Objective Pre-eclampsia, one of the most dangerous cardiometabolic complications of pregnancy, claims the lives of 50,000 mothers and almost one million babies annually. Pre-eclampsia and other hypertensive disorders of pregnancy remain the second most common cause of maternal death. The incidence of pre-eclampsia in Central Asian countries is over twice as high as in western Europe. Inter-population differences in genetic variants may be partly responsible for variation in predisposition to the condition.The AIMS of the InterPregGen consortium proposal are to establish sustainable and productive collaborative links between research groups in Central Asia (Kazakhstan and Uzbekistan) and Europe (Finland, Iceland, Norway, UK); and to identify and compare the genetic variants which predispose to pre-eclampsia. We shall achieve the first aim through scientific co-operation, and through training of Central Asian researchers in centres of excellence in Europe. We shall address the limited knowledge of genetic diversity in Central Asian populations by undertaking whole genome sequencing, analogous to the 1000 Genomes project. We will establish the first pre-eclampsia biobanks of DNA and plasma samples from a total of 4000 affected women, their partners and babies, and matched control samples from healthy pregnant women, in Kazakhstan and Uzbekistan. Existing genome-wide screening data, and data generated as part of this project, from a total of 10400 maternal cases and 7800 affected babies, will be used to identify pre-eclampsia susceptibility genes. We will maximise the information available by conducting meta-analyses of maternal and fetal datasets, and examining maternal-fetal gene interaction effects.By identifying genetic variants which predispose to pre-eclampsia we will gain insights into the underlying pathological mechanisms. This will generate novel hypotheses on the aetiology of pre-eclampsia, and provide targets for improved prediction, prevention and treatment Fields of science natural sciencesbiological sciencesgeneticsDNAmedical and health sciencesclinical medicineobstetricsnatural sciencesbiological sciencesgeneticsgenomes Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2011.2.1.1-4 - Population genetics studies on cardio-metabolic disorders in EU/AC and EECA populations Call for proposal FP7-HEALTH-2011-single-stage See other projects for this call Funding Scheme CP-FP-SICA - Small/medium-scale focused research project for specific cooperation actions dedicated to international cooperation partner countries(SICA) Coordinator THE UNIVERSITY OF NOTTINGHAM EU contribution € 434 441,00 Address University Park NG7 2RD Nottingham United Kingdom See on map Region East Midlands (England) Derbyshire and Nottinghamshire Nottingham Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (11) Sort alphabetically Sort by EU Contribution Expand all Collapse all REPUBLICAN STATE ENTERPRISE WITH ECONOMIC MANAGEMENT SCIENTIFIC CENTRE OF OBSTETRICS, GYNECOLOGY AND PERINATOLOGY OF MINISTRY OF HEALTH Kazakhstan EU contribution € 400 420,00 Address DOSTYK AVE 125 050020 ALMATY See on map Activity type Research Organisations Links Contact the organisation Opens in new window Total cost No data RESPUBLIKA ISTISOSLASHTIRILGAN AKUSHERLIK VA GINEKOLOGIYA ILMIY-AMALIY TIBBIYOT MARKAZI Uzbekistan EU contribution € 107 200,00 Address MIRZO ULUGBEK 132-A 100 Tashkent See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Total cost No data ISLENSK ERFDAGREINING EHF Iceland EU contribution € 1 424 550,00 Address STURLUGOTU 8 101 Reykjavik See on map Region Ísland Ísland Höfuðborgarsvæði Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HELSINGIN YLIOPISTO Finland EU contribution € 209 761,20 Address YLIOPISTONKATU 3 00014 Helsingin Yliopisto See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU Norway EU contribution € 71 010,00 Address HOGSKOLERINGEN 1 7491 Trondheim See on map Region Norge Trøndelag Trøndelag Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FOLKEHELSEINSTITUTTET Norway EU contribution € 280 045,00 Address LOVISENBERGGATA 8 0456 Oslo See on map Region Norge Oslo og Viken Oslo Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER United Kingdom EU contribution € 482 450,00 Address KEPPEL STREET WC1E 7HT London See on map Region London Inner London — West Camden and City of London Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GENOME RESEARCH LIMITED United Kingdom EU contribution € 1 963 929,62 Address WELLCOME SANGER INSTITUTE WELLCOME GENOME CAMPUS HINXTON CB10 1SA SAFFRON WALDEN See on map Region East of England East Anglia Cambridgeshire CC Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF GLASGOW United Kingdom EU contribution € 172 983,60 Address UNIVERSITY AVENUE G12 8QQ Glasgow See on map Region Scotland West Central Scotland Glasgow City Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF LEEDS United Kingdom EU contribution € 114 048,00 Address WOODHOUSE LANE LS2 9JT Leeds See on map Region Yorkshire and the Humber West Yorkshire Leeds Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Total cost No data IMMUNOLOGIYA INSTITUTI O'ZBEKISTONRESPUBLIKASI FANLAR AKADEMIYASI Uzbekistan EU contribution € 300 810,00 Address YA GULAMOV STREET 74 100 TASHKENT See on map Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Total cost No data