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CORDIS - Resultados de investigaciones de la UE
CORDIS

GUT VIrus BRain Axis Technology In OrgaNoid Science

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Protocol for establishing the gut-epithelial model in STACKS [M6]. A standard protocol for the transfer of gut epithelial monolayer model from Transwell to STACKS will be provided. [R] [PU] (se abrirá en una nueva ventana)

Protocol for establishing the gutepithelial model in STACKS M6 A standard protocol for the transfer of gut epithelial monolayer model from Transwell to STACKS will be provided R PU

Report on diffusion properties through the Biosilk matrix [M12]. Diffusion properties of fluorochromes in the Biosilk network with and without cells will be reported. [R] [PU] (se abrirá en una nueva ventana)

Report on diffusion properties through the Biosilk matrix M12 Diffusion properties of fluorochromes in the Biosilk network with and without cells will be reported R PU

Definition of standard values for specific immune response parameters in the gut epithelial-immune cell co-culture model [M24]. A report on the measured standard values for immune markers will be available. [R] [PU] (se abrirá en una nueva ventana)
Manuscript on the effect of fibroblasts on gut epithelial differentiation [M24]. The role of fibroblasts within the Biosilk network to effect gut differentiation in vitro will be elucidated. [R] [PU] (se abrirá en una nueva ventana)
Manuscript describing viral infection of the gut mucosa model [M42] [R] [PU] (se abrirá en una nueva ventana)
Protocol for cytotoxicity assay in gut mucosa model [M30] [Report on the best method for cytotoxicity assessment] [R] [PU] (se abrirá en una nueva ventana)
Manuscript on antiviral testing in complex gut/brain models [M48] [R] [PU] (se abrirá en una nueva ventana)
Protocol for iPSC-derived BBB model [M24] [A standard protocol for establishing a BBB model will be provided]. [R] [PU] (se abrirá en una nueva ventana)
Data Management Plan [M6, M30, M48] Regular updates of DMP is uploaded to the website. [R] [PU] (se abrirá en una nueva ventana)
Manuscript on the method to co-culture gut-epithelial model with immune cells [M24]. [R] [PU] (se abrirá en una nueva ventana)
Report on the properties of the Biosilk network [M24]. The complete properties of the Biosilk network such as tensile and cell motility will be characterised. [R] [PU] (se abrirá en una nueva ventana)
Characterisation panel for iPSC-derived BBB model. [M24] [Report on standard range of parameters for BBB model] [R] [PU] (se abrirá en una nueva ventana)
Manuscript describing viral infection of the BBB-brain model [M42] [R] [PU] (se abrirá en una nueva ventana)
Report on the properties of the Biosilk nanomembrane [M24]. The complete properties of the Biosilk nanomembrane such as porosity and mass transport will be characterised. [R] [PU] (se abrirá en una nueva ventana)
"Protocol for patterning ""crypt-villi"" features on Biosilk [M9]. A standard protocol for embossing or casting ""crypt-villi"" structures will be delivered. [R] [PU]" (se abrirá en una nueva ventana)

Protocol for patterning cryptvilli features on Biosilk M9 A standard protocol for embossing or casting cryptvilli structures will be delivered R PU

Publicaciones

What is a neurotropic virus: Discrepancies in terminology between clinical and basic science (se abrirá en una nueva ventana)

Autores: Pamela E. Capendale, Katja C. Wolthers, Dasja Pajkrt
Publicado en: Med, Edición 4, 2024, Página(s) 660-663, ISSN 2666-6340
Editor: Elsevier BV
DOI: 10.1016/j.medj.2023.07.001

A quantitative meta-analysis: Is organ on a chip cell cultures better than static cell cultures? (se abrirá en una nueva ventana)

Autores: Martin Dufva
Publicado en: Scientific Reports, 2023, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.21203/rs.3.rs-2208798/v1

Parechovirus infection in human brain organoids: host innate inflammatory response and not neuro-infectivity correlates to neurologic disease (se abrirá en una nueva ventana)

Autores: Pamela E. Capendale, Inés García-Rodríguez, Anoop T. Ambikan, Lance A. Mulder, Josse A. Depla, Eline Freeze, Gerrit Koen, Carlemi Calitz, Vikas Sood, Renata Vieira de Sá, Ujjwal Neogi, Dasja Pajkrt, Adithya Sridhar, Katja C. Wolthers
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-46634-9

Non-Polio Enterovirus C Replicate in Both Airway and Intestine Organotypic Cultures (se abrirá en una nueva ventana)

Autores: Giulia Moreni, Hetty van Eijk, Gerrit Koen, Nina Johannesson, Carlemi Calitz, Kimberley Benschop, Jeroen Cremer, Dasja Pajkrt, Adithya Sridhar, Katja Wolthers
Publicado en: Viruses, Edición 15, 2025, Página(s) 1823, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v15091823

Tissue Like Density Sheets of Hepatoblastoma Cultures Obtained with Thin Suspended Hydrogels Mimicking In Vivo Inter‐Capillary Distances (se abrirá en una nueva ventana)

Autores: Alexander Jönsson, Hakan Gürbüz, Louise Wildfang, Pernille Rose Jensen, Martin Dufva
Publicado en: Advanced Materials Technologies, 2024, ISSN 2365-709X
Editor: Advanced Materials
DOI: 10.1002/admt.202401204

Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Third International Conference on 3Rs Research and Progress, Vishakhapatnam, 2022 (se abrirá en una nueva ventana)

Autores: Nikita Narayan Naik, Bharadwaja Vadloori, Suresh Poosala, Pratima Srivastava, Sandra Coecke, Adrian Smith, Aysha Akhtar, Clive Roper, Sridhar Radhakrishnan, Balaji Bhyravbhatla, Madhujit Damle, Venkat Koushik Pulla, Johannes Hackethal, Reyk Horland, Albert P. Li, Falguni Pati, Manu Smriti Singh, Paola Occhetta, Rohit Bisht, Prajakta Dandekar, Krishna Bhagavatula, Dasja Pajkrt, Michael Johnson, Til
Publicado en: Alternatives to Laboratory Animals, Edición 51, 2025, Página(s) 263-288, ISSN 0261-1929
Editor: Fund for the Replacement of Animals in Medical Experiments
DOI: 10.1177/02611929231180428

Assessment of the broad-spectrum host targeting antiviral efficacy of halofuginone hydrobromide in human airway, intestinal and brain organotypic models. (se abrirá en una nueva ventana)

Autores: Inés García-Rodríguez, Giulia Moreni, Pamela E. Capendale, Lance Mulder, Ikrame Aknouch, Renata Vieira de Sá, Nina Johannesson, Eline Freeze, Hetty van Eijk, Gerrit Koen, Katja C. Wolthers, Dasja Pajkrt, Adithya Sridhar, Carlemi Calitz
Publicado en: Antiviral Research, Edición 222, 2024, Página(s) 105798, ISSN 0166-3542
Editor: Elsevier BV
DOI: 10.1016/j.antiviral.2024.105798

Enhanced biocompatibility of 3D printed resin parts <i>via</i> wet autoclave postprocessing: implications for stem cell organ-on-a-chip culture (se abrirá en una nueva ventana)

Autores: Alexander Jönsson, Antonia Iatrou, Louise Wildfang, Dana J. Neumann, Hakan Gürbüz, Carina A. A. Schoenmaker, Marlene Danner Dalgaard, Pernille Rose Jensen, Martin Dufva
Publicado en: Materials Advances, 2025, ISSN 2633-5409
Editor: Materials Advances
DOI: 10.1039/d4ma01191k

A beginner’s guide on the use of brain organoids for neuroscientists: a systematic review (se abrirá en una nueva ventana)

Autores: Lance A. Mulder, Josse A. Depla, Adithya Sridhar, Katja Wolthers, Dasja Pajkrt, Renata Vieira de Sá
Publicado en: Stem Cell Research &amp; Therapy, Edición 14, 2023, ISSN 1757-6512
Editor: BioMed Central
DOI: 10.1186/s13287-023-03302-x

Editorial: Human organoid technology for virus research (se abrirá en una nueva ventana)

Autores: Dasja Pajkrt, Veronica Krenn, Joana Rocha-Pereira
Publicado en: Frontiers in Cellular and Infection Microbiology, Edición 13, 2023, ISSN 2235-2988
Editor: Frontiers Media S. A.
DOI: 10.3389/fcimb.2023.1155252

Understanding neurotropic enteric viruses: routes of infection and mechanisms of attenuation (se abrirá en una nueva ventana)

Autores: Valeria Lulla, Adithya Sridhar
Publicado en: Cellular and Molecular Life Sciences, Edición 81, 2024, ISSN 1420-682X
Editor: Birkhauser Verlag
DOI: 10.1007/s00018-024-05450-6

A quantitative meta-analysis comparing cell models in perfused organ on a chip with static cell cultures (se abrirá en una nueva ventana)

Autores: Martin Dufva
Publicado en: Scientific Reports, Edición 13, 2023, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-35043-5

Evaluation of 3D Human Intestinal Organoids as a Platform for EV-A71 Antiviral Drug Discovery (se abrirá en una nueva ventana)

Autores: Fatma Masmoudi, Nanci Santos-Ferreira, Dasja Pajkrt, Katja C. Wolthers, Jeroen DeGroot, Maria L. H. Vlaming, Joana Rocha-Pereira, Ludovico Buti
Publicado en: Cells, Edición 12, 2023, Página(s) 1138, ISSN 2073-4409
Editor: MDPI AG
DOI: 10.3390/cells12081138

Current and Future Antiviral Strategies to Tackle Gastrointestinal Viral Infections (se abrirá en una nueva ventana)

Autores: Nanci Santos-Ferreira, Jana Van Dycke, Johan Neyts, Joana Rocha-Pereira
Publicado en: Microorganisms, Edición 9, 2024, Página(s) 1599, ISSN 2076-2607
Editor: Microorganisms
DOI: 10.3390/microorganisms9081599

Human milk inhibits some enveloped virus infections, including SARS-CoV-2, in an intestinal model (se abrirá en una nueva ventana)

Autores: Ikrame Aknouch, Adithya Sridhar, Eline Freeze, Francesca Paola Giugliano, Britt J van Keulen, Michelle Romijn, Carlemi Calitz, Inés García-Rodríguez, Lance Mulder, Manon E Wildenberg, Vanesa Muncan, Marit J van Gils, Johannes B van Goudoever, Koert J Stittelaar, Katja C Wolthers, Dasja Pajkrt
Publicado en: Life Science Alliance, Edición 5, 2024, Página(s) e202201432, ISSN 2575-1077
Editor: Frontiers
DOI: 10.26508/lsa.202201432

Amino acid variation at VP1-145 of enterovirus A71 determines the viral infectivity and receptor usage in a primary human intestinal model (se abrirá en una nueva ventana)

Autores: Ikrame Aknouch, Inés García-Rodríguez, Francesca Paola Giugliano, Carlemi Calitz, Gerrit Koen, Hetty van Eijk, Nina Johannessson, Sjoerd Rebers, Lieke Brouwer, Vanesa Muncan, Koert J. Stittelaar, Dasja Pajkrt, Katja C. Wolthers, Adithya Sridhar
Publicado en: Frontiers in Microbiology, Edición 14, 2023, ISSN 1664-302X
Editor: Frontiers Media
DOI: 10.3389/fmicb.2023.1045587

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