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Exploring Extended Field-of-view PET for precision medicine

Objective

Recently, long axial field of view (LAFOV) PET/CT systems have been introduced in the market (more than 15 in EU) and an increasing number of systems are becoming available in Europe. These systems have an ultra-large anatomical coverage, allowing dynamic imaging covering all major organs. With a sensitivity up to 20x higher than current state of the art PET/CT, molecular imaging can now be performed with ultra-low radiation doses, allowing more repeat imaging, either for multi-radiotracer studies for comprehensive disease characterization or longitudinal studies/follow up diagnostics. This is of particular interest with the advent of novel targeted drugs and cell therapies for which there is an unmet need to achieve better in vivo phenotyping and/or characterization of disease for a more precise diagnosis as well as better understanding of drug delivery and targeting to predict treatment response. Our proposed training network, PREFERENCE, will train 15 doctoral candidates (DCs) to fully exploit the benefits of large axial FOV PET/CT imaging. The network involves 13 PET centres, all with LAFOV PET/CT, a leading global manufacturer of LAFOV PET/CT systems and SMEs developing imaging software. Our individual research projects will develop new LAFOV methodologies to improve image quality and diagnosis, to enable studying human whole body disease connectomes, to allow for non-invasive full kinetic analysis, to facilitate low dose multi-tracer and/or multi-repeat LAFOV PET/CT imaging. Several DCs will use LAFOV PET/CT in clinical research to gain new insights and knowledge of pathophysiology and precision medicine in clinical research and patient care, increased understanding of pathophysiological processes and diagnosis for various clinical applications by using multi-tracer as well as dynamic imaging procedures. DCs will also experience a cutting-edge doctoral training programme including data analysis, artificial intelligence, innovation and entrepreneurship.

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Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks

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Call for proposal

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(opens in new window) HORIZON-MSCA-2025-DN-01

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Coordinator

STICHTING AMSTERDAM UMC
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 610 571,52
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

No data

Participants (13)

Partners (7)

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