BUILDING A SUSTAINABLE EUROPEAN INNOVATION PLATFORM TO ENHANCE THE REPURPOSING OF MEDICINES FOR ALL

Project Information

REMEDi4ALL

Grant agreement ID: 101057442

DOI

10.3030/101057442

EC signature date 19 May 2022

Start date 1 September 2022

End date 31 August 2027

Funded under

• Health

Total cost

€ 22 561 532,00

EU contribution

€ 22 561 532,00

Coordinated by

EATRIS ERIC
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (6)

Report on AI tools and data resource

Report on existing AI tools and data resources carefully tested, ranked and classified for various repurposing applications.

Training landscape map

Report summarising existing information training and support in DR with publicfacing signposting to existing repurposing resources and trainings

Report on establishment of the Funders network

Documentation of commitment of funders that are motivated to join the Repurposing Funders Network, including Charter.

Report on the strategy and roadmap for collaboration with other synergies

This report will provide a guide of synergies with other projects and networks to be implemented during the project the methodological framework process and sources for the identification of projects with which to build synergies

Report on the 1st Annual Conference

Report on the 1st Annual Conference describing program highlights, attendees, interactions with key stakeholders and suggestions for agenda and organisation of next conference.

Report on services, expertise, barriers in the clinical development

Report describing the mapping of the clinical drug repruposing landscape identification of barriers gap analysis and blueprint report focusing on the clinical development

Publications

Peer reviewed articles (16)

Integrated drug profiling and CRISPR screening identify BCR::ABL1-independent vulnerabilities in chronic myeloid leukemia

Author(s): Adnan Awad, Shady; Dufva, Olli; Klievink, Jay; Karjalainen, Ella; Ianevski, Aleksandr; Pietarinen, Paavo; Kim, Daehong; Potdar, Swapnil; Wolf, Maija; Lotfi, Kourosh; Aittokallio, Tero; Wennerberg, Krister; Porkka, Kimmo; Mustjoki, Satu
Published in: Cell Reports Medicine, 2024, ISSN 2666-3791
Publisher: Elsevier
DOI: 10.1016/J.XCRM.2024.101521

Medical Management for Fracture Prevention in Children with Osteogenesis Imperfecta

Author(s): Paul Arundel; Nick Bishop
Published in: Calcified Tissue International, 2024, ISSN 1432-0827
Publisher: Springer Nature
DOI: 10.1007/S00223-024-01202-7

Robust scoring of selective drug responses for patient-tailored therapy selection

Author(s): Yingjia Chen; Liye He; Aleksandr Ianevski; Pilar Ayuda-Durán; Swapnil Potdar; Jani Saarela; Juho J. Miettinen; Sari Kytölä; Susanna Miettinen; Mikko Manninen; Caroline A. Heckman; Jorrit M. Enserink; Krister Wennerberg; Tero Aittokallio
Published in: Nature Protocols, 2023, ISSN 1750-2799
Publisher: Nature Portfolio
DOI: 10.1038/S41596-023-00903-X

Randomized phase 2 study of valproic acid combined with simvastatin and gemcitabine/nab-paclitaxel-based regimens in untreated metastatic pancreatic adenocarcinoma patients: the VESPA trial study protocol

Author(s): Alfredo Budillon, Alessandra Leone, Eugenia Passaro, Lucrezia Silvestro, Francesca Foschini, Federica Iannelli, Maria Serena Roca, Marina Macchini, Francesca Bruzzese, Maria Laura Garcia Bermejo, Mercedes Rodriguez Garrote, Giampaolo Tortora, Michele Mile
Published in: BMC Cancer, 2024, ISSN 1471-2407
Publisher: BioMed Central
DOI: 10.1186/S12885-024-12936-W

Improved Detection of Drug-Induced Liver Injury by Integrating Predicted<i>in vivo</i>and<i>in vitro</i>Data

Author(s): Srijit Seal; Dominic P. Williams; Layla Hosseini-Gerami; Manas Mahale; Anne E. Carpenter; Ola Spjuth; Andreas Bender
Published in: Chemical Research in Toxicology, 2024, ISSN 1520-5010
Publisher: American Chemical Society
DOI: 10.1021/ACS.CHEMRESTOX.4C00015

Nature Communications

Author(s): Aleksandr Ianevski; Kristen Nader; Kyriaki Driva; Wojciech Senkowski; Daria Bulanova; Lidia Moyano-Galceran; Tanja Ruokoranta; Heikki Kuusanmäki; Nemo Ikonen; Philipp Sergeev; Markus Vähä-Koskela; Anil K. Giri; Anna Vähärautio; Mika Kontro; Kimmo Porkka; Esa Pitkänen; Caroline A. Heckman; Krister Wennerberg; Tero Aittokallio
Published in: Single-cell transcriptomes identify patient-tailored therapies for selective co-inhibition of cancer clones, 2024, ISSN 2041-1723
Publisher: Springer Nature
DOI: 10.1038/S41467-024-52980-5

