environmentAL Toxicity chEmical mixtuRes through aN innovative platform based on aged cardiac tissue model

Informations projet

ALTERNATIVE

N° de convention de subvention: 101037090

DOI

10.3030/101037090

Projet clôturé

Date de signature de la CE 2 Septembre 2021

Date de début 1 Octobre 2021

Date de fin 31 Mars 2025

Financé au titre de

• SOCIETAL CHALLENGES - Climate action, Environment, Resource Efficiency and Raw Materials

Coût total

€ 5 499 757,25

Contribution de l’UE

€ 5 499 757,25

Coordonné par

POLITECNICO DI TORINO
Italy

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (5)

Draft Guidance for regulatory use of the ALTERNATIVE platform

The guidance will include a detailed characterization of the individual ALTERNATIVE platform methods and describe how the data generated with these methods should be used by regulators, either as such or as a building block of the developed IATA for cardiotoxicity (D2.4). This deliverable is linked to T7.2 and could contain policy relevant information as it relates to how regulators should use/interpret information obtained by the ALTERNATIVE platform.

Intermediate dissemination and communication report

Provides an impact assessment of the dissemination and communication activities performed in the first 18 months of the project according to the plan outlined in D8.1. It describes the major performed activities and provides an updated plan for dissemination and communication in the second half of the project. This deliverable is linked to T8.1.

Documentation of regulatory needs for cardiotoxicity methods and data which can be used for consultation of national and European PARERE networks

Current regulatory data requirements across regulations will be reviewed and contextualized with ongoing European policy initiatives, scientific concern for cardiotoxicity and options for NAM based improvements. The resulting report shall be easily readable for regulators, shall contain questions for regulators and will be disseminated within the WP leads PARERE network of regulators. The resulting feedback will be evaluated. This deliverable is linked to T2.1 and is a policy related document.

Initial dissemination and communication plan

Describes the dissemination and communication strategy for the whole project and especially the first period up to M18. It describes the goals and target audiences and outlines the major planned dissemination and communication activities for the first half of the project. This deliverable is linked to T8.1.

Toxicological evidence

Systematic reviews for the identified compounds published as monographs and/or in scientific journals. This deliverable is linked to T3.2.

Open Research Data Pilot (1)

Data management plan

Outlines the data management policy and methods applicable to ALTERNATIVE data. It details actions for the overall control of data and summarises the types of data and sources, as well as how to handle the data. This deliverable is linked to T8.2.

Publications

Peer reviewed articles (9)

A systematic review and meta-analysis of human population studies on the association between exposure to toxic environmental chemicals and left ventricular dysfunction (LVD)

Auteurs: G. Donzelli, F. Sera, M.A. Morales, F. Vozzi, T. Roos, A. Schaffert, M. Paparella, S. Murugadoss, B. Mertens, R. Gehring, N. Linzalone
Publié dans: Environmental Research, Numéro 249, 2024, Page(s) 118429, ISSN 0013-9351
Éditeur: Academic Press
DOI: 10.1016/j.envres.2024.118429

Use of Polyesters in Fused Deposition Modeling for Biomedical Applications

Auteurs: Gianluca Ciardelli, Monica Boffito, Arianna Grivet-Brancot
Publié dans: Macromolecular bioscience, 2022, Page(s) -
Éditeur: Wiley Online Library
DOI: 10.1002/mabi.202200039

Artificial Intelligence and Machine Learning Methods to Evaluate Cardiotoxicity following the Adverse Outcome Pathway Frameworks

Auteurs: Edoardo Luca Viganò, Davide Ballabio, Alessandra Roncaglioni
Publié dans: Toxics, Numéro 12, 2024, Page(s) 87, ISSN 2305-6304
Éditeur: MDPI
DOI: 10.3390/toxics12010087

P14-03 Addressing cardiotoxicity in environmental chemical regulation: an integrated approach to cardiotoxicity testing

Auteurs: A. Schaffert, S. Murugadoss, B. Mertens, M. Paparella
Publié dans: Toxicology Letters, Numéro 399, 2024, Page(s) S226-S227, ISSN 0378-4274
Éditeur: Elsevier BV
DOI: 10.1016/j.toxlet.2024.07.556

