We purified novel danger signals released upon injury, which play a key role in triggering inflammatory responses. We determined the structure of these signals along with that of their receptors to better understand their interactions and explore how small molecules could be used to disrupt their binding. Additionally, we investigated their expression in animal models during episodes of inflammation.
We also explored how the SARS-CoV-2 spike protein may contribute to cytokine storm development, and how bacteria related to tuberculosis can induce inflammation.
To visualize inflammatory processes in living organisms, we developed new fluorescent tools and innovative imaging strategies, enabling us to observe how inflammatory episodes are initiated and propagated throughout the body. We further implemented computational algorithms and developed mathematical models to reconstruct the attractant fields that guide leukocyte migration during inflammation.
Moreover, we applied transcriptomic approaches—ranging from single-cell analysis to whole tissue profiling—to gain deeper insights into the molecular networks driving immune cell responses.
By analyzing patient data, we identified a novel human mutation responsible for a familial inflammatory disease. This discovery paves the way for the development of new therapeutic strategies targeting such conditions.
Building on our original findings, we have also developed new approaches for screening potential drugs to treat inflammatory diseases.
Numerous biological tools, software applications, and experimental protocols developed within the framework of the INFLANET project were shared across the consortium. These resources are regularly published and made available for use by external developers and scientific community. All scientific publications and related datasets are available in open access. Project results were presented at numerous national and international conferences throughout the duration of the project, with particular emphasis during our final dissemination meeting held in 2024 in Visegrád, Hungary.
