The power of grape extracts: antimicrobial and antioxidant properties to prevent the use of antibiotics in farmed animals

Informations projet

NeoGiANT

N° de convention de subvention: 101036768

DOI

10.3030/101036768

Projet clôturé

Date de signature de la CE 22 Septembre 2021

Date de début 1 Octobre 2021

Date de fin 31 Mars 2026

Financé au titre de

• SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy

Coût total

€ 9 332 246,49

Contribution de l’UE

€ 8 374 688,42

Coordonné par

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Spain

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (28)

MIC and IC50 for the tested for Toxoplasma gondii using the formulation
Optimized grape extracts

Optimized grape extracts and corresponding reports after formulation refinements

MIC and IC50 for the tested microbial species using the formulation

MIC and IC50 for the tested microbial species using the formulations

MIC and IC50 for Toxoplasma gondii using the extract
Stakeholders perspectives

Report on Stakeholders perspectives

Eco design of the formulations production process and guidance for a correct scale-up
Deep chemical characterization report of bioactive compounds of grape extracts
First grape extracts & characterization reports (Lab-scale)

First grape extracts characterization reports Labscale

Knowledge transfer strategy in Latin America
In vivo antimicrobial effects of the active compound to treat exudative epidermitis
In vitro eubiotic effect of the active compound on pathogenic E. coli derived from pigs

In vitro eubiotic effect of the active compound on pathogenic E coli derived from pigs

MIC and IC50 for the tested microbial species using the polyphenolic extract
In vivo antimicrobial effects to treat specific fish diseases

In vivo antimicrobial effects of the use of different extract-based formulations to treat specific fish diseases

1st Report on the contribution to standardization
Template for data collection for Life Cycle Sustainability Assessment
Exploitation Plan & Innovative Business Model for Exploitation
Database regarding the effectiveness of the extract against bacteria
Growth performance in calves

Results on Growth performance in calves

Project Risk Management Plan
Project Management Guidelines
Communication & Dissemination Plan

Communication Dissemination Plan

2nd Report on the contribution to standardization
Effects of extracts on cattle mammary glands
1st collection of Practice abstracts

10 Practice abstracts

In vivo effects of the use of different extract-based formulations in broilers
First Technology Watch Report
standardization landscape and applicable standards

Report on the standardization landscape and applicable standards

2nd collection of Practice abstracts

15 Practice abstracts

Websites, patent fillings, videos etc. (1)

NeoGiANT Website

Open Research Data Pilot (1)

Data Management Plan

Data Management Plan The project optouts from the Open Research Data

Publications

Other (1)

The NeoGiANT project: unlocking the power of white grape marc to improve animal welfare

Auteurs: Marta Lores; Iciar Serrano
Publié dans: Ae:ther, 2023, ISSN 2976-5544
Éditeur: Research Aether limited
DOI: 10.58214/USCN2702

Peer reviewed articles (25)

Detection of the ST111 Global High-Risk Pseudomonas aeruginosa Clone in a Subway Underpass

Auteurs: Balázs Libisch, Chioma Lilian Ozoaduche, Tibor Keresztény, Anniek Bus, Tommy Van Limbergen, Katalin Posta, Ferenc Olasz
Publié dans: Current Numéros in Molecular Biology, Numéro 47, 2025, Page(s) 532, ISSN 1467-3045
Éditeur: MDPI AG
DOI: 10.3390/cimb47070532

Microalgae and phytase dietary supplementation improved growth and gut microbiota in juvenile European seabass (Dicentrarchus labrax)

Auteurs: Juan Manuel Peralta-Sánchez, Miguel Rabelo-Ruiz, Antonio Manuel Martín-Platero, Antonio Jesús Vizcaíno, Sara Flores-Moreno, Judit Macías-Vidal, Juan Antonio Martos-Sitcha, Francisco Javier Alarcón-López, Alberto Baños, Eva Valdivia & Manuel Martínez-Bueno
Publié dans: BMC Genomics, Numéro 25, 2024, Page(s) 838, ISSN 1471-2164
Éditeur: BioMed Central
DOI: 10.1186/s12864-024-10760-x

In vitro evaluation of algae and their effect as dietary ingredient on growth, chemical composition and intestinal functionality in juvenile turbot (Scophthalmus maximus)

Auteurs: A. Galafat, M.I. Sáez, C. Rodríguez, A. Hernández de Rojas, A.J. Vizcaíno, T.F. Martínez, F.J. Alarcón-López
Publié dans: Aquaculture, Numéro 592, 2024, Page(s) 741208, ISSN 0044-8486
Éditeur: Elsevier BV
DOI: 10.1016/j.aquaculture.2024.741208

Fighting antibiotic resistance in the local management of bovine mastitis

Auteurs: Lara Touza-Otero, Mariana Landin, Patricia Diaz-Rodriguez
Publié dans: Biomedicine & Pharmacotherapy, Numéro 170, 2024, Page(s) 115967, ISSN 0753-3322
Éditeur: Elsevier Masson
DOI: 10.1016/j.biopha.2023.115967

Assessing the effect of gastrointestinal conditions and solubility on the bioaccessibility of polyphenolic compounds from a white grape marc extract

Auteurs: Lorena G. Calvo, Maria Celeiro, Marta Lores, Ana G. Abril, Trinidad de Miguel
Publié dans: Food Chemistry, Numéro 480, 2025, Page(s) 143810, ISSN 0308-8146
Éditeur: Elsevier BV
DOI: 10.1016/j.foodchem.2025.143810

Bioprocessed plant protein diets enriched with hydrolyzed microalgae-grape marc extracts improve growth and welfare in Sparus aurata juveniles

Auteurs: A. Caderno, V. de las Heras, M. Román-Arias, M. Oliva, J. Román-Padilla, J.M. Mancera, F.J. Alarcón-López, G. Martínez-Rodríguez, J.A. Martos-Sitcha
Publié dans: Aquaculture, Numéro 621, 2026, Page(s) 744020, ISSN 0044-8486
Éditeur: Elsevier BV
DOI: 10.1016/j.aquaculture.2026.744020

Detection of Acquired Antibiotic Resistance Genes in Domestic Pig (Sus scrofa) and Common Carp (Cyprinus carpio) Intestinal Samples by Metagenomics Analyses in Hungary

Auteurs: Balazs Libisch, Sahabi Abdulkadir, Tibor Keresztény, Péter P. Papp, Ferenc Olasz, Hedvig Fébel, Zsuzsanna J. Sándor, Geertrui Rasschaert, Ellen Lambrecht, Marc Heyndrickx, András Szabo, Melinda Kovács, Katalin Posta
Publié dans: Antibiotics, Numéro 11 (10), 2022, Page(s) 1441, ISSN 2079-6382
Éditeur: MDPI
DOI: 10.3390/antibiotics11101441

Effects of different concentrations of a white grape marc extract on broiler performance, apparent ileal digestibility, antioxidant capacity, intestinal barrier function and nutrient transport markers

Auteurs: Huilin Ouyang, Jürgen Zentek, Luisa Ebersbach, María Celeiro, Marta Lores, Beatriz Martínez-Vallespín
Publié dans: Poultry Science, Numéro 104, 2025, Page(s) 105366, ISSN 0032-5791
Éditeur: Poultry Science Association Inc.
DOI: 10.1016/j.psj.2025.105366

Economically viable bioprocess for inclusion of microalga Nannochloropsis gaditana in aquaculture feeds: Evaluation of antioxidant addition in preventing lipid oxidation during storage

Auteurs: J. Camacho-Rodríguez, A. Vizcaíno-Torres, M.D. Macías-Sánchez, E. Navarro-López, Y. Soriano-Jerez, F.J. Alarcón-López, M.C. Cerón-García
Publié dans: Biosource Technology, 2024, ISSN 1873-2976
Éditeur: Elsevier
DOI: 10.1016/j.biortech.2024.131024

Effects of dietary inclusion of crude or hydrolyzed Arthrospira platensis on intestinal microbiota in gilthead seabream (Sparus aurata) fry

Auteurs: Juan Manuel Peralta-Sánchez, Miguel Rabelo-Ruiz, Antonio Manuel Martín-Platero, Marta Arizcun, Alba Galafat, Francisco Javier Alarcón-López, Alberto Baños, Claudia Teso Pérez, Manuel Martínez-Bueno
Publié dans: Discover Animals, Numéro 2, 2025, ISSN 3004-894X
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/s44338-025-00152-0

Assessment of low dietary inclusion of nutraceuticals derived from microalgae to enhance intestinal function in gilthead seabream (Sparus aurata) juveniles

