The power of grape extracts: antimicrobial and antioxidant properties to prevent the use of antibiotics in farmed animals

Informazioni relative al progetto

NeoGiANT

ID dell’accordo di sovvenzione: 101036768

DOI

10.3030/101036768

Progetto chiuso

Data della firma CE 22 Settembre 2021

Data di avvio 1 Ottobre 2021

Data di completamento 31 Marzo 2026

Finanziato da

• SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy

Costo totale

€ 9 332 246,49

Contributo UE

€ 8 374 688,42

Coordinato da

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Spain

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (28)

MIC and IC50 for the tested for Toxoplasma gondii using the formulation
Optimized grape extracts

Optimized grape extracts and corresponding reports after formulation refinements

MIC and IC50 for the tested microbial species using the formulation

MIC and IC50 for the tested microbial species using the formulations

MIC and IC50 for Toxoplasma gondii using the extract
Stakeholders perspectives

Report on Stakeholders perspectives

Eco design of the formulations production process and guidance for a correct scale-up
Deep chemical characterization report of bioactive compounds of grape extracts
First grape extracts & characterization reports (Lab-scale)

First grape extracts characterization reports Labscale

Knowledge transfer strategy in Latin America
In vivo antimicrobial effects of the active compound to treat exudative epidermitis
In vitro eubiotic effect of the active compound on pathogenic E. coli derived from pigs

In vitro eubiotic effect of the active compound on pathogenic E coli derived from pigs

MIC and IC50 for the tested microbial species using the polyphenolic extract
In vivo antimicrobial effects to treat specific fish diseases

In vivo antimicrobial effects of the use of different extract-based formulations to treat specific fish diseases

1st Report on the contribution to standardization
Template for data collection for Life Cycle Sustainability Assessment
Exploitation Plan & Innovative Business Model for Exploitation
Database regarding the effectiveness of the extract against bacteria
Growth performance in calves

Results on Growth performance in calves

Project Risk Management Plan
Project Management Guidelines
Communication & Dissemination Plan

Communication Dissemination Plan

2nd Report on the contribution to standardization
Effects of extracts on cattle mammary glands
1st collection of Practice abstracts

10 Practice abstracts

In vivo effects of the use of different extract-based formulations in broilers
First Technology Watch Report
standardization landscape and applicable standards

Report on the standardization landscape and applicable standards

2nd collection of Practice abstracts

15 Practice abstracts

Websites, patent fillings, videos etc. (1)

NeoGiANT Website

Open Research Data Pilot (1)

Data Management Plan

Data Management Plan The project optouts from the Open Research Data

Pubblicazioni

Other (1)

The NeoGiANT project: unlocking the power of white grape marc to improve animal welfare

Autori: Marta Lores; Iciar Serrano
Pubblicato in: Ae:ther, 2023, ISSN 2976-5544
Editore: Research Aether limited
DOI: 10.58214/USCN2702

Peer reviewed articles (25)

Detection of the ST111 Global High-Risk Pseudomonas aeruginosa Clone in a Subway Underpass

Autori: Balázs Libisch, Chioma Lilian Ozoaduche, Tibor Keresztény, Anniek Bus, Tommy Van Limbergen, Katalin Posta, Ferenc Olasz
Pubblicato in: Current Numeros in Molecular Biology, Numero 47, 2025, Pagina/e 532, ISSN 1467-3045
Editore: MDPI AG
DOI: 10.3390/cimb47070532

Microalgae and phytase dietary supplementation improved growth and gut microbiota in juvenile European seabass (Dicentrarchus labrax)

Autori: Juan Manuel Peralta-Sánchez, Miguel Rabelo-Ruiz, Antonio Manuel Martín-Platero, Antonio Jesús Vizcaíno, Sara Flores-Moreno, Judit Macías-Vidal, Juan Antonio Martos-Sitcha, Francisco Javier Alarcón-López, Alberto Baños, Eva Valdivia & Manuel Martínez-Bueno
Pubblicato in: BMC Genomics, Numero 25, 2024, Pagina/e 838, ISSN 1471-2164
Editore: BioMed Central
DOI: 10.1186/s12864-024-10760-x

In vitro evaluation of algae and their effect as dietary ingredient on growth, chemical composition and intestinal functionality in juvenile turbot (Scophthalmus maximus)

Autori: A. Galafat, M.I. Sáez, C. Rodríguez, A. Hernández de Rojas, A.J. Vizcaíno, T.F. Martínez, F.J. Alarcón-López
Pubblicato in: Aquaculture, Numero 592, 2024, Pagina/e 741208, ISSN 0044-8486
Editore: Elsevier BV
DOI: 10.1016/j.aquaculture.2024.741208

Fighting antibiotic resistance in the local management of bovine mastitis

Autori: Lara Touza-Otero, Mariana Landin, Patricia Diaz-Rodriguez
Pubblicato in: Biomedicine & Pharmacotherapy, Numero 170, 2024, Pagina/e 115967, ISSN 0753-3322
Editore: Elsevier Masson
DOI: 10.1016/j.biopha.2023.115967

Assessing the effect of gastrointestinal conditions and solubility on the bioaccessibility of polyphenolic compounds from a white grape marc extract

Autori: Lorena G. Calvo, Maria Celeiro, Marta Lores, Ana G. Abril, Trinidad de Miguel
Pubblicato in: Food Chemistry, Numero 480, 2025, Pagina/e 143810, ISSN 0308-8146
Editore: Elsevier BV
DOI: 10.1016/j.foodchem.2025.143810

Bioprocessed plant protein diets enriched with hydrolyzed microalgae-grape marc extracts improve growth and welfare in Sparus aurata juveniles

Autori: A. Caderno, V. de las Heras, M. Román-Arias, M. Oliva, J. Román-Padilla, J.M. Mancera, F.J. Alarcón-López, G. Martínez-Rodríguez, J.A. Martos-Sitcha
Pubblicato in: Aquaculture, Numero 621, 2026, Pagina/e 744020, ISSN 0044-8486
Editore: Elsevier BV
DOI: 10.1016/j.aquaculture.2026.744020

Detection of Acquired Antibiotic Resistance Genes in Domestic Pig (Sus scrofa) and Common Carp (Cyprinus carpio) Intestinal Samples by Metagenomics Analyses in Hungary

Autori: Balazs Libisch, Sahabi Abdulkadir, Tibor Keresztény, Péter P. Papp, Ferenc Olasz, Hedvig Fébel, Zsuzsanna J. Sándor, Geertrui Rasschaert, Ellen Lambrecht, Marc Heyndrickx, András Szabo, Melinda Kovács, Katalin Posta
Pubblicato in: Antibiotics, Numero 11 (10), 2022, Pagina/e 1441, ISSN 2079-6382
Editore: MDPI
DOI: 10.3390/antibiotics11101441

Effects of different concentrations of a white grape marc extract on broiler performance, apparent ileal digestibility, antioxidant capacity, intestinal barrier function and nutrient transport markers

Autori: Huilin Ouyang, Jürgen Zentek, Luisa Ebersbach, María Celeiro, Marta Lores, Beatriz Martínez-Vallespín
Pubblicato in: Poultry Science, Numero 104, 2025, Pagina/e 105366, ISSN 0032-5791
Editore: Poultry Science Association Inc.
DOI: 10.1016/j.psj.2025.105366

Economically viable bioprocess for inclusion of microalga Nannochloropsis gaditana in aquaculture feeds: Evaluation of antioxidant addition in preventing lipid oxidation during storage

Autori: J. Camacho-Rodríguez, A. Vizcaíno-Torres, M.D. Macías-Sánchez, E. Navarro-López, Y. Soriano-Jerez, F.J. Alarcón-López, M.C. Cerón-García
Pubblicato in: Biosource Technology, 2024, ISSN 1873-2976
Editore: Elsevier
DOI: 10.1016/j.biortech.2024.131024

Effects of dietary inclusion of crude or hydrolyzed Arthrospira platensis on intestinal microbiota in gilthead seabream (Sparus aurata) fry

Autori: Juan Manuel Peralta-Sánchez, Miguel Rabelo-Ruiz, Antonio Manuel Martín-Platero, Marta Arizcun, Alba Galafat, Francisco Javier Alarcón-López, Alberto Baños, Claudia Teso Pérez, Manuel Martínez-Bueno
Pubblicato in: Discover Animals, Numero 2, 2025, ISSN 3004-894X
Editore: Springer Science and Business Media LLC
DOI: 10.1007/s44338-025-00152-0

Assessment of low dietary inclusion of nutraceuticals derived from microalgae to enhance intestinal function in gilthead seabream (Sparus aurata) juveniles

Autori: Alba Galafat, M. I. Sáez, A. J. Vizcaíno, A. Barany, E. Perera, D. Sánchez-Ruiz, T. F. Martínez, J. Fuentes, J. A. Martos-Sitcha, F. J. Alarcón-López
Pubblicato in: Scientific Reports, Numero 16, 2026, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-026-36087-z

A Comparative Study of the Effect of Including Full-Fat Tenebrio molitor for Replacing Conventional Ingredients in Practical Diets for Dicentrarchus labrax Juveniles

Autori: Sara Flores-Moreno, Francisco Javier Alarcón-López, Antonio J. Coronel-Domínguez, Eugenia Zuasti, Ismael Hachero-Cruzado
Pubblicato in: Animals, Numero 15, 2025, Pagina/e 131, ISSN 2076-2615
Editore: MDPI AG
DOI: 10.3390/ani15020131

Dietary supplementation of a plant-based diet with hydrolyzed microalgae–grape marc extracts: effect on oxidative status, intestinal functionality and microbiota in Sparus aurata juveniles

Autori: Alba Galafat, Isabel del Carmen Ruiz-Rodríguez, Alejandro Morcillo-Guillén, Anyell Caderno, Jorge García-Márquez, Isabel Maria Cerezo, Marta Román, Verónica de las Heras, Antonio J. Vizcaíno, Maria Isabel Sáez, Tomás F. Martínez, Amalia E. Morales, Maria Celeiro, Marta Lores, Juan Antonio Martos-Sitcha, Francisco Javier Alarcón-López
Pubblicato in: Frontiers in Marine Science, Numero 13, 2026, ISSN 2296-7745
Editore: Frontiers Media SA
DOI: 10.3389/fmars.2026.1792212

Optimizing Extracellular Products from Vibrio proteolyticus for Their Use as Postbiotics in Aquaculture

Autori: Jorge García-Márquez, Marta Domínguez-Maqueda, Olivia Pérez-Gómez, Isabel M. Cerezo, Cristóbal Espinosa-Ruíz, M. Ángeles Esteban, Fernando Vallejo, Francisco Javier Alarcón-López, Eduardo Martínez-Manzanares, Silvana Teresa Tapia-Paniagua, María Carmen Balebona, Miguel Ángel Moriñigo, Salvador Arijo
Pubblicato in: Marine Biotechnology, Numero 27, 2025, Pagina/e 120, ISSN 1436-2228
Editore: Springer Verlag
DOI: 10.1007/s10126-025-10500-6

Effects of Phytase and Microalgae Supplementation on the Utilization of Aquafeeds for European Seabass (Dicentrarchus labrax) Formulated with a High Inclusion Level of Plant Protein

Autori: S. Flores-Moreno, A.J. Vizcaíno, M.I. Sáez, J. Macías-Vidal, T F. Martínez, J. A. Martos-Sitcha, F.J. Alarcón-López
Pubblicato in: Aquaculture Research, 2024, ISSN 1365-2109
Editore: Wiley
DOI: 10.1155/2024/4775004

Spatiotemporal characterization of ghrelin and cholecystokinin levels in the gastrointestinal tract of juvenile Sparus aurata: effects of feeding status and diet composition

Autori: Anyell Caderno, Patrik Tang, Verónica de las Heras, Naouel Gharbi, Francisco Javier Alarcón-López, Juan Miguel Mancera, Juan Antonio Martos-Sitcha, Neda Gilannejad
Pubblicato in: Frontiers in Endocrinology, Numero 17, 2026, ISSN 1664-2392
Editore: Frontiers Media SA
DOI: 10.3389/fendo.2026.1734169

Effects of feeding European seabass (Dicentrarchus labrax) juveniles with crude, hydrolysed and fermented biomass of the invasive macroalga Rugulopteryx okamurae (Ochrophyta)

Autori: A.J. Vizcaíno, M.I. Sáez, A. Galafat, R. Galindo-Melero, E. Perera, I. Casal-Porras, E. Zubía, J. Vega, F.L. Figueroa, T.F. Martínez, J.A. Martos-Sitcha, F.J. Alarcón
Pubblicato in: Aquaculture Reports, Numero 34, 2025, Pagina/e 101877, ISSN 2352-5134
Editore: Elsevier BV
DOI: 10.1016/j.aqrep.2023.101877

Evaluation of White Grape Marc Extract as an Additive to Extend the Shelf-Life of Fish Fillets

Autori: María Isabel Sáez, Javier Sabio, Alba Galafat, Antonio Jesús Vizcaíno, Francisco Javier Alarcón-López, Tomás Francisco Martínez Moya
Pubblicato in: Foods, Numero 14, 2025, Pagina/e 1438, ISSN 2304-8158
Editore: MDPI AG
DOI: 10.3390/foods14081438

Isolation and Characterization of Lactic Acid Bacteria With Probiotic Attributes From Different Parts of the Gastrointestinal Tract of Free-living Wild Boars in Hungary

Autori: Tibor Keresztény, Balázs Libisch, Stephanya Corral Orbe, Tibor Nagy, Zoltán Kerényi, Róbert Kocsis, Katalin Posta, Péter P. Papp, Ferenc Olasz
Pubblicato in: Probiotics and Antimicrobial Proteins, Numero 16, 2024, Pagina/e 1221-1239, ISSN 1867-1306
Editore: Springer Pub. Co.,
DOI: 10.1007/s12602-023-10113-2

Optimization of bioactives extraction from grape marc via a medium scale ambient temperature system and stability study

Autori: Aly Castillo, María Celeiro, Laura Rubio, Andrea Bañobre, Miguel Otero-Otero, Carmen Garcia-Jares, Marta Lores
Pubblicato in: Frontiers in Nutrition, Numero 9, 2022, ISSN 2296-861X
Editore: Frontiers
DOI: 10.3389/fnut.2022.1008457

Evaluation of the Antimicrobial Capacity of a White Grape Marc Extract Through Gastrointestinal Digestion

Autori: Lorena G. Calvo, María Celeiro, Rosa-Antía Villarino, Ana G. Abril, Sandra Sánchez, José Luis R. Rama, Trinidad de Miguel
Pubblicato in: Applied Sciences, Numero 15, 2025, Pagina/e 6390, ISSN 2076-3417
Editore: MDPI AG
DOI: 10.3390/app15126390

In vivo tracking of grape marc biomarkers, bioconversion, metabolic tracers, and microbiota modulation in swine fed a polyphenol-rich extract diet

Autori: Aly Castillo, Maria Celeiro, Beatriz Martínez-Vallespín, Laura Rubio, Diego Gonzalez-Iglesias, Rocío Facorro, Carmen Garcia-Jares, Jürgen Zentek, Marta Lores
Pubblicato in: PLOS One, Numero 20, 2025, Pagina/e e0325079, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0325079

The effects of microalgal feed supplementation on growth and digestive function of Acipenser baerii and Sparus aurata

Autori: Jorge García-Márquez, Alejandro Morcillo-Guillén, Antonio J. Vizcaíno, Alba Galafat, María Isabel Sáez, Tomás Francisco Martínez, Luciano Foglio, Lorenzo Proietti, Tiziana Bongiorno, Francisco Gabriel Acién, Katia Parati, Francisco Javier Alarcón-López
Pubblicato in: Aquaculture, Numero 610, 2025, Pagina/e 742920, ISSN 0044-8486
Editore: Elsevier BV
DOI: 10.1016/j.aquaculture.2025.742920

Effects of Microalgae-Based Nutraceuticals on Muscle Composition and Intestinal Function in Juvenile Gilthead Seabream Fed Plant Protein-Based Diets

Autori: Alba Galafat, Isabel del Carmen Ruiz-Rodríguez, Alejandro Morcillo-Guillén, Anyell Caderno, Milagrosa Oliva, María Isabel Sáez, Antonio Jesús Vizcaíno, Tomás F. Martínez, Juan Antonio Martos-Sitcha, Francisco Javier Alarcón-López
Pubblicato in: Animals, Numero 16, 2026, Pagina/e 1350, ISSN 2076-2615
Editore: MDPI AG
DOI: 10.3390/ani16091350

Food Additives Derived from Fruits and Vegetables for Sustainable Animal Production and Their Impact in Latin America: An Alternative to the Use of Antibiotics

Autori: Marina Golowczyc, Andrea Gomez-Zavaglia
Pubblicato in: Foods, Numero 13, 2025, Pagina/e 2921, ISSN 2304-8158
Editore: MDPI AG
DOI: 10.3390/foods13182921