environmentAL Toxicity chEmical mixtuRes through aN innovative platform based on aged cardiac tissue model

Informacje na temat projektu

ALTERNATIVE

Identyfikator umowy o grant: 101037090

DOI

10.3030/101037090

Projekt został zamknięty

Data podpisania przez KE 2 Września 2021

Data rozpoczęcia 1 Października 2021

Data zakończenia 31 Marca 2025

Finansowanie w ramach

• SOCIETAL CHALLENGES - Climate action, Environment, Resource Efficiency and Raw Materials

Koszt całkowity

€ 5 499 757,25

Wkład UE

€ 5 499 757,25

Koordynowany przez

POLITECNICO DI TORINO
Italy

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (5)

Draft Guidance for regulatory use of the ALTERNATIVE platform

The guidance will include a detailed characterization of the individual ALTERNATIVE platform methods and describe how the data generated with these methods should be used by regulators, either as such or as a building block of the developed IATA for cardiotoxicity (D2.4). This deliverable is linked to T7.2 and could contain policy relevant information as it relates to how regulators should use/interpret information obtained by the ALTERNATIVE platform.

Intermediate dissemination and communication report

Provides an impact assessment of the dissemination and communication activities performed in the first 18 months of the project according to the plan outlined in D8.1. It describes the major performed activities and provides an updated plan for dissemination and communication in the second half of the project. This deliverable is linked to T8.1.

Documentation of regulatory needs for cardiotoxicity methods and data which can be used for consultation of national and European PARERE networks

Current regulatory data requirements across regulations will be reviewed and contextualized with ongoing European policy initiatives, scientific concern for cardiotoxicity and options for NAM based improvements. The resulting report shall be easily readable for regulators, shall contain questions for regulators and will be disseminated within the WP leads PARERE network of regulators. The resulting feedback will be evaluated. This deliverable is linked to T2.1 and is a policy related document.

Initial dissemination and communication plan

Describes the dissemination and communication strategy for the whole project and especially the first period up to M18. It describes the goals and target audiences and outlines the major planned dissemination and communication activities for the first half of the project. This deliverable is linked to T8.1.

Toxicological evidence

Systematic reviews for the identified compounds published as monographs and/or in scientific journals. This deliverable is linked to T3.2.

Open Research Data Pilot (1)

Data management plan

Outlines the data management policy and methods applicable to ALTERNATIVE data. It details actions for the overall control of data and summarises the types of data and sources, as well as how to handle the data. This deliverable is linked to T8.2.

Publikacje

Peer reviewed articles (9)

A systematic review and meta-analysis of human population studies on the association between exposure to toxic environmental chemicals and left ventricular dysfunction (LVD)

Autorzy: G. Donzelli, F. Sera, M.A. Morales, F. Vozzi, T. Roos, A. Schaffert, M. Paparella, S. Murugadoss, B. Mertens, R. Gehring, N. Linzalone
Opublikowane w: Environmental Research, Numer 249, 2024, Strona(/y) 118429, ISSN 0013-9351
Wydawca: Academic Press
DOI: 10.1016/j.envres.2024.118429

Use of Polyesters in Fused Deposition Modeling for Biomedical Applications

Autorzy: Gianluca Ciardelli, Monica Boffito, Arianna Grivet-Brancot
Opublikowane w: Macromolecular bioscience, 2022, Strona(/y) -
Wydawca: Wiley Online Library
DOI: 10.1002/mabi.202200039

Artificial Intelligence and Machine Learning Methods to Evaluate Cardiotoxicity following the Adverse Outcome Pathway Frameworks

Autorzy: Edoardo Luca Viganò, Davide Ballabio, Alessandra Roncaglioni
Opublikowane w: Toxics, Numer 12, 2024, Strona(/y) 87, ISSN 2305-6304
Wydawca: MDPI
DOI: 10.3390/toxics12010087

P14-03 Addressing cardiotoxicity in environmental chemical regulation: an integrated approach to cardiotoxicity testing

Autorzy: A. Schaffert, S. Murugadoss, B. Mertens, M. Paparella
Opublikowane w: Toxicology Letters, Numer 399, 2024, Strona(/y) S226-S227, ISSN 0378-4274
Wydawca: Elsevier BV
DOI: 10.1016/j.toxlet.2024.07.556

Cardiac tissue engineering: Multiple approaches and potential applications

Autorzy: Ilaria Gisone, Antonella Cecchettini, Elisa Ceccherini, Elisa Persiani, Maria Aurora Morales, Federico Vozzi
Opublikowane w: Frontiers in Bioengineering and Biotechnology, Numer 3, 2022, Strona(/y) 1, ISSN 2296-4185
Wydawca: Frontiers
DOI: 10.3389/fbioe.2022.980393

CEC01-01 Introduction into the AOP framework: Integrating Theory and Practice in AOP Development

Autorzy: A. Schaffert, S. Murugadoss
Opublikowane w: Toxicology Letters, Numer 399, 2024, Strona(/y) S4, ISSN 0378-4274
Wydawca: Elsevier BV
DOI: 10.1016/j.toxlet.2024.07.014

Ligand-based prediction of hERG-mediated cardiotoxicity based on the integration of different machine learning techniques

Autorzy: Pietro Delre, Giovanna J. Lavado, Giuseppe Lamanna, Michele Saviano, Alessandra Roncaglioni, Emilio Benfenati, Giuseppe Felice Nagiatordi, Domenico Gadaleta
Opublikowane w: Frontiers in Pharmacology, Numer 13, 2022, Strona(/y) 1-13, ISSN 1663-9812
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fphar.2022.951083

Protocol for a Systematic Review and Meta-Analysis of Observational Studies on the Association of Exposure to Toxic Environmental Pollutants and Left Ventricular Dysfunction

Autorzy: Nunzia Linzalone, Maria Aurora Morales, Federico Vozzi, Gabriele Donzelli
Opublikowane w: International Journal of Environmental Research and Public Health, Numer 19, 2022, Strona(/y) 1-8, ISSN 1661-7827
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijerph19127482

Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals

Autorzy: Sivakumar Murugadoss, Birgit Mertens, Martin Paparella, Alexandra Schaffert
Opublikowane w: Alternatives to Animal Experimentation, Numer Vol. 41 No. 1 (2024), 2024, Strona(/y) 14, ISSN 1868-8551
Wydawca: ALTEX
DOI: 10.14573/altex.2305011

Conference proceedings (23)

Designing 3D bioengineered in vitro cardiac tissue models as reliable tools for the evaluation of chemical cardiotoxicity

Autorzy: Monica Boffito, Susanna Sartori, Valeria Chiono, Federico Vozzi, Arianna Grivet-Brancot, Rossella Laurano,Roberta Pappalardo, Gianluca Ciardelli
Opublikowane w: ALTEX proceedings, Numer Volume 10, page 64, No. 2, (2022), 2022
Wydawca: ALTEX Edition
DOI: 10.5281/zenodo.8367045

A Comprehensive Approach to Cardiotoxicity Assessment using Adverse Outcome Pathways

Autorzy: A. Schaffert, S. Murugadoss, B. Mertens, T. Roos, R. Gehring, N. Linzalone, G. Donzelli, M. Paparella
Opublikowane w: ALTEX Proceedings, 2024
Wydawca: ALTEX Edition
DOI: 10.58847/ap2402

Engineering 3D in vitro cardiac tissue models for cardiotoxicity assessment

Autorzy: Vozzi, F., Boffito, M., Gisone, I., Cecchettini, A., Del Ry, S., Cabiati, M., Sartori, S., Laurano, R., Grivet-Brancot, A., Pappalardo, R., & Ciardelli, G.
Opublikowane w: 2022
Wydawca: Biofabrication 2022
DOI: 10.5281/zenodo.8177565

Custom-made poly(ester urethane) tailored for 3D printing by Fused Deposition Modelling

Autorzy: Gianluca Ciardelli, Andrea Alliaud, Ariana Grivet Brancot, Rosella Laurano, Susanna Sartori, Moncia Boffito
Opublikowane w: TERMIS, 2023, Strona(/y) 843
Wydawca: TERMIS 2023 conference
DOI: 10.5281/zenodo.8186421

Innovative non-animal based testing platform to detect chemical-induced cardiotoxicity - A roadmap for regulatory uptake

