Objective
Every 45 minutes, someone in Europe dies from amyotrophic lateral sclerosis (ALS), a fatal disease that causes progressive muscle weakness, paralysis, and, eventually, death. With no cure available, there is an urgent need to explore new mechanisms and human-relevant models that could inform treatments. While most research has focused on the nerve cells, called neurons, that die in ALS, growing evidence suggests that other cells in the brain and spinal cord, particularly astrocytes which normally help and protect neurons, may actually contribute to their loss.
This project will investigate whether a chemical imbalance in astrocytes plays a hidden but important role in ALS, a fresh but well-grounded concept. Specifically, I will focus on polyamines, small molecules that are vital for healthy brain function, including cell stress responses and communication between cells. In ALS, astrocytes may lose control over polyamine levels, turning a helpful process into a harmful one that damages neurons. The research aims to dissect the cell-type-specific role of polyamine metabolism in ALS pathogenesis and to test whether restoring polyamine balance can rescue disease-related phenotypes.
To explore this, I will use stem cell technology to create miniature 3D human brain-like structures (organoids) from the cells of people with ALS. This will allow me to study how astrocytes malfunction in ALS, how polyamine metabolism is disrupted, and whether spermidine, a naturally occurring polyamine found in certain foods, can restore balance and reduce cellular damage. By uncovering and targeting a hidden metabolic weakness in ALS, this research could open the door to new therapies that aim to slow disease progression and preserve the cells and connections that keep people moving, speaking, and living.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been human-validated.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been human-validated.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
CB2 1TN CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.