The power of grape extracts: antimicrobial and antioxidant properties to prevent the use of antibiotics in farmed animals

Project Information

NeoGiANT

Grant agreement ID: 101036768

DOI

10.3030/101036768

Project closed

EC signature date 22 September 2021

Start date 1 October 2021

End date 31 March 2026

Funded under

• SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy

Total cost

€ 9 332 246,49

EU contribution

€ 8 374 688,42

Coordinated by

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (28)

MIC and IC50 for the tested for Toxoplasma gondii using the formulation
Optimized grape extracts

Optimized grape extracts and corresponding reports after formulation refinements

MIC and IC50 for the tested microbial species using the formulation

MIC and IC50 for the tested microbial species using the formulations

MIC and IC50 for Toxoplasma gondii using the extract
Stakeholders perspectives

Report on Stakeholders perspectives

Eco design of the formulations production process and guidance for a correct scale-up
Deep chemical characterization report of bioactive compounds of grape extracts
First grape extracts & characterization reports (Lab-scale)

First grape extracts characterization reports Labscale

Knowledge transfer strategy in Latin America
In vivo antimicrobial effects of the active compound to treat exudative epidermitis
In vitro eubiotic effect of the active compound on pathogenic E. coli derived from pigs

In vitro eubiotic effect of the active compound on pathogenic E coli derived from pigs

MIC and IC50 for the tested microbial species using the polyphenolic extract
In vivo antimicrobial effects to treat specific fish diseases

In vivo antimicrobial effects of the use of different extract-based formulations to treat specific fish diseases

1st Report on the contribution to standardization
Template for data collection for Life Cycle Sustainability Assessment
Exploitation Plan & Innovative Business Model for Exploitation
Database regarding the effectiveness of the extract against bacteria
Growth performance in calves

Results on Growth performance in calves

Project Risk Management Plan
Project Management Guidelines
Communication & Dissemination Plan

Communication Dissemination Plan

2nd Report on the contribution to standardization
Effects of extracts on cattle mammary glands
1st collection of Practice abstracts

10 Practice abstracts

In vivo effects of the use of different extract-based formulations in broilers
First Technology Watch Report
standardization landscape and applicable standards

Report on the standardization landscape and applicable standards

2nd collection of Practice abstracts

15 Practice abstracts

Websites, patent fillings, videos etc. (1)

NeoGiANT Website

Open Research Data Pilot (1)

Data Management Plan

Data Management Plan The project optouts from the Open Research Data

Publications

Other (1)

The NeoGiANT project: unlocking the power of white grape marc to improve animal welfare

Author(s): Marta Lores; Iciar Serrano
Published in: Ae:ther, 2023, ISSN 2976-5544
Publisher: Research Aether limited
DOI: 10.58214/USCN2702

Peer reviewed articles (25)

Detection of the ST111 Global High-Risk Pseudomonas aeruginosa Clone in a Subway Underpass

Author(s): Balázs Libisch, Chioma Lilian Ozoaduche, Tibor Keresztény, Anniek Bus, Tommy Van Limbergen, Katalin Posta, Ferenc Olasz
Published in: Current Issues in Molecular Biology, Issue 47, 2025, Page(s) 532, ISSN 1467-3045
Publisher: MDPI AG
DOI: 10.3390/cimb47070532

Microalgae and phytase dietary supplementation improved growth and gut microbiota in juvenile European seabass (Dicentrarchus labrax)

Author(s): Juan Manuel Peralta-Sánchez, Miguel Rabelo-Ruiz, Antonio Manuel Martín-Platero, Antonio Jesús Vizcaíno, Sara Flores-Moreno, Judit Macías-Vidal, Juan Antonio Martos-Sitcha, Francisco Javier Alarcón-López, Alberto Baños, Eva Valdivia & Manuel Martínez-Bueno
Published in: BMC Genomics, Issue 25, 2024, Page(s) 838, ISSN 1471-2164
Publisher: BioMed Central
DOI: 10.1186/s12864-024-10760-x

In vitro evaluation of algae and their effect as dietary ingredient on growth, chemical composition and intestinal functionality in juvenile turbot (Scophthalmus maximus)

Author(s): A. Galafat, M.I. Sáez, C. Rodríguez, A. Hernández de Rojas, A.J. Vizcaíno, T.F. Martínez, F.J. Alarcón-López
Published in: Aquaculture, Issue 592, 2024, Page(s) 741208, ISSN 0044-8486
Publisher: Elsevier BV
DOI: 10.1016/j.aquaculture.2024.741208

Fighting antibiotic resistance in the local management of bovine mastitis

Author(s): Lara Touza-Otero, Mariana Landin, Patricia Diaz-Rodriguez
Published in: Biomedicine & Pharmacotherapy, Issue 170, 2024, Page(s) 115967, ISSN 0753-3322
Publisher: Elsevier Masson
DOI: 10.1016/j.biopha.2023.115967

Assessing the effect of gastrointestinal conditions and solubility on the bioaccessibility of polyphenolic compounds from a white grape marc extract

Author(s): Lorena G. Calvo, Maria Celeiro, Marta Lores, Ana G. Abril, Trinidad de Miguel
Published in: Food Chemistry, Issue 480, 2025, Page(s) 143810, ISSN 0308-8146
Publisher: Elsevier BV
DOI: 10.1016/j.foodchem.2025.143810

Bioprocessed plant protein diets enriched with hydrolyzed microalgae-grape marc extracts improve growth and welfare in Sparus aurata juveniles

Author(s): A. Caderno, V. de las Heras, M. Román-Arias, M. Oliva, J. Román-Padilla, J.M. Mancera, F.J. Alarcón-López, G. Martínez-Rodríguez, J.A. Martos-Sitcha
Published in: Aquaculture, Issue 621, 2026, Page(s) 744020, ISSN 0044-8486
Publisher: Elsevier BV
DOI: 10.1016/j.aquaculture.2026.744020

Detection of Acquired Antibiotic Resistance Genes in Domestic Pig (Sus scrofa) and Common Carp (Cyprinus carpio) Intestinal Samples by Metagenomics Analyses in Hungary

Author(s): Balazs Libisch, Sahabi Abdulkadir, Tibor Keresztény, Péter P. Papp, Ferenc Olasz, Hedvig Fébel, Zsuzsanna J. Sándor, Geertrui Rasschaert, Ellen Lambrecht, Marc Heyndrickx, András Szabo, Melinda Kovács, Katalin Posta
Published in: Antibiotics, Issue 11 (10), 2022, Page(s) 1441, ISSN 2079-6382
Publisher: MDPI
DOI: 10.3390/antibiotics11101441

Effects of different concentrations of a white grape marc extract on broiler performance, apparent ileal digestibility, antioxidant capacity, intestinal barrier function and nutrient transport markers

Author(s): Huilin Ouyang, Jürgen Zentek, Luisa Ebersbach, María Celeiro, Marta Lores, Beatriz Martínez-Vallespín
Published in: Poultry Science, Issue 104, 2025, Page(s) 105366, ISSN 0032-5791
Publisher: Poultry Science Association Inc.
DOI: 10.1016/j.psj.2025.105366

Economically viable bioprocess for inclusion of microalga Nannochloropsis gaditana in aquaculture feeds: Evaluation of antioxidant addition in preventing lipid oxidation during storage

Author(s): J. Camacho-Rodríguez, A. Vizcaíno-Torres, M.D. Macías-Sánchez, E. Navarro-López, Y. Soriano-Jerez, F.J. Alarcón-López, M.C. Cerón-García
Published in: Biosource Technology, 2024, ISSN 1873-2976
Publisher: Elsevier
DOI: 10.1016/j.biortech.2024.131024

Effects of dietary inclusion of crude or hydrolyzed Arthrospira platensis on intestinal microbiota in gilthead seabream (Sparus aurata) fry

Author(s): Juan Manuel Peralta-Sánchez, Miguel Rabelo-Ruiz, Antonio Manuel Martín-Platero, Marta Arizcun, Alba Galafat, Francisco Javier Alarcón-López, Alberto Baños, Claudia Teso Pérez, Manuel Martínez-Bueno
Published in: Discover Animals, Issue 2, 2025, ISSN 3004-894X
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s44338-025-00152-0

Assessment of low dietary inclusion of nutraceuticals derived from microalgae to enhance intestinal function in gilthead seabream (Sparus aurata) juveniles

Author(s): Alba Galafat, M. I. Sáez, A. J. Vizcaíno, A. Barany, E. Perera, D. Sánchez-Ruiz, T. F. Martínez, J. Fuentes, J. A. Martos-Sitcha, F. J. Alarcón-López
Published in: Scientific Reports, Issue 16, 2026, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-026-36087-z

A Comparative Study of the Effect of Including Full-Fat Tenebrio molitor for Replacing Conventional Ingredients in Practical Diets for Dicentrarchus labrax Juveniles

Author(s): Sara Flores-Moreno, Francisco Javier Alarcón-López, Antonio J. Coronel-Domínguez, Eugenia Zuasti, Ismael Hachero-Cruzado
Published in: Animals, Issue 15, 2025, Page(s) 131, ISSN 2076-2615
Publisher: MDPI AG
DOI: 10.3390/ani15020131

Dietary supplementation of a plant-based diet with hydrolyzed microalgae–grape marc extracts: effect on oxidative status, intestinal functionality and microbiota in Sparus aurata juveniles

Author(s): Alba Galafat, Isabel del Carmen Ruiz-Rodríguez, Alejandro Morcillo-Guillén, Anyell Caderno, Jorge García-Márquez, Isabel Maria Cerezo, Marta Román, Verónica de las Heras, Antonio J. Vizcaíno, Maria Isabel Sáez, Tomás F. Martínez, Amalia E. Morales, Maria Celeiro, Marta Lores, Juan Antonio Martos-Sitcha, Francisco Javier Alarcón-López
Published in: Frontiers in Marine Science, Issue 13, 2026, ISSN 2296-7745
Publisher: Frontiers Media SA
DOI: 10.3389/fmars.2026.1792212

Optimizing Extracellular Products from Vibrio proteolyticus for Their Use as Postbiotics in Aquaculture

Author(s): Jorge García-Márquez, Marta Domínguez-Maqueda, Olivia Pérez-Gómez, Isabel M. Cerezo, Cristóbal Espinosa-Ruíz, M. Ángeles Esteban, Fernando Vallejo, Francisco Javier Alarcón-López, Eduardo Martínez-Manzanares, Silvana Teresa Tapia-Paniagua, María Carmen Balebona, Miguel Ángel Moriñigo, Salvador Arijo
Published in: Marine Biotechnology, Issue 27, 2025, Page(s) 120, ISSN 1436-2228
Publisher: Springer Verlag
DOI: 10.1007/s10126-025-10500-6

Effects of Phytase and Microalgae Supplementation on the Utilization of Aquafeeds for European Seabass (Dicentrarchus labrax) Formulated with a High Inclusion Level of Plant Protein

Author(s): S. Flores-Moreno, A.J. Vizcaíno, M.I. Sáez, J. Macías-Vidal, T F. Martínez, J. A. Martos-Sitcha, F.J. Alarcón-López
Published in: Aquaculture Research, 2024, ISSN 1365-2109
Publisher: Wiley
DOI: 10.1155/2024/4775004

Spatiotemporal characterization of ghrelin and cholecystokinin levels in the gastrointestinal tract of juvenile Sparus aurata: effects of feeding status and diet composition

Author(s): Anyell Caderno, Patrik Tang, Verónica de las Heras, Naouel Gharbi, Francisco Javier Alarcón-López, Juan Miguel Mancera, Juan Antonio Martos-Sitcha, Neda Gilannejad
Published in: Frontiers in Endocrinology, Issue 17, 2026, ISSN 1664-2392
Publisher: Frontiers Media SA
DOI: 10.3389/fendo.2026.1734169

Effects of feeding European seabass (Dicentrarchus labrax) juveniles with crude, hydrolysed and fermented biomass of the invasive macroalga Rugulopteryx okamurae (Ochrophyta)

Author(s): A.J. Vizcaíno, M.I. Sáez, A. Galafat, R. Galindo-Melero, E. Perera, I. Casal-Porras, E. Zubía, J. Vega, F.L. Figueroa, T.F. Martínez, J.A. Martos-Sitcha, F.J. Alarcón
Published in: Aquaculture Reports, Issue 34, 2025, Page(s) 101877, ISSN 2352-5134
Publisher: Elsevier BV
DOI: 10.1016/j.aqrep.2023.101877

Evaluation of White Grape Marc Extract as an Additive to Extend the Shelf-Life of Fish Fillets

Author(s): María Isabel Sáez, Javier Sabio, Alba Galafat, Antonio Jesús Vizcaíno, Francisco Javier Alarcón-López, Tomás Francisco Martínez Moya
Published in: Foods, Issue 14, 2025, Page(s) 1438, ISSN 2304-8158
Publisher: MDPI AG
DOI: 10.3390/foods14081438

Isolation and Characterization of Lactic Acid Bacteria With Probiotic Attributes From Different Parts of the Gastrointestinal Tract of Free-living Wild Boars in Hungary

Author(s): Tibor Keresztény, Balázs Libisch, Stephanya Corral Orbe, Tibor Nagy, Zoltán Kerényi, Róbert Kocsis, Katalin Posta, Péter P. Papp, Ferenc Olasz
Published in: Probiotics and Antimicrobial Proteins, Issue 16, 2024, Page(s) 1221-1239, ISSN 1867-1306
Publisher: Springer Pub. Co.,
DOI: 10.1007/s12602-023-10113-2

Optimization of bioactives extraction from grape marc via a medium scale ambient temperature system and stability study

Author(s): Aly Castillo, María Celeiro, Laura Rubio, Andrea Bañobre, Miguel Otero-Otero, Carmen Garcia-Jares, Marta Lores
Published in: Frontiers in Nutrition, Issue 9, 2022, ISSN 2296-861X
Publisher: Frontiers
DOI: 10.3389/fnut.2022.1008457

Evaluation of the Antimicrobial Capacity of a White Grape Marc Extract Through Gastrointestinal Digestion

Author(s): Lorena G. Calvo, María Celeiro, Rosa-Antía Villarino, Ana G. Abril, Sandra Sánchez, José Luis R. Rama, Trinidad de Miguel
Published in: Applied Sciences, Issue 15, 2025, Page(s) 6390, ISSN 2076-3417
Publisher: MDPI AG
DOI: 10.3390/app15126390

In vivo tracking of grape marc biomarkers, bioconversion, metabolic tracers, and microbiota modulation in swine fed a polyphenol-rich extract diet

Author(s): Aly Castillo, Maria Celeiro, Beatriz Martínez-Vallespín, Laura Rubio, Diego Gonzalez-Iglesias, Rocío Facorro, Carmen Garcia-Jares, Jürgen Zentek, Marta Lores
Published in: PLOS One, Issue 20, 2025, Page(s) e0325079, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0325079

The effects of microalgal feed supplementation on growth and digestive function of Acipenser baerii and Sparus aurata

Author(s): Jorge García-Márquez, Alejandro Morcillo-Guillén, Antonio J. Vizcaíno, Alba Galafat, María Isabel Sáez, Tomás Francisco Martínez, Luciano Foglio, Lorenzo Proietti, Tiziana Bongiorno, Francisco Gabriel Acién, Katia Parati, Francisco Javier Alarcón-López
Published in: Aquaculture, Issue 610, 2025, Page(s) 742920, ISSN 0044-8486
Publisher: Elsevier BV
DOI: 10.1016/j.aquaculture.2025.742920

Effects of Microalgae-Based Nutraceuticals on Muscle Composition and Intestinal Function in Juvenile Gilthead Seabream Fed Plant Protein-Based Diets

Author(s): Alba Galafat, Isabel del Carmen Ruiz-Rodríguez, Alejandro Morcillo-Guillén, Anyell Caderno, Milagrosa Oliva, María Isabel Sáez, Antonio Jesús Vizcaíno, Tomás F. Martínez, Juan Antonio Martos-Sitcha, Francisco Javier Alarcón-López
Published in: Animals, Issue 16, 2026, Page(s) 1350, ISSN 2076-2615
Publisher: MDPI AG
DOI: 10.3390/ani16091350

Food Additives Derived from Fruits and Vegetables for Sustainable Animal Production and Their Impact in Latin America: An Alternative to the Use of Antibiotics

Author(s): Marina Golowczyc, Andrea Gomez-Zavaglia
Published in: Foods, Issue 13, 2025, Page(s) 2921, ISSN 2304-8158
Publisher: MDPI AG
DOI: 10.3390/foods13182921