Objective
The ability of eukaryotic cells to generate and resist mechanical forces, locomote and spatially organize their subcellular structures relies on the cytoskeleton. The hallmark of cytoskeletal proteins is their ability to polymerize into filaments, which in turn organize into cellular-scale networks that support a variety of functions that require the generation of mechanical force. Decades of work have significantly increased our knowledge of the composition and mechanisms of force generation by networks of actin, tubulin and intermediate filaments. In contrast, the mechanisms and function of cytoskeletal networks, whose primary component is centrin remain unexplored. Centrins are conserved proteins across all eukaryotes that localize ubiquitously to microtubule organizing centers. In unicellular eukaryotes, centrins form filaments and networks that support the extreme morphodynamics required for the behavioral responses of these free living organisms. By combining approaches from cell biology and biophysics we will establish the function of centrin as a cytoskeletal polymer and uncover the mechanisms by which it assembles into large-scale structures capable of force generation in ultrafast timescales. Our studies will establish novel mechanisms by which cytoskeletal networks generate, transmit and respond to mechanical signals. Beyond their biological significance, our findings will provide blueprints for the design of novel bio-inspired materials capable of withstanding large strains and undergoing extreme elastic deformations.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences chemical sciences polymer sciences
- natural sciences biological sciences biophysics
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2025-STG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1015 LAUSANNE
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.