Conception by artificial reproductive technologies and offspring health

Project Information

ART-HEALTH

Grant agreement ID: 101021566

DOI

10.3030/101021566

EC signature date 19 November 2021

Start date 1 December 2021

End date 30 November 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 951,00

EU contribution

€ 2 499 951,00

Coordinated by

UNIVERSITY OF BRISTOL
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (21)

Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course: a multi-cohort study

Author(s): Ahmed Elhakeem; Justiina Ronkainen; Toby Mansell; Katherine Lange; Tuija Mikkola; Binisha H Mishra; Rama Wahab; Tim Cadman; Tiffany Yang; David Burgner; Johan G Eriksson; Marjo-Riitta Järvelin; Romy Gaillard; Vincent WV Jaddoe; Terho Lehtimäki; Olli T Raitakari; Richard Saffery; Melissa Wake; John Wright; Sylvain Sebert; Deborah A Lawlor
Published in: VOLUME=21;ISSUE=1;ISSN=1741-7015;TITLE=BMC Medicine, Issue 7, 2023, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-022-02711-8

The challenges of selective fertility and carryover effects in within-sibship analyses: the effect of assisted reproductive technology on perinatal mortality as an example

Author(s): Kjersti Westvik-Johari; Siri E Håberg; Deborah A Lawlor; Liv Bente Romundstad; Christina Bergh; Ulla-Britt Wennerholm; Mika Gissler; Anna-Karina A Henningsen; Aila Tiitinen; Anja Pinborg; Signe Opdahl
Published in: International Journal of Epidemiology, Issue 3, 2023, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyad003

Association between infertility treatment and hypertensive disorders of pregnancy in the Japan Birth Cohort Consortium: a meta-analysis

Author(s): Ishikuro M, Nishimura T, Iwata H, et al.
Published in: Journal of human hypertension, 2024, ISSN 0950-9240
Publisher: Nature Publishing Group
DOI: 10.1038/s41371-023-00890-2

Estimating the health impact of nicotine exposure by dissecting the effects of nicotine versus non-nicotine constituents of tobacco smoke: A multivariable Mendelian randomisation study

Author(s): Jasmine N. Khouja; Eleanor Sanderson; Robyn E. Wootton; Amy E. Taylor; Billy A. Church; Rebecca C. Richmond; Marcus R. Munafò
Published in: PLoS Genetics, Vol 20, Iss 2, p e1011157 (2024), Issue 1, 2024, ISSN 1553-7390
Publisher: Public Library of Science
DOI: 10.1371/journal.pgen.1011157

Using Mendelian Randomisation to Prioritise Candidate Maternal Metabolic Traits Influencing Offspring Birthweight

Author(s): Ciarrah-Jane Shannon Barry; Deborah A. Lawlor; Chin Yang Shapland; Eleanor Sanderson; Maria Carolina Borges
Published in: Metabolites, Issue 1, 2022, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo12060537

Maternal Risk of Cardiovascular Disease After Use of Assisted Reproductive Technologies

Author(s): Magnus MC, Fraser A, Håberg, SC, Rönö, C Romundstad LV, Bergh C, Spangmose AL, Pinborg A, Gissler M, Wennerholm U-B, Åsvold B, Lawlor DA, OpdahlS
Published in: JAMA Cardiology, 2023, ISSN 2380-6583
Publisher: Online
DOI: 10.1001/jamacardio.2023.2324

Risk of cardiovascular disease in women and men with subfertility: the Trøndelag Health Study

Author(s): Skåra KH, Åsvold BO, Hernáez Á, Fraser A, Rich-Edwards JW, Farland LV, Næss Ø, Lawlor DA, Brumpton B, Magnus MC
Published in: Fertility and Sterility, 2022, ISSN 0015-0282
Publisher: Elsevier BV
DOI: 10.1016/j.fertnstert.2022.05.038

Evaluation and comparison of nine growth- and development-based measures of pubertal timing

Author(s): Ahmed Elhakeem, Monika Frysz, Ana G Soares, Joshua A Bell, Tim J Cole, Jon Heron, Laura D Howe, Sylvain Sebert, Kate Tilling, Nicholas J Timpson, Deborah A Lawlor
Published in: Communications Medicine, Issue 4, 2026, Page(s) 159, ISSN 2730-664X
Publisher: Nature Portfolio
DOI: 10.1101/2023.06.12.23290796

Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood

Author(s): Ahmed Elhakeem, Amy E. Taylor, Hazel M. Inskip, Jonathan Huang, Muriel Tafflet, Johan L. Vinther, Federica Asta, Jan S. Erkamp, Luigi Gagliardi, Kathrin Guerlich, Jane Halliday, Margreet W. Harskamp-van Ginkel, Jian-Rong He, Vincent W. V. Jaddoe, Sharon Lewis, Gillian M. Maher, Yannis Manios, Toby Mansell, Fergus P. McCarthy, Sheila W. McDonald, Emanuela Medda, Lorenza Nisticò, Angela Pinot de Mo
Published in: Obstetrics and Gynecology, 2022, ISSN 0002-9378
Publisher: Mosby Inc.
DOI: 10.1001/jamanetworkopen.2022.22106

Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study

Author(s): Álvaro Hernáez; Karoline H. Skåra; Christian M. Page; Vera R. Mitter; Marta H. Hernández; Per Magnus; Pål R. Njølstad; Ole A. Andreassen; Elizabeth C. Corfield; Alexandra Havdahl; Øyvind Næss; Ben Brumpton; Bjørn Olav Åsvold; Deborah A. Lawlor; Abigail Fraser; Maria Christine Magnus
Published in: BMC Medicine, Vol 22, Iss 1, Pp 1-11 (2024), Issue 6, 2024, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-023-03223-9

Parental infertility and offspring cardiometabolic trajectories: a pooled analysis of three European cohorts

Author(s): Hernáez A, Elhakeem A, Barros H, et al
Published in: Fertility and Sterility, 2024, ISSN 0015-0282
Publisher: Elsevier BV
DOI: 10.1016/j.fertnstert.2024.01.017

Prenatal Urban Environment and Blood Pressure Trajectories From Childhood to Early Adulthood

Author(s): Ana Gonçalves Soares; Susana Santos; Emie Seyve; Rozenn Nedelec; Soile Puhakka; Aino-Maija Eloranta; Santtu Mikkonen; Wen Lun Yuan; Deborah A Lawlor; Jon Heron; Martine Vrijheid; Johanna Lepeule; Mark Nieuwenhuijsen; Serena Fossati; Vincent W V Jaddoe; Timo Lakka; Sylvain Sebert; Barbara Heude; Janine F Felix; Ahmed Elhakeem; Nicholas J Timpson
Published in: Soares , A G , Santos , S , Seyve , E , Nedelec , R , Puhakka , S , Eloranta , A-M , Mikkonen , S , Yuan , W L , Lawlor , D A , Heron , J , Vrijheid , M , Lepeule , J , Nieuwenhuijsen , M , Fossati , S , Jaddoe , V W V , Lakka , T , Sebert , S , Heude , B , Felix , J F , Elhakeem , A & Timpson , N J 2023 ' Prenatal urban environment and blood pressure trajectories from childhood to early adulthood, Issue 11, 2024, ISSN 2772-963X
Publisher: online
DOI: 10.1016/j.jacadv.2023.100808

Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis

Author(s): Ahmed Elhakeem; Amy E Taylor; Hazel M Inskip; Jonathan Y Huang; Toby Mansell; Carina Rodrigues; Federica Asta; Sophia M Blaauwendraad; Siri E Håberg; Jane Halliday; Margreet W Harskamp-van Ginkel; Jian-Rong He; Vincent W V Jaddoe; Sharon Lewis; Gillian M Maher; Yannis Manios; Fergus P McCarthy; Irwin K M Reiss; Franca Rusconi; Theodosia Salika; Muriel Tafflet; Xiu Qiu; Bjørn O Åsvold; David Bur
Published in: 1-11, Issue 4, 2023, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehac726

General health in a cohort of children conceived after assisted reproductive technology in the United Kingdom: a population-based record-linkage study

Author(s): Alastair G.Sutcliffe, Mitana Purkayastha, Daniel R.Brison, Scott M.Nelson, Stephen A.Roberts, Deborah A.Lawlor
Published in: American Journal of Obstetrics & Gynecology, 2022, ISSN 0002-9378
Publisher: Mosby Inc.
DOI: 10.1016/j.ajog.2022.07.032

Impaired glucose tolerance and cardiovascular risk factors in relation to infertility: a Mendelian randomization analysis in the Norwegian Mother, Father and Child Cohort Study

Author(s): Álvaro Hernáez; Yunsung Lee; Christian M Page; Karoline H Skåra; Siri E Håberg; Per Magnus; Pål R Njølstad; Ole A Andreassen; Elizabeth C Corfield; Alexandra Havdahl; Abigail Fraser; Stephen Burgess; Deborah A Lawlor; Maria C Magnus
Published in: Human Reproduction, Issue 4, 2024, ISSN 1460-2350
Publisher: Online
DOI: 10.1101/2023.01.26.23285048

Social inequalities in pregnancy metabolic profile: findings from the multi-ethnic Born in Bradford cohort study

Author(s): Ahmed Elhakeem, Gemma L. Clayton, Ana Goncalves Soares, Kurt Taylor, Léa Maitre, Gillian Santorelli, John Wright, Deborah A. Lawlor, Martine Vrijheid
Published in: BMC Pregnancy and Childbirth, Issue 24, 2024, Page(s) 333, ISSN 1471-2393
Publisher: BioMed Central
DOI: 10.1186/s12884-024-06538-4

Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum

Author(s): Samvida S. Venkatesh, Laura B. L. Wittemans, Duncan S. Palmer, Nikolas A. Baya, Teresa Ferreira, Barney Hill, Frederik Heymann Lassen, Melody J. Parker, Saskia Reibe, Ahmed Elhakeem, Karina Banasik, Mie T. Bruun, Christian Erikstrup, Bitten Aagard Jensen, Anders Juul, Christina Mikkelsen, Henriette S. Nielsen, Sisse R. Ostrowski, Ole B. Pedersen, Palle Duun Rohde, Erik Sørensen, Henrik Ullum, Dav
Published in: Nature Genetics, Issue 57, 2025, Page(s) 1107-1118, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-025-02156-8

Risk of stillbirth and neonatal death in singletons born after fresh and frozen embryo transfer: cohort study from the Committee of Nordic Assisted Reproduction Technology and Safety

Author(s): Kjersti Westvik-Johari; Deborah A. Lawlor; Liv Bente Romundstad; Christina Bergh; Ulla-Britt Wennerholm; Mika Gissler; Anna-Karina A. Henningsen; Siri E. Håberg; Aila Tiitinen; Anne Lærke Spangmose; Anja Pinborg; Signe Opdahl
Published in: Fertility and Sterility, Issue 2, 2023, ISSN 0015-0282
Publisher: Elsevier BV
DOI: 10.1016/j.fertnstert.2022.10.020

Associations between health behaviours, fertility and reproductive outcomes: triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa)

Author(s): Robyn E. Wootton; Rebecca B. Lawn; Maria C. Magnus; Jorien L. Treur; Elizabeth C. Corfield; Pål R. Njølstad; Ole A. Andreassen; Deborah A. Lawlor; Marcus R. Munafò; Siri E. Håberg; George Davey Smith; Ted Reichborn-Kjennerud; Per Magnus; Alexandra Havdahl
Published in: 1-17, Issue 7, 2023, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-023-02831-9

Cardiovascular disease risk factors and infertility: multivariable analyses and one-sample Mendelian randomization analyses in the Trøndelag Health Study

Author(s): Karoline H Skåra, Álvaro Hernáez, Øyvind Næss, Abigail Fraser, Deborah A Lawlor, Stephen Burgess, Ben M Brumpton, Maria C Magnus
Published in: Human Reproduction Open, Issue 2024, 2024, Page(s) hoae033, ISSN 2399-3529
Publisher: Oxford University Press (OUP)
DOI: 10.1093/hropen/hoae033

A framework for conducting GWAS using repeated measures data with an application to childhood BMI

Author(s): Kimberley Burrows, Anni Heiskala, Jonathan P. Bradfield, Zhanna Balkhiyarova, Lijiao Ning, Mathilde Boissel, Yee-Ming Chan, Philippe Froguel, Amelie Bonnefond, Hakon Hakonarson, Alexessander Couto Alves, Deborah A. Lawlor, Marika Kaakinen, Marjo-Riitta Järvelin, Struan F. A. Grant, Kate Tilling, Inga Prokopenko, Sylvain Sebert, Mickaël Canouil, Nicole M. Warrington
Published in: Nature Communications, Issue 15, 2024, Page(s) 10067, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-53687-3