Cardiac tissue engineering: Multiple approaches and potential applications

Auteurs: Ilaria Gisone, Antonella Cecchettini, Elisa Ceccherini, Elisa Persiani, Maria Aurora Morales, Federico Vozzi
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 3, 2022, Page(s) 1, ISSN 2296-4185
Éditeur: Frontiers
DOI: 10.3389/fbioe.2022.980393

CEC01-01 Introduction into the AOP framework: Integrating Theory and Practice in AOP Development

Auteurs: A. Schaffert, S. Murugadoss
Publié dans: Toxicology Letters, Numéro 399, 2024, Page(s) S4, ISSN 0378-4274
Éditeur: Elsevier BV
DOI: 10.1016/j.toxlet.2024.07.014

Ligand-based prediction of hERG-mediated cardiotoxicity based on the integration of different machine learning techniques

Auteurs: Pietro Delre, Giovanna J. Lavado, Giuseppe Lamanna, Michele Saviano, Alessandra Roncaglioni, Emilio Benfenati, Giuseppe Felice Nagiatordi, Domenico Gadaleta
Publié dans: Frontiers in Pharmacology, Numéro 13, 2022, Page(s) 1-13, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2022.951083

Protocol for a Systematic Review and Meta-Analysis of Observational Studies on the Association of Exposure to Toxic Environmental Pollutants and Left Ventricular Dysfunction

Auteurs: Nunzia Linzalone, Maria Aurora Morales, Federico Vozzi, Gabriele Donzelli
Publié dans: International Journal of Environmental Research and Public Health, Numéro 19, 2022, Page(s) 1-8, ISSN 1661-7827
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijerph19127482

Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals

Auteurs: Sivakumar Murugadoss, Birgit Mertens, Martin Paparella, Alexandra Schaffert
Publié dans: Alternatives to Animal Experimentation, Numéro Vol. 41 No. 1 (2024), 2024, Page(s) 14, ISSN 1868-8551
Éditeur: ALTEX
DOI: 10.14573/altex.2305011

Conference proceedings (23)

Designing 3D bioengineered in vitro cardiac tissue models as reliable tools for the evaluation of chemical cardiotoxicity

Auteurs: Monica Boffito, Susanna Sartori, Valeria Chiono, Federico Vozzi, Arianna Grivet-Brancot, Rossella Laurano,Roberta Pappalardo, Gianluca Ciardelli
Publié dans: ALTEX proceedings, Numéro Volume 10, page 64, No. 2, (2022), 2022
Éditeur: ALTEX Edition
DOI: 10.5281/zenodo.8367045

A Comprehensive Approach to Cardiotoxicity Assessment using Adverse Outcome Pathways

Auteurs: A. Schaffert, S. Murugadoss, B. Mertens, T. Roos, R. Gehring, N. Linzalone, G. Donzelli, M. Paparella
Publié dans: ALTEX Proceedings, 2024
Éditeur: ALTEX Edition
DOI: 10.58847/ap2402

Engineering 3D in vitro cardiac tissue models for cardiotoxicity assessment

Auteurs: Vozzi, F., Boffito, M., Gisone, I., Cecchettini, A., Del Ry, S., Cabiati, M., Sartori, S., Laurano, R., Grivet-Brancot, A., Pappalardo, R., & Ciardelli, G.
Publié dans: 2022
Éditeur: Biofabrication 2022
DOI: 10.5281/zenodo.8177565

Custom-made poly(ester urethane) tailored for 3D printing by Fused Deposition Modelling

Auteurs: Gianluca Ciardelli, Andrea Alliaud, Ariana Grivet Brancot, Rosella Laurano, Susanna Sartori, Moncia Boffito
Publié dans: TERMIS, 2023, Page(s) 843
Éditeur: TERMIS 2023 conference
DOI: 10.5281/zenodo.8186421

Innovative non-animal based testing platform to detect chemical-induced cardiotoxicity - A roadmap for regulatory uptake

Auteurs: Sivakumar Murugadoss, Alexandra Schaffert, Ronette Gehring, Tom Roos, Nunzia Linzalone, Gabriele Donzelli, Martin Paparella, Birgit Mertens
Publié dans: 2023
Éditeur: ASPIS Open Symposium 2023
DOI: 10.5281/zenodo.11382201

Tissue replica generation: the multifaceted contributions of cells and biomaterials

Auteurs: Federico Vozzi
Publié dans: 2023
Éditeur: ESB2023
DOI: 10.5281/zenodo.11367853

BIOENGINEERED 3D CARDIAC TISSUE MODEL FOR CARDIOTOXICITY STUDIES

Auteurs: Ilaria Gisone, Andrea Alliaud, Elisa Persiani, Rossella Laurano, Elisa Ceccherini, Maria Aurora Morales, Monica Boffito, Antonella Cecchettini, Gianluca Ciardelli
Publié dans: Abstracts of the 2nd Microphysiological Systems World Summit 2023, 2023
Éditeur: Altex
DOI: 10.58847/ap.2301

Design of 3D bioengineered cardiac tissue models for the evaluation of chemical cardiotoxicity

Auteurs: Ciardelli, Gianluca; Grivet-Brancot, Arianna; Chiono, Valeria; Sartori, Susanne, & Boffito, Monica
Publié dans: 2022
Éditeur: ESB 2022 conference
DOI: 10.5281/zenodo.8178217

ALTERNATIVE platform: an innovative tool for chemical cardiotoxicity detection

Auteurs: Gianluca Ciardelli, Susanna Sartori, Andrea Alliaud, Arianna Grivet-Brancot, Monica Boffito, Silvia Del Ry, Manuela Cabiati, Elisa Persiani, Elisa Ceccherini, Antonella Cecchettini, Federico Vozzi
Publié dans: 2024
Éditeur: Zenodo
DOI: 10.5281/zenodo.11353657

Multi-omics fingerprint of in vitro bioengineered heart-on-chip platform

Auteurs: Ilaria Gisone, Maria Guirro, Lorena García, Nerea Abasolo, Federico Vozzi, Nuria Canela, Salvador Fernández Arroyo
Publié dans: 2024
Éditeur: Zenodo
DOI: 10.5281/zenodo.11400752

3D printed PU/GelMA biphasic scaffold as cardiac tissue model.

Auteurs: Susanna Sartori, Andrea Alliaud, Monica Boffito, Gianluca Ciardelli, Arianna Grivet-Brancot
Publié dans: 2024
Éditeur: Zenodo
DOI: 10.5281/zenodo.11353780

The role of physiologically based kinetic modeling in interpreting the results of in vitro cell-based toxicity assays

Auteurs: Ronette Gehring
Publié dans: ESB2022 Main abstract book, 2022, Page(s) 333
Éditeur: ESB2022 conference
DOI: 10.5281/zenodo.8185809

Engineering of poly(urethane)-based porous constructs for cardiac tissue model design

Auteurs: Andrea Alliaud, Monica Boffito, Rossella Laurano, Susanna Sartori, Gianluca Ciardelli
Publié dans: 2024
Éditeur: Zenodo
DOI: 10.5281/zenodo.11350948

Proteomics reveals mechanisms of metabolic disruptive effects of emerging di-(2-ethylhexyl) phthalate substitutes

Auteurs: Alexandra Schaffert, Isabel Karkossa, Elke Ueberham, Rita Schlichting, Katharina Walter, Josi Arnold, Matthias Blüher, John T. Heiker, Jörg Lehmann, Martin Wabitsch, Beate I. Escher, Martin von Bergen, Kristin Schubert
Publié dans: ALTEX proceedings, Numéro Volume 10, No. 2, (2022), 2022, Page(s) 202, ISSN 2194-0479
Éditeur: ALTEX
DOI: 10.5281/zenodo.8367087

Evidenze sull'associazione tra l'esposizione a sostanze tossiche ambientali e disfunzione ventricolare sinistra: protocollo per una revisione sistematica e meta-analisi di letteratura.

