Obiettivo ULTRA-DD (Unrestricted Leveraging of Targets for Research Advancement and Drug Discovery) will be an European-wide, highly collaborative and inclusive consortium, to validate new targets for drug discovery by (1) generating high quality research tools, with an emphasis on chemical probes; (2) generating the chemical probes in the most cost-effective manner, using structure-guided methods and harnessing the chemical libraries and medicinal chemistry skills of the EFPIA participants; (3) testing the chemical probes in models of human disease based on continuous access to cells from patients with selected inflammatory diseases; and (4) making all reagents and knowledge available to the research community without restriction on use, to expand the impact well beyond the ULTRA-DD partners. In addition to our focus on chemical probes, we will also generate a defined set of antibodies targeting extracellular and membrane bound proteins of relevance to disease. To accomplish the above, ULTRA-DD will create two scientific Cores and formalize a collaborative network of SMEs, academic scientists and clinicians. The Protein Characterization and Tool-Generation Core will comprise four integrated laboratories: University of Oxford’s Structural Genomics Consortium laboratory, led by Chas Bountra (OXF-SGC), ETH in Zurich (ETHZ), led by Ruedi Aebersold, Karolinska Institutet (KI-MBB), led by Susanne Gräslund, and the University of Toronto’s SGC laboratory (UTOR-SGC, will not receive IMI funds), led by Cheryl Arrowsmith, and chemical biology teams in Bayer (Bayer), Janssen (JPNV), Novartis (NOV) and Pfizer (Pfizer). The Clinical Immunology Core will generate high quality assays from patient-derived cells and tissues in selected inflammatory diseases, and test effects of the chemical and antibody probes. This Core comprises the Kennedy Institute (UOXF-KENN) in the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences at the University of Oxford (UOXF-NDORMS), led by Marc Feldmann, the Centre for Molecular Medicine (KI-CMM) at Karolinska Institutet, led by Lars Klareskog and Per-Johan Jakobsson, and DiscoveRx (DRX, Sanj Kumar), an SME based in Birmingham, UK (will not receive IMI funds). The activities within the Cores will be enhanced significantly and the impact of the output expanded dramatically through the involvement of a Collaborative Network of SMEs, IMI projects, academic scientists and Disease Foundations (Appendices 1-3; none of these networks will receive IMI funds). The network will include a Target Prioritization Network (TPN) of top genomicists and clinicians; a Science and Technology Network (STN) that contributes expertise across the ULTRA-DD “gene to chemical probe” pipeline; and an Inflammatory Disease Network (IDN) of clinicians and translational scientists that provides enhanced access to disease-relevant expertise and patient tissue, as well as an expanded array of innovative assays. Each member of the ULTRA-DD network will commit to the open access policy. ULTRA-DD will be managed by the SGC (London, UK), which is a charitable company that has an enviable track record in managing the scientific, legal and financial aspects of open access public-private partnerships. The vision of ULTRA-DD is to create an open access consortium that provides industry with a stream of high quality target-disease associations and tools to study them. Our aspiration is to provide the evidence that convinces industry to launch >10 novel proprietary drug discovery programs based on ULTRA-DD open access output during the course of the project and in the nearest years following completion (2020).ULTRA-DD will meet the deliverables by integrating teams of tool-generating scientists with expert clinicians with access to patient tissue, under an open access, milestone-driven framework, and will expand its output through organized collaborations with innovative European scientists, leading non-European scientists Campo scientifico medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesclinical medicinerheumatologymedical and health scienceshealth sciencesinflammatory diseasesmedical and health sciencesbasic medicinemedicinal chemistrymedical and health sciencesclinical medicineorthopaedics Programma(i) FP7-JTI - Specific Programme "Cooperation": Joint Technology Initiatives Argomento(i) IMI-JU-11-2013-05 - Generation Of Research Tools To Enable The Translation Of Genomic Discoveries Into Drug Discovery Projects Invito a presentare proposte IMI-JU-11-2013 Vedi altri progetti per questo bando Meccanismo di finanziamento JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI) Coordinatore NOVARTIS PHARMA AG Contributo UE Nessun dato Indirizzo LICHTSTRASSE 35 4056 Basel Svizzera Mostra sulla mappa Regione Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Ricercatore principale Nils Ostermann (Dr) Contatto amministrativo Stephan Korte (Dr) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (9) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto STRUCTURAL GENOMICS CONSORTIUM LBG Regno Unito Contributo UE € 1 353 696,00 Indirizzo EUSTON ROAD 215 NW1 2BE London Mostra sulla mappa Regione London Inner London — West Camden and City of London Tipo di attività Research Organisations Contatto amministrativo Paul Van Damme (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato BAYER AKTIENGESELLSCHAFT Germania Contributo UE Nessun dato Indirizzo KAISER-WILHELM-ALLEE 1 51373 Leverkusen Mostra sulla mappa Regione Nordrhein-Westfalen Köln Leverkusen, Kreisfreie Stadt Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Petra Freitag (Mrs) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato DiscoveRx Corp Ltd Regno Unito Contributo UE Nessun dato Indirizzo Faraday Wharf, Innovation Birmingham Campus, Holt Street, Birmingham Science Park Aston B7 4BB Birmingham Mostra sulla mappa Contatto amministrativo Richard Price (Mr) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Svizzera Contributo UE € 1 440 970,00 Indirizzo Raemistrasse 101 8092 Zuerich Mostra sulla mappa Regione Schweiz/Suisse/Svizzera Zürich Zürich Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Martin Pestalozzi (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato JANSSEN PHARMACEUTICA NV Belgio Contributo UE Nessun dato Indirizzo TURNHOUTSEWEG 30 2340 Beerse Mostra sulla mappa Regione Vlaams Gewest Prov. 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Turnhout Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Henk Sipma (Mr) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato KAROLINSKA INSTITUTET Svezia Contributo UE € 4 902 660,00 Indirizzo Nobels Vag 5 17177 Stockholm Mostra sulla mappa Regione Östra Sverige Stockholm Stockholms län Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Caroline HAMILTON (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Regno Unito Contributo UE € 13 502 674,00 Indirizzo WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford Mostra sulla mappa Regione South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Gill Wells (Ms) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato PFIZER LIMITED Regno Unito Contributo UE Nessun dato Indirizzo RAMSGATE ROAD CT13 9NJ Sandwich Mostra sulla mappa Regione South East (England) Kent East Kent Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Carla Cox (Dr) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO Canada Contributo UE Nessun dato Indirizzo KINGS COLLEGE CIRCLE 27 M5S 1A1 Toronto Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Arij Al Chawaf (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato