Harold Snieder, Reinhard W. Holl, Michael Stumvoll, Matthias Blüher, Wieland Kiess, Antje Körner
Published in: The Lancet Regional Health - Europe, Issue 30, 2023, Page(s) 100652, ISSN 2666-7762
Publisher: Elsevier BV
DOI: 10.1016/j.lanepe.2023.100652

Not All Type-2-Diabetes Patients Increase Body Mass Index After Initiating Insulin: Results of Latent Class Analysis from the DPV Registry

Author(s): Nicole Prinz; Anke Schwandt; Bernadette Borgert; Bettina Hartmann; Hans-Peter Kempe; Julia K. Mader; Sigrund Merger; Rosmarie Weber-Lauffer; Frank-Jürgen Wosch; Reinhard W. Holl;
Published in: Diabetes Technology & Therapeutics, 2021, ISSN 1520-9156
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/dia.2021.0144

Who benefits most from outpatient lifestyle intervention? An <scp>IMI‐SOPHIA</scp> study on pediatric individuals living with overweight and obesity

Author(s): Nicole Prinz, Hugo Pomares‐Millan, Almut Dannemann, Giuseppe N. Giordano, Christine Joisten, Antje Körner, Daniel Weghuber, Susann Weihrauch‐Blüher, Susanna Wiegand, Reinhard W. Holl, Stefanie Lanzinger, null null
Published in: Obesity, Issue 31, 2024, Page(s) 2375-2385, ISSN 1930-7381
Publisher: Wiley-Blackwell
DOI: 10.1002/oby.23844

Next-generation epidemiology: the role of high-resolution molecular phenotyping in diabetes research

Author(s): Paul W. Franks, Hugo Pomares-Millan
Published in: Diabetologia, Issue 63, 2022, Page(s) 2521-2532, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-020-05246-w

The lived experience of patients with obesity: A systematic review and qualitative synthesis

Author(s): Emma Farrell, Eva Hollmann, Carel W. le Roux, Marta Bustillo, Joe Nadglowski, Deirdre McGillicuddy
Published in: Obesity Reviews, 2021, ISSN 1467-7881
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/obr.13334

“Treated as second class citizens” - the lived experience of obesity-related stigma: an IMI2 SOPHIA study

Author(s): Eva Hollmann, Emma Farrell, Carel Le Roux, Joe Nadglowski, Deirdre McGillicuddy
Published in: International Journal of Qualitative Studies on Health and Well-being, Issue 19, 2024, ISSN 1748-2631
Publisher: Informa UK Limited
DOI: 10.1080/17482631.2024.2344232

Baseline phenotypes with preserved β-cell function and high insulin concentrations have the best improvements in glucose tolerance after weight loss: results from the prospective DEXLIFE and EGIR-RISC studies

Author(s): Silvia Sabatini, John J. Nolan, Grainne O'Donoghue, Aileen Kennedy, John Petrie, Mark Walker, Donal J. O'Gorman, Amalia Gastaldelli
Published in: Metabolism, Issue 155, 2024, Page(s) 155910, ISSN 0026-0495
Publisher: Elsevier BV
DOI: 10.1016/j.metabol.2024.155910

Body Mass Index's influence on arterial hypertension in Type 1 diabetes – A brief report from IMI-SOPHIA study

Author(s): Laurence D. Petty, Enrique Soto-Pedre, Rory J. McCrimmon, Ewan R. Pearson
Published in: Journal of Diabetes and its Complications, Issue 38, 2024, Page(s) 108747, ISSN 1056-8727
Publisher: Elsevier BV
DOI: 10.1016/j.jdiacomp.2024.108747

Accurate liquid biopsy for the diagnosis of non-alcoholic steatohepatitis and liver fibrosis

Author(s): Giulia Angelini, Simona Panunzi, Lidia Castagneto-Gissey, Francesca Pellicanò, Andrea De Gaetano, Maurizio Pompili, Laura Riccardi, Matteo Garcovich, Marco Raffaelli, Luigi Ciccoritti, Ornella Verrastro, Maria Francesca Russo, Fabio Maria Vecchio, Giovanni Casella, James Casella-Mariolo, Luigi Papa, Pier Luigi Marini, Francesco Rubino, Carel W le Roux, Stefan Bornstein, Geltrude Mingrone
Published in: Gut, Issue 72, 2023, Page(s) 392-403, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2022-327498

Subclassification of obesity for precision prediction of cardiometabolic diseases

Author(s): Daniel E. Coral, Femke Smit, Ali Farzaneh, Alexander Gieswinkel, Juan Fernandez Tajes, Thomas Sparsø, Carl Delfin, Pierre Bauvin, Kan Wang, Marinella Temprosa, Diederik De Cock, Jordi Blanch, José Manuel Fernández-Real, Rafael Ramos, M. Kamran Ikram, Maria F. Gomez, Maryam Kavousi, Marina Panova-Noeva, Philipp S. Wild, Carla van der Kallen, Michiel Adriaens, Marleen van Greevenbroek, Ilja Arts,
Published in: Nature Medicine, Issue 31, 2025, Page(s) 534-543, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-024-03299-7

“What would be left of me?” Patient perspectives on the risks of obesity treatment: An innovative health initiative stratification of obesity phenotypes to optimise future obesity therapy (IMI2 SOPHIA) qualitative study

Author(s): Emma Farrell, Joseph Nadglowski, Eva Hollmann, Carel W. le Roux, Deirdre McGillicuddy
Published in: Obesity Pillars, Issue 12, 2024, Page(s) 100129, ISSN 2667-3681
Publisher: Elsevier BV
DOI: 10.1016/j.obpill.2024.100129

Patient perspectives on personalised medicine for obesity: An IMI2 SOPHIA Study

Author(s): Emma Farrell, Carel W. le Roux, Eva Hollmann, Joseph Nadglowski, Deirdre McGillicuddy
Published in: Obesity Research & Clinical Practice, Issue 18, 2024, Page(s) 216-221, ISSN 1871-403X
Publisher: Elsevier BV
DOI: 10.1016/j.orcp.2024.06.004

ForePass endoscopic bypass device for obesity and insulin resistance—metabolic treatment in a swine model

Author(s): Giulia Angelini, Manoel Galvao Neto, Ivo Boskoski, Maria Emiliana Caristo, Sara Russo, Luca Proto, Elena Previti, Lisa Olsson, Hobby Aggarwal, Samantha Pezzica, Elisa Ferrari, Vincenzo Bove, Alfredo Genco, Stefan Bornstein, Valentina Tremaroli, Amalia Gastaldelli, Geltrude Mingrone
Published in: Gut, 2024, Page(s) gutjnl-2023-331335, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-331335

Treated as second class citizens” - the lived experience of obesity-related stigma: an IMI2 SOPHIA study

Author(s): Eva Hollmann,Emma Farrell,Carel Le Roux (Prof.),Joe Nadglowski,Deirdre McGillicuddy
Published in: International Journal of Qualitative Studies on Health and Well-being, 2024, ISSN 1748-2623
Publisher: Taylor & Francis

Disease heterogeneity of adult diabetes based on routine clinical variables at diagnosis: Results from the German/Austrian Diabetes Follow-up Registry

Author(s): Julia M. Grimsmann; Sascha R. Tittel; Peter Bramlage; Benjamin Mayer; Andreas Fritsche; Jochen Seufert; Markus Laimer; Stefan Zimny; Sebastian M. Meyhoefer; Michael Hummel; Reinhard W. Holl
Published in: Diabetes, Obesity and Metabolism, 2022, ISSN 1463-1326
Publisher: Diabetes, Obesity and Metabolism
DOI: 10.1111/dom.14812

Genetic Evidence of Causal Relation Between Intestinal Glucose Absorption and Early Postprandial Glucose Response: A Mendelian Randomization Study

Author(s): Simon Peschard, Violeta Raverdy, Pierre Bauvin, Rebecca Goutchtat, Veronique Touche, Bruno Derudas, Celine Gheeraert, Julie Dubois-Chevalier, Robert Caiazzo, Gregory Baud, Camille Marciniak, Helene Verkindt, Naima Oukhouya Daoud, Carel W. Le Roux, Philippe Lefebvre, Bart Staels, Sophie Lestavel, François Pattou
Published in: Diabetes, Issue 73, 2024, Page(s) 983-992, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db23-0805

Characterisation and clinical outcomes in children and adolescents with diabetes according to newly defined subgroups: a cohort study from the DPV registry

Author(s): Katharina Warncke, Alexander Eckert, Ezio Bonifacio, Peter Achenbach, Olga Kordonouri, Thomas Meissner, Ute Ohlenschläger, Walter Bonfig, Anette-G. Ziegler, Reinhard W. Holl
Published in: eClinicalMedicine, Issue 64, 2024, Page(s) 102208, ISSN 2589-5370
Publisher: eClinicalMedicine
DOI: 10.1016/j.eclinm.2023.102208

Access to Healthcare for Children and Adolescents with a Chronic Health Condition during the COVID-19 Pandemic: First Results from the KICK-COVID Study in Germany

Author(s): Julia M. Göldel, Clemens Kamrath, Kirsten Minden, Susanna Wiegand, Stefanie Lanzinger, Claudia Sengler, Susann Weihrauch-Blüher, Reinhard W. Holl, Sascha R. Tittel, Petra Warschburger
Published in: Children, Issue 10, 2024, Page(s) 10, ISSN 2227-9067
Publisher: Children
DOI: 10.3390/children10010010

Special diet in type 1 diabetes: do gender and BMI-SDS differ?

Author(s): Alena Gerlinde Thiele; Nicole Prinz; Monika Flury; Melanie Hess; Daniela Klose; Thomas Meissner; Klemens Raile; Klemens Raile; Sabine Wenzel; Sascha Tittel; Thomas Kapellen; Reinhard Holl
Published in: Child and Adolescent Obesity, 2021, ISSN 2227-9067
Publisher: Taylor & Francis
DOI: 10.1080/2574254x.2021.2002061

Serum Metabolomic Profiling of Incident Type 2 Diabetes Mellitus in the Multi-ethnic Study of Atherosclerosis and Rotterdam Study

Author(s): Xuanwei Jiang, Fang Zhu, Gonçalo Graça, Xihao Du, Jinjun Ran, Fariba Ahmadizar, Alexis C Wood, Yanqiu Zhou, Denise M Scholtens, Ali Farzaneh, M Arfan Ikram, Alan Kuang, Carel W le Roux, Meghana D Gadgil, Marilyn C Cornelis, Kent D Taylor, Xiuqing Guo, Mohsen Ghanbari, Laura J Rasmussen-Torvik, Russell P Tracy, Alain G Bertoni, Jerome I Rotter, David M Herrington, Philip Greenland, Maryam Kavousi
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue 110, 2025, Page(s) e2700-e2710, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/clinem/dgae812

Microbiota-gut-brain axis: relationships among the vagus nerve, gut microbiota, obesity, and diabetes

Author(s): Susanna Longo, Stefano Rizza, Massimo Federici
Published in: Acta Diabetologica, Issue 60, 2023, Page(s) 1007-1017, ISSN 1432-5233
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s00592-023-02088-x

Plasma circulating microRNAs associated with obesity, body fat distribution, and fat mass: the Rotterdam Study

Author(s): Yasir J. Abozaid; Xiaofang Zhang; Michelle M. J. Mens; Fariba Ahmadizar; Marlou Limpens; M. Arfan Ikram; Fernando Rivadeneira; Trudy Voortman; Maryam Kavousi; Mohsen Ghanbari
Published in: International Journal of Obesity, 2022, ISSN 1476-4687
Publisher: Nature
DOI: 10.1038/s41366-022-01227-8

BMI variability and cardiovascular outcomes within clinical trial and real-world environments in type 2 diabetes: an IMI2 SOPHIA study

Author(s): Robert J. Massey, Yu Chen, Marina Panova-Noeva, Michaela Mattheus, Moneeza K. Siddiqui, Nanette C. Schloot, Antonio Ceriello, Ewan R. Pearson, Adem Y. Dawed
Published in: Cardiovascular Diabetology, Issue 23, 2024, ISSN 1475-2840
Publisher: BioMed Central
DOI: 10.1186/s12933-024-02299-8

Investigating the causal relationships between excess adiposity and cardiometabolic health in men and women

Author(s): Pascal M. Mutie, Hugo Pomares-Millan, Naeimeh Atabaki-Pasdar, Daniel Coral, Hugo Fitipaldi, Neli Tsereteli, Juan Fernandez Tajes, Paul W. Franks, Giuseppe N. Giordano
Published in: Diabetologia, Issue 66, 2024, Page(s) 321-335, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-022-05811-5

Achieving consensus on the language of obesity: a modified Delphi study

Author(s): Cecilie Heerdegen Jepsen, Jacqueline Bowman-Busato, Thomas Allvin, Niamh Arthurs, Gijs H. Goossens, Elisabeth Govers, Benjamin Assad Jaghutriz, Vicki Mooney, Bart Van der Schueren, Carel W. le Roux
Published in: eClinicalMedicine, Issue 62, 2024, Page(s) 102061, ISSN 2589-5370
Publisher: eClinical Medicine
DOI: 10.1016/j.eclinm.2023.102061

Anti‐obesity treatment preferences of healthcare providers and people living with obesity: A survey‐based study

Author(s): Carel W. Le Roux, Anna Koroleva, Sara Larsen, Ellie Foot
Published in: Clinical Obesity, Issue 15, 2025, ISSN 1758-8103
Publisher: Wiley
DOI: 10.1111/cob.12704

Data-driven cluster analysis identifies distinct types of metabolic dysfunction-associated steatotic liver disease

Author(s): Violeta Raverdy, Federica Tavaglione, Estelle Chatelain, Guillaume Lassailly, Antonio De Vincentis, Umberto Vespasiani-Gentilucci, Sami F. Qadri, Robert Caiazzo, Helene Verkindt, Chiara Saponaro, Julie Kerr-Conte, Gregory Baud, Camille Marciniak, Mikael Chetboun, Naima Oukhouya-Daoud, Samuel Blanck, Jimmy Vandel, Lisa Olsson, Rima Chakaroun, Viviane Gnemmi, Emmanuelle Leteurtre, Philippe Lefebvre,
Published in: Nature Medicine, Issue 30, 2025, Page(s) 3624-3633, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-024-03283-1

The Gut Microbiota and Diabetes: Research, Translation, and Clinical Applications—2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum

Author(s): Mariana Byndloss, Suzanne Devkota, Frank Duca, Jan Hendrik Niess, Max Nieuwdorp, Marju Orho-Melander, Yolanda Sanz, Valentina Tremaroli, Liping Zhao
Published in: Diabetes Care, 2024, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dci24-0052

Fetal alleles predisposing to metabolically favorable adiposity are associated with higher birth weight

Author(s): William D Thompson, Robin N Beaumont, Alan Kuang, Nicole M Warrington, Yingjie Ji, Jessica Tyrrell, Andrew R Wood, Denise M Scholtens, Bridget A Knight, David M Evans, William L Lowe Jr, Gillian Santorelli, Raq Azad, Dan Mason, Andrew T Hattersley, Timothy M Frayling, Hanieh Yaghootkar, Maria Carolina Borges, Deborah A Lawlor, Rachel M Freathy
Published in: Human Molecular Genetics, Issue 31, 2022, Page(s) 1762-1775, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddab356

Stratification of obesity phenotypes to optimize future therapy (SOPHIA)

Author(s): Abd A Tahrani, Marina Panova-Noeva, Nanette C Schloot, Anita M Hennige, Jeannette Soderberg, Joe Nadglowski, Lisa Tarasenko, Nadia N Ahmad, Barbara SC Sleypen, Rafael Bravo, Werd Al-Najim, Carel W le Roux
Published in: Expert Review of Gastroenterology & Hepatology, Issue 17, 2024, Page(s) 1031-1039, ISSN 1747-4124
Publisher: Future Drugs Ltd.
DOI: 10.1080/17474124.2023.2264783

Upper gut heat shock proteins HSP70 and GRP78 promote insulin resistance, hyperglycemia, and non-alcoholic steatohepatitis

Author(s): Giulia Angelini; Lidia Castagneto-Gissey; Serenella Salinari; Alessandro Bertuzzi; Danila Anello; Meenakshi Pradhan; Marlen Zschätzsch; Paul Ritter; CarelW. Le Roux; Francesco Rubino; Nicola Basso; Giovanni Casella; Stefan R. Bornstein; Valentina Tremaroli; Geltrude Mingrone
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-35310-5

Three‐variate trajectories of metabolic control, body mass index, and insulin dose: Heterogeneous response to initiation of pump therapy in youth with type 1 diabetes

Author(s): Martin Tauschmann, Anke Schwandt, Nicole Prinz, Marianne Becker, Torben Biester, Melanie Hess, Martin Holder, Beate Karges, Andrea Näke, Oliver Kuss, Simone Sengbusch, Reinhard W. Holl, null null
Published in: Pediatric Diabetes, Issue 23, 2022, Page(s) 330-340, ISSN 1399-543X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pedi.13320

Comparison of BMI and HbA1c changes before and during the COVID-19 pandemic in type 1 diabetes: a longitudinal population-based study

Author(s): Marie Auzanneau, Dorothee M. Kieninger, Katharina Laubner, Christian Renner, Joaquina Mirza, Gerhard Däublin, Kirsten Praedicow, Holger Haberland, Claudia Steigleder-Schweiger, Bettina Gohlke, Angela Galler, Reinhard W. Holl, null null
Published in: Journal of Diabetes & Metabolic Disorders, Issue 23, 2024, Page(s) 573-583, ISSN 2251-6581
Publisher: BioMed Central
DOI: 10.1007/s40200-023-01316-z

Patient perspectives about treatment preferences for obesity with complications

Author(s): Hilary C. Craig, Dalal Alsaeed, Suzanne Norris, John Holian, Cormac Kennedy, Alix Feldman, Carel Le Roux
Published in: Obesity Science & Practice, Issue 10, 2024, ISSN 2055-2238
Publisher: Wiley
DOI: 10.1002/osp4.720

Adipose tissue macrophage infiltration and hepatocyte stress increase GDF-15 throughout development of obesity to MASH

Author(s): Laurent L’homme, Benan Pelin Sermikli, Joel T. Haas, Sébastien Fleury, Sandrine Quemener, Valentine Guinot, Emelie Barreby, Nathalie Esser, Robert Caiazzo, Hélène Verkindt, Benjamin Legendre, Violeta Raverdy, Lydie Cheval, Nicolas Paquot, Jacques Piette, Sylvie Legrand-Poels, Myriam Aouadi, François Pattou, Bart Staels, David Dombrowicz
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-51078-2

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Author(s): Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno De
Published in: Hepatology, 2024, Page(s) n/a-n/a, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.32631

Prevalence of obesity in people with and without type 1 diabetes across Belgium, Kuwait, and Mexico: an IMI2 SOPHIA study

Author(s): Ebaa Al Ozairi, Nele Steenackers, Sofia Pazmino, Abdulnabi T. Alattar, Jumana Al Kandari, Paloma Almeda-Valdes, Neftali Eduardo Antonio-Villa, Carl Delfin, Raquel N. Faradji, Aili García-Tuomola A, Mohammad Irshad, Joseph C. Longenecker, Jonathan Rosen, Carmen Hurtado del Pozo, Thomas Sparsø, Astrid Lavens, Chantal Mathieu, Bart Van der Schueren, Carel W. le Roux
Published in: eClinicalMedicine, Issue 77, 2025, Page(s) 102869, ISSN 2589-5370
Publisher: Elsevier BV
DOI: 10.1016/j.eclinm.2024.102869

The association between perinatal factors and cardiometabolic risk factors in children and adolescents with overweight or obesity: A retrospective two-cohort study

Author(s): Nicole Prinz, Resthie R. Putri, Thomas Reinehr, Pernilla Danielsson, Daniel Weghuber, Mikael Norman, Niels Rochow, Claude Marcus, Reinhard W. Holl, Emilia Hagman
Published in: PLOS Medicine, Issue 20, 2023, Page(s) e1004165, ISSN 1549-1676
Publisher: PLoS Med
DOI: 10.1371/journal.pmed.1004165

Disease heterogeneity of adult diabetes based on routine clinical parameters at diagnosis: Results from the German/Austrian DPV registry.

Author(s): Grimsmann, Julia M; Tittel, Sascha R; Bramlage, Peter; Mayer, Benjamin; Fritsche, Andreas; Seufert, Jochen; Laimer, Markus; Zimny, Stefan; Meyhoefer, Sebastian M; Hummel, Michael; Holl, Reinhard W
Published in: Grimsmann, Julia M; Tittel, Sascha R; Bramlage, Peter; Mayer, Benjamin; Fritsche, Andreas; Seufert, Jochen; Laimer, Markus; Zimny, Stefan; Meyhoefer, Sebastian M; Hummel, Michael; Holl, Reinhard W (2022). Disease heterogeneity of adult diabetes based on routine clinical parameters at diagnosis: Results from the German/Austrian DPV registry. Diabetes, obesity & metabolism, 24(11), pp. 2253-2262. Wi, Issue 1, 2022, ISSN 1463-1326
Publisher: Diabetes, obesity & metabolism
DOI: 10.48350/171154

Heterogeneity in response to GLP-1 receptor agonists in type 2 diabetes in real-world clinical practice: insights from the DPV register – an IMI-SOPHIA study

Author(s): Martin Heni, Lisa Frühwald, Wolfram Karges, Michael Naudorf, Kathrin Niemöller, Frank Pagnia, Jörg Reindel, Jochen Seufert, Gisa Ufer, Christian Wagner, Reinhard W. Holl, Nicole Prinz
Published in: Diabetologia, Issue 68, 2025, Page(s) 1666-1673, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-025-06448-w

Obesity in people living with type 1 diabetes

Author(s): Bart Van der Schueren Darcy Ellis Raquel NFaradji Eeba Al-Ozairi Jonathan Rosen Chantal Mathieu
Published in: The Lancet Diabetes & Endocrinology, 2021, ISSN 2213-8587
Publisher: Elsevier BV
DOI: 10.1016/s2213-8587(21)00246-1

Impact of the COVID-19 Pandemic on Psychosocial Distress in Adolescents with Obesity Compared to Those with Type 1 Diabetes: Results from the KICK-COVID Study in Germany

Author(s): Susann Weihrauch-Blüher, Susanna Wiegand, Sascha Tittel, Susanne Greber-Platzer, Stefanie Lanzinger, Clemens Kamrath, Kirsten Minden, Claudia Sengler, Sabine Linke, Antje Büssenschütt, Felix Reschke, Julia Göldel, Petra Warschburger, Reinhard W. Holl
Published in: Obesity Facts, Issue 18, 2025, Page(s) 305-318, ISSN 1662-4025
Publisher: Karger AG
DOI: 10.1159/000542756

The effect of physical activity on glycaemic control in people with type 1 diabetes mellitus: A systematic literature review and meta‐analysis

Author(s): Diederik De Cock, Lucas Schreurs, Nele Steenackers, Sofia Pazmino, Wilfried Cools, Lauren Eykerman, Hannah Thiels, Chantal Mathieu, Bart Van der Schueren
Published in: Diabetic Medicine, Issue 41, 2024, ISSN 0742-3071
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/dme.15415

Mendelian Randomization Analyses Suggest Childhood Body Size Indirectly Influences End Points From Across the Cardiovascular Disease Spectrum Through Adult Body Size

Author(s): Grace M. Power, Jessica Tyrrell, Timothy M. Frayling, George Davey Smith, Tom G. Richardson
Published in: Journal of the American Heart Association, Issue 10, 2024, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.121.021503

Combining diabetes, sex, and menopause as meaningful clinical features associated with NASH and liver fibrosis in individuals with class II and III obesity: A retrospective cohort study

Author(s): Violeta Raverdy, Estelle Chatelain, Guillaume Lasailly, Robert Caiazzo, Jimmy Vandel, Helene Verkindt, Camille Marciniak, Benjamin Legendre, Pierre Bauvin, Naima Oukhouya‐Daoud, Gregory Baud, Mikael Chetboun, Marie‐Christine Vantyghem, Viviane Gnemmi, Emmanuelle Leteurtre, Bart Staels, Philippe Lefebvre, Philippe Mathurin, Guillemette Marot, Francois Pattou
Published in: Obesity, Issue 31, 2024, Page(s) 3066-3076, ISSN 1930-7381
Publisher: Wiley-Blackwell
DOI: 10.1002/oby.23904

Development and validation of an interpretable machine learning-based calculator for predicting 5-year weight trajectories after bariatric surgery: a multinational retrospective cohort SOPHIA study

Author(s): Patrick Saux, Pierre Bauvin, Violeta Raverdy, Julien Teigny, Hélène Verkindt, Tomy Soumphonphakdy, Maxence Debert, Anne Jacobs, Daan Jacobs, Valerie Monpellier, Phong Ching Lee, Chin Hong Lim, Johanna C Andersson-Assarsson, Lena Carlsson, Per-Arne Svensson, Florence Galtier, Guelareh Dezfoulian, Mihaela Moldovanu, Severine Andrieux, Julien Couster, Marie Lepage, Erminia Lembo, Ornella Verrastro,
Published in: The Lancet Digital Health, Issue 5, 2023, Page(s) e692-e702, ISSN 2589-7500
Publisher: Lancet Digital Health
DOI: 10.1016/s2589-7500(23)00135-8

Environment-wide association study (EWAS) on cardiometabolic traits: A systematic assessment of the association of lifestyle variables on a longitudinal setting

Author(s): Alaitz Poveda, Yan Chen, Hugo Pomares-Millan, Azra Kurbasic, Chirag J Patel, Frida Renström, Göran Hallmans, Ingegerd Johansson, Paul W. Franks
Published in: Scientific Reports, 2024, ISSN 2070-0245
Publisher: Scientific Reports
DOI: 10.1101/2021.03.22.21254099

At home and at risk: The experiences of Irish adults living with obesity during the COVID-19 pandemic

Author(s): Emma Farrell; Eva Hollmann; Carel Le Roux; Joe Nadglowski; Deirdre McGillicuddy
Published in: EClinicalMedicine, 2022, ISSN 2589-5370
Publisher: Elsevier
DOI: 10.1016/j.eclinm.2022.101568

Healthcare professionals perceptions of obesity management: An IMI2 SOPHIA qualitative study

Author(s): Nele Steenackers, Seppe Willio, Anne Bruneel, Ellen Deleus, Matthias Lannoo, Christophe Matthys, Ann Mertens, Eline Van Craeyveld, Roman Vangoitsenhoven, Bart Van der Schueren
Published in: Clinical Obesity, 2024, ISSN 1758-8103
Publisher: Wiley
DOI: 10.1111/cob.12686

“I am terrified of something happening to me” The lived experience of people with obesity during the COVID ‐19 pandemic

Author(s): Andrew Grannell, Carel W. Roux, Deirdre McGillicuddy
Published in: Clinical Obesity, Issue 10/6, 2020, ISSN 1758-8103
Publisher: Clinical Obesity
DOI: 10.1111/cob.12406

Association between arterial stiffness/remodeling and new-onset type 2 diabetes mellitus in general population

Author(s): Fariba Ahmadizar; Kan Wang; Maurits Roos; Maxime Bos; Francesco Mattace- Raso; Maryam Kavousi
Published in: Diabetes Research and Clinical Practice, 2023, ISSN 0168-8227
Publisher: Elsevier BV
DOI: 10.1016/j.diabres.2023.110237

Weight development in children and adolescents with obesity during the COVID-19 pandemic

Author(s): Angela Galler, Markus Röbl, Nicole Prinz, Almut Dannemann, Ines Gellhaus, Thomas Kapellen, Sabine Linke, Gerd Schauerte, Robert Stein, Daniel Weghuber, Susann Weihrauch-Blüher, Susanna Wiegand, Reinhard Holl
Published in: Deutsches Ärzteblatt international, 2022, ISSN 1866-0452
Publisher: Deutscher Arzte-Verlag
DOI: 10.3238/arztebl.m2022.0155

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