Plastics fate and effects in the human body

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Regular events to present and discuss project output and help shape future activities with external stakeholders

Three workshops will be organized to address knowledge gaps regarding standardization and regulation. In addition, at least three events will be organized in collaboration with existing external events to maximize opportunities to engage stakeholders. Their purpose is to present and discuss PlasticsFate results and help shape policy recommendations.

Integrated human health and environmental RA strategy

This report specifies the integration of human health relevant environments (i.e. agricultural soils, water and ambient air) including both functional (e.g. soil respiration) and structural (e.g. species diversity) components into the human health RA strategy. This will be done in the format of IATAs (Integrated Approach to Testing and Assessment). Interim report by M24.

Review of current regulations, and policy and market

This will identify any knowledge gaps that need to be addressed through project activities, as well as understanding the current state of the art, including products on the market, and identifying key stakeholders.

Stakeholder roundtables

Two roundtables will be organized with key stakeholders in the final year of the project to validate project recommendations.

Biomarkers for exposure monitoring and specific endpoints of MP/NP

Report on the validity of the selected biomarkers to monitor human exposure to NP/MP.

Report on results from the ILS on methods developed for hazard assessment of MP/NP and A/C in the human body

A selection of methodologies will be suggested that are most suitable for Risk Assessment, in close cooperation with WP4. Interim Report M36 (confidential but available to EC and project partners).

Formulated recommendations for standards and regulations, and guidelines for their use

These will identify the necessary data (and data gaps) to develop new regulations and standards, and deliver recommendations to relevant committees and working groups that PlasticsFatE partners are already engaged in.

Joint policy briefs 2

Joint policy briefs 2.

Human health hazard of MP/NP and A/C

A MP/NP selection of materials will be screened to evaluate the toxicity of MP/NP in immortalized human cell lines from different origins, i.e. pulmonary (A549), intestinal (Caco-2) and immune (THP-1). The impact of the MP/NPs on these cells will be studied using new in vitro assays and modelling approaches. Interim report M36 (confidential but available to EC and project partners).

Report on selected MP/NP and basic PChem features

In the report it will be explained how the selection, storage, distribution and basic characterization of material is performed. In addition, some techniques for labeling and traceability of materials will be described.

Overview of human exposure sources and levels of MP/NP

Report with a comprehensive overview of the human exposure levels of MP/NP related to their different sources based on the recent literature and measured and modelled data from previous projects.

Specifications of a decision support system (DSS)

The DSS will be optimized and finalized based on the input provided by the partners.

Fate of MP/NP in the human body

Report on the exposure levels and fate of micro- and nanoplastics in the human gastro-intestinal tract, the human body, and human excretion determined by static and dynamic models.

Final conference

This event will be organized in collaboration with other projects in the European MNP cluster on human health to present final results and recommendations to relevant stakeholders.

Effects of physicochemical properties of plastic particles on their toxicity

The particle size, surface properties, crystallinity, and shape as determinants of cytotoxicity, biodistribution and persistence in the human body will be studied. Interim report M24 (confidential but available to EC and project partners).

Cluster brochure

The cluster brochure will be developed.

Report with relevant outputs of the collaboration with other projects/activities

During the project lifetime all relevant activities/projects at European level on dispersion and physico-chemical characterization of MP/NP will be monitored in T1.5. The available related protocols, recommendations and databased, generated in WP1 and outside of the project, will be collated together and transferred to WP7. Interim report in M26.

Establishing a human health RA strategy for MP/NP

This will be implemented in the form of an integrated testing strategy (ITS) which specifies a tied, step-by-step procedure with the associated test systems (IATAs). Interim report by M24.

Report on improvements following the use of key performance indicators

The report will gather information about how the use of KPI will improve quality and performance of the results within WP1-4. Interim report (M33).

Recommendations to policymakers for future strategy on Plastics and the Bioeconomy

This consists of at least 4 short, targeted, policy briefs summarizing and contextualizing key project results for policymakers, supported by a short animation that is accessible and understandable to a broad audience.

Strategies defined for occupational exposure monitoring

Report in which the methodologies defined and established for the occupational exposure assessment and biomonitoring will be detailed.

Joint policy briefs 3

Joint policy briefs 3.

Report on long-term effects of MP/NP and A/C in the human body

Report in which the results of investigations on long-term effects relevant for human (inhalation study and biomarkers data) and media (bioaccumulation in aquatic organisms) will be presented. Interim report (M33).

State of the art in microplastic risk assessement

The report will summarise the legal requirements for the regulation of plastic. Possible gaps in the current legal frameworks as well as data needs will be identified and specified.

Prototype of the prospective multi criteria decision support system (PMCDS)

The PMCSD will support end-users through an early decision-making process in an prospective approach integrating data on applications, performance needs, exposure and hazard. This prototype will allow the conduction of case studies.

Joint activities with other relevant projects and programs on risk assessment of MP/NP

This activity will foster the communication and cooperation with other initiatives in the field of risk assessment of MP/NP.

Joint policy briefs 1

Joint policy briefs 1.

Risk assessment of MP/NP to act as pathogen vectors

Report with the results obtained through flow cytometry-based method and molecular tools.

Human exposure to micro- and nanoplastics

The report will describe the exposure levels of humans to micro- and nanoplastics related to inhalation, ingestion of food and potables, and personal care products.

Results of the ILS on measurement and sample preparation methods for hazard and exposure testing

The most suitable MP/NP materials selected in T1.1 as well as tested in other projects will be defined in T1.4 for analyses in various matrices relevant to human exposure. The main goal is the comparability between the results of selected properties in different laboratories and obtained by different methods. The envisaged platform is VAMAS within the new formed technical work area TWA 45 Materials and Environment. D1.6 has an interim preliminary report in M38.

