Objectif The project will focus on the pre-clinical development of carbon monoxide releasing molecules (CORMs) for the treatment of rheumatoid arthritis (RA). Carbon monoxide (CO) has been shown, by several renowned laboratories around the world, to have a number of anti-inflammatory properties which turn it into an exceptionally promising compound against chronic inflammatory diseases such as RA. In its gaseous form CO will hardly be applicable as a drug in a clinical setting. One proponent SME, has conceived and produced a large number of molecules which will release or donate CO, inside the organism, in specific physiological or pathological conditions. These molecules, called CORMs, hold the promise of delivering CO in controlled amounts, at specific rates and in a targeted manner to inflamed tissues such as arthritic joints. In recent months some of these CORMs have been tested in preliminary experiments using rodent models of RA, and have yielded encouraging results in terms of efficacy and toxicity. The main goal of this project will be: to select a small number of exceptionally promising CORMs for the treatment of RA, to develop the best formulations for those compounds, to test their detailed pharmacological and toxicological properties, and ultimately arrive at one lead candidate for clinical development. With this aim, three different SMEs will join their resources, critical mass and knowledge in the field of CORMs, pharmacological test, analysis and standardization and validation of developed assays to gain the ambitious, but reasonable goal: at least one new molecule in clinical trials. Champ scientifique medical and health sciencesclinical medicinerheumatologymedical and health scienceshealth sciencesinflammatory diseasesnatural scienceschemical sciencesinorganic chemistryinorganic compounds Programme(s) FP7-SME - Specific Programme "Capacities": Research for the benefit of SMEs Thème(s) SME-1 - Research for SMEs Appel à propositions FP7-SME-2008-1 Voir d’autres projets de cet appel Régime de financement BSG-SME - Research for SMEs Coordinateur Alfama - Investigacao e Desenvolvimento de Produtos Farmaceuticos, Lda. Contribution de l’UE € 475 500,00 Adresse Av. da Republica, Quinta do Marques, Estacao Agronomica Nacional IBET/ITQB, Lab.7.14 2780-157 Oeiras Portugal Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Agnes Lopes (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (6) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire Frimorfo SA Suisse Contribution de l’UE € 209 500,00 Adresse Chemin du musée 12 CH-1705 Fribourg Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Willi Hunziker (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Micron Research Service Italie Contribution de l’UE € 359 500,00 Adresse Largo della Fiera 10 57021 Venturina (Livorno) Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Claudio M. D'urso (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITA DEGLI STUDI DI CATANIA Italie Contribution de l’UE € 3 500,00 Adresse PIAZZA UNIVERSITA 2 95131 Catania Voir sur la carte Région Isole Sicilia Catania Type d’activité Higher or Secondary Education Establishments Contact administratif Ornella Lo Presti (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES Portugal Contribution de l’UE € 3 500,00 Adresse AVENIDA PROF EGAS MONIZ 1649 028 Lisboa Voir sur la carte Région Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Type d’activité Research Organisations Contact administratif Margarida Pinto Gado (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Swiss BioQuant AG Suisse Contribution de l’UE € 3 500,00 Adresse Christoph Merian-Ring 29a 4153 Reinach Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Christoph Siethoff (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU Italie Contribution de l’UE € 45 000,00 Adresse VIA FIORENTINA 151 53100 Siena Voir sur la carte Région Centro (IT) Toscana Siena Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Cristiana Tozzi (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
