Cardiac open reading frame edition to study cardiomyopathies in pigs

Project Information

Cor-Edit-P

Grant agreement ID: 101021043

DOI

10.3030/101021043

EC signature date 9 December 2021

Start date 1 January 2022

End date 31 December 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 375,00

EU contribution

€ 2 499 375,00

Coordinated by

KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

Thymosin ß4 and MRTF-A mitigate vessel regression despite cardiovascular risk factors

Author(s): Kupatt C, Ziegler T, Bähr A, Le Noble F
Published in: International immunopharmacology, Issue 117, 2023, Page(s) 109786, ISSN 1878-1705
Publisher: Elsevier Science
DOI: 10.1016/j.intimp.2023.109786

Endothelial Retargeting of AAV9 In Vivo

Author(s): Bozoglu T, Lee S, Ziegler T, Jurisch V, Maas S, Baehr A, Hinkel R, Hoenig A, Hariharan A, Kim CI, Decker S, Sami H, Koppara T, Oellinger R, Müller OJ, Frank D, Megens R, Nelson P, Weber C, Schnieke A, Sperandio M, Santamaria G, Rad R, Moretti A, Laugwitz KL, Soehnlein O, Ogris M, Kupatt C
Published in: Advanced Science, Issue 9, 2022, Page(s) e2103867, ISSN 2198-3844
Publisher: WILEY-VCH
DOI: 10.1002/advs.202103867

Cold and hot fibrosis define clinically distinct cardiac pathologies

Author(s): Shoval Miyara, Miri Adler, Kfir B. Umansky, Daniel Häußler, Elad Bassat, Yalin Divinsky, Jacob Elkahal, David Kain, Daria Lendengolts, Ricardo O. Ramirez Flores, Hanna Bueno-Levy, Ofra Golani, Tali Shalit, Michael Gershovits, Eviatar Weizman, Alexander Genzelinakh, Danielle M. Kimchi, Avraham Shakked, Lingling Zhang, Jingkui Wang, Andrea Baehr, Zachary Petrover, Rachel Sarig, Tatjana Dorn, Aless
Published in: Cell Systems, Issue 16, 2025, Page(s) 101198, ISSN 2405-4712
Publisher: Cell Press
DOI: 10.1016/j.cels.2025.101198

Cellular pathophysiology of Duchenne muscular dystrophy: insights from a novel rhesus macaque model

Author(s): Alessandra Moretti, Christian Kupatt, Eckhard Wolf
Published in: Signal Transduction and Targeted Therapy, Issue 9, 2024, Page(s) 357, ISSN 2059-3635
Publisher: Nature Publishing Group
DOI: 10.1038/s41392-024-02061-2

Recapitulating porcine cardiac development in vitro: from expanded potential stem cell to embryo culture models

Author(s): Rawat H, Kornherr J, Zawada D, Bakhshiyeva S, Kupatt C, Laugwitz KL, Bähr A, Dorn T, Moretti A, Nowak-Imialek M
Published in: Frontiers in cell and developmental biology, Issue 11, 2023, Page(s) 1111684, ISSN 2296-634X
Publisher: Frontiers Media S.A.
DOI: 10.3389/fcell.2023.1111684

Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors

Author(s): Poch CM, Foo KS, De Angelis MT, Jennbacken K, Santamaria G, Bähr A, Wang QD, Reiter F, Hornaschewitz N, Zawada D, Bozoglu T, My I, Meier A, Dorn T, Hege S, Lehtinen ML, Tsoi YL, Hovdal D, Hyllner J, Schwarz S, Sudhop S, Jurisch V, Sini M, Fellows MD, Cummings M, Clarke J, Baptista R, Eroglu E, Wolf E, Klymiuk N, Lu K, Tomasi R, Dendorfer A, Gaspari M, Parrotta E, Cuda G, Krane M, Sinnecker D, Hop
Published in: Nature Cell Biology, Issue 24, 2022, Page(s) 659-671, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-022-00899-8

Reduced Muscle Force in Dystrophic <i>DMD</i> Δ52 Pigs Is Incompletely Restored by Systemic Transcript Reframing ( <i>DMD</i> Δ51–52)

Author(s): Michaela Blasi, Hristiyan Hristov, Jan B. Stöckl, Martin Kraetzl, Sonja Fiedler, Elisabeth Kemter, Mayuko Kurome, Barbara Kessler, Josep M. Cambra, Valeri Zakhartchenko, Maggie C. Walter, Christian Kupatt, Nikolai Klymiuk, Thomas Fröhlich, Andreas Blutke, Michael Stirm, Florian Jaudas, Eckhard Wolf
Published in: Journal of Cachexia, Sarcopenia and Muscle, Issue 16, 2025, Page(s) e70084, ISSN 2190-5991
Publisher: Springer Verlag
DOI: 10.1002/jcsm.70084

Systemic deletion of DMD exon 51 rescues clinically severe Duchenne muscular dystrophy in a pig model lacking DMD exon 52

Author(s): Stirm M, Shashikadze B, Blutke A, Kemter E, Lange A, Stöckl JB, Jaudas F, Laane L, Kurome M, Keßler B, Zakhartchenko V, Bähr A, Klymiuk N, Nagashima H, Walter MC, Wurst W, Kupatt C, Fröhlich T, Wolf E
Published in: Proceedings of the National Academy of Sciences of the United States of America, Issue 120, 2023, Page(s) e2301250120, ISSN 1091-6490
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2301250120

Parenchymal cues define Vegfa-driven venous angiogenesis by activating a sprouting competent venous endothelial subtype

Author(s): Préau L, Lischke A, Merkel M, Oegel N, Weissenbruch M, Michael A, Park H, Gradl D, Kupatt C, le Noble F
Published in: Nature communications, Issue 15, 2024, Page(s) 3118, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-47434-x

Other (1)

Pig models for translational Duchenne muscular dystrophy research

Author(s): Stirm M, Klymiuk N, Nagashima H, Kupatt C, Wolf E
Published in: Trends in molecular medicine, Issue 2024 May 14, 2024, Page(s) S1471-4914(24)00101-1, ISSN 1471-4914
Publisher: Elsevier BV
DOI: 10.1016/j.molmed.2024.04.013

Intellectual Property Rights

Patent (1)

AAV VECTORS FOR GENE THERAPY IN ENDOTHELIAL CELLS

Application/Publication number: 20 22086634
Date: 2022-12-19
Applicant(s): KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)