Bioaccumulation, effects and cell uptake mechanisms of plastics particles and additives/contaminants

Uptake and possible cellular bioaccumulation of MP/NP particles will be studied to understand the number of particles, size and chemical composition of particles bioaccumulated and taken up by cells. Interim report M36 (confidential but available to EC and project partners).

Transport of plastics particles and additives/contaminants across biological barriers and its impact on barrier properties

The barriers used will include, primary cells from lung epithelium grown in an air-liquid interphase, a gastro-intestinal barrier co-culture model of epithelial cells and macrophages, and a blood brain barrier consisting. Interim report in M24.

Annual training workshops based on new knowledge generated within the project

This consists of two physical and two virtual training events to impart knowledge gained within PlasticsFatE to the wider research community. Material will also be downloadable from the website and information provided that is accessible to a wider audience.

Human immune effects of MP/NP

The three major immune systems will be investigated in vitro and in mice: the innate immune response, the adaptive immune and the induced tolerance will be investigated in addition to the effect of adsorption of bacteria, fungi and bacteriophages on MP/NP particles in inducing these immune systems. Interim Report M36 (confidential but available to EC and project partners).

Modelling of MP/NP for environmental fate, human exposure and toxicokinetics

The mathematical equations that compose the environmental fate, human exposure, and toxicokinectic prediction models as well as the parameters considered will be collected and explained in a report.

Web and social media presence

A project website will be produced that acts as a repository and shop front for all publishable project output. This will connect with social media channels such as LinkedIn, Twitter and YouTube (Task 6.1).

Prototype of a web-based decision support system

A web-based e-tool will be developed to estimate human and environmental health risks along the lifecycle of plastic materials and products. The prototype will include most of the features and presented for discussion to the partners.

Final Prospective multi criteria decision support system (PMCDS)

By integrating the findings made in the case studies, the PMCDS will be finalized and implemented in the web-based platform.

Cluster web portal and visual identity

The cluster web portal and visual identity will be developed.

Veröffentlichungen

Plastic debris in lakes and reservoirs

Autoren: Veronica Nava, Sudeep Chandra, Julian Aherne, María B. Alfonso, Ana M. Antão-Geraldes, Katrin Attermeyer, Roberto Bao, Mireia Bartrons, Stella A. Berger, Marcin Biernaczyk, Raphael Bissen, Justin D. Brookes, David Brown, Miguel Cañedo-Argüelles, Moisés Canle, Camilla Capelli, Rafael Carballeira, José Luis Cereijo, Sakonvan Chawchai, Søren T. Christensen, Kirsten S. Christoffersen, Elvira de
Veröffentlicht in: Nature, Ausgabe 619, 2023, Seite(n) 317-322, ISSN 0028-0836
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41586-023-06168-4

From principles to reality. FAIR implementation in the nanosafety community

Autoren: Dumit, Verónica I.; Ammar, Ammar; Bakker, Martine; Bañares, Miguel A.; Bossa, Cecilia; Costa, Anna; Cowie, Hilary; Drobne, Damjana; Exner, Thomas E.; Farcal, Lucian; Friedrichs, Steffi; Furxhi, Irini; Grafström, Roland; Haase, Andrea; Himly, Martin; Jeliazkova, Nina; Lynch, Iseult; Maier, Dieter; Noorlander, Cornelle W.; Shin, Hyun Kil; Soler-Illia, Galo J.A.A.; Suarez-Merino, Blanca; Willighag
Veröffentlicht in: Nano Today, Ausgabe 3, 2023, ISSN 1748-0132
Herausgeber: Elsevier BV
DOI: 10.1016/j.nantod.2023.101923

Nano- and microplastics commonly cause adverse impacts on plants at environmentally relevant levels: A systematic review

Autoren: Zantis, L.J.; Borchi, C.; Vijver, M.G.; Peijnenburg, W.J.G.M.; Di Lonardo, S.; Bosker, T.
Veröffentlicht in: Science of the total environment 867 (2023). doi:10.1016/j.scitotenv.2022.161211, Ausgabe 3, 2023, ISSN 0048-9697
Herausgeber: Elsevier BV
DOI: 10.1016/j.scitotenv.2022.161211

Strategy towards producing relevant and reliable data for the hazard assessment of micro- and nanoplastics in agricultural soils

Autoren: Anita Jemec Kokalj, Gabriela Kalčíková, Salla Selonen, Thijs Bosker, Damjana Drobne, Darina Dvořáková, Jakub Hofman, Rachel Hurley, Sarmite Kernchen, Christian Laforsch, Martin G.J. Löder, Sam van Loon, Paula E. Redondo-Hasselerharm, Vili Saartama, Klára Šmídová, Aristeidis S. Tsagkaris, Laura J. Zantis, Luca Nizzetto, Cornelis A.M. van Gestel
Veröffentlicht in: TrAC Trends in Analytical Chemistry, Ausgabe 172, 2024, Seite(n) 117567, ISSN 0165-9936
Herausgeber: Elsevier BV
DOI: 10.1016/j.trac.2024.117567

The analytical quest for sub-micron plastics in biological matrices

Autoren: Fazel Abdolahpur Monikh; Fazel Abdolahpur Monikh; Martina G. Vijver; Denise M. Mitrano; Heather A. Leslie; Zhiling Guo; Peng Zhang; Iseult Lynch; Eugenia Valsami-Jones; Willie J.G.M. Peijnenburg
Veröffentlicht in: Nano Today, 41, Ausgabe 3, 2021, ISSN 1748-0132
Herausgeber: Elsevier BV
DOI: 10.1016/j.nantod.2021.101296

perspectives on toxicokinetics of nanoscale plastic debris in organisms

Autoren: Fazel Abdolahpur Monikh; Martina G. Vijver; Raine Kortet; Iseult Lynch; Willie J. G. M. Peijnenburg
Veröffentlicht in: Environmental Science: Nano, Ausgabe 3, 2022, ISSN 2051-8161
Herausgeber: RSC
DOI: 10.1039/d1en00425e

Submicron Plastic Adsorption by Peat, Accumulation in Sphagnum Mosses and Influence on Bacterial Communities in Peatland Ecosystems

Autoren: Mandar Bandekar; Fazel Abdolahpur Monikh; Jukka Kekäläinen; Teemu Tahvanainen; Raine Kortet; Peng Zhang; Zhiling Guo; Jarkko Akkanen; Jari T. T. Leskinen; Miguel A. Gomez-Gonzalez; Gopala Krishna Darbha; Hans-Peter Grossart; Eugenia Valsami-Jones; Jussi V. K. Kukkonen
Veröffentlicht in: Environmental Science and Technology, Ausgabe 3, 2022, Seite(n) 15661–15671, ISSN 0013-936X
Herausgeber: American Chemical Society
DOI: 10.1021/acs.est.2c04892

From properties to toxicity: Comparing microplastics to other airborne microparticles

Autoren: Simon Wieland, Aylin Balmes, Julian Bender, Jonas Kitzinger, Felix Meyer, Anja FRM Ramsperger, Franz Roeder, Caroline Tengelmann, Benedikt H. Wimmer, Christian Laforsch, Holger Kress
Veröffentlicht in: Journal of Hazardous Materials, Ausgabe Volume 428,, 2022, ISSN 0304-3894
Herausgeber: Elsevier BV
DOI: 10.1016/j.jhazmat.2021.128151

Biomarkers of oxidative stress, inflammation, and genotoxicity to assess exposure to micro- and nanoplastics. A literature review

Autoren: Panizzolo, Marco; Martins, Vitor Hugo; Ghelli, Federica; Squillacioti, Giulia; Bellisario, Valeria; Garzaro, Giacomo; Bosio, Davide; Colombi, Nicoletta; Bono, Roberto; Bergamaschi, Enrico
Veröffentlicht in: Ecotoxicology and Environmental Safety Volume 267, 15 November 2023, 115645, Ausgabe Volume 267, 15 November 2023, 115645, 2023, ISSN 1090-2414
Herausgeber: Elsevier
DOI: 10.1016/j.ecoenv.2023.115645

The gut microbiota, a key to understanding the health implications of micro(nano)plastics and their biodegradation

Autoren: Cristina Jiménez‐Arroyo; Alba Tamargo; Natalia Molinero; M. Victoria Moreno‐Arribas
Veröffentlicht in: Microbial Biotechnology, Vol 16, Iss 1, Pp 34-53 (2023), Ausgabe 2, 2022, ISSN 1751-7915
Herausgeber: Microbial Biotechnology
DOI: 10.1111/1751-7915.14182

Increasing microplastics pollution: An emerging vector for potentially pathogenic bacteria in the environment

Autoren: Ülkü Nihan Tavşanoğlu, Gülçin Akca, Tülay Pekmez, Gökben Başaran Kankılıç, Tamer Çırak, Ali Serhan Çağan, Selin Özkan Kotiloğlu, Hans-Peter Grossart
Veröffentlicht in: Water Research, Ausgabe 274, 2025, Seite(n) 123142, ISSN 0043-1354
Herausgeber: Elsevier BV
DOI: 10.1016/j.watres.2025.123142

Quantitative tracing of uptake and transport of submicrometre plastics in crop plants using lanthanide chelates as a dual-functional tracer

Autoren: Yongming Luo, Lianzhen Li, Yudong Feng, Ruijie Li, Jie Yang, Willie J. G. M. Peijnenburg, Chen Tu
Veröffentlicht in: Nature Nanotechnology, Ausgabe 17, 2022, Seite(n) 424-431, ISSN 1748-3387
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41565-021-01063-3

A systematic review of the impacts of exposure to micro- and nano-plastics on human tissue accumulation and health

Autoren: Yudong Feng, Chen Tu, Ruijie Li, Di Wu, Jie Yang, Yankai Xia, Willie J.G.M. Peijnenburg, Yongming Luo
Veröffentlicht in: Eco-Environment & Health, Ausgabe 2, 2025, Seite(n) 195-207, ISSN 2772-9850
Herausgeber: Elsevier BV
DOI: 10.1016/j.eehl.2023.08.002

Estrogenic activity of plastic nanoparticle mixtures under <i>in vitro</i> settings

Autoren: Lucija Božičević; Korinna Altmann; Jana Hildebrandt; Xenia Knigge; Valerije Vrček; Nikolina Peranić; Nikolina Kalčec; Ivana Vinković Vrček
Veröffentlicht in: Environmental Science: Nano, Ausgabe 2, 2024, Seite(n) Ausgabe 5, 2024, ISSN 2051-8161
Herausgeber: RSC
DOI: 10.1039/d3en00883e

Exposure protocol for ecotoxicity testing of microplastics and nanoplastics

Autoren: Fazel Abdolahpur Monikh; Anders Baun; Nanna B. Hartmann; Raine Kortet; Jarkko Akkanen; Jae-Seong Lee; Huahong Shi; Elma Lahive; Emilia Uurasjärvi; Nathalie Tufenkji; Korinna Altmann; Yosri Wiesner; Hans-Peter Grossart; Willie Peijnenburg; Jussi V. K. Kukkonen
Veröffentlicht in: NATURE PROTOCOLS, Ausgabe 3, 2023, Seite(n) 3534–3564, ISSN 1750-2799
Herausgeber: NATURE.COM
DOI: 10.1038/s41596-023-00886-9

Effects of tire wear particles on freshwater bacterial-fungal community dynamics and subsequent elemental cycles using microcosms

Autoren: Yuanyuan Mo, Fazel Abdolahpur Monikh, Yousuf Dar Jaffer, Richard Mugani, Danny Ionescu, Guogui Chen, Jun Yang, Hans-Peter Grossart
Veröffentlicht in: Journal of Hazardous Materials, Ausgabe 487, 2025, Seite(n) 137062, ISSN 0304-3894
Herausgeber: Elsevier BV
DOI: 10.1016/j.jhazmat.2024.137062

Sub-micro- and nano-sized polyethylene terephthalate deconstruction with engineered protein nanopores

Autoren: Robles-Martín, Ana; Amigot-Sánchez, Rafael; Fernandez-Lopez, Laura; Gonzalez-Alfonso, Jose L; Roda, Sergi; Alcolea-Rodriguez, Víctor; Heras-Márquez, Diego; Almendral, David; Coscolín, Cristina; Plou, Francisco J; Portela, Raquel; Bañares, Miguel A; Martínez-del-Pozo, Álvaro; García-Linares, Sara; Ferrer, Manuel; Guallar, Víctor
Veröffentlicht in: Nature Catalysis, Ausgabe 3, 2023, Seite(n) 1174–1185, ISSN 2520-1158
Herausgeber: Nature Catalysis
DOI: 10.1038/s41929-023-01048-6

Can Current Regulations Account for Intentionally Produced Nanoplastics?

Autoren: Fazel Abdolahpur Monikh, Steffen Foss Hansen, Martina G. Vijver, Esther Kentin, Maria Bille Nielsen, Anders Baun, Kristian Syberg, Iseult Lynch, Eugenia Valsami-Jones, Willie J.G.M. Peijnenburg
Veröffentlicht in: Environmental Science & Technology, Ausgabe 56, 2023, Seite(n) 3836-3839, ISSN 0013-936X
Herausgeber: American Chemical Society
DOI: 10.1021/acs.est.2c00965

Effect of micro- and nanoplastic particles on human macrophages

Autoren: Maike Y. Adler, Insaf Issoual, Michael Rückert, Lisa Deloch, Carola Meier, Thomas Tschernig, Christoph Alexiou, Felix Pfister, Anja FRM Ramsperger, Christian Laforsch, Udo S. Gaipl, Katharina Jüngert, Friedrich Paulsen
Veröffentlicht in: Journal of Hazardous Materials, Ausgabe 471, 2024, Seite(n) 134253, ISSN 0304-3894
Herausgeber: Elsevier BV
DOI: 10.1016/j.jhazmat.2024.134253

Convergence effect during spatiotemporal succession of lacustrine plastisphere: loss of priority effects and turnover of microbial species

Autoren: Weihong Zhang, Shuxin Liang, Hans-Peter Grossart, Joseph Alexander Christie-Oleza, Geoffrey Michael Gadd, Yuyi Yang
Veröffentlicht in: ISME Communications, Ausgabe 4, 2024, ISSN 2730-6151
Herausgeber: Oxford University Press (OUP)
DOI: 10.1093/ismeco/ycae056

Nano- and microplastics: a comprehensive review on their exposure routes, translocation, and fate in humans

Autoren: Ramsperger, Anja FRM; Bergamaschi, Enrico; Panizzolo, Marco; Fenoglio, Ivana; Barbero, Francesco; Peters, Ruud; Undas, Anna; Purker, Sebastian; Giese, Bernd; Lalyer, Carina R; Tamargo, Alba; Moreno-Arribas, M Victoria; Grossart, Hans-Peter; Kühnel, Dana; Dietrich, Jana; Paulsen, Friedrich; Afanou, Anani K; Zienolddiny-Narui, Shan; Eriksen Hammer, Stine; Kringlen Ervik, Torunn; Graff, Pål; Brinch
Veröffentlicht in: NanoImpact, Ausgabe 2, 2022, ISSN 2452-0748
Herausgeber: Elsevier B.V.
DOI: 10.1016/j.impact.2022.100441

Quantifying the trophic transfer of sub-micron plastics in an assembled food chain

Autoren: Monikh, Fazel Abdolahpur; Holm, Sille; Kortet, Raine; Bandekar, Mandar; Kekäläinen, Jukka; Koistinen, Arto; Leskinen, Jari TT; Akkanen, Jarkko; Huuskonen, Hannu; Valtonen, Anu; Dupuis, Lan; Peijnenburg, Willie; Lynch, Iseult; Valsami-Jones, Eugenia; Kukkonen, Jussi V.K.
Veröffentlicht in: Nano Today, Ausgabe 3, 2022, ISSN 1878-044X
Herausgeber: Elsevier
DOI: 10.1016/j.nantod.2022.101611

A Multidisciplinary Perspective on the Role of Plastic Pollution in the Triple Planetary Crisis

Autoren: Christian Schmidt, Dana Kuehnel, Dušan Materić, Jessica Stubenrauch, Kristin Schubert, Anran Luo, Katrin Wendt-Potthoff, Annika Jahnke
Veröffentlicht in: Environment International, Ausgabe Volume 193, November 2024, 109059, 2024, ISSN 1873-6750
Herausgeber: Elsevier
DOI: 10.2139/ssrn.4814220

Simulated Gastrointestinal Digestion of Polylactic Acid (Pla) Biodegradable Microplastics and Their Interaction with Gut Microbiota

Autoren: Jiménez Arroyo, Cristina; Tamargo, Alba; Molinero, Natalia; Reinosa, J. J.; Alcolea-Rodríguez, Víctor; Portela, Raquel; Bañares, Miguel A.; Fernández Lozano, José Francisco; Moreno-Arribas, M. Victoria
Veröffentlicht in: Crossref, Ausgabe 1, 2023, Seite(n) 166003, ISSN 0048-9697
Herausgeber: Elsevier BV
DOI: 10.2139/ssrn.4463181

Characterization of polyethylene and polyurethane microplastics and their adsorption behavior on Cu2+ and Fe3+ in environmental matrices

Autoren: Ilaria Zanoni, Lucia Briccolani, Lara Faccani, Magda Blosi, Simona Ortelli, Matteo Crosera, Giovanna Marussi, Stefania Albonetti, Anna Luisa Costa
Veröffentlicht in: Environmental Sciences Europe, Ausgabe 37, 2025, ISSN 2190-4715
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1186/s12302-025-01061-5

Role of the Protein Corona in the Colloidal Behavior of Microplastics

Autoren: Marion Schvartz; Florent Saudrais; Stéphanie Devineau; Stéphane Chédin; Frédéric Jamme; Jocelyne Leroy; Karol Rakotozandriny; Olivier Taché; Guillaume Brotons; Serge Pin; Yves Boulard; Jean-Philippe Renault
Veröffentlicht in: "Langmuir, 2023, 39 (12), pp.4291-4303. ⟨10.1021/acs.langmuir.2c03237⟩", Ausgabe 3, 2023, Seite(n) 4291–4303, ISSN 1520-5827
Herausgeber: American Chemical Society
DOI: 10.1021/acs.langmuir.2c03237

Tire wear particles enhance horizontal gene transfer of antibiotic resistance genes in aquatic ecosystems

Autoren: Yousuf Dar Jaffer, Fazel Abdolahpur Monikh, Klümper Uli, Hans-Peter Grossart
Veröffentlicht in: Environmental Research, Ausgabe 263, 2025, Seite(n) 120187, ISSN 0013-9351
Herausgeber: Academic Press
DOI: 10.1016/j.envres.2024.120187

Defining Quality Criteria for Nanoplastic Hazard Evaluation: The Case of Polystyrene Nanoplastics and Aquatic Invertebrate Daphnia spp.

Autoren: Jemec Kokalj, Anita; Heinlaan, Margit; Novak, Sara; Drobne, Damjana; Kühnel, Dana
Veröffentlicht in: Volume 13, Ausgabe 3, 2023, ISSN 2079-4991
Herausgeber: MDPI
DOI: 10.3390/nano13030536

Nominally identical microplastic models differ greatly in their particle-cell interactions

Autoren: Simon Wieland; Anja F. R. M. Ramsperger; Wolfgang Gross; Moritz Lehmann; Thomas Witzmann; Anja Caspari; Martin Obst; Stephan Gekle; Günter K. Auernhammer; Andreas Fery; Christian Laforsch; Holger Kress
Veröffentlicht in: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024), Ausgabe 1, 2024, Seite(n) 15:922, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41467-024-45281-4

Digestión gastrointestinal y fermentación colónica de microplásticos biodegradables de ácido poliláctico (PLA) y su interacción con la microbiota intestinal

Autoren: Jiménez Arroyo, Cristina; Tamargo García, Alba; Molinero, Natalia; Jiménez Reinosa, Julián; Alcolea-Rodríguez, Víctor; Portela, Raquel; Bañares, Miguel A.; Fernández Lozano, José Francisco; Moreno-Arribas, M. Victoria
Veröffentlicht in: instname:Consejo Superior de Investigaciones Científicas (CSIC), Ausgabe 1, 2023
Herausgeber: DIGITAL CSIC

Culture conditions matter: how A549 morphology differs in submerged or air-liquid interface culture systems.

Autoren: Michelini, Sara; Kurešepi, Ema; Repar, Neza; Šimunovič, Katarina; Mandić Mulec, Ines; Erman, Andreja; Drobne, Damjana
Veröffentlicht in: Ausgabe 1, 2024
Herausgeber: Zenodo
DOI: 10.5281/zenodo.11259406

Contribution of additive-related effects to LDPE microplastics toxicity for aquatic organisms: a case study with model metal and organic additives

Autoren: Perc, Valentina; Jemec Kokalj, Anita; Zoons, Alisha; Drobne, Damjana; Müller-Köhn, Axel; Potthoff, Annegret; Kühnel, Dana
Veröffentlicht in: Ausgabe 1, 2024
Herausgeber: https://zenodo.org/records/11276845
DOI: 10.5281/zenodo.11276845

Useful Gut Model for Plastic Particles Assessing

Autoren: Giulia, Antonello; Esposito, Marianna; Barbero, Francesco; Macaraig Mansilungan, Camille; Fenoglio, Ivana; Riganti, Chiara; Bergamaschi, Enrico
Veröffentlicht in: CUSP Meeting, 2022
Herausgeber: CUSP
DOI: 10.5281/zenodo.7267318

PET microplastics affect human gut microbiota communities during simulated gastrointestinal digestion, first evidence of plausible polymer biodegradation during human digestion

Autoren: Tamargo, Alba
Veröffentlicht in: Ausgabe 2, 2022
Herausgeber: https://zenodo.org/records/7152690
DOI: 10.5281/zenodo.7152690

Novel approaches to risk assessment and decision support

Autoren: Ballesteros Riaza, Arantxa; Drobne, Damjana; Giese, Bernd; Hipfinger, Christina; Jemec Kokalj, Anita; Laforsch, Christian; Löder, Martin GJ; Peijnenburg, Willie; Pozuelo Rollón, Blanca María; Purker, Sebastian; Ramsperger, Anja FRM; Kühnel, Dana
Veröffentlicht in: Ausgabe 2, 2022
Herausgeber: https://zenodo.org/records/7111718
DOI: 10.5281/zenodo.7111718

Impact of Polystyrene Nanoparticles on Lung Epithelial Barrier Formation and Functionality

Autoren: Michelini, Sara; Repar, Neza; Kurešepi, Ema; Šimunović, Katarina; Barbero, Francesco; Martin, Shicht; Jüngert, Katharina; Ganin, Victor; Fenoglio, Ivana; Paulsen, Friedrich; Erman, Andreja; Šetina Batič, Barbara; Mandić Mulec, Ines; Jemec Kokalj, Anita; Drobne, Damjana
Veröffentlicht in: Ausgabe 1, 2025
Herausgeber: Zenodo
DOI: 10.5281/zenodo.11258651

Co-culture of human type I and type II pneumocyte cell lines as a model of alveolar epithelium

Autoren: Boland, Sonja; Brookes, Oliver; Kuen, Rene Lai; Miremont, Dorian; Eon-Bertho; Mawas, Safaa; Baeza-Squiban, Amelle
Veröffentlicht in: STCM 2022, 2022
Herausgeber: STCM 2022
DOI: 10.5281/zenodo.7142483

Rapid Detection and Quantification of Micro-plastic Particles using MuScan® Technology

Autoren: van Doorn, Ronald; Ash, Edward; Klerks, Michel
Veröffentlicht in: Ausgabe 2, 2022
Herausgeber: ZENODO
DOI: 10.5281/zenodo.7111693

Recent advances in the Analysis and Impact of Microplastics in Food

Autoren: Vitali, Clementina; Undas, Anna
Veröffentlicht in: Ausgabe 1, 2022
Herausgeber: https://zenodo.org/records/11313744
DOI: 10.5281/zenodo.11313744

Immune Effects of Pristine and Microbially Contaminated PET Nanoplastics

Autoren: Haugen, Øyvind P.; Solberg Sagen, Andreas; Kringlen Ervik, Torunn; Graff, Pål; Brinchmann, Bendik; Alcolea-Rodriguez, Victor; Portela, Raquel; Wallin, Håkan; Nordby, Karl-Christian; Zienolddiny-Narui, Shan; Afanou, Anani J. K.
Veröffentlicht in: Ausgabe 1, 2024
Herausgeber: https://zenodo.org/records/11262488
DOI: 10.5281/zenodo.11262488

Evaluation of possible interactions of proteins and lipids with microplastics

Autoren: Micheletto, Marta
Veröffentlicht in: Ausgabe 1, 2024
Herausgeber: https://zenodo.org/records/11257860
DOI: 10.5281/zenodo.11257860

Mass balance equations model to assess environmental fate of micro- and nanoplastics

Autoren: Pozuelo, Blanca; Larraz, Alberto; Ballesteros, Arantxa
Veröffentlicht in: Ausgabe 1, 2024
Herausgeber: https://zenodo.org/records/11265734
DOI: 10.5281/zenodo.11265734

Identification of toxicologically relevant functional groups on micro- and nanoplastic particles' surface by means of X-Ray photoelectron spectroscopy

Autoren: Ciornii, Dmitri
Veröffentlicht in: Ausgabe 2, 2024
Herausgeber: ZENODO
DOI: 10.5281/zenodo.11280922

How to Investigate Additive-Related Effects from Microplastics

Autoren: Potthoff, Annegret; Müller-Köhn, Axel; Jemec Kokalj, Anita; Kühnel, Dana
Veröffentlicht in: Ausgabe 3, 2022
Herausgeber: https://zenodo.org/records/7111648
DOI: 10.5281/zenodo.7111648

Influence of Simulated Gastrointestinal Digestion on the Toxicity of HDPE and PET Microplastics with and without V. parahaemolyticus Biofilm

Autoren: Polanca Garriz, Itziar; Antonello, Giulia
Veröffentlicht in: Ausgabe 1, 2024
Herausgeber: https://zenodo.org/records/11263819
DOI: 10.5281/zenodo.11263819

Impact of polystyrene nanoparticles on the ultrastructure of human lung epithelial A549 cells.

Autoren: Kurešepi, Ema; Michelini, Sara; Erman, Andreja; Repar, Neza; Drobne, Damjana
Veröffentlicht in: Ausgabe 1, 2024
Herausgeber: ZENODO
DOI: 10.5281/zenodo.11258079

Impact of Polystyrene Nanoparticles on Lung Epithelial Barrier Formation and Functionality

Autoren: Michelini, Sara; Repar, Neza; Kurešepi, Ema; Šimunović, Katarina; Barbero, Francesco; Martin, Shicht; Jüngert, Katharina; Ganin, Victor; Fenoglio, Ivana; Paulsen, Friedrich; Erman, Andreja; Šetina Batič, Barbara; Mandić Mulec, Ines; Jemec Kokalj, Anita; Drobne, Damjana
Veröffentlicht in: Ausgabe 2, 2024
Herausgeber: https://zenodo.org/records/11258652
DOI: 10.5281/zenodo.11258652

How to investigate additive-related effects from microplastics? (PlasticsFatE)

Autoren: Potthoff, Annegret; Müller-Köhn, Axel; Jemec Kokalj, Anita; Kühnel, Dana
Veröffentlicht in: Ausgabe 1, 2022
Herausgeber: ZENODO
DOI: 10.5281/zenodo.10118491

MNP & A/C in the airways methodological advances on the Dr Sonja BOLAND methodological advances on the assessment of hazards associated with the respiratory tract

Autoren: Boland, Sonja
Veröffentlicht in: Ausgabe 1, 2024
Herausgeber: ZENODO
DOI: 10.5281/zenodo.10959587

Hazards assessment of micro- and nanoplastics and associated additives/contaminants to human health

Autoren: Katsumiti, Alberto; Rodríguez-Llopis, Isabel; Boland, S; Devineau, S; Miremont, D; Ramsperger, A.F.R.M; Löder, MGJ; Laforsch, C; Drobne, D; Michelini, S; Repar, N; Hoekstra, L; Duivenvoorde, L; van der Zande, M; Tamargo, A; Di Maira, G; Tedesco, E; Benetti, F; Antonello, G; Fenoglio, I; Riganti, C; Bergamaschi, E; Jacobsen, N.R; Kazour, M; Peijnenburg, W; Kühnel, D; Haugen, Ø. P; Wallin, H; Na
Veröffentlicht in: Ausgabe 2, 2022
Herausgeber: PLASTICSFATE
DOI: 10.5281/zenodo.7099453

Microplásticos y microbiota. Impacto de la ingesta de diferentes tipos de microplásticos sobre la microbiota colónica humana

Autoren: Tamargo García, Alba; Molinero, Natalia; Jiménez Arroyo, Cristina; Jiménez Reinosa, Julián; Alcolea-Rodriguez, Victor; Portela, Raquel; Bañares, Miguel A.; Fernández, Jose F.; Moreno-Arribas, M. Victoria
Veröffentlicht in: instname:, Ausgabe 1, 2022
Herausgeber: CSIC

Interlaboratory comparison for obtaining reliable data on microplastic detection methods

Autoren: Dmitri Ciornii
Veröffentlicht in: Ausgabe 1, 2024
Herausgeber: ZENODO
DOI: 10.5281/zenodo.11281347

PlasticsFatE Deliverable Summary D6.1 Plan for Exploitation and Dissemination of Results (PEDR)

Autoren: Tobin, Lesley; Morrison, Mark; Reuther, Rudolf
Veröffentlicht in: Ausgabe 3, 2023
Herausgeber: zenodo
DOI: 10.5281/zenodo.8094789

PlasticsFatE Deliverable Report D6.2 Web and social media presence

Autoren: Tobin, Lesley
Veröffentlicht in: Ausgabe 2, 2023
Herausgeber: ZENODO
DOI: 10.5281/zenodo.8092109

Hazard effects associated with microplastics mixed with Pseudomonas Lurida in human lung alveolar A549 cells

Autoren: Alsaedi, Sarah; Sagen, Andreas; Haugen, Øyvind P; Afanou, Anani K
Veröffentlicht in: Ausgabe 3, 2023
Herausgeber: https://zenodo.org/records/7760071
DOI: 10.5281/zenodo.7760071

CUSP Brochure

Autoren: CUSP
Veröffentlicht in: Ausgabe 3, 2022
Herausgeber: https://zenodo.org/records/5837595
DOI: 10.5281/zenodo.5837595

PlasticsFatE Deliverable Report D4.1 Compilation of existing regulatory documents applicable to microplastic particles of various origin

Autoren: Afanou, Anani; Wallin, Hakan; Giese, Bernd; Jemec Kokalj, Anita; Drobne, Damjana; Ramsperger, Anja; Kühnel, Dana
Veröffentlicht in: Ausgabe 5, 2023
Herausgeber: PLASTICSFATE
DOI: 10.5281/zenodo.8092057

On the importance of study quality criteria for the hazard assessment of nanoplastics in aquatic organisms

Autoren: Kühnel, Dana; Jemec Kokalj, Anita; Drobne, Damjana; Heinlaan, Margit; Novak, Sara
Veröffentlicht in: Ausgabe 1, 2023
Herausgeber: ZENODO
DOI: 10.5281/zenodo.10213371

Toxicological evaluation of co-exposure to microplastics and benzo(a)pyrene on a 3D human bronchial epithelium model

Autoren: Mawas, Safaa; Miremont, Dorian; Izabelle, Charlotte; Bui, Linh Chi; Renault, Justine; Devineau, Stéphanie; Boland, Sonja
Veröffentlicht in: Ausgabe 2, 2023
Herausgeber: zenodo
DOI: 10.5281/zenodo.8038706

Impact of polystyrene nanoparticles on the ultrastructure of human lung epithelial A549 cells.

Autoren: Kurešepi, Ema; Michelini, Sara; Erman, Andreja; Repar, Neza; Drobne, Damjana
Veröffentlicht in: Ausgabe 1, 2024
Herausgeber: zenodo
DOI: 10.5281/zenodo.11258080

Stability and Dispersibility of Microplastics in Experimental Exposure Medium and Their Dimensional Characterization by Smls, Saxs, Raman Microscopy, and Sem

Autoren: Chardel Ompala, Jean-Philippe Renault, Olivier Taché, Emeline Cournède, Stéphanie Devineau, Carine Chivas-Joly
Veröffentlicht in: 2023
Herausgeber: Elsevier BV
DOI: 10.2139/ssrn.4678819

PlasticsFatE Deliverable Report D7.6 Cluster Brochure

Autoren: Tobin, Lesley; Kienzl, Sabine; Mata, Virginia; Vivani, Laura; Muncke, Jane; Boucher, Justin
Veröffentlicht in: Ausgabe 3, 2023
Herausgeber: https://zenodo.org/records/8092258
DOI: 10.5281/zenodo.8092258

Culture conditions matter: how A549 morphology differs in submerged or air-liquid interface culture systems

Autoren: Michelini, Sara; Kurešepi, Ema; Repar, Neza; Šimunovič, Katarina; Mandić Mulec, Ines; Erman, Andreja; Drobne, Damjana
Veröffentlicht in: Ausgabe 1, 2025
Herausgeber: zenodo
DOI: 10.5281/zenodo.12545026

Development and application of an immunocompetent human induced pluripotent stem cell-derived intestinal epithelial cell model for hazard assessment of the oral exposure route

Autoren: Van der Zande, Meike; Duivenvoorde, Loes; Fabrizi, Benedetta; Vos, Paul; Bastiaan-Net, Shanna; Tomassen, Monic; Janssen, Aafke
Veröffentlicht in: Ausgabe 1, 2025
Herausgeber: ZENODO
DOI: 10.5281/zenodo.10890105

What are the Fate and Effects of Micro-/Nano-Plastics on Human Health?

Autoren: Rudolf Reuther; Mark Morrison; Lesley Tobin
Veröffentlicht in: Ausgabe 1, 2021
Herausgeber: zenodo
DOI: 10.5281/zenodo.4774985

PlasticsFatE Deliverable Report D7.7 Joint policy briefs 1

Autoren: Foss Hansen, Stephen; Hernandez, Alba
Veröffentlicht in: Ausgabe 3, 2023
Herausgeber: https://zenodo.org/records/8092279
DOI: 10.5281/zenodo.8092278

PlasticsFatE Deliverable Report D1.1 Report on selected MP/NP and basic Physico Chem features

Autoren: Costa, Anna Luisa; Altman, Korinna; Barbato, Francesco; Portela, Raquel
Veröffentlicht in: Ausgabe 3, 2023
Herausgeber: https://zenodo.org/records/8092005
DOI: 10.5281/zenodo.8092005

Hazards associated with microplastics mixed with Candida albicans in granulocyte-like cells HL-60

Autoren: Sagen, Andreas; Alsaedi, Sarah; Haugen, Øyvind P.; Afanou, Anani K.
Veröffentlicht in: Ausgabe 3, 2023
Herausgeber: https://zenodo.org/records/7760063
DOI: 10.5281/zenodo.7760062

PlasticsFatE Deliverable Summary D7.4 Common dissemination and communication strategy for the cluster

Autoren: Tobin, Lesley; Morrison, Mark; Reuther, Rudolf; Boucher, Justin; Muncke, Jane; Kienzl, Sabine; Mata, Virginia; Vivani, Laura
Veröffentlicht in: Ausgabe 3, 2023
Herausgeber: https://zenodo.org/records/8094900
DOI: 10.5281/zenodo.8094899

Simgi® as an advanced model for the study of the interaction between food-derived microplastics, the human gastrointestinal tract and gut microbiota

Autoren: Tamargo, Alba; Cueva, Carolina; Alcolea, Víctor; Portela, Raquel; Bañares, Miguel Ángel; Reinosa, Julián Jiménez; del Campo, Alfonso; Fernández, Jose Francisco; Moreno-Arribas, M. Victoria
Veröffentlicht in: Ausgabe 3, 2021
Herausgeber: https://zenodo.org/records/4747440
DOI: 10.5281/zenodo.4747440

PlasticsFatE Deliverable Summary D1.2 Analytical characterization data for the first set of MP-NP samples as distributed to partners

Autoren: Potthoff, Annegret
Veröffentlicht in: Ausgabe 5, 2023
Herausgeber: PLASTICSFATE
DOI: 10.5281/zenodo.8094747

Best Practices and Method Validation: A guide for scientists investigating the occurrence of microplastics (MPs) and nanoplastics (NPs)

Autoren: Undas, Anna; Bañares, Miguel A.; Barbero, Francesco; Benetti, Federico; Fenoglio, Ivana; Giovannozzi, Andrea; Klerks, Michel; Laforsch, Christian; Löder, Martin; Perini, Alessandro; Portela, Raquel; Ramsperger, Anja; Zanella, Michela
Veröffentlicht in: Ausgabe 1, 2025
Herausgeber: ZENODO
DOI: 10.5281/zenodo.15520861

PlasticsFatE Deliverable Report D2.1 Overview of human exposure sources and levels of MP/NP

Autoren: Ramsperger, Anja; Löder, Martin; Laforsch
Veröffentlicht in: Ausgabe 1, 2023
Herausgeber: zenodo
DOI: 10.5281/zenodo.8092047

PlasticsFatE Deliverable Report D7.5 Cluster web portal and visual identity

Autoren: Tobin, Lesley; Muncke, Jane; Vivani, Laura; Kienzl, Sabine; Mata Marcano, Virginia; Steinbach, Christoph; Roordink, Danielle; Boucher, Justin
Veröffentlicht in: Ausgabe 3, 2023
Herausgeber: https://zenodo.org/records/8092194
DOI: 10.5281/zenodo.8092193

PlasticsFatE Deliverable Report D6.3 Review of current regulations, policy and markets

Autoren: Braun, Ulrike; Morrison, Mark
Veröffentlicht in: Ausgabe 2, 2023
Herausgeber: ZENODO
DOI: 10.5281/zenodo.8092132

Evaluation of Nanoparticle Tracking Analysis (NTA) for the Measurement of Nanoplastics in Drinking Water

Autoren: Ruud J.B. Peters; Emma Relou; Eelco L.E. Sijtsma; Anna K. Undas
Veröffentlicht in: Research Square, Ausgabe 1, 2024, ISSN 2693-5015
Herausgeber: Research Square
DOI: 10.21203/rs.3.rs-1809144/v1

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