Objetivo The goal of this project was to develop a new concept for a small-diameter vascular prosthesis which interacts with the human biological system. This research developed and tested a special polymer type and coated it with cells from the human umbilical vein to encourage its compatibility with the body.THIS RESEARCH PROJECT WILL MAKE A DECISIVE CONTRIBUTION TO DEVOLOPING A POLYMER FOR USE AS A CARDIOVASCULAR IMPLANT.FOR THE FIRST TIME, THE ATTEMPT WILL BE MADE TO COLONIZE A SYNTHETIC POLYMER DURABLY WITH HUMAN INTIMA CELLS BY BONDING A NATURAL ADHESION PROMOTER COVALENTLY TO THE POLYMER SURFACE. AS THE SUPPORT POLYMER, A SEMIPERMEABLE, BIOCOMPATIBLE POLYURETHANE FILM IS TO BE DEVELOPED.BEFORE THE BIOPOLYMER IS APPLIED, SUITABLE FUNCTIONAL GROUPS WILL BE GRAFTED TO THE SURFACE OF THE POLYETHER URETHANE BY PLASMA POLYMERIZATION.THE CONCEPT DESCRIBED WILL BE FEASIBLE ONLY BY COMBINING THE EXPERIENCE OF SEVERAL DISCIPLINES, SUCH AS INDUSTRIAL POLYMER PROCESSING, POLYMER CHEMISTRY AND CELL BIOCHEMISTRY.THE DEVELOPMENT OF A POLYETHER URETHANE FILM COLONIZED WITH ENDOTHELIAL CELLS WILL ALLOW THE EUROPEAN INDUSTRY TO PENETRATE FURTHER INTO THE INTERNATIONAL MARKET FOR BIOCOMPATIBLE POLYMERS. THE "ARTIFICIAL VESSELS" NOW ON THE MARKET ARE ONLY OF LIMITED USEFULNESS AND HAVE TO BE IMPROVED. Ámbito científico natural sciencesbiological sciencesbiochemistrynatural scienceschemical sciencespolymer sciencespolyurethanemedical and health sciencesmedical biotechnologyimplants Programa(s) FP1-BRITE - Multiannual research and development programme (EEC) in the fields of basic technological research and the applications of new technologies (BRITE), 1985-1988 Tema(s) Data not available Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador AACHEN UNIVERSITY OF TECHNOLOGY Aportación de la UE Sin datos Dirección Templergraben 55 52056 AACHEN Alemania Ver en el mapa Coste total Sin datos Participantes (5) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Deutsches Wollforschungsinstitut an der Technischen Hochschule Aachen eV Alemania Aportación de la UE Sin datos Dirección Veltmanplatz 8 52062 Aachen Ver en el mapa Coste total Sin datos Ercros España Aportación de la UE Sin datos Dirección 28,Castello 28001 Madrid Ver en el mapa Coste total Sin datos UNIVERSIDADE DE SANTIAGO DE COMPOSTELA España Aportación de la UE Sin datos Dirección Pazo de San Xerome - Plaza do Obradoiro s/n SANTIAGO DE COMPOSTELA Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos UNIVERSITE PIERRE ET MARIE CURIE - PARIS VI Francia Aportación de la UE Sin datos Dirección Place Jussieu 4 75252 PARIS Ver en el mapa Coste total Sin datos VYGON GmbH & Co KG Alemania Aportación de la UE Sin datos Dirección Goebbelstraße 100 5100 Aachen Ver en el mapa Coste total Sin datos