Autorzy: Sivakumar Murugadoss, Alexandra Schaffert, Ronette Gehring, Tom Roos, Nunzia Linzalone, Gabriele Donzelli, Martin Paparella, Birgit Mertens
Opublikowane w: 2023
Wydawca: ASPIS Open Symposium 2023
DOI: 10.5281/zenodo.11382201

Tissue replica generation: the multifaceted contributions of cells and biomaterials

Autorzy: Federico Vozzi
Opublikowane w: 2023
Wydawca: ESB2023
DOI: 10.5281/zenodo.11367853

BIOENGINEERED 3D CARDIAC TISSUE MODEL FOR CARDIOTOXICITY STUDIES

Autorzy: Ilaria Gisone, Andrea Alliaud, Elisa Persiani, Rossella Laurano, Elisa Ceccherini, Maria Aurora Morales, Monica Boffito, Antonella Cecchettini, Gianluca Ciardelli
Opublikowane w: Abstracts of the 2nd Microphysiological Systems World Summit 2023, 2023
Wydawca: Altex
DOI: 10.58847/ap.2301

Design of 3D bioengineered cardiac tissue models for the evaluation of chemical cardiotoxicity

Autorzy: Ciardelli, Gianluca; Grivet-Brancot, Arianna; Chiono, Valeria; Sartori, Susanne, & Boffito, Monica
Opublikowane w: 2022
Wydawca: ESB 2022 conference
DOI: 10.5281/zenodo.8178217

ALTERNATIVE platform: an innovative tool for chemical cardiotoxicity detection

Autorzy: Gianluca Ciardelli, Susanna Sartori, Andrea Alliaud, Arianna Grivet-Brancot, Monica Boffito, Silvia Del Ry, Manuela Cabiati, Elisa Persiani, Elisa Ceccherini, Antonella Cecchettini, Federico Vozzi
Opublikowane w: 2024
Wydawca: Zenodo
DOI: 10.5281/zenodo.11353657

Multi-omics fingerprint of in vitro bioengineered heart-on-chip platform

Autorzy: Ilaria Gisone, Maria Guirro, Lorena García, Nerea Abasolo, Federico Vozzi, Nuria Canela, Salvador Fernández Arroyo
Opublikowane w: 2024
Wydawca: Zenodo
DOI: 10.5281/zenodo.11400752

3D printed PU/GelMA biphasic scaffold as cardiac tissue model.

Autorzy: Susanna Sartori, Andrea Alliaud, Monica Boffito, Gianluca Ciardelli, Arianna Grivet-Brancot
Opublikowane w: 2024
Wydawca: Zenodo
DOI: 10.5281/zenodo.11353780

The role of physiologically based kinetic modeling in interpreting the results of in vitro cell-based toxicity assays

Autorzy: Ronette Gehring
Opublikowane w: ESB2022 Main abstract book, 2022, Strona(/y) 333
Wydawca: ESB2022 conference
DOI: 10.5281/zenodo.8185809

Engineering of poly(urethane)-based porous constructs for cardiac tissue model design

Autorzy: Andrea Alliaud, Monica Boffito, Rossella Laurano, Susanna Sartori, Gianluca Ciardelli
Opublikowane w: 2024
Wydawca: Zenodo
DOI: 10.5281/zenodo.11350948

Proteomics reveals mechanisms of metabolic disruptive effects of emerging di-(2-ethylhexyl) phthalate substitutes

Autorzy: Alexandra Schaffert, Isabel Karkossa, Elke Ueberham, Rita Schlichting, Katharina Walter, Josi Arnold, Matthias Blüher, John T. Heiker, Jörg Lehmann, Martin Wabitsch, Beate I. Escher, Martin von Bergen, Kristin Schubert
Opublikowane w: ALTEX proceedings, Numer Volume 10, No. 2, (2022), 2022, Strona(/y) 202, ISSN 2194-0479
Wydawca: ALTEX
DOI: 10.5281/zenodo.8367087

Evidenze sull'associazione tra l'esposizione a sostanze tossiche ambientali e disfunzione ventricolare sinistra: protocollo per una revisione sistematica e meta-analisi di letteratura.

