Artificial Intelligence-driven, Decentralized Production for Advanced Therapies in the Hospital

Project Information

AIDPATH

Grant agreement ID: 101016909

DOI

10.3030/101016909

Project closed

EC signature date 7 December 2020

Start date 1 January 2021

End date 31 December 2025

Funded under

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT)

Total cost

€ 10 964 007,50

EU contribution

€ 9 860 991,51

Coordinated by

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data management plan

Documents, reports (3)

Societal Guide for implementing Smart Manufacturing Hospitals
Results dissemination campaign plan
Stakeholder centric design principles ensuring trust and acceptance

Publications

Other (6)

Elaborating the potential of Artificial Intelligence in automated CAR-T cell manufacturing

Author(s): Niklas Bäckel, Tamás Kis, David F. Nettleton, Joseph R. Egan, John J. L. Jacobs, Dennis Grunert, Robert H. Schmitt
Published in: Frontiers in Molecular Medicine, 2023
Publisher: Frontiers
DOI: 10.3389/fmmed.2023.1250508

How can digitalisation and AI improve CAR-T cell manufacturing?

Author(s): Simon Hort
Published in: Advanced Therapies Europe 2023, 2023
Publisher: Fraunhofer Publica
DOI: 10.24406/publica-2433

Process Development and Manufacturing: Impact Of Xeno-Free And Serum Free Medium Formulations For Car-T Cell Manufacturing

Author(s): P. Silva Couto, P. Springuel, Q.A. Rafiq
Published in: 2023
Publisher: Elsevier
DOI: 10.1016/s1465-3249(23)00527-3

AIDPATH - Modular Approach to AI-Enabled CAR-T Cell Manufacturing

Author(s): Erkens, Frederik
Published in: Issue 1, 2022
Publisher: International Forum on Cell Manufacturing & Engineeing 2022
DOI: 10.24406/publica-574

Optimising Perfusion Parameters Using Quality By Design For The Intensified Production Of Car T Cells In A Single-Use Automated Stirred-Tank Bioreactor

Author(s): P. Springuel, T. Hood, F. Slingsby, N. Bevan, W. Geis, V. Sandner, T. Schmidberger, J. Hengst, N. Dianat, Q.A. Rafiq
Published in: 2023
Publisher: Elsevier
DOI: 10.1016/s1465-3249(23)00528-5

How can digitalization and automation enable large-scale application of CAR-T cell therapies?

Author(s): Frederik Erkens
Published in: 2023
Publisher: Fraunhofer publica
DOI: 10.24406/publica-2040

Peer reviewed articles (9)

Trust in and Acceptance of Artificial Intelligence Applications in Medicine: Mixed Methods Study

Author(s): Daria Shevtsova 1, 2 Author Orcid Image ; Anam Ahmed 1 Author Orcid Image ; Iris W A Boot 1 Author Orcid Image ; Carmen Sanges 3 Author Orcid Image ; Michael Hudecek 3 Author Orcid Image ; John J L Jacobs 4 Author Orcid Image ; Simon Hort 5 Author Orcid Image ; Hubertus J M Vrijhoef 1 Author Orcid Image
Published in: JMIR Human Factors, 2024, ISSN 2292-9495
Publisher: JMIR Publications
DOI: 10.2196/47031

Smart Sensor Control and Monitoring of an Automated Cell Expansion Process

Author(s): David F. Nettleton; Núria Marí-Buyé; Helena Marti-Soler; Joseph R. Egan; Simon Hort; David Horna; Miquel Costa; Elia Vallejo Benítez-Cano; Stephen Goldrick; Qasim A. Rafiq; Niels König; Robert H. Schmitt; Aldo R. Reyes
Published in: Sensors, 2023, ISSN 1424-8220
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s23249676

A production scheduling and control system for CAR T cell manufacturing

Author(s): Tamás Kis, Simon Hort, Péter Györgyi, Evelin Szögi, Robert H. Schmitt
Published in: Procedia CIRP, Issue 125, 2026, Page(s) 36-41, ISSN 2212-8271
Publisher: Elsevier BV
DOI: 10.1016/j.procir.2024.08.007

Reinforcement Learning Based Resource Management for CAR T-Cell Therapies

Author(s): Szabolcs Szentpéteri, Krisztián B. Kis, Péter Egri, Carmen Sanges, Sophia Danhof, Katrin Mestermann, Michael Hudecek, Sergio Navarro Velázquez, Manel Juan, Balázs Cs. Csáji
Published in: Procedia CIRP, Issue 125, 2026, Page(s) 154-159, ISSN 2212-8271
Publisher: Elsevier BV
DOI: 10.1016/j.procir.2024.08.027

Optimising and adapting perfusion feeds in serum-free medium to intensify CAR-T cell expansion in stirred-tank bioreactors

Author(s): Pierre Springuel, Tiffany Hood, Fern Slingsby, Timo Schmidberger, Nicola Bevan, Noushin Dianat, Julia Hengst, Qasim A. Rafiq
Published in: Frontiers in Bioengineering and Biotechnology, Issue 13, 2025, Page(s) 1-13, ISSN 2296-4185
Publisher: Frontiers Media SA
DOI: 10.3389/fbioe.2025.1593895

Societal factors influencing the implementation of AI-driven technologies in (smart) hospitals

Author(s): Ysanne de Graaf, Anam Ahmed, Carmen Sanges, Laura Herbst, Hubertus J.M. Vrijhoef
Published in: PLOS One, Issue 20, 2025, Page(s) e0325718, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0325718

Toward Rapid, Widely Available Autologous CAR-T Cell Therapy – Artificial Intelligence and Automation Enabling the Smart Manufacturing Hospital

Author(s): Hort S, Herbst L, Bäckel N, Erkens F, Niessing B, Frye M, König N, Papantoniou I, Hudecek M, Jacobs JJL and Schmitt RH
Published in: Frontiers in Medicine, 2022, ISSN 2296-858X
Publisher: Frontiers Media
DOI: 10.3389/fmed.2022.913287

A data management system for precision medicine

Author(s): John J. L. Jacobs, Inés Beekers, Inge Verkouter, Levi B. Richards, Alexandra Vegelien, Lizan D. Bloemsma, Vera A. M. C. Bongaerts, Jacqueline Cloos, Frederik Erkens, Patrycja Gradowska, Simon Hort, Michael Hudecek, Manel Juan, Anke H. Maitland-van der Zee, Sergio Navarro-Velázquez, Lok Lam Ngai, Qasim A. Rafiq, Carmen Sanges, Jesse Tettero, Hendrikus J. A. van Os, Rimke C. Vos, Yolanda de Wit, S
Published in: PLOS Digital Health, Issue 4, 2025, Page(s) e0000464, ISSN 2767-3170
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/journal.pdig.0000464

Digital transformation of CAR-T cell therapy – challenges and potential for Industry 4.0

Author(s): Simon Hort, Carmen Sanges, John J.L. Jacobs, Michael Hudecek, Robert H. Schmitt
Published in: Procedia CIRP, Issue 120, 2025, Page(s) 1034-1040, ISSN 2212-8271
Publisher: Elsevier BV
DOI: 10.1016/j.procir.2023.09.121

Conference proceedings (2)

Towards Automated Car-T Cell Manufacturing - Keeping up with Technological Advancement

Author(s): Laura Herbst
Published in: 2023
Publisher: Fraunhofer publica
DOI: 10.1016/s1465-3249(22)00437-6

Digital transformation of CAR-T cell therapy – challenges and potential for Industry 4.0

Author(s): Simon Hort , Carmen Sanges , John J.L. Jacobs , Michael Hudecek , Robert H. Schmitt
Published in: Procedia CIRP International Conference on Manufacturing Systems 2023, 2023, ISSN 2212-8271
Publisher: Elsevier BV
DOI: 10.1016/j.procir.2023.09.121