RepurposeDrugs: an interactive web-portal and predictive platform for repurposing mono- and combination therapies

Author(s): Aleksandr Ianevski; Aleksandr Kushnir; Kristen Nader; Mitro Miihkinen; Henri Xhaard; Tero Aittokallio; Ziaurrehman Tanoli
Published in: Briefings in Bioinformatics, 2024, ISSN 1477-4054
Publisher: Oxford University Press
DOI: 10.1093/BIB/BBAE328

Cell Painting: a decade of discovery and innovation in cellular imaging

Author(s): Seal, Srijit; Trapotsi, Maria-Anna; Spjuth, Ola; Singh, Shantanu; Carreras-Puigvert, Jordi; Greene, Nigel; Bender, Andreas; Carpenter, Anne E
Published in: Nature Methods, 2024, ISSN 1548-7105
Publisher: Nature Portfolio
DOI: 10.17863/CAM.112378

Artificial intelligence for high content imaging in drug discovery

Author(s): Jordi Carreras-Puigvert; Ola Spjuth
Published in: Current Opinion in Structural Biology, 2024, ISSN 1879-033X
Publisher: Elsevier
DOI: 10.1016/J.SBI.2024.102842

HPR155 Drug Repurposing: Policy Barriers to Using Existing Pharmaceuticals in New Indications: Results of a Systematic Literature Review

Author(s): Z Petykó, D Hosszú, M Csanádi, GD Obeng, D Ameyaw, K Gyöngyösi, HG van der Meer, P Pantziarka, Z Kalo, A Inotai
Published in: Value in Health, Issue 27, 2024, ISSN 1098-3015
Publisher: Elsevier BV
DOI: 10.1016/J.JVAL.2024.10.1581

From pixels to phenotypes: Integrating image-based profiling with cell health data as BioMorph features improves interpretability

Author(s): Srijit Seal; Jordi Carreras-Puigvert; Shantanu Singh; Anne E. Carpenter; Ola Spjuth; Andreas Bender
Published in: Molecular Biology of the Cell, 2024, ISSN 1939-4586
Publisher: American Society for Cell Biology
DOI: 10.1091/MBC.E23-08-0298

Attention-based approach to predict drug-target interactions across seven target superfamilies

Author(s): Aron Schulman; Juho Rousu; Tero Aittokallio; Ziaurrehman Tanoli
Published in: Bioinformatics, 2024, ISSN 1367-4811
Publisher: Oxford University Press
DOI: 10.1093/BIOINFORMATICS/BTAE496

Drug repurposing in Rett and Rett-like syndromes: a promising yet underrated opportunity?

Author(s): Claudia Fuchs; Peter A. C. ‘t Hoen; Annelieke R. Müller; Annelieke R. Müller; Annelieke R. Müller; Friederike Ehrhart; Clara D. M. Van Karnebeek; Clara D. M. Van Karnebeek; Clara D. M. Van Karnebeek
Published in: Frontiers in Medicine, 2024, ISSN 2296-858X
Publisher: Frontiers Media
DOI: 10.3389/FMED.2024.1425038

Exploring SureChEMBL from a drug discovery perspective

Author(s): Yojana Gadiya; Simran Shetty; Martin Hofmann-Apitius; Philip Gribbon; Andrea Zaliani
Published in: Nature Scientific Data, 2024, ISSN 2052-4463
Publisher: Nature Portfolio
DOI: 10.1038/S41597-024-03371-4

Drug repurposing for rare: progress and opportunities for the rare disease community

Author(s): Anneliene Hechtelt Jonker; Anneliene Hechtelt Jonker; Daniel O’Connor; Daniel O’Connor; Maria Cavaller-Bellaubi; Maria Cavaller-Bellaubi; Christine Fetro; Christine Fetro; Maria Gogou; Maria Gogou; Peter A. C. ’T Hoen; Peter A. C. ’T Hoen; Martin de Kort; Martin de Kort; Heather Stone; Heather Stone; Nivedita Valentine; Nivedita Valentine; Anna Maria Gerdina Pasmooij; Anna Maria Gerdina Pasmooij
Published in: Frontiers in Medicine, 2024, ISSN 2296-858X
Publisher: Frontiers Media
DOI: 10.3389/FMED.2024.1352803

Insights into Drug Cardiotoxicity from Biological and Chemical Data: The First Public Classifiers for FDA Drug-Induced Cardiotoxicity Rank

Author(s): Srijit Seal; Ola Spjuth; Layla Hosseini-Gerami; Miguel García-Ortegón; Shantanu Singh; Andreas Bender; Anne E. Carpenter
Published in: Journal of Chemical Information and Modeling, 2024, ISSN 1520-5142
Publisher: American Chemical Society
DOI: 10.1021/ACS.JCIM.3C01834

Other (1)

REMEDi4ALL - Standard Operating Guideline - Fair Data Assessment

Author(s): Gadiya, Yojana; Zaliani, Andrea
Published in: Zenodo, 2025
Publisher: Zenodo
DOI: 10.5281/ZENODO.14605175