Objective
The objective of this proposal is to characterise differentially displayed (dd) proteins and mRNAs whose expression patterns are specific to cystic fibrosis (CF) in order to get a better understanding of the mechanisms underlying this disease, and to improve diagnosis and/or therapy. CF is the most common lethal monogenic disease in Europe. It is recognised that CFTR, the key protein whose dysfunction causes CF, is at the crossroad of important pathways and plays major roles, most of them unknown, within a network of proteins central to a whole series of cellular functions. As a result, not only genetic predisposition but also many environmental and/or pharmacological factors can affect CF severity. So far, the reponses of CF to these various factors have been studied in a limited context such as, for instance, one gene or pathway at a time. Thus studies of proteomics of CF are needed. We will use high performance techniques to analyse the protein patterns from cells of CF patients vs. non-affected individuals and will establish a database of dd-proteins and mRNAs. Our new techniques for proteome analysis will be useful for other applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences computer and information sciences databases
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75730 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.