Auteurs: Nunzia Linzalone, Gabriele Donzelli, Maria Aurora Morales, Federico Vozzi
Publié dans: 2022
Éditeur: XLVI Convegno dell’Associazione Italiana di Epidemiologia. Decisioni in contesti di incertezza: il ruolo dell'epidemiologia
DOI: 10.5281/zenodo.8177446

Collagen-derived biomaterials in tissue engineering and organ modelling

Auteurs: Ciardelli, Gianluca; Boffito, Monica; Tonda-Turo, Chiara; & Chiono, Valeria
Publié dans: 2022
Éditeur: ESIB CONFERENCE
DOI: 10.5281/zenodo.8177934

3D printed PU/GelMA biphasic scaffold for detecting the cardiotoxicity of chemicals

Auteurs: Susanna Sartori, Gianluca Ciardelli, Andrea Alliaud, Monica Boffito, Federico Vozzi, Ilaria Gisone, Antonella Cecchettini, Manuela Cabiati, Letizia Guiducci, Silvia Del Ry
Publié dans: 2022
Éditeur: Zenodo
DOI: 10.5281/zenodo.11352529

LIFTING THE BURDEN FROM ANIMALS AND THE HEART: A COMPREHENSIVE APPROACH TO CARDIOTOXICITY EVALUATION

Auteurs: Alexandra Schaffert, Sivakumar Murugadoss, Birgit Mertens, Tom Roos, Ronette Gehring, Nunzia Linzalone, Gabriele Donzelli, Martin Paparella
Publié dans: 2023
Éditeur: Austrian 3R Center
DOI: 10.5281/zenodo.11350443

Co-culture of hiPSC-CMs and ECs to mimic cardiac tissue

Auteurs: Ilaria Gisone, Manuela Cabiati, Elisa Ceccherini, Elisa Persiani, Letizia Guiducci, Antonella Cecchettini, Monica Boffito, Rossella Laurano, Gianluca Ciardelli, Federico Vozzi
Publié dans: 2023
Éditeur: SIOoC
DOI: 10.5281/zenodo.11368020

From Data Exploration to Predictive Models: Advanced ML and AI Techniques for Cardiotoxicity Analysis

Auteurs: Edoardo Viganò, Alessandra Roncaglioni
Publié dans: biomedical science and engineering, Numéro Volume 4, No. 1, 2023, ISSN 2531-9892
Éditeur: Pagepress
DOI: 10.4081/bse.226

ALTERNATIVE - Horizon 2020 project for building an innovative platform to assess the cardiotoxicity of chemicals

Auteurs: Gianluca Ciardelli
Publié dans: 2022
Éditeur: ESB 2022 conference
DOI: 10.5281/zenodo.11279640

Microfluidics for the pharmacological characterization of compounds on neurotransmitters transporters

Auteurs: Francesca Romana Brugnoli, Benjamin Garlan
Publié dans: 2024
Éditeur: Zenodo
DOI: 10.5281/zenodo.11350781

Reducing the Burden on Animals and the Heart: An Evidence-Based Approach to Cardiotoxicity

Auteurs: Alexandra Schaffert, Sivakumar Murugadoss, Martin Paparella, Birgit Mertens, Tom Roos, Ronette Gehring, Nunzia Linzalone, Gabriele Donzelli
Publié dans: Abstracts of the 12th World Congress on Alternatives and Animal Use in the Life Sciences, Niagara Falls 2023, 2023
Éditeur: ALTEX
DOI: 10.58847/ap.2302

Other (11)

White paper on REGULATION OF CHEMICAL EXPOSURES AND CARDIAC HEALTH: CURRENT GAPS AND FUTURE SOLUTIONS

Auteurs: A. Schaffert, S. Murugadoss, M. Paprella, B. Mertens, A. Gavras, P. Mohnani
Publié dans: 2023
Éditeur: Zenodo
DOI: 10.5281/zenodo.10021900

TAILOR-MADE POLYMERS: AN ADDITIONAL DEGREE OF FREEDOM IN THE TUNING OF MECHANICAL PROPERTIES IN TISSUE MODELING

Auteurs: Gianluca Ciardelli
Publié dans: 2022
Éditeur: Zenodo
DOI: 10.5281/zenodo.12705562

The role of physiologically-based kinetic (PBK) models within the new approach methodologies framework for predicting cardiotoxicity

Auteurs: Ronette Gehring, Tom Roos, Zhicheng Zhang
Publié dans: 2022
Éditeur: EUSAAT congress
DOI: 10.5281/zenodo.11281251

ALTERNATIVE project flyer

Auteurs: Pooja Mohnani
Publié dans: 2021
Éditeur: ALTERNATIVE

White paper on MPS

Auteurs: Susanna Sartori, Federico Vozzi, Gianluca Ciardelli, Monica Boffito, Tommaso Sbrana, Miguel Berenguel Alonso, Salvador Fernández Arroyo, Adam Anglart
Publié dans: 2022
Éditeur: ALTERNATIVE project
DOI: 10.5281/zenodo.7350571

Innovative non-animal based testing platform to detect chemical-induced cardiotoxicity - A roadmap for regulatory uptake

Auteurs: Sivakumar Murugadoss, Birgit Mertens, Martin Paparella, Ronette Gehring, Nunzia Linzalone, Tom Roos, Alexandra Schaffert, Gabriele Donzelli
Publié dans: 2023
Éditeur: EUROTOX 2023
DOI: 10.5281/zenodo.11381430

Achieving zero pollution by 2050 needs regulatory change: a call for policy support of New Approach Methodologies (NAMs)

Auteurs: Martin Paparella, Alexandra Schaffert
Publié dans: 2024
Éditeur: Zenodo
DOI: 10.5281/zenodo.13378369

Monitoring environmental parameters in microfluidic cell culture

Auteurs: C. Betterelli Giuliano, L. Muiznieks, M. Kopf
Publié dans: 2022
Éditeur: Zenodo
DOI: 10.5281/zenodo.14923212

Cardiotoxicity of chemicals: Current regulatory guidelines, knowledge gaps, and needs

Auteurs: Alexandra Schaffert, Sivakumar Murugadoss, Birgit Mertens, Martin Paparella
Publié dans: 2023, Page(s) 337-340
Éditeur: ALTEX
DOI: 10.14573/altex.2301121

WHITE PAPER ON ARTIFICIAL INTELLIGENCE (AI) AND MACHINE LEARNING (ML) APPLIED TO TOXICOLOGY FOR HUMAN HEALTH PROTECTION WITH A FOCUS ON EPIDEMIOLOGY

Auteurs: N. Linzalone, F. Vozzi, B. Mertens
Publié dans: 2025
Éditeur: Zenodo
DOI: 10.5281/zenodo.14832230

Stimulating the regulatory acceptance of a novel platform developed for the assessment of chemical-induced cardiotoxicity

Auteurs: Sivakumar Murugadoss, Birgit Mertens, Martin Paparella, Ronette Gehring, Alexandra Schaffert, Tom Roos, Nunzia Linzalone
Publié dans: BELTOX ANNUAL MEETING 2022 ON THE CURRENT STATE OF KNOWLEDGE OF THE TOXICOLOGY AND ECOTOXICOLOGY OF PFAS, 2024
Éditeur: Beltox
DOI: 10.5281/zenodo.11381282

Non-peer reviewed articles (1)

S11-03 New Approach Methodologies for cardiac toxicity assessment: the ALTERNATIVE perspective

Auteurs: F. Vozzi
Publié dans: Toxicology Letters, Numéro 399, 2024, Page(s) S25, ISSN 0378-4274
Éditeur: Elsevier BV
DOI: 10.1016/j.toxlet.2024.07.079

Book chapters (1)

Artificial Intelligence Methods for Evaluating Mitochondrial Dysfunction: Exploring Various Chemical Notations Suitable for Neural Language Processing Models

Auteurs: Edoardo Luca Viganò, Erika Colombo, Davide Ballabio, Alessandra Roncaglioni
Publié dans: Lecture Notes in Computer Science, AI in Drug Discovery, 2024, Page(s) 116-131
Éditeur: Springer Nature Switzerland
DOI: 10.1007/978-3-031-72381-0_10