Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes – Sofia ref.: 115797 | INNODIA | Projet | Résultats | H2020 | CORDIS

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Characterization of the role for post- translational modifications, alternative splicing and endoplasmic reticulum stress for β-cell recognition by the immune system

Migration

Discovery and pre-clinical validation of novel biomarkers of β-cell mass, dysfunction and death in human T1D

Migration

Relationships between immune response/regulation, genome, transcriptome, epigenome, proteome, metabolome and metagenome

Migration

A comprehensive pan-European research network for the study of the aetiology and prevention of T1D

Migration

Successful start-up of the project - Kick Off Meeting

Migration

EUnPOD functioning

Migration

Discovery and pre-clinical validation of biomarkers of immune activation and regulation in human T1D

Migration

Imaging tool for -cell inflammation/death

Migration

Development of novel approaches for in vivo β-cell imaging

Migration

Plan for access to the CTN by third parties

Migration

Modelling the role for T1D candidate genes in the beta-cell-immune system dialog, and using this information to develop novel approaches to prevent β-cell death in diabetes.

Migration

Novel models of the cross talk between human β-cells and the human system in vitro

Migration

Discovery analysis of novel biomarkers in β- cell-omics, immunomics, genomics, transcriptomics, proteomics, metabolomics and lipidomics

Migration

Launch public website

Migration

Publications

Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?

Auteurs: Alexia Carré, Sarah J. Richardson, Etienne Larger, Roberto Mallone
Publié dans: Diabetologia, Numéro 64/1, 2021, Page(s) 15-25, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-020-05298-y

Characterisation and clinical outcomes in children and adolescents with diabetes according to newly defined subgroups: a cohort study from the DPV registry

Auteurs: Katharina Warncke, Alexander Eckert, Ezio Bonifacio, Peter Achenbach, Olga Kordonouri, Thomas Meissner, Ute Ohlenschläger, Walter Bonfig, Anette-G. Ziegler, Reinhard W. Holl
Publié dans: eClinicalMedicine, Numéro 64, 2024, Page(s) 102208, ISSN 2589-5370
Éditeur: London: The Lancet
DOI: 10.1016/j.eclinm.2023.102208

The SAgA of Antigen-Specific Immunotherapy for Type 1 Diabetes.

Auteurs: Mallone R, You S.
Publié dans: Diabetes, Numéro 70(6), 2021, Page(s) 1247-1249, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/dbi21-0011

Arresting or curing type 1 diabetes: an elusive goal, but closing the gap.

Auteurs: Martens PJ, Gysemans C, Mathieu C.
Publié dans: The Journal of endocrinology, Numéro 249(2), 2021, Page(s) T1-T11, ISSN 0022-0795
Éditeur: Society for Endocrinology
DOI: 10.1530/joe-20-0552

Persistent coxsackievirus B1 infection triggers extensive changes in the transcriptome of human pancreatic ductal cells

Auteurs: Buchacher T, Honkimaa A, Välikangas T, Lietzén N, Hirvonen MK, Laiho JE, Sioofy-Khojine AB, Eskelinen EL, Hyöty H, Elo LL, Lahesmaa R.
Publié dans: iScience, 2022, ISSN 2589-0042
Éditeur: Cell Press
DOI: 10.1016/j.isci.2021.103653

The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults

Auteurs: M. Loredana Marcovecchio, A. Emile J. Hendriks, Carl Delfin, Tadej Battelino, Thomas Danne, Mark L. Evans, Jesper Johannesen, Simranjeet Kaur, Mikael Knip, Lut Overbergh, Flemming Pociot, John A. Todd, Bart Van der Schueren, Linda S. Wicker, Mark Peakman, Chantal Mathieu, null null
Publié dans: Diabetologia, Numéro 67, 2024, Page(s) 995-1008, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-024-06124-5

A single-cell human islet interactome atlas identifies disrupted autocrine and paracrine communications in type 2 diabetes.

Auteurs: Bosi E, Marselli L, Suleiman M, Tesi M, De Luca C, Del Guerra S, Cnop M, Eizirik DL, Marchetti P.
Publié dans: NAR genomics and bioinformatics, Numéro 4(4), 2022, Page(s) lqac084, ISSN 2631-9268
Éditeur: [Oxford] : Oxford University Press, [2019]-
DOI: 10.1093/nargab/lqac084

Whole-Slide Image Analysis of Human Pancreas Samples to Elucidate the Immunopathogenesis of Type 1 Diabetes Using the QuPath Software.

