Training European Experts in Inflammation: from the molecular players to animal models and the bedside

Informations projet

INFLANET

N° de convention de subvention: 955576

DOI

10.3030/955576

Projet clôturé

Date de signature de la CE 28 Août 2020

Date de début 1 Mars 2021

Date de fin 31 Mai 2025

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 3 977 117,28

Contribution de l’UE

€ 3 977 117,28

Coordonné par

UNIVERSITE DE MONTPELLIER
France

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (26)

Final Report on Congress Presentations

Final Report on Congress Presentations due Month 48

Danger signal gradients

Report on the methods to integrate danger signal gradients in optic flow analysis

Inflammatory models

Cross validation of inflammatory models

Congress Presentations

Second report on Congress Presentations by ESRs di to the PO at Month 36

INFLANET brochure, website and advertising of vacancies

Documents to be provided to the PO including INFLANET brochure, website and advertising of vacancies

Screens to look for novel anti-inflammatory drugs

New screens to look for novel anti-inflammatory drugs

Inflammation & autophagy

Manipulation of inflammation & autophagy to fight tuberculosis

First Report on Scientific Publications

First Report on Scientific Publications due at Month

Image processing methods

Image processing methods for 3Dtime segmentation and tracking

New protocols for Genomic and transcriptomic analysis

New protocols for Genomic and transcriptomic analysis for the naalysis of the gentic basis of hereditary inflammatory diseases

3D+T trajectories and cell shapes during inflammatory episodes

Model 3D+T trajectories and cell shapes during inflammatory episodes

ASC specks and proteases in inflammation

Report on the role of ASC specks and proteases in the spreading of inflammation

Draft of the plan for the use and dissemination of knowledge
Structures and inhibitors

Report on Structures of macromolecules and inhibitors of inflammation

Reporters and labels

New reporters and labels for in vivo imaging

Consortium agreement and Supervisory Board of the network

Report to the PO Consortium agreement and Supervisory Board of the network

New reporters, sensors and mutants

New reporters, sensors and mutants to study inflammation

Single cells & specific cellular population purifications

Single cells & specific cellular population purifications for RNAseq

First Report on Congress Presentations

First Report on Congress Presentations by ESRs due at Months 20

Contributions to outreach activities

Record of all participants contributions to outreach activities targeted at schools and the general public

Medical image analysis

Software tools for medical images from patients with inflammatory diseases

Final Report on Scientific Publications

Final Report on Scientific Publications due Month 48

Transduction pathways

Report on transduction pathways stimulated during inflammation

Second report on Scientific Publications

Second report on Scientific Publications at Months 36

Large data sets

Report on the new tools to analyse and handle large sets of imaging data

Toxicology tests and screens

Results of toxicology tests and screen using the output of D2.5

Demonstrators, pilots, prototypes (2)

New multimodal and multispectral microscope setups
Imaging windows

New imaging windows for murine intravital microscopy

Websites, patent fillings, videos etc. (3)

Wikipedia articles and YouTube Channel
Video series

Video series for outreach activities

MOOC and Serious Game

Open Research Data Pilot (2)

Data Management Plan (DMP)

Data Management Plan DMP to be send to the PO

Final version of the Data Management Plan (DMP)

Publications

Other (4)

Teleost-specific ictacalcins exhibit similar structural organization, cation-dependent activation and transcriptional regulation as human S100 proteins

Auteurs: Liz Hernández, Théo Paris, Maria Demou, Catherine Birck, Christina Begon-Pescia, Juan Francisco Rodríguez-Vidal, Sylwia D. Tyrkalska, Charlotte Bureau, Catherine Gonzalez, Juliette Gracia, Etienne Lelièvre, Victoriano Mulero, Mai Nguyen-Chi, Laure Yatime
Publié dans: bioRxiv, 2025
Éditeur: bioRxiv
DOI: 10.1101/2025.06.10.658860

Macrophage Inflammasome Activation Drives Anti-inflammatory Responses via Neutrophil-Derived ASC Speck Transfer and Gasdermin-Dependent Caspase-1 Inhibition

Auteurs: Annamaria Pedoto, Juan M. Lozano-Gil, Mai E. Nguyen-Chi, Georges Lutfalla, Diana García-Moreno, Victoriano Mulero, Sylwia D. Tyrkalska
Publié dans: Macrophage Inflammasome Activation Drives Anti-inflammatory Responses via Neutrophil-Derived ASC Speck Transfer and Gasdermin-Dependent Caspase-1 Inhibition, 2025
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.22.634381

Mathematical and numerical methods for understanding immune cell motion during wound healing

Auteurs: Giulia Lupi, Seol Ah Park, Martin Ambroz, Resul Ozbilgic, Mai Nguyen Chi, Georges Lutfalla, Karol Mikula
Publié dans: arXiv, 2025
Éditeur: arXiv

Beneficios y riesgos del inflamasoma, pieza clave de los procesos inflamatorios

Auteurs: Tyrkalska SD, Pedoto A, Lozano-Gil M, Mulero V.
Publié dans: 2024
Éditeur: The Conversation 2024

Peer reviewed articles (17)

Autoinflammatory encephalopathy due to PTPN1 haploinsufficiency: a case series

Auteurs: Gaofeng Zhu, Blaise Didry-Barca, Luis Seabra, Gillian I Rice, Carolina Uggenti, Moncef Touimy, Mathieu P Rodero, Rolando Hernandez Trapero, Vincent Bondet, Darragh Duffy, Philippe Gautier, Katie Livingstone, Fraser J H Sutherland, Pierre Lebon, Mélanie Parisot, Christine Bole-Feysot, Cécile Masson, Nicolas Cagnard, Patrick Nitschké, Glenn Anderson, Birgit Assmann, Magalie Barth, Odile Boespflug
Publié dans: The Lancet Neurology, Numéro 24, 2025, Page(s) 218-229, ISSN 1474-4422
Éditeur: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(24)00526-x

Curcumin-mediated NRF2 induction limits inflammatory damage in, preclinical models of cystic fibrosis

Auteurs: Stephen A. Leon-Icaza, Maxence Frétaud, Sarahdja Cornélie, Charlotte Bureau, Laure Yatime, R.Andres Floto, Stephen A. Renshaw, Jean-Louis Herrmann, Christelle Langevin, Céline Cougoule, Audrey Bernut
Publié dans: Biomedicine & Pharmacotherapy, Numéro 186, 2025, Page(s) 117957, ISSN 0753-3322
Éditeur: Elsevier Masson
DOI: 10.1016/j.biopha.2025.117957

Dynamical swirl structures powered by microswimmers in active nematics

Auteurs: Partha Sarathi Mondal, Pawan Kumar Mishra, Tamás Vicsek, Shradha Mishra
Publié dans: Physica A: Statistical Mechanics and its Applications, Numéro 659, 2025, Page(s) 130338, ISSN 0378-4371
Éditeur: Elsevier BV
DOI: 10.1016/j.physa.2024.130338

Macrophages undergo a behavioural switch during wound healing in zebrafish

Auteurs: Sipka T., Park S.A., Ozbilgic R., Balas L., Durand T., Mikula K., Lutfalla G., Nguyen-Chi M.
Publié dans: Free Radical Biology and Medicine, 2022, Page(s) 200-212, ISSN 0891-5849
Éditeur: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2022.09.021

The Spike protein of SARS-CoV-2 signals via Tlr2 in zebrafish

Auteurs: Sylwia D. Tyrkalska, Alicia Martìnez-Lòpez, Annamaria Pedoto, Sergio Candel, Maria L. Cayuela, Victoriano Mulero
Publié dans: Developmental & Comparative Immunology, 2023, ISSN 0145-305X
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.dci.2022.104626

3D cell segregation geometry and dynamics are governed by tissue surface tension regulation

Auteurs: Elod Méhes, Enys Mones, Máté Varga, Áron Zsigmond, Beáta Biri-Kovács, László Nyitray, Vanessa Barone, Gabriel Krens, Carl-Philipp Heisenberg, Tamás Vicsek
Publié dans: Communications Biology, Numéro 6, 2024, ISSN 2399-3642
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s42003-023-05181-7

Zebrafish models of COVID-19

Auteurs: Sylwia D Tyrkalska; Sergio Candel; Annamaria Pedoto; Diana García-Moreno; Francisca Alcaraz-Pérez; Álvaro Sánchez-Ferrer; María L Cayuela; Victoriano Mulero
Publié dans: Crossref, Numéro 2, 2023, ISSN 2398-7316
Éditeur: Oxford Academic Press
DOI: 10.1093/femsre/fuac042

Delay-induced phase transitions in active matter

Auteurs: Fatemeh Pakpour, Tamás Vicsek
Publié dans: Physica A: Statistical Mechanics and its Applications, Numéro 634, 2024, Page(s) 129453, ISSN 0378-4371
Éditeur: Elsevier BV
DOI: 10.1016/j.physa.2023.129453

Using zebrafish to understand reciprocal interactions between the nervous and immune systems and the microbial world

Auteurs: Jean-Pierre Levraud; John F. Rawls; Anne E. Clatworthy
Publié dans: Journal of Neuroinflammation, Numéro 3, 2022, ISSN 1742-2094
Éditeur: BioMed Central
DOI: 10.1186/s12974-022-02506-x

Plasticity of cancer invasion and energy metabolism

Auteurs: Maria Parlani, Carolina Jorgez, and Peter Friedl
Publié dans: Trends in Cell Biology, 2022, ISSN 1879-3088
Éditeur: Elsevier
DOI: 10.1016/j.tcb.2022.09.009

Type I Interferonopathy due to a Homozygous Loss-of-Inhibitory Function Mutation in STAT2

Auteurs: Gaofeng Zhu, Mihaly Badonyi, Lina Franklin, Luis Seabra, Gillian I. Rice, null Anne-Boland-Auge, Jean-François Deleuze, Salima El-Chehadeh, Mathieu Anheim, Anne de Saint-Martin, Sandra Pellegrini, Joseph A. Marsh, Yanick J. Crow, Marie-Therese El-Daher
Publié dans: Journal of Clinical Immunology, Numéro 43, 2023, Page(s) 808-818, ISSN 0271-9142
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10875-023-01445-3

Dissecting the recruitment and self-organization of αSMA-positive fibroblasts in the foreign body response

Auteurs: Maria Parlani, Matthew L. Bedell, Antonios G. Mikos, Peter Friedl, and Eleonora Dondossola
Publié dans: Science Advances, 2022, ISSN 2375-2548
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/sciadv.add0014

Molecular Actors of Inflammation and Their Signaling Pathways: Mechanistic Insights from Zebrafish

Auteurs: Leiba J., Ozbilgic R., Hernandez L., Demou M., Lutfalla G., Yatime L., Nguyen-Chi M.
Publié dans: Biology, 2023, ISSN 2079-7737
Éditeur: Biology
DOI: 10.3390/biology12020153

Virtual Orientation Tools (VOTj): Fiji plugins for object centering and alignment

Auteurs: Satheesan, S., Gehrig, J., & Thomas, L. S. V. (2024).
Publié dans: microPublication Biology, 2024, ISSN 2578-9430
Éditeur: Caltech Library
DOI: 10.17912/micropub.biology.001221

Macrophages Trajectories Smoothing by Evolving Curves

Auteurs: Giulia Lupi, Karol Mikula, Seol Ah Park
Publié dans: Tatra Mountains Mathematical Publications, Numéro 87, 2025, Page(s) 145-170, ISSN 1338-9750
Éditeur: Walter de Gruyter GmbH
DOI: 10.2478/tmmp-2023-0031

Silica crystals activate toll-like receptors and inflammasomes to promote local and systemic immune responses in zebrafish

Auteurs: Sylwia D. Tyrkalska, Annamaria Pedoto, Alicia Martìnez-Lòpez,José A.Ros-Lucas, Pablo Mesa-del-Castillo, Sergio Candel, Victoriano Mulero
Publié dans: Developmental & Comparative Immunology, Volume 138, January 2023, 104523, 2023, ISSN 0145-305X
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.dci.2022.104523

Dynamics of macrophage polarization support Salmonella persistence in a whole living organism

Auteurs: Jade Leiba, Tamara Sipka, Christina Begon-Pescia, Matteo Bernardello, Sofiane Tairi, Lionello Bossi, Anne-Alicia Gonzalez, Xavier Mialhe, Emilio J Gualda, Pablo Loza-Alvarez, Anne Blanc-Potard, Georges Lutfalla, Mai E Nguyen-Chi
Publié dans: eLife, Numéro 13, 2024, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.89828

Conference proceedings (3)

Automated Completion of Segmented Fragments of Macrophages using Weighted Dilation and Erosion in 2D+time microscopy videos

Auteurs: Seol Ah Park, Karol Mikula
Publié dans: Proceedings of the Conference ALGORITMY 2024, 2024, Page(s) pp. 11 – 20
Éditeur: Algoritmy

Vector field reconstruction from sparse samples by triple-Laplacian

Auteurs: Giulia Lupi, Karol Mikula
Publié dans: Proceedings of the Conference Algoritmy, 2024, Page(s) pp. 85–98
Éditeur: Algoritmy

Automatic Path Extraction Inside the Aorta from CT Data

Auteurs: Konan A. Allaly Jozef Urbán
Publié dans: Proceedings of the Conference Algoritmy 2024, 2024, Page(s) 255 - 263, ISBN 978-80-89829-33-0
Éditeur: Jednota slovenských matematikov a fyzikov

Thesis and dissertations (1)

In the Eye of the Swarm: Unravelling Neutrophil Swarming Dynamics in Zebrafish

Auteurs: Olijhoek, Nils Ingmar
Publié dans: White Rose eTheses Online, 2025
Éditeur: White Rose Libraries