Autorzy: Nunzia Linzalone, Gabriele Donzelli, Maria Aurora Morales, Federico Vozzi
Opublikowane w: 2022
Wydawca: XLVI Convegno dell’Associazione Italiana di Epidemiologia. Decisioni in contesti di incertezza: il ruolo dell'epidemiologia
DOI: 10.5281/zenodo.8177446

Collagen-derived biomaterials in tissue engineering and organ modelling

Autorzy: Ciardelli, Gianluca; Boffito, Monica; Tonda-Turo, Chiara; & Chiono, Valeria
Opublikowane w: 2022
Wydawca: ESIB CONFERENCE
DOI: 10.5281/zenodo.8177934

3D printed PU/GelMA biphasic scaffold for detecting the cardiotoxicity of chemicals

Autorzy: Susanna Sartori, Gianluca Ciardelli, Andrea Alliaud, Monica Boffito, Federico Vozzi, Ilaria Gisone, Antonella Cecchettini, Manuela Cabiati, Letizia Guiducci, Silvia Del Ry
Opublikowane w: 2022
Wydawca: Zenodo
DOI: 10.5281/zenodo.11352529

LIFTING THE BURDEN FROM ANIMALS AND THE HEART: A COMPREHENSIVE APPROACH TO CARDIOTOXICITY EVALUATION

Autorzy: Alexandra Schaffert, Sivakumar Murugadoss, Birgit Mertens, Tom Roos, Ronette Gehring, Nunzia Linzalone, Gabriele Donzelli, Martin Paparella
Opublikowane w: 2023
Wydawca: Austrian 3R Center
DOI: 10.5281/zenodo.11350443

Co-culture of hiPSC-CMs and ECs to mimic cardiac tissue

Autorzy: Ilaria Gisone, Manuela Cabiati, Elisa Ceccherini, Elisa Persiani, Letizia Guiducci, Antonella Cecchettini, Monica Boffito, Rossella Laurano, Gianluca Ciardelli, Federico Vozzi
Opublikowane w: 2023
Wydawca: SIOoC
DOI: 10.5281/zenodo.11368020

From Data Exploration to Predictive Models: Advanced ML and AI Techniques for Cardiotoxicity Analysis

Autorzy: Edoardo Viganò, Alessandra Roncaglioni
Opublikowane w: biomedical science and engineering, Numer Volume 4, No. 1, 2023, ISSN 2531-9892
Wydawca: Pagepress
DOI: 10.4081/bse.226

ALTERNATIVE - Horizon 2020 project for building an innovative platform to assess the cardiotoxicity of chemicals

Autorzy: Gianluca Ciardelli
Opublikowane w: 2022
Wydawca: ESB 2022 conference
DOI: 10.5281/zenodo.11279640

Microfluidics for the pharmacological characterization of compounds on neurotransmitters transporters

Autorzy: Francesca Romana Brugnoli, Benjamin Garlan
Opublikowane w: 2024
Wydawca: Zenodo
DOI: 10.5281/zenodo.11350781

Reducing the Burden on Animals and the Heart: An Evidence-Based Approach to Cardiotoxicity

Autorzy: Alexandra Schaffert, Sivakumar Murugadoss, Martin Paparella, Birgit Mertens, Tom Roos, Ronette Gehring, Nunzia Linzalone, Gabriele Donzelli
Opublikowane w: Abstracts of the 12th World Congress on Alternatives and Animal Use in the Life Sciences, Niagara Falls 2023, 2023
Wydawca: ALTEX
DOI: 10.58847/ap.2302

Other (11)

White paper on REGULATION OF CHEMICAL EXPOSURES AND CARDIAC HEALTH: CURRENT GAPS AND FUTURE SOLUTIONS

Autorzy: A. Schaffert, S. Murugadoss, M. Paprella, B. Mertens, A. Gavras, P. Mohnani
Opublikowane w: 2023
Wydawca: Zenodo
DOI: 10.5281/zenodo.10021900

TAILOR-MADE POLYMERS: AN ADDITIONAL DEGREE OF FREEDOM IN THE TUNING OF MECHANICAL PROPERTIES IN TISSUE MODELING

Autorzy: Gianluca Ciardelli
Opublikowane w: 2022
Wydawca: Zenodo
DOI: 10.5281/zenodo.12705562

The role of physiologically-based kinetic (PBK) models within the new approach methodologies framework for predicting cardiotoxicity

Autorzy: Ronette Gehring, Tom Roos, Zhicheng Zhang
Opublikowane w: 2022
Wydawca: EUSAAT congress
DOI: 10.5281/zenodo.11281251

ALTERNATIVE project flyer

Autorzy: Pooja Mohnani
Opublikowane w: 2021
Wydawca: ALTERNATIVE

White paper on MPS

Autorzy: Susanna Sartori, Federico Vozzi, Gianluca Ciardelli, Monica Boffito, Tommaso Sbrana, Miguel Berenguel Alonso, Salvador Fernández Arroyo, Adam Anglart
Opublikowane w: 2022
Wydawca: ALTERNATIVE project
DOI: 10.5281/zenodo.7350571

Innovative non-animal based testing platform to detect chemical-induced cardiotoxicity - A roadmap for regulatory uptake

Autorzy: Sivakumar Murugadoss, Birgit Mertens, Martin Paparella, Ronette Gehring, Nunzia Linzalone, Tom Roos, Alexandra Schaffert, Gabriele Donzelli
Opublikowane w: 2023
Wydawca: EUROTOX 2023
DOI: 10.5281/zenodo.11381430

Achieving zero pollution by 2050 needs regulatory change: a call for policy support of New Approach Methodologies (NAMs)

Autorzy: Martin Paparella, Alexandra Schaffert
Opublikowane w: 2024
Wydawca: Zenodo
DOI: 10.5281/zenodo.13378369

Monitoring environmental parameters in microfluidic cell culture

Autorzy: C. Betterelli Giuliano, L. Muiznieks, M. Kopf
Opublikowane w: 2022
Wydawca: Zenodo
DOI: 10.5281/zenodo.14923212

Cardiotoxicity of chemicals: Current regulatory guidelines, knowledge gaps, and needs

Autorzy: Alexandra Schaffert, Sivakumar Murugadoss, Birgit Mertens, Martin Paparella
Opublikowane w: 2023, Strona(/y) 337-340
Wydawca: ALTEX
DOI: 10.14573/altex.2301121

WHITE PAPER ON ARTIFICIAL INTELLIGENCE (AI) AND MACHINE LEARNING (ML) APPLIED TO TOXICOLOGY FOR HUMAN HEALTH PROTECTION WITH A FOCUS ON EPIDEMIOLOGY

Autorzy: N. Linzalone, F. Vozzi, B. Mertens
Opublikowane w: 2025
Wydawca: Zenodo
DOI: 10.5281/zenodo.14832230

Stimulating the regulatory acceptance of a novel platform developed for the assessment of chemical-induced cardiotoxicity

Autorzy: Sivakumar Murugadoss, Birgit Mertens, Martin Paparella, Ronette Gehring, Alexandra Schaffert, Tom Roos, Nunzia Linzalone
Opublikowane w: BELTOX ANNUAL MEETING 2022 ON THE CURRENT STATE OF KNOWLEDGE OF THE TOXICOLOGY AND ECOTOXICOLOGY OF PFAS, 2024
Wydawca: Beltox
DOI: 10.5281/zenodo.11381282

Non-peer reviewed articles (1)

S11-03 New Approach Methodologies for cardiac toxicity assessment: the ALTERNATIVE perspective

Autorzy: F. Vozzi
Opublikowane w: Toxicology Letters, Numer 399, 2024, Strona(/y) S25, ISSN 0378-4274
Wydawca: Elsevier BV
DOI: 10.1016/j.toxlet.2024.07.079

Book chapters (1)

Artificial Intelligence Methods for Evaluating Mitochondrial Dysfunction: Exploring Various Chemical Notations Suitable for Neural Language Processing Models

Autorzy: Edoardo Luca Viganò, Erika Colombo, Davide Ballabio, Alessandra Roncaglioni
Opublikowane w: Lecture Notes in Computer Science, AI in Drug Discovery, 2024, Strona(/y) 116-131
Wydawca: Springer Nature Switzerland
DOI: 10.1007/978-3-031-72381-0_10