Auteurs: Apaolaza PS, Petropoulou PI, Rodriguez-Calvo T.
Publié dans: Frontiers in molecular biosciences., Numéro 8:689799, 2021, ISSN 2296-889X
Éditeur: Frontiers Media S.A.,
DOI: 10.3389/fmolb.2021.689799

The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes

Auteurs: Huerta-Chagoya A, Schroeder P, Mandla R, Deutsch AJ, Zhu W, Petty L, Yi X, Cole JB, Udler MS, Dornbos P, Porneala B, DiCorpo D, Liu CT, Li JH, Szczerbiński L, Kaur V, Kim J, Lu Y, Martin A, Eizirik DL, Marchetti P, Marselli L, Chen L, Srinivasan S, Todd J, Flannick J, Gubitosi-Klug R, Levitsky L, Shah R, Kelsey M, Burke B, Dabelea DM, Divers J, Marcovina S, Stalbow L, Loos RJF, Darst BF, Kooperbe
Publié dans: Diabetologia, Numéro 66(7), 2023, Page(s) 1273-1288, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-023-05912-9

Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes.

Auteurs: Guyer P, Arribas-Layton D, Manganaro A, Speake C, Lord S, Eizirik DL, Kent SC, Mallone R, James EA.
Publié dans: Diabetes., Numéro 72(1), 2022, Page(s) 85-96, ISSN 1939-327X
Éditeur: [New York, American Diabetes Association]
DOI: 10.2337/db22-0191

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

Auteurs: Décio L. Eizirik, Lorenzo Pasquali, Miriam Cnop
Publié dans: Nature Reviews Endocrinology, Numéro 16/7, 2020, Page(s) 349-362, ISSN 1759-5029
Éditeur: Nature Publishing Group
DOI: 10.1038/s41574-020-0355-7

Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes distinguishes markers of disease and C-peptide trajectory

Auteurs: Moulder R, Välikangas T, Hirvonen MK, Suomi T, Brorsson CA, Lietzén N, Bruggraber SFA, Overbergh L, Dunger DB, Peakman M, Chmura PJ, Brunak S, Schulte AM, Mathieu C, Knip M, Elo LL, Lahesmaa R; INNODIA consortium
Publié dans: Diabetologia, Numéro 66(11), 2023, Page(s) 1983-1996, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-023-05974-9

Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis

Auteurs: Christian M. Cohrs, Julia K. Panzer, Denise M. Drotar, Stephen J. Enos, Nicole Kipke, Chunguang Chen, Robert Bozsak, Eyke Schöniger, Florian Ehehalt, Marius Distler, Ana Brennand, Stefan R. Bornstein, Jürgen Weitz, Michele Solimena, Stephan Speier
Publié dans: Cell Reports, Numéro 31/1, 2020, Page(s) 107469, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2020.03.033

Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes

Auteurs: Farooq Syed, Sarah A. Tersey, Jean-Valery Turatsinze, Jamie L. Felton, Nicole Jiyun Kang, Jennifer B. Nelson, Emily K. Sims, Mathieu Defrance, Martin Bizet, Francois Fuks, Miriam Cnop, Marco Bugliani, Piero Marchetti, Anette-Gabriele Ziegler, Ezio Bonifacio, Bobbie-Jo Webb-Robertson, Appakalai N. Balamurugan, Carmella Evans-Molina, Decio L. Eizirik, Kieren J. Mather, Silva Arslanian, Raghavendra G
Publié dans: Clinical Epigenetics, Numéro 12/1, 2020, Page(s) 116, ISSN 1868-7075
Éditeur: Springer Verlag
DOI: 10.1186/s13148-020-00906-5

YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress

Auteurs: Elisa De Franco, Maria Lytrivi, Hazem Ibrahim, Hossam Montaser, Matthew N. Wakeling, Federica Fantuzzi, Kashyap Patel, Céline Demarez, Ying Cai, Mariana Igoillo-Esteve, Cristina Cosentino, Väinö Lithovius, Helena Vihinen, Eija Jokitalo, Thomas W. Laver, Matthew B. Johnson, Toshiaki Sawatani, Hadis Shakeri, Nathalie Pachera, Belma Haliloglu, Mehmet Nuri Ozbek, Edip Unal, Ruken Yıldırım, Tusha
Publié dans: Journal of Clinical Investigation, Numéro 130/12, 2020, Page(s) 6338-6353, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci141455

Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes.

Auteurs: Colli ML, Szymczak F, Eizirik DL.
Publié dans: Frontiers in endocrinology., 2020, Page(s) 11:568446, ISSN 1664-2392
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fendo.2020.568446

Area Deprivation and Regional Disparities in Treatment and Outcome Quality of 29,284 Pediatric Patients With Type 1 Diabetes in Germany: A Cross-sectional Multicenter DPV Analysis

Auteurs: Marie Auzanneau, Stefanie Lanzinger, Barbara Bohn, Peter Kroschwald, Ursula Kuhnle-Krahl, Paul Martin Holterhus, Kerstin Placzek, Johannes Hamann, Rainer Bachran, Joachim Rosenbauer, Werner Maier
Publié dans: Diabetes Care, Numéro 41/12, 2018, Page(s) 2517-2525, ISSN 0149-5992
Éditeur: American Diabetes Association
DOI: 10.2337/dc18-0724

RedRibbon: A new rank-rank hypergeometric overlap for gene and transcript expression signatures

Auteurs: Piron A, Szymczak F, Papadopoulou T, Alvelos MI, Defrance M, Lenaerts T, Eizirik DL, Cnop M
Publié dans: Life science alliance, Numéro 7(2), 2023, Page(s) e202302203, ISSN 2575-1077
Éditeur: Life Science Alliance, LLC
DOI: 10.26508/lsa.202302203

Proprotein convertase PCSK9 affects expression of key surface proteins in human pancreatic beta cells via intracellular and extracellular regulatory circuits.

Auteurs: Saitoski K, Ryaboshapkina M, Hamza GM, Jarnuczak AF, Berthault C, Carlotti F, Armanet M, Sengupta K, Underwood CR, Andersson S, Guillas I, Le Goff W, Scharfmann R.
Publié dans: The Journal of biological chemistry., Numéro 298, 2022, Page(s) 7, ISSN 1083-351X
Éditeur: Baltimore, MD : American Society for Biochemistry and Molecular Biology
DOI: 10.1016/j.jbc.2022.102096

Fast Track Adaptation of Oncolytic Coxsackie B3 Virus to Resistant Colorectal Cancer Cells - a Method to Personalize Virotherapy

Auteurs: Leslie Elsner, Lisanne Heimann, Anja Geisler, Babette Dieringer, Klaus-Peter Knoch, Luisa Hinze, Karin Klingel, Michel Solimena, Jens Kurreck, Henry Fechner
Publié dans: Biological Procedures Online, Numéro 26, 2024, ISSN 1480-9222
Éditeur: BioMed Central
DOI: 10.1186/s12575-024-00237-2

Preventing type 1 diabetes in childhood.

Auteurs: Dayan CM, Besser REJ, Oram RA, Hagopian W, Vatish M, Bendor-Samuel O, Snape MD, Todd JA.
Publié dans: Science, Numéro 373(6554), 2021, Page(s) 506-510, ISSN 0036-8075
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/science.abi4742

Endogenous mitochondrial double-stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells.

Auteurs: Coomans de Brachène A, Castela A, Musuaya AE, Marselli L, Marchetti P, Eizirik DL.
Publié dans: Auto- immunity highlights., Numéro 12(1), 2021, Page(s) 6, ISSN 2038-0305
Éditeur: Springer Verlag Italia
DOI: 10.1186/s13317-021-00148-2

The Role of Beta Cell Recovery in Type 2 Diabetes Remission.

Auteurs: Suleiman M, Marselli L, Cnop M, Eizirik DL, De Luca C, Femia FR, Tesi M, Del Guerra S, Marchetti P.
Publié dans: International journal of molecular sciences., Numéro 23(13), 2022, Page(s) 7435, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23137435

Plasma Exosome-Enriched Extracellular Vesicles From Lactating Mothers With Type 1 Diabetes Contain Aberrant Levels of miRNAs During the Postpartum Period.

Auteurs: Frørup C, Mirza AH, Yarani R, Nielsen LB, Mathiesen ER, Damm P, Svare J, Engelbrekt C, Størling J, Johannesen J, Mortensen HB, Pociot F, Kaur S.
Publié dans: Frontiers in immunology., Numéro 12:744509, 2021, ISSN 1664-3224
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.744509

The need and benefit of immune monitoring to define patient and disease heterogeneity, mechanisms of therapeutic action and efficacy of intervention therapy for precision medicine in type 1 diabetes

Auteurs: Bart O Roep
Publié dans: Frontiers in immunology, Numéro 14, 2023, Page(s) 14:1112858, ISSN 1664-3224
Éditeur: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2023.1112858

Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes?

Auteurs: Rodriguez-Calvo T, Christoffersson G, Bender C, von Herrath MG, Mallone R, Kent SC, James EA.
Publié dans: Frontiers in immunology, Numéro 12:683091, 2021, ISSN 1664-3224
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.683091

The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events?

Auteurs: Mallone R, Halliez C, Rui J, Herold KC.
Publié dans: Diabetes, Numéro 71(8), 2022, Page(s) 1603-1610, ISSN 1939-327X
Éditeur: [New York, American Diabetes Association]
DOI: 10.2337/dbi21-0036

The Protective Action of Metformin against Pro-Inflammatory Cytokine-Induced Human Islet Cell Damage and the Mechanisms Involved.

Auteurs: Giusti L, Tesi M, Ciregia F, Marselli L, Zallocco L, Suleiman M, De Luca C, Del Guerra S, Zuccarini M, Trerotola M, Eizirik DL, Cnop M, Mazzoni MR, Marchetti P, Lucacchini A, Ronci M.
Publié dans: Cells, Numéro 11(15), 2022, Page(s) 2465, ISSN 2073-4409
Éditeur: Basel, Switzerland : MDPI
DOI: 10.3390/cells11152465

Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes.

Auteurs: Yang JHM, Ward-Hartstonge KA, Perry DJ, Blanchfield JL, Posgai AL, Wiedeman AE, Diggins K, Rahman A, Tree TIM, Brusko TM, Levings MK, James EA, Kent SC, Speake C, Homann D, Long SA; Immunology of Diabetes Society T-Cell Cytometry Group.
Publié dans: European journal of immunology., Numéro 52(3), 2022, Page(s) 372–388., ISSN 1521-4141
Éditeur: Weinheim, Verlag Chemie GmbH.
DOI: 10.1002/eji.202049067

A set of circulating microRNAs belonging to the 14q32 chromosome locus identifies two subgroups of individuals with recent-onset type 1 diabetes

Auteurs: Guido Sebastiani, Giuseppina Emanuela Grieco, Marco Bruttini, Stefano Auddino, Alessia Mori, Mattia Toniolli, Daniela Fignani, Giada Licata, Elena Aiello, Laura Nigi, Caterina Formichi, Juan Fernandez-Tajes, Alberto Pugliese, Carmella Evans-Molina, Lut Overbergh, Timothy Tree, Mark Peakman, Chantal Mathieu, Francesco Dotta
Publié dans: Cell Reports Medicine, Numéro 5, 2024, Page(s) 101591, ISSN 2666-3791
Éditeur: Cambridge, MA
DOI: 10.1016/j.xcrm.2024.101591

The extent and magnitude of islet T cell infiltration as powerful tools to define the progression to type 1 diabetes

Auteurs: Apaolaza PS, Balcacean D, Zapardiel-Gonzalo J, Rodriguez-Calvo T.
Publié dans: Diabetologia, Numéro 66(6), 2023, Page(s) 1129–1141, ISSN 1432-0428
Éditeur: Berlin Springer Verlag
DOI: 10.1007/s00125-023-05888-6

ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation

Auteurs: Szymczak F, Cohen-Fultheim R, Thomaidou S, de Brachène AC, Castela A, Colli M, Marchetti P, Levanon E, Eizirik D, Zaldumbide A.
Publié dans: Frontiers in endocrinology, Numéro 13, 2022, Page(s) 1058345, ISSN 1664-2392
Éditeur: [Lausanne : Frontiers Research Foundation]
DOI: 10.3389/fendo.2022.1058345

Characterization of diabetes following pancreatic surgery in patients with congenital hyperinsulinism

Auteurs: Alena Welters, Thomas Meissner, Jürgen Grulich-Henn, Elke Fröhlich-Reiterer, Katharina Warncke, Klaus Mohnike, Oliver Blankenstein, Ulrike Menzel, Nicolin Datz, Esther Bollow, Reinhard W. Holl
Publié dans: Orphanet Journal of Rare Diseases, Numéro 13/1, 2018, ISSN 1750-1172
Éditeur: BioMed Central
DOI: 10.1186/s13023-018-0970-8

Validation of radiolabelled exendin for beta cell imaging by ex vivo autoradiography and immunohistochemistry of human pancreas

Auteurs: Theodorus J.P. Jansen, Sevilay Tokgöz, Mijke Buitinga, Sanne A.M. van Lith, Lieke Joosten, Cathelijne Frielink, Esther M. M. Smeets, Martijn W.J. Stommel, Marion B. van der Kolk, Bastiaan E. de Galan, Maarten Brom, Marti Boss, Martin Gotthardt
Publié dans: EJNMMI Research, Numéro 14, 2024, Page(s) 96, ISSN 2191-219X
Éditeur: Springer Berlin
DOI: 10.1186/s13550-024-01159-6

Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators

Auteurs: Perez-Hernandez J, Chiurchiu V, Perruche S, You S
Publié dans: Frontiers in immunology, Numéro 12, 2021, Page(s) 768133, ISSN 1664-3224
Éditeur: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.768133

Monitoring islet specific immune responses in type 1 diabetes clinical immunotherapy trials

Auteurs: Arif S, Domingo-Vila C, Pollock E, Christakou E, Williams E, Tree T.
Publié dans: Frontiers in immunology, Numéro 14, 2023, Page(s) 14:1183909, ISSN 1664-3224
Éditeur: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2023.1183909

Making Insulin and Staying Out of Autoimmune Trouble: The Beta-Cell Conundrum.

Auteurs: Carré A, Mallone R.
Publié dans: Frontiers in immunology., Numéro 12:639682, 2020, ISSN 1664-3224
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.639682

The Impact of Pancreatic Head Resection on Blood Glucose Homeostasis in Patients with Chronic Pancreatitis.

Auteurs: Hempel S, Oehme F, Ehehalt F, Solimena M, Kolbinger FR, Bogner A, Welsch T, Weitz J, Distler M.
Publié dans: Journal of Clinical Medicine, Numéro 11(3), 2022, Page(s) 663, ISSN 2077-0383
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm11030663

Comparing clinical characteristics of pediatric patients with pancreatic diabetes to patients with type 1 diabetes: A matched case‐control study

Auteurs: Stefanie Lanzinger, Alena Welters, Angelika Thon, Katja Konrad, Thomas Kapellen, Jürgen Grulich‐Henn, Dirk Raddatz, Reinhard W. Holl
Publié dans: Pediatric Diabetes, Numéro 20/7, 2019, Page(s) 955-963, ISSN 1399-543X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/pedi.12894

Functional Impact of Risk Gene Variants on the Autoimmune Responses in Type 1 Diabetes.

Auteurs: Gootjes C, Zwaginga JJ, Roep BO, Nikolic T.
Publié dans: Frontiers in immunology., Numéro 13, 2022, Page(s) 886736, ISSN 1664-3224
Éditeur: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2022.886736

Structure, interaction and nervous connectivity of beta cell primary cilia

Auteurs: Andreas Müller, Nikolai Klena, Song Pang, Leticia Elizabeth Galicia Garcia, Oleksandra Topcheva, Solange Aurrecoechea Duran, Davud Sulaymankhil, Monika Seliskar, Hassan Mziaut, Eyke Schöniger, Daniela Friedland, Nicole Kipke, Susanne Kretschmar, Carla Münster, Jürgen Weitz, Marius Distler, Thomas Kurth, Deborah Schmidt, Harald F. Hess, C. Shan Xu, Gaia Pigino, Michele Solimena
Publié dans: Nature Communications, Numéro 15, 2024, Page(s) 15(1):9168, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-024-53348-5

A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis.

Auteurs: Alvelos MI, Szymczak F, Castela Â, Marín-Cañas S, de Souza BM, Gkantounas I, Colli M, Fantuzzi F, Cosentino C, Igoillo-Esteve M, Marselli L, Marchetti P, Cnop M, Eizirik DL.
Publié dans: Islwts, Numéro 13(3-4), 2021, Page(s) 51-65, ISSN 1938-2014
Éditeur: Landes Bioscience
DOI: 10.1080/19382014.2021.1948282

Aberrant expression of transglutaminase 2 in pancreas and thymus of NOD mice underscores the importance of deamidation in neoantigen generation.

Auteurs: Callebaut A, Bruggeman Y, Zamit C, Sodré FMC, Irla M, Mathieu C, Buitinga M, Overbergh L.
Publié dans: Frontiers in endocrinology., Numéro 13, 2022, Page(s) 908248, ISSN 1664-2392
Éditeur: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fendo.2022.908248

Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Auteurs: Balboa D, Barsby T, Lithovius V, Saarimäki-Vire J, Omar-Hmeadi M, Dyachok O, Montaser H, Lund PE, Yang M, Ibrahim H, Näätänen A, Chandra V, Vihinen H, Jokitalo E, Kvist J, Ustinov J, Nieminen AI, Kuuluvainen E, Hietakangas V, Katajisto P, Lau J, Carlsson PO, Barg S, Tengholm A, Otonkoski T.
Publié dans: Nature biotechnology., Numéro 40(7), 2022, Page(s) 1042–1055, ISSN 1546-1696
Éditeur: Nature Publishing Company
DOI: 10.1038/s41587-022-01219-z

Endoplasmic Reticulum-Mitochondria Crosstalk and Beta-Cell Destruction in Type 1 Diabetes.

Auteurs: Vig S, Lambooij JM, Zaldumbide A, Guigas B.
Publié dans: Frontiers in immunology, Numéro 12:669492, 2021, ISSN 1664-3224
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.669492

Towards a Functional Cure for Diabetes Using Stem Cell-Derived Beta Cells: Are We There Yet?

Auteurs: Bourgeois S, Sawatani T, Van Mulders A, De Leu N, Heremans Y, Heimberg H, Cnop M, Staels W.
Publié dans: Cells, Numéro 10(1), 2021, Page(s) 191, ISSN 2073-4409
Éditeur: Basel, Switzerland : MDPI
DOI: 10.3390/cells10010191

Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis.

Auteurs: Tesi M, Bugliani M, Ferri G, Suleiman M, De Luca C, Bosi E, Masini M, De Tata V, Gysemans C, Cardarelli F, Cnop M, Eizirik DL, Marchetti P, Marselli L.
Publié dans: Biomolecules, Numéro 11(2), 2021, Page(s) 320, ISSN 2218-273X
Éditeur: Basel, Switzerland : MDPI
DOI: 10.3390/biom11020320

Self-antigens, benign autoimmunity and type 1 diabetes: a beta-cell and T-cell perspective.

Auteurs: Samassa F, Mallone R.
Publié dans: Current opinion in endocrinology, diabetes, and obesity., Numéro 29(4), 2022, Page(s) 370-378, ISSN 1752-2978
Éditeur: London : Lippincott, Williams & Wilkins, 2007-
DOI: 10.1097/med.0000000000000735

Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances

Auteurs: Simi Ahmed, Karen Cerosaletti, Eddie James, S. Alice Long, Stuart Mannering, Cate Speake, Maki Nakayama, Timothy Tree, Bart O. Roep, Kevan C. Herold, Todd M. Brusko
Publié dans: Diabetes, Numéro 68/7, 2019, Page(s) 1366-1379, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/db19-0119

The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells.

Auteurs: Alvelos MI, Brüggemann M, Sutandy FR, Juan-Mateu J, Colli ML, Busch A, Lopes M, Castela Â, Aartsma-Rus A, König J, Zarnack K, Eizirik DL.
Publié dans: Life science alliance, Numéro 4(3), 2020, Page(s) e202000825, ISSN 2575-1077
Éditeur: Life Science Alliance, LLC,
DOI: 10.26508/lsa.202000825

Immunoregulated insulitis and slow-progressing type 1 diabetes after duodenopancreatectomy.

Auteurs: Faucher P, Beuvon F, Fignani D, Sebastiani G, Afonso G, Zhou Z, Dousset B, Boitard C, Dotta F, Mallone R, Larger E.
Publié dans: Diabetologia, Numéro 64(12), 2021, Page(s) 2731-2740, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-021-05563-8

Why does the immune system destroy pancreatic β-cells but not α-cells in type 1 diabetes?

Auteurs: Eizirik DL, Szymczak F, Mallone R.
Publié dans: Nature reviews. Endocrinology, Numéro 19(7), 2023, Page(s) 425-434, ISSN 1759-5029
Éditeur: Nature Publishing Group
DOI: 10.1038/s41574-023-00826-3

Concise Review: Human Pluripotent Stem Cells for the Modeling of Pancreatic β-Cell Pathology

Auteurs: Diego Balboa, Jonna Saarimäki-Vire, Timo Otonkoski
Publié dans: STEM CELLS, Numéro 37/1, 2019, Page(s) 33-41, ISSN 1066-5099
Éditeur: AlphaMed Press Inc
DOI: 10.1002/stem.2913

Conjugation to a cell-penetrating peptide drives the tumour accumulation of the GLP1R antagonist exendin(9-39)

Auteurs: Collado Camps E, van Lith SAM, Kip A, Frielink C, Joosten L, Brock R, Gotthardt M.
Publié dans: European journal of nuclear medicine and molecular imaging, Numéro 50(4), 2022, Page(s) 996–1004, ISSN 1619-7070
Éditeur: Springer Verlag
DOI: 10.1007/s00259-022-06041-y

SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas Microvasculature

Auteurs: Daniela Fignani, Giada Licata, Noemi Brusco, Laura Nigi, Giuseppina E. Grieco, Lorella Marselli, Lut Overbergh, Conny Gysemans, Maikel L. Colli, Piero Marchetti, Chantal Mathieu, Decio L. Eizirik, Guido Sebastiani, Francesco Dotta
Publié dans: Frontiers in Endocrinology, Numéro 11, 2020, ISSN 1664-2392
Éditeur: Front Endocrinol (Lausanne)
DOI: 10.3389/fendo.2020.596898

Coxsackievirus and type 1 diabetes: diabetogenic mechanisms and implications for prevention

Auteurs: Carré A, Vecchio F, Flodstrom-Tullberg M, You S, Mallone R.
Publié dans: Endocrine reviews, Numéro 44(4), 2023, Page(s) 737-751, ISSN 1945-7189
Éditeur: Endocrine Society
DOI: 10.1210/endrev/bnad007

Epitope-based precision immunotherapy of Type 1 diabetes

Auteurs: Firdessa Fite R, Bechi Genzano C, Mallone R, Creusot RJ.
Publié dans: Human vaccines and immunotherapeutics, Numéro 19(1), 2023, Page(s) 2154098, ISSN 2164-5515
Éditeur: Landes Bioscience
DOI: 10.1080/21645515.2022.2154098

Unveiling nanoscale optical signatures of cytokine-induced β-cell dysfunction

Auteurs: Pugliese LA, De Lorenzi V, Bernardi M, Ghignoli S, Tesi M, Marchetti P, Pesce L, Cardarelli F
Publié dans: Scientific reports, Numéro 13(1), 2023, Page(s) 13342, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-023-40272-9

Antigen-based immune modulation therapy for type 1 diabetes: the era of precision medicine

Auteurs: Bart O Roep, Daniel C S Wheeler, Mark Peakman
Publié dans: The Lancet Diabetes & Endocrinology, Numéro 7/1, 2019, Page(s) 65-74, ISSN 2213-8587
Éditeur: Elsevier BV
DOI: 10.1016/s2213-8587(18)30109-8

Transcription factors that shape the mammalian pancreas

Auteurs: Rachel E. Jennings, Raphael Scharfmann, Willem Staels
Publié dans: Diabetologia, Numéro 63/10, 2020, Page(s) 1974-1980, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-020-05161-0

Inhibition of the type 1 diabetes candidate gene PTPN2 aggravates TNF-α-induced human beta cell dysfunction and death

Auteurs: Roca-Rivada A, Marín-Cañas S, Colli ML, Vinci C, Sawatani T, Marselli L, Cnop M, Marchetti P, Eizirik DL
Publié dans: Diabetologia, Numéro 66(8), 2023, Page(s) 1544-1556, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-023-05908-5

An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells

Auteurs: Maikel L. Colli, Mireia Ramos-Rodríguez, Ernesto S. Nakayasu, Maria I. Alvelos, Miguel Lopes, Jessica L. E. Hill, Jean-Valery Turatsinze, Alexandra Coomans de Brachène, Mark A. Russell, Helena Raurell-Vila, Angela Castela, Jonàs Juan-Mateu, Bobbie-Jo M. Webb-Robertson, Lars Krogvold, Knut Dahl-Jorgensen, Lorella Marselli, Piero Marchetti, Sarah J. Richardson, Noel G. Morgan, Thomas O. Metz, Lor
Publié dans: Nature Communications, Numéro 11/1, 2020, Page(s) 2584, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-16327-0

Every islet matters: improving the impact of human islet research

Auteurs: Gloyn AL, Ibberson M, Marchetti P, Powers AC, Rorsman P, Sander M, Solimena M.
Publié dans: Nature metabolism, Numéro 4(8), 2022, Page(s) 970-977, ISSN 2522-5812
Éditeur: Berlin : Springer Nature
DOI: 10.1038/s42255-022-00607-8

Pancreatic Islet Cells Response to IFNγ Relies on Their Spatial Location within an Islet

Auteurs: De Burghgrave M, Lourenço C, Berthault C, Aiello V, Villalba A, Fouque A, Diedisheim M, You S, Oshima M, Scharfmann R.
Publié dans: Cells, Numéro 12(1), 2022, Page(s) 113, ISSN 2073-4409
Éditeur: Basel, Switzerland : MDPI
DOI: 10.3390/cells12010113

Lipidomic Abnormalities During the Pathogenesis of Type 1 Diabetes: a Quantitative Review

Auteurs: Tommi Suvitaival
Publié dans: Current diabetes reports, Numéro 20(9), 2020, Page(s) 46, ISSN 1534-4827
Éditeur: Current Science Inc.
DOI: 10.1007/s11892-020-01326-8

Glucose treatment of human pancreatic β-cells enhances translation of mRNAs involved in energetics and insulin secretion.

Auteurs: Zakaria A, Berthault C, Cosson B, Jung V, Guerrera IC, Rachdi L, Scharfmann R.
Publié dans: The Journal of biological chemistry., Numéro 297(1), 2021, Page(s) 100839, ISSN 0021-9258
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100839

Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells.

Auteurs: Kaur S, Frørup C, Mirza AH, Fløyel T, Yarani R, Colli ML, Johannesen J, Størling J, Eizirik DL, Pociot F.
Publié dans: Non-coding RNA, Numéro 8(5), 2022, Page(s) 69, ISSN 2311-553X
Éditeur: Basel, Switzerland : MDPI AG, [2015]-
DOI: 10.3390/ncrna8050069

Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention

Auteurs: Ernesto S. Nakayasu, Farooq Syed, Sarah A. Tersey, Marina A. Gritsenko, Hugh D. Mitchell, Chi Yuet Chan, Ercument Dirice, Jean-Valery Turatsinze, Yi Cui, Rohit N. Kulkarni, Decio L. Eizirik, Wei-Jun Qian, Bobbie-Jo M. Webb-Robertson, Carmella Evans-Molina, Raghavendra G. Mirmira., Thomas O. Metz
Publié dans: Cell Metabolism, Numéro 31/2, 2020, Page(s) 363-374.e6, ISSN 1550-4131
Éditeur: Cell Press
DOI: 10.1016/j.cmet.2019.12.005

Angiotensin I-converting enzyme type 2 expression is increased in pancreatic islets of type 2 diabetic donors

Auteurs: Fignani D, Pedace E, Licata G, Grieco GE, Aiello E, de Luca C, Marselli L, Marchetti P, Sebastiani G, Dotta F
Publié dans: Diabetes/metabolism research and reviews, Numéro 39(8), 2023, Page(s) e3696, ISSN 1520-7560
Éditeur: Wiley-Blackwell
DOI: 10.1002/dmrr.3696

Interferons are key cytokines acting on pancreatic islets in type 1 diabetes

Auteurs: Alexandra Coomans de Brachène, Maria Ines Alvelos, Florian Szymczak, Priscila L. Zimath, Angela Castela, Bianca Marmontel de Souza, Arturo Roca Rivada, Sandra Marín-Cañas, Xiaoyan Yi, Anne Op de Beeck, Noel G. Morgan, Sebastian Sonntag, Sayro Jawurek, Alexandra C. Title, Burcak Yesildag, François Pattou, Julie Kerr-Conte, Eduard Montanya, Montserrat Nacher, Lorella Marselli, Piero Marchetti, S
Publié dans: Diabetologia, Numéro 67, 2025, Page(s) 908-927, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-024-06106-7

Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8 <sup>+</sup> T cell responses

Auteurs: Federica Vecchio, Alexia Carré, Daniil Korenkov, Zhicheng Zhou, Paola Apaolaza, Soile Tuomela, Orlando Burgos-Morales, Isaac Snowhite, Javier Perez-Hernandez, Barbara Brandao, Georgia Afonso, Clémentine Halliez, John Kaddis, Sally C. Kent, Maki Nakayama, Sarah J. Richardson, Joelle Vinh, Yann Verdier, Jutta Laiho, Raphael Scharfmann, Michele Solimena, Zuzana Marinicova, Elise Bismuth, Nadine Luc
Publié dans: Science Advances, Numéro 10, 2024, Page(s) eadl1122, ISSN 2375-2548
Éditeur: Washington, DC : American Association for the Advancement of Science
DOI: 10.1126/sciadv.adl1122

IFNɣ but not IFNα increases recognition of insulin defective ribosomal product-derived antigen to amplify islet autoimmunity

Auteurs: Thomaidou S, Munoz Garcia A, de Lange S, Gan J, van der Slik AR, Hoeben RC, Roep BO, Carlotti F, Zaldumbide A
Publié dans: Diabetologia, Numéro 66(11), 2023, Page(s) 2075-2086, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-023-05991-8

100 Years of Insulin: Lifesaver, immune target, and potential remedy for prevention

Auteurs: Ziegler AG, Danne T, Daniel C, Bonifacio E.
Publié dans: Med, Numéro 2(10), 2021, Page(s) 1120-1137, ISSN 2666-6340
Éditeur: Cell Press
DOI: 10.1016/j.medj.2021.08.003

Bioluminescent reporter assay for monitoring ER stress in human beta cells

Auteurs: Maria J. L. Kracht, Eelco J. P. de Koning, Rob C. Hoeben, Bart O. Roep, Arnaud Zaldumbide
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-36142-4

Personalized Immunotherapies for Type 1 Diabetes: Who, What, When, and How?

Auteurs: Deligne C, You S, Mallone R.
Publié dans: Journal of Personalized Medicine, Numéro 12(4):, 2022, Page(s) 543, ISSN 2075-4426
Éditeur: Basel, Switzerland : MDPI AG, 2011-
DOI: 10.3390/jpm12040542

Gene expression signatures of target tissues in type 1 diabetes, lupus erythematosus, multiple sclerosis, and rheumatoid arthritis.

Auteurs: Szymczak F, Colli ML, Mamula MJ, Evans-Molina C, Eizirik DL.
Publié dans: Science Advances, Numéro 7(2), 2021, Page(s) eabd7600, ISSN 2375-2548
