A Personalised Living Cell Synthetic Computing Circuit for Sensing and Treating Neurodegenerative Disorders

Informazioni relative al progetto

PRIME

ID dell’accordo di sovvenzione: 964712

DOI

10.3030/964712

Progetto chiuso

Data della firma CE 19 Gennaio 2021

Data di avvio 1 Febbraio 2021

Data di completamento 31 Luglio 2025

Finanziato da

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Costo totale

€ 4 401 252,50

Contributo UE

€ 4 401 252,50

Coordinato da

SOUTH EAST TECHNOLOGICAL UNIVERSITY
Ireland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (4)

Updated dissemination and exploitation plan period 2

Updated Plan for Dissemination Communication and Exploitation of Results

Initial dissemination and exploitation plan

Plan for Dissemination Communication and Exploitation of Results

Updated dissemination and exploitation plan period 1

Updated Plan for Dissemination Communication and Exploitation of Results

End-to-end molecular communication chain model for sensing tRNAs, actuation, and release of GDNF

Direct outcome of T2.1 documenting the development of a MC model for sensing tRNAs, actuation, and release of GDNF.

Open Research Data Pilot (1)

Repository for simulation code

Direct outcome of T25 reporting creation of an opensource repository where code for simulations will be maintained

Pubblicazioni

Peer reviewed articles (9)

Shaping the future of European epilepsy research: Final meeting report from EPICLUSTER

Autori: David C. Henshall a, Alexis Arzimanoglou b, Stefanie Dedeurwaerdere c, Renzo Guerrini d, Sergiusz Jozwiak e, Merab Kokaia f, Holger Lerche g, Asla Pitkänen h, Philippe Ryvlin i, Michele Simonato j l, Sanjay M. Sisodiya k
Pubblicato in: Epilepsy Research, Numero Volume 189, January 2023, 107068, 2023, ISSN 0346-251X
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.eplepsyres.2022.107068

Sampling Cerebrospinal Fluid and Blood from Lateral Tail Vein in Rats During EEG Recordings

Autori: Marie Soukupová, Annunziata Guarino, Laila Asth, Pietro Marino, Mario Barbieri, Michele Simonato, Silvia Zucchini
Pubblicato in: JoVE Journal Neuroscience, 2023, ISSN 1940-087X
Editore: MYJoVE Corporation
DOI: 10.3791/65636

Shaping the future of European epilepsy research: Final meeting report from EPICLUSTER

Autori: David C. Henshall a, Alexis Arzimanoglou b, Stefanie Dedeurwaerdere c, Renzo Guerrini d, Sergiusz Jozwiak e, Merab Kokaia f, Holger Lerche g, Asla Pitkänen h, Philippe Ryvlin i, Michele Simonato j l, Sanjay M. Sisodiya k
Pubblicato in: Epilepsy Research, Numero Volume 189, 107068, 2022
Editore: Elsevier B.V.
DOI: 10.1016/j.eplepsyres.2022.107068

Nanopore long-read sequencing of circRNAs

Autori: Karim Rahimi a b, Anne Færch Nielsen b c, Morten T. Venø d, Jørgen Kjems
Pubblicato in: Methods, Numero Volume 196, December 2021, 2021, Pagina/e 23-29, ISSN 0000-0000
Editore: Elsevier Inc.
DOI: 10.1016/j.ymeth.2021.09.010

tsRNAsearch: a pipeline for the identification of tRNA and ncRNA fragments from small RNA-sequencing data

Autori: Paul D Donovan, Natalie M McHale, Morten T Venø, Jochen H M Prehn
Pubblicato in: Bioinformatics, Numero Volume 37, Numero 23, December 2021, 2021, Pagina/e Pages 4424–4430, ISSN 1367-4811
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btab515

A kainic acid-induced seizure model in human pluripotent stem cell-derived cortical neurons for studying the role of IL-6 in the functional activity

Autori: Ropafadzo Mzezewa a, Johanna Lotila a, Heikki Kiiski b, Andrey Vinogradov a, Fikret Emre Kapucu a, Jukka Peltola c, Sanna Hagman a, Susanna Narkilahti
Pubblicato in: Stem Cell Research, Numero (2.02), 2022, ISSN 0000-0000
Editore: Elsevier B.V.
DOI: 10.1016/j.scr.2022.102665

Nanopore sequencing of brain-derived full-length circRNAs reveals circRNA-specific exon usage, intron retention and microexons

Autori: Karim Rahimi, Morten T. Venø, Daniel M. Dupont & Jørgen Kjems
Pubblicato in: Nature Communications (Nat Commun), Numero 12, Article number: 4825 (2021), 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-24975-z

Cyclic Hypoxia Conditioning Alters the Content of Myoblast-Derived Extracellular Vesicles and Enhances Their Cell-Protective Functions

Autori: Yan Yan, Tingting Gu, Stine Christensen, Junyi Su, Thomas Lassen, Marie Hjortbak, IJu Lo, Susanne Venø, Andrea Tóth, Ping Song, Morten Nielsen, Hans Bøtker, Blagoy Blagoev, Kim Drasbek, Jørgen Kjems.
Pubblicato in: Biomedicines, Numero 9(9), 1211, 2021, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines9091211

Distinct non-coding RNA cargo of extracellular vesicles from M1 and M2 human primary macrophages

Autori: Paschalia Pantazi, Toby Clements, Morten Venø, Vikki M. Abrahams, Beth Holder
Pubblicato in: Journal of Extracellular Vesicles, Numero Volume 11, Numero 12, 2022, ISSN 2001-3078
Editore: Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.
DOI: 10.1002/jev2.12293