Objectif Inflammation is a complex biochemical and cellular response essential for the viability of higher organisms because of its requirement in anti-microbial defence and protection from the consequences of tissue injury. However, uncontrolled or sustained inflammation leads to several diseases with a huge social impact, ranging from autoimmune diseases to septic shock and cancer. While the requirement for specific transcription factors (TF) in inflammatory gene transcription is known, quantitative models describing how their interactions with genomic sequences leads to normal or pathological outcomes are not available. Unravelling how genomic organization underlies the orchestrated expression of inflammatory genes is crucial to understand how to pharmacologically tune pathological inflammatory responses. Now is the right moment to tackle this question as for the first time we have genomic technologies and computational abilities to generate the necessary quantitative data and to build computational models describing spatiotemporal coordination of transcription of hundreds of inflammatory genes by multiple TFs. To implement this objective, we have assembled a consortium of top-level scientists in the European Research Area who reached documented excellence in complementary aspects of transcriptional control, namely quantitative measurement of TF-DNA interactions, in vitro and in vivo analysis of chromatin organization, manipulation of genomic sequences by homologous recombination, computational and systems biology applied to transcriptional circuits. The network provides the critical mass required to generate ample quantitative and complementary datasets describing the minimal transcriptional regulatory blocks relevant for inflammation, thus enabling the integration of their coordinated activities via systems approaches. Each research group complements the other participants and the whole projects, and as such this proposal can not be carried out on any individual level. Champ scientifique natural sciencesbiological sciencesgeneticsmedical and health sciencesbasic medicineimmunologyautoimmune diseasesmedical and health sciencesclinical medicineoncologynatural sciencesmathematicsapplied mathematicsmathematical model Mots‑clés inflammation multidisciplinary approaches quantitative data system modelling Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Thème(s) HEALTH-2007-2.1.2-5 - Multidisciplinary fundamental genomics and molecular biology approaches to study basic biological processes relevant to health and diseases Appel à propositions FP7-HEALTH-2007-B Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Contribution de l’UE € 485 877,45 Adresse WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford Royaume-Uni Voir sur la carte Région South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Type d’activité Higher or Secondary Education Establishments Contact administratif Sue Stoneham (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (10) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Participation terminée Royaume-Uni Contribution de l’UE € 331 011,55 Adresse SOUTH KENSINGTON CAMPUS EXHIBITION ROAD SW7 2AZ LONDON Voir sur la carte Région London Inner London — West Westminster Type d’activité Higher or Secondary Education Establishments Contact administratif Julie Williams (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITE JOSEPH FOURIER GRENOBLE 1 France Contribution de l’UE € 208 800,00 Adresse Avenue Centrale, Domaine Universitaire 621 38041 GRENOBLE Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Leslie Hollett (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée ECOLE NORMALE SUPERIEURE DE LYON France Contribution de l’UE € 316 800,00 Adresse 46 Allee d'Italie 69364 LYON Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Valerie Tessier (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITA VITA-SALUTE SAN RAFFAELE Italie Contribution de l’UE € 280 800,00 Adresse VIA OLGETTINA 58 20132 Milano Voir sur la carte Région Nord-Ovest Lombardia Milano Type d’activité Higher or Secondary Education Establishments Contact administratif Raffaella Voltolini (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée ISTITUTO EUROPEO DI ONCOLOGIA SRL Italie Contribution de l’UE € 242 400,00 Adresse VIA FILODRAMMATICI 10 20121 Milano Voir sur la carte Région Nord-Ovest Lombardia Milano Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Ilaria Foti (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée WEIZMANN INSTITUTE OF SCIENCE Israël Contribution de l’UE € 166 380,00 Adresse HERZL STREET 234 7610001 Rehovot Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Talia Tzahor (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée THE HEBREW UNIVERSITY OF JERUSALEM Israël Contribution de l’UE € 193 500,00 Adresse EDMOND J SAFRA CAMPUS GIVAT RAM 91904 Jerusalem Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Eran Vardi (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITAT ZU KOLN Allemagne Contribution de l’UE € 349 200,00 Adresse ALBERTUS MAGNUS PLATZ 50931 Koln Voir sur la carte Région Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Contact administratif Petra Schreiner-Kaub (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée OXFORD NANOPORE TECHNOLOGIES LTD Royaume-Uni Contribution de l’UE € 90 000,00 Adresse ROBERT ROBINSON AVENUE - OXFORD SCIENCE PARK 4 OX4 4GA Oxford Voir sur la carte Région South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Jim Bruce (Dr.) Liens Contacter l’organisation Opens in new window Coût total Aucune donnée IC CONSULTANTS LTD Royaume-Uni Contribution de l’UE € 261 536,00 Adresse Sherfield Building, Imperial College of Science, Technology and Medicine SW7 2AZ LONDON Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Michiyo Shima (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée