Cel The project will focus on the pre-clinical development of carbon monoxide releasing molecules (CORMs) for the treatment of rheumatoid arthritis (RA). Carbon monoxide (CO) has been shown, by several renowned laboratories around the world, to have a number of anti-inflammatory properties which turn it into an exceptionally promising compound against chronic inflammatory diseases such as RA. In its gaseous form CO will hardly be applicable as a drug in a clinical setting. One proponent SME, has conceived and produced a large number of molecules which will release or donate CO, inside the organism, in specific physiological or pathological conditions. These molecules, called CORMs, hold the promise of delivering CO in controlled amounts, at specific rates and in a targeted manner to inflamed tissues such as arthritic joints. In recent months some of these CORMs have been tested in preliminary experiments using rodent models of RA, and have yielded encouraging results in terms of efficacy and toxicity. The main goal of this project will be: to select a small number of exceptionally promising CORMs for the treatment of RA, to develop the best formulations for those compounds, to test their detailed pharmacological and toxicological properties, and ultimately arrive at one lead candidate for clinical development. With this aim, three different SMEs will join their resources, critical mass and knowledge in the field of CORMs, pharmacological test, analysis and standardization and validation of developed assays to gain the ambitious, but reasonable goal: at least one new molecule in clinical trials. Dziedzina nauki medical and health sciencesclinical medicinerheumatologymedical and health scienceshealth sciencesinflammatory diseasesnatural scienceschemical sciencesinorganic chemistryinorganic compounds Program(-y) FP7-SME - Specific Programme "Capacities": Research for the benefit of SMEs Temat(-y) SME-1 - Research for SMEs Zaproszenie do składania wniosków FP7-SME-2008-1 Zobacz inne projekty w ramach tego zaproszenia System finansowania BSG-SME - Research for SMEs Koordynator Alfama - Investigacao e Desenvolvimento de Produtos Farmaceuticos, Lda. Wkład UE € 475 500,00 Adres Av. da Republica, Quinta do Marques, Estacao Agronomica Nacional IBET/ITQB, Lab.7.14 2780-157 Oeiras Portugalia Zobacz na mapie Rodzaj działalności Private for-profit entities (excluding Higher or Secondary Education Establishments) Kontakt administracyjny Agnes Lopes (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (6) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko Frimorfo SA Szwajcaria Wkład UE € 209 500,00 Adres Chemin du musée 12 CH-1705 Fribourg Zobacz na mapie Rodzaj działalności Private for-profit entities (excluding Higher or Secondary Education Establishments) Kontakt administracyjny Willi Hunziker (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Micron Research Service Włochy Wkład UE € 359 500,00 Adres Largo della Fiera 10 57021 Venturina (Livorno) Zobacz na mapie Rodzaj działalności Private for-profit entities (excluding Higher or Secondary Education Establishments) Kontakt administracyjny Claudio M. D'urso (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITA DEGLI STUDI DI CATANIA Włochy Wkład UE € 3 500,00 Adres PIAZZA UNIVERSITA 2 95131 Catania Zobacz na mapie Region Isole Sicilia Catania Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Ornella Lo Presti (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES Portugalia Wkład UE € 3 500,00 Adres AVENIDA PROF EGAS MONIZ 1649 028 Lisboa Zobacz na mapie Region Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Rodzaj działalności Research Organisations Kontakt administracyjny Margarida Pinto Gado (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Swiss BioQuant AG Szwajcaria Wkład UE € 3 500,00 Adres Christoph Merian-Ring 29a 4153 Reinach Zobacz na mapie Rodzaj działalności Private for-profit entities (excluding Higher or Secondary Education Establishments) Kontakt administracyjny Christoph Siethoff (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU Włochy Wkład UE € 45 000,00 Adres VIA FIORENTINA 151 53100 Siena Zobacz na mapie Region Centro (IT) Toscana Siena Rodzaj działalności Private for-profit entities (excluding Higher or Secondary Education Establishments) Kontakt administracyjny Cristiana Tozzi (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
