Objetivo The project will focus on the pre-clinical development of carbon monoxide releasing molecules (CORMs) for the treatment of rheumatoid arthritis (RA). Carbon monoxide (CO) has been shown, by several renowned laboratories around the world, to have a number of anti-inflammatory properties which turn it into an exceptionally promising compound against chronic inflammatory diseases such as RA. In its gaseous form CO will hardly be applicable as a drug in a clinical setting. One proponent SME, has conceived and produced a large number of molecules which will release or donate CO, inside the organism, in specific physiological or pathological conditions. These molecules, called CORMs, hold the promise of delivering CO in controlled amounts, at specific rates and in a targeted manner to inflamed tissues such as arthritic joints. In recent months some of these CORMs have been tested in preliminary experiments using rodent models of RA, and have yielded encouraging results in terms of efficacy and toxicity. The main goal of this project will be: to select a small number of exceptionally promising CORMs for the treatment of RA, to develop the best formulations for those compounds, to test their detailed pharmacological and toxicological properties, and ultimately arrive at one lead candidate for clinical development. With this aim, three different SMEs will join their resources, critical mass and knowledge in the field of CORMs, pharmacological test, analysis and standardization and validation of developed assays to gain the ambitious, but reasonable goal: at least one new molecule in clinical trials. Ámbito científico medical and health sciencesclinical medicinerheumatologymedical and health scienceshealth sciencesinflammatory diseasesnatural scienceschemical sciencesinorganic chemistryinorganic compounds Programa(s) FP7-SME - Specific Programme "Capacities": Research for the benefit of SMEs Tema(s) SME-1 - Research for SMEs Convocatoria de propuestas FP7-SME-2008-1 Consulte otros proyectos de esta convocatoria Régimen de financiación BSG-SME - Research for SMEs Coordinador Alfama - Investigacao e Desenvolvimento de Produtos Farmaceuticos, Lda. Aportación de la UE € 475 500,00 Dirección Av. da Republica, Quinta do Marques, Estacao Agronomica Nacional IBET/ITQB, Lab.7.14 2780-157 Oeiras Portugal Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Agnes Lopes (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (6) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Frimorfo SA Suiza Aportación de la UE € 209 500,00 Dirección Chemin du musée 12 CH-1705 Fribourg Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Willi Hunziker (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Micron Research Service Italia Aportación de la UE € 359 500,00 Dirección Largo della Fiera 10 57021 Venturina (Livorno) Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Claudio M. 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