Obiettivo Inflammation is a complex biochemical and cellular response essential for the viability of higher organisms because of its requirement in anti-microbial defence and protection from the consequences of tissue injury. However, uncontrolled or sustained inflammation leads to several diseases with a huge social impact, ranging from autoimmune diseases to septic shock and cancer. While the requirement for specific transcription factors (TF) in inflammatory gene transcription is known, quantitative models describing how their interactions with genomic sequences leads to normal or pathological outcomes are not available. Unravelling how genomic organization underlies the orchestrated expression of inflammatory genes is crucial to understand how to pharmacologically tune pathological inflammatory responses. Now is the right moment to tackle this question as for the first time we have genomic technologies and computational abilities to generate the necessary quantitative data and to build computational models describing spatiotemporal coordination of transcription of hundreds of inflammatory genes by multiple TFs. To implement this objective, we have assembled a consortium of top-level scientists in the European Research Area who reached documented excellence in complementary aspects of transcriptional control, namely quantitative measurement of TF-DNA interactions, in vitro and in vivo analysis of chromatin organization, manipulation of genomic sequences by homologous recombination, computational and systems biology applied to transcriptional circuits. The network provides the critical mass required to generate ample quantitative and complementary datasets describing the minimal transcriptional regulatory blocks relevant for inflammation, thus enabling the integration of their coordinated activities via systems approaches. Each research group complements the other participants and the whole projects, and as such this proposal can not be carried out on any individual level. Campo scientifico natural sciencesbiological sciencesgeneticsmedical and health sciencesbasic medicineimmunologyautoimmune diseasesmedical and health sciencesclinical medicineoncologynatural sciencesmathematicsapplied mathematicsmathematical model Parole chiave inflammation multidisciplinary approaches quantitative data system modelling Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH-2007-2.1.2-5 - Multidisciplinary fundamental genomics and molecular biology approaches to study basic biological processes relevant to health and diseases Invito a presentare proposte FP7-HEALTH-2007-B Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Contributo UE € 485 877,45 Indirizzo WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford Regno Unito Mostra sulla mappa Regione South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Sue Stoneham (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (10) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Partecipazione conclusa Regno Unito Contributo UE € 331 011,55 Indirizzo SOUTH KENSINGTON CAMPUS EXHIBITION ROAD SW7 2AZ LONDON Mostra sulla mappa Regione London Inner London — West Westminster Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Julie Williams (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITE JOSEPH FOURIER GRENOBLE 1 Francia Contributo UE € 208 800,00 Indirizzo Avenue Centrale, Domaine Universitaire 621 38041 GRENOBLE Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Leslie Hollett (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ECOLE NORMALE SUPERIEURE DE LYON Francia Contributo UE € 316 800,00 Indirizzo 46 Allee d'Italie 69364 LYON Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Valerie Tessier (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITA VITA-SALUTE SAN RAFFAELE Italia Contributo UE € 280 800,00 Indirizzo VIA OLGETTINA 58 20132 Milano Mostra sulla mappa Regione Nord-Ovest Lombardia Milano Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Raffaella Voltolini (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ISTITUTO EUROPEO DI ONCOLOGIA SRL Italia Contributo UE € 242 400,00 Indirizzo VIA FILODRAMMATICI 10 20121 Milano Mostra sulla mappa Regione Nord-Ovest Lombardia Milano Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Ilaria Foti (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato WEIZMANN INSTITUTE OF SCIENCE Israele Contributo UE € 166 380,00 Indirizzo HERZL STREET 234 7610001 Rehovot Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Talia Tzahor (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato THE HEBREW UNIVERSITY OF JERUSALEM Israele Contributo UE € 193 500,00 Indirizzo EDMOND J SAFRA CAMPUS GIVAT RAM 91904 Jerusalem Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Eran Vardi (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITAT ZU KOLN Germania Contributo UE € 349 200,00 Indirizzo ALBERTUS MAGNUS PLATZ 50931 Koln Mostra sulla mappa Regione Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Petra Schreiner-Kaub (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato OXFORD NANOPORE TECHNOLOGIES LTD Regno Unito Contributo UE € 90 000,00 Indirizzo ROBERT ROBINSON AVENUE - OXFORD SCIENCE PARK 4 OX4 4GA Oxford Mostra sulla mappa Regione South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Jim Bruce (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato IC CONSULTANTS LTD Regno Unito Contributo UE € 261 536,00 Indirizzo Sherfield Building, Imperial College of Science, Technology and Medicine SW7 2AZ LONDON Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Michiyo Shima (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato