Artificial Intelligence-driven, Decentralized Production for Advanced Therapies in the Hospital

Informazioni relative al progetto

AIDPATH

ID dell’accordo di sovvenzione: 101016909

DOI

10.3030/101016909

Progetto chiuso

Data della firma CE 7 Dicembre 2020

Data di avvio 1 Gennaio 2021

Data di completamento 31 Dicembre 2025

Finanziato da

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT)

Costo totale

€ 10 964 007,50

Contributo UE

€ 9 860 991,51

Coordinato da

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Data management plan

Documents, reports (3)

Societal Guide for implementing Smart Manufacturing Hospitals
Results dissemination campaign plan
Stakeholder centric design principles ensuring trust and acceptance

Pubblicazioni

Other (6)

Elaborating the potential of Artificial Intelligence in automated CAR-T cell manufacturing

Autori: Niklas Bäckel, Tamás Kis, David F. Nettleton, Joseph R. Egan, John J. L. Jacobs, Dennis Grunert, Robert H. Schmitt
Pubblicato in: Frontiers in Molecular Medicine, 2023
Editore: Frontiers
DOI: 10.3389/fmmed.2023.1250508

How can digitalisation and AI improve CAR-T cell manufacturing?

Autori: Simon Hort
Pubblicato in: Advanced Therapies Europe 2023, 2023
Editore: Fraunhofer Publica
DOI: 10.24406/publica-2433

Process Development and Manufacturing: Impact Of Xeno-Free And Serum Free Medium Formulations For Car-T Cell Manufacturing

Autori: P. Silva Couto, P. Springuel, Q.A. Rafiq
Pubblicato in: 2023
Editore: Elsevier
DOI: 10.1016/s1465-3249(23)00527-3

AIDPATH - Modular Approach to AI-Enabled CAR-T Cell Manufacturing

Autori: Erkens, Frederik
Pubblicato in: Numero 1, 2022
Editore: International Forum on Cell Manufacturing & Engineeing 2022
DOI: 10.24406/publica-574

Optimising Perfusion Parameters Using Quality By Design For The Intensified Production Of Car T Cells In A Single-Use Automated Stirred-Tank Bioreactor

Autori: P. Springuel, T. Hood, F. Slingsby, N. Bevan, W. Geis, V. Sandner, T. Schmidberger, J. Hengst, N. Dianat, Q.A. Rafiq
Pubblicato in: 2023
Editore: Elsevier
DOI: 10.1016/s1465-3249(23)00528-5

How can digitalization and automation enable large-scale application of CAR-T cell therapies?

Autori: Frederik Erkens
Pubblicato in: 2023
Editore: Fraunhofer publica
DOI: 10.24406/publica-2040

Peer reviewed articles (9)

Trust in and Acceptance of Artificial Intelligence Applications in Medicine: Mixed Methods Study

Autori: Daria Shevtsova 1, 2 Author Orcid Image ; Anam Ahmed 1 Author Orcid Image ; Iris W A Boot 1 Author Orcid Image ; Carmen Sanges 3 Author Orcid Image ; Michael Hudecek 3 Author Orcid Image ; John J L Jacobs 4 Author Orcid Image ; Simon Hort 5 Author Orcid Image ; Hubertus J M Vrijhoef 1 Author Orcid Image
Pubblicato in: JMIR Human Factors, 2024, ISSN 2292-9495
Editore: JMIR Publications
DOI: 10.2196/47031

Smart Sensor Control and Monitoring of an Automated Cell Expansion Process

Autori: David F. Nettleton; Núria Marí-Buyé; Helena Marti-Soler; Joseph R. Egan; Simon Hort; David Horna; Miquel Costa; Elia Vallejo Benítez-Cano; Stephen Goldrick; Qasim A. Rafiq; Niels König; Robert H. Schmitt; Aldo R. Reyes
Pubblicato in: Sensors, 2023, ISSN 1424-8220
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s23249676

A production scheduling and control system for CAR T cell manufacturing

Autori: Tamás Kis, Simon Hort, Péter Györgyi, Evelin Szögi, Robert H. Schmitt
Pubblicato in: Procedia CIRP, Numero 125, 2026, Pagina/e 36-41, ISSN 2212-8271
Editore: Elsevier BV
DOI: 10.1016/j.procir.2024.08.007

Reinforcement Learning Based Resource Management for CAR T-Cell Therapies

Autori: Szabolcs Szentpéteri, Krisztián B. Kis, Péter Egri, Carmen Sanges, Sophia Danhof, Katrin Mestermann, Michael Hudecek, Sergio Navarro Velázquez, Manel Juan, Balázs Cs. Csáji
Pubblicato in: Procedia CIRP, Numero 125, 2026, Pagina/e 154-159, ISSN 2212-8271
Editore: Elsevier BV
DOI: 10.1016/j.procir.2024.08.027

Optimising and adapting perfusion feeds in serum-free medium to intensify CAR-T cell expansion in stirred-tank bioreactors

Autori: Pierre Springuel, Tiffany Hood, Fern Slingsby, Timo Schmidberger, Nicola Bevan, Noushin Dianat, Julia Hengst, Qasim A. Rafiq
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 13, 2025, Pagina/e 1-13, ISSN 2296-4185
Editore: Frontiers Media SA
DOI: 10.3389/fbioe.2025.1593895

Societal factors influencing the implementation of AI-driven technologies in (smart) hospitals

Autori: Ysanne de Graaf, Anam Ahmed, Carmen Sanges, Laura Herbst, Hubertus J.M. Vrijhoef
Pubblicato in: PLOS One, Numero 20, 2025, Pagina/e e0325718, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0325718

Toward Rapid, Widely Available Autologous CAR-T Cell Therapy – Artificial Intelligence and Automation Enabling the Smart Manufacturing Hospital

Autori: Hort S, Herbst L, Bäckel N, Erkens F, Niessing B, Frye M, König N, Papantoniou I, Hudecek M, Jacobs JJL and Schmitt RH
Pubblicato in: Frontiers in Medicine, 2022, ISSN 2296-858X
Editore: Frontiers Media
DOI: 10.3389/fmed.2022.913287

A data management system for precision medicine

Autori: John J. L. Jacobs, Inés Beekers, Inge Verkouter, Levi B. Richards, Alexandra Vegelien, Lizan D. Bloemsma, Vera A. M. C. Bongaerts, Jacqueline Cloos, Frederik Erkens, Patrycja Gradowska, Simon Hort, Michael Hudecek, Manel Juan, Anke H. Maitland-van der Zee, Sergio Navarro-Velázquez, Lok Lam Ngai, Qasim A. Rafiq, Carmen Sanges, Jesse Tettero, Hendrikus J. A. van Os, Rimke C. Vos, Yolanda de Wit, S
Pubblicato in: PLOS Digital Health, Numero 4, 2025, Pagina/e e0000464, ISSN 2767-3170
Editore: Public Library of Science (PLoS)
DOI: 10.1371/journal.pdig.0000464

Digital transformation of CAR-T cell therapy – challenges and potential for Industry 4.0

Autori: Simon Hort, Carmen Sanges, John J.L. Jacobs, Michael Hudecek, Robert H. Schmitt
Pubblicato in: Procedia CIRP, Numero 120, 2025, Pagina/e 1034-1040, ISSN 2212-8271
Editore: Elsevier BV
DOI: 10.1016/j.procir.2023.09.121

Conference proceedings (2)

Towards Automated Car-T Cell Manufacturing - Keeping up with Technological Advancement

Autori: Laura Herbst
Pubblicato in: 2023
Editore: Fraunhofer publica
DOI: 10.1016/s1465-3249(22)00437-6

Digital transformation of CAR-T cell therapy – challenges and potential for Industry 4.0

Autori: Simon Hort , Carmen Sanges , John J.L. Jacobs , Michael Hudecek , Robert H. Schmitt
Pubblicato in: Procedia CIRP International Conference on Manufacturing Systems 2023, 2023, ISSN 2212-8271
Editore: Elsevier BV
DOI: 10.1016/j.procir.2023.09.121