Auteurs: Alba Galafat, M. I. Sáez, A. J. Vizcaíno, A. Barany, E. Perera, D. Sánchez-Ruiz, T. F. Martínez, J. Fuentes, J. A. Martos-Sitcha, F. J. Alarcón-López
Publié dans: Scientific Reports, Numéro 16, 2026, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-026-36087-z

A Comparative Study of the Effect of Including Full-Fat Tenebrio molitor for Replacing Conventional Ingredients in Practical Diets for Dicentrarchus labrax Juveniles

Auteurs: Sara Flores-Moreno, Francisco Javier Alarcón-López, Antonio J. Coronel-Domínguez, Eugenia Zuasti, Ismael Hachero-Cruzado
Publié dans: Animals, Numéro 15, 2025, Page(s) 131, ISSN 2076-2615
Éditeur: MDPI AG
DOI: 10.3390/ani15020131

Dietary supplementation of a plant-based diet with hydrolyzed microalgae–grape marc extracts: effect on oxidative status, intestinal functionality and microbiota in Sparus aurata juveniles

Auteurs: Alba Galafat, Isabel del Carmen Ruiz-Rodríguez, Alejandro Morcillo-Guillén, Anyell Caderno, Jorge García-Márquez, Isabel Maria Cerezo, Marta Román, Verónica de las Heras, Antonio J. Vizcaíno, Maria Isabel Sáez, Tomás F. Martínez, Amalia E. Morales, Maria Celeiro, Marta Lores, Juan Antonio Martos-Sitcha, Francisco Javier Alarcón-López
Publié dans: Frontiers in Marine Science, Numéro 13, 2026, ISSN 2296-7745
Éditeur: Frontiers Media SA
DOI: 10.3389/fmars.2026.1792212

Optimizing Extracellular Products from Vibrio proteolyticus for Their Use as Postbiotics in Aquaculture

Auteurs: Jorge García-Márquez, Marta Domínguez-Maqueda, Olivia Pérez-Gómez, Isabel M. Cerezo, Cristóbal Espinosa-Ruíz, M. Ángeles Esteban, Fernando Vallejo, Francisco Javier Alarcón-López, Eduardo Martínez-Manzanares, Silvana Teresa Tapia-Paniagua, María Carmen Balebona, Miguel Ángel Moriñigo, Salvador Arijo
Publié dans: Marine Biotechnology, Numéro 27, 2025, Page(s) 120, ISSN 1436-2228
Éditeur: Springer Verlag
DOI: 10.1007/s10126-025-10500-6

Effects of Phytase and Microalgae Supplementation on the Utilization of Aquafeeds for European Seabass (Dicentrarchus labrax) Formulated with a High Inclusion Level of Plant Protein

Auteurs: S. Flores-Moreno, A.J. Vizcaíno, M.I. Sáez, J. Macías-Vidal, T F. Martínez, J. A. Martos-Sitcha, F.J. Alarcón-López
Publié dans: Aquaculture Research, 2024, ISSN 1365-2109
Éditeur: Wiley
DOI: 10.1155/2024/4775004

Spatiotemporal characterization of ghrelin and cholecystokinin levels in the gastrointestinal tract of juvenile Sparus aurata: effects of feeding status and diet composition

Auteurs: Anyell Caderno, Patrik Tang, Verónica de las Heras, Naouel Gharbi, Francisco Javier Alarcón-López, Juan Miguel Mancera, Juan Antonio Martos-Sitcha, Neda Gilannejad
Publié dans: Frontiers in Endocrinology, Numéro 17, 2026, ISSN 1664-2392
Éditeur: Frontiers Media SA
DOI: 10.3389/fendo.2026.1734169

Effects of feeding European seabass (Dicentrarchus labrax) juveniles with crude, hydrolysed and fermented biomass of the invasive macroalga Rugulopteryx okamurae (Ochrophyta)

Auteurs: A.J. Vizcaíno, M.I. Sáez, A. Galafat, R. Galindo-Melero, E. Perera, I. Casal-Porras, E. Zubía, J. Vega, F.L. Figueroa, T.F. Martínez, J.A. Martos-Sitcha, F.J. Alarcón
Publié dans: Aquaculture Reports, Numéro 34, 2025, Page(s) 101877, ISSN 2352-5134
Éditeur: Elsevier BV
DOI: 10.1016/j.aqrep.2023.101877

Evaluation of White Grape Marc Extract as an Additive to Extend the Shelf-Life of Fish Fillets

Auteurs: María Isabel Sáez, Javier Sabio, Alba Galafat, Antonio Jesús Vizcaíno, Francisco Javier Alarcón-López, Tomás Francisco Martínez Moya
Publié dans: Foods, Numéro 14, 2025, Page(s) 1438, ISSN 2304-8158
Éditeur: MDPI AG
DOI: 10.3390/foods14081438

Isolation and Characterization of Lactic Acid Bacteria With Probiotic Attributes From Different Parts of the Gastrointestinal Tract of Free-living Wild Boars in Hungary

Auteurs: Tibor Keresztény, Balázs Libisch, Stephanya Corral Orbe, Tibor Nagy, Zoltán Kerényi, Róbert Kocsis, Katalin Posta, Péter P. Papp, Ferenc Olasz
Publié dans: Probiotics and Antimicrobial Proteins, Numéro 16, 2024, Page(s) 1221-1239, ISSN 1867-1306
Éditeur: Springer Pub. Co.,
DOI: 10.1007/s12602-023-10113-2

Optimization of bioactives extraction from grape marc via a medium scale ambient temperature system and stability study

Auteurs: Aly Castillo, María Celeiro, Laura Rubio, Andrea Bañobre, Miguel Otero-Otero, Carmen Garcia-Jares, Marta Lores
Publié dans: Frontiers in Nutrition, Numéro 9, 2022, ISSN 2296-861X
Éditeur: Frontiers
DOI: 10.3389/fnut.2022.1008457

Evaluation of the Antimicrobial Capacity of a White Grape Marc Extract Through Gastrointestinal Digestion

Auteurs: Lorena G. Calvo, María Celeiro, Rosa-Antía Villarino, Ana G. Abril, Sandra Sánchez, José Luis R. Rama, Trinidad de Miguel
Publié dans: Applied Sciences, Numéro 15, 2025, Page(s) 6390, ISSN 2076-3417
Éditeur: MDPI AG
DOI: 10.3390/app15126390

In vivo tracking of grape marc biomarkers, bioconversion, metabolic tracers, and microbiota modulation in swine fed a polyphenol-rich extract diet

Auteurs: Aly Castillo, Maria Celeiro, Beatriz Martínez-Vallespín, Laura Rubio, Diego Gonzalez-Iglesias, Rocío Facorro, Carmen Garcia-Jares, Jürgen Zentek, Marta Lores
Publié dans: PLOS One, Numéro 20, 2025, Page(s) e0325079, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0325079

The effects of microalgal feed supplementation on growth and digestive function of Acipenser baerii and Sparus aurata

Auteurs: Jorge García-Márquez, Alejandro Morcillo-Guillén, Antonio J. Vizcaíno, Alba Galafat, María Isabel Sáez, Tomás Francisco Martínez, Luciano Foglio, Lorenzo Proietti, Tiziana Bongiorno, Francisco Gabriel Acién, Katia Parati, Francisco Javier Alarcón-López
Publié dans: Aquaculture, Numéro 610, 2025, Page(s) 742920, ISSN 0044-8486
Éditeur: Elsevier BV
DOI: 10.1016/j.aquaculture.2025.742920

Effects of Microalgae-Based Nutraceuticals on Muscle Composition and Intestinal Function in Juvenile Gilthead Seabream Fed Plant Protein-Based Diets

Auteurs: Alba Galafat, Isabel del Carmen Ruiz-Rodríguez, Alejandro Morcillo-Guillén, Anyell Caderno, Milagrosa Oliva, María Isabel Sáez, Antonio Jesús Vizcaíno, Tomás F. Martínez, Juan Antonio Martos-Sitcha, Francisco Javier Alarcón-López
Publié dans: Animals, Numéro 16, 2026, Page(s) 1350, ISSN 2076-2615
Éditeur: MDPI AG
DOI: 10.3390/ani16091350

Food Additives Derived from Fruits and Vegetables for Sustainable Animal Production and Their Impact in Latin America: An Alternative to the Use of Antibiotics

Auteurs: Marina Golowczyc, Andrea Gomez-Zavaglia
Publié dans: Foods, Numéro 13, 2025, Page(s) 2921, ISSN 2304-8158
Éditeur: MDPI AG
DOI: 10.3390/foods13182921