Objective
Polyaromatics are ubiquitous structural motif present in bioactive compounds and functional organic materials. Despite their importance, the synthesis of complex polyaromatic structures is implemented by customized, target-specific synthetic routes. Unlike peptide and oligosaccharide chemistry, where iterative and automated assembly strategies have transformed discovery, there is no general platform that employs commercially available building blocks for the iterative construction of carbon-carbon bonds. Current state-of-the-art approaches require specialized building blocks, such as bifunctional masked halo-boron reagents.
This Proof of Concept project introduces Pi-LOOP, an iterative synthesis platform for polyaromatic compounds that directly uses commercially available aryl chlorides. The approach exploits π-metal-arene complexation as a multifunctional control element to enable stepwise carbon-carbon bond formation, regioselective C-H borylation, and controlled photorelease of the growing polyaromatic framework. Immobilization of the metal complex on a solid support should facilitate recovery and reuse of the chromium control unit. The project aims to validate the robustness and effectiveness of the Pi-LOOP platform for iterative polyaromatic assembly using off-the-shelf building blocks. By circumventing the need for highly customized reagents, Pi-LOOP can expand polyaryl’s chemical space and open the possibilities toward automation and parallel synthesis. This is relevant to industrial R&D users in pharmaceuticals, agrochemicals, and functional organic materials, where rapid access to structurally diverse polyaromatic scaffolds remains a major bottleneck.
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2026-POC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
53113 Bonn
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.