Objetivo Inflammation is a complex biochemical and cellular response essential for the viability of higher organisms because of its requirement in anti-microbial defence and protection from the consequences of tissue injury. However, uncontrolled or sustained inflammation leads to several diseases with a huge social impact, ranging from autoimmune diseases to septic shock and cancer. While the requirement for specific transcription factors (TF) in inflammatory gene transcription is known, quantitative models describing how their interactions with genomic sequences leads to normal or pathological outcomes are not available. Unravelling how genomic organization underlies the orchestrated expression of inflammatory genes is crucial to understand how to pharmacologically tune pathological inflammatory responses. Now is the right moment to tackle this question as for the first time we have genomic technologies and computational abilities to generate the necessary quantitative data and to build computational models describing spatiotemporal coordination of transcription of hundreds of inflammatory genes by multiple TFs. To implement this objective, we have assembled a consortium of top-level scientists in the European Research Area who reached documented excellence in complementary aspects of transcriptional control, namely quantitative measurement of TF-DNA interactions, in vitro and in vivo analysis of chromatin organization, manipulation of genomic sequences by homologous recombination, computational and systems biology applied to transcriptional circuits. The network provides the critical mass required to generate ample quantitative and complementary datasets describing the minimal transcriptional regulatory blocks relevant for inflammation, thus enabling the integration of their coordinated activities via systems approaches. Each research group complements the other participants and the whole projects, and as such this proposal can not be carried out on any individual level. Ámbito científico natural sciencesbiological sciencesgeneticsmedical and health sciencesbasic medicineimmunologyautoimmune diseasesmedical and health sciencesclinical medicineoncologynatural sciencesmathematicsapplied mathematicsmathematical model Palabras clave inflammation multidisciplinary approaches quantitative data system modelling Programa(s) FP7-HEALTH - Specific Programme "Cooperation": Health Tema(s) HEALTH-2007-2.1.2-5 - Multidisciplinary fundamental genomics and molecular biology approaches to study basic biological processes relevant to health and diseases Convocatoria de propuestas FP7-HEALTH-2007-B Consulte otros proyectos de esta convocatoria Régimen de financiación CP-FP - Small or medium-scale focused research project Coordinador THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Aportación de la UE € 485 877,45 Dirección WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford Reino Unido Ver en el mapa Región South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Sue Stoneham (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (10) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE La participación finalizó Reino Unido Aportación de la UE € 331 011,55 Dirección SOUTH KENSINGTON CAMPUS EXHIBITION ROAD SW7 2AZ LONDON Ver en el mapa Región London Inner London — West Westminster Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Julie Williams (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos UNIVERSITE JOSEPH FOURIER GRENOBLE 1 Francia Aportación de la UE € 208 800,00 Dirección Avenue Centrale, Domaine Universitaire 621 38041 GRENOBLE Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Leslie Hollett (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos ECOLE NORMALE SUPERIEURE DE LYON Francia Aportación de la UE € 316 800,00 Dirección 46 Allee d'Italie 69364 LYON Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Valerie Tessier (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos UNIVERSITA VITA-SALUTE SAN RAFFAELE Italia Aportación de la UE € 280 800,00 Dirección VIA OLGETTINA 58 20132 Milano Ver en el mapa Región Nord-Ovest Lombardia Milano Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Raffaella Voltolini (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos ISTITUTO EUROPEO DI ONCOLOGIA SRL Italia Aportación de la UE € 242 400,00 Dirección VIA FILODRAMMATICI 10 20121 Milano Ver en el mapa Región Nord-Ovest Lombardia Milano Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Ilaria Foti (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos WEIZMANN INSTITUTE OF SCIENCE Israel Aportación de la UE € 166 380,00 Dirección HERZL STREET 234 7610001 Rehovot Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Talia Tzahor (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos THE HEBREW UNIVERSITY OF JERUSALEM Israel Aportación de la UE € 193 500,00 Dirección EDMOND J SAFRA CAMPUS GIVAT RAM 91904 Jerusalem Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Eran Vardi (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos UNIVERSITAT ZU KOLN Alemania Aportación de la UE € 349 200,00 Dirección ALBERTUS MAGNUS PLATZ 50931 Koln Ver en el mapa Región Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Petra Schreiner-Kaub (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos OXFORD NANOPORE TECHNOLOGIES LTD Reino Unido Aportación de la UE € 90 000,00 Dirección ROBERT ROBINSON AVENUE - OXFORD SCIENCE PARK 4 OX4 4GA Oxford Ver en el mapa Región South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Jim Bruce (Dr.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos IC CONSULTANTS LTD Reino Unido Aportación de la UE € 261 536,00 Dirección Sherfield Building, Imperial College of Science, Technology and Medicine SW7 2AZ LONDON Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Michiyo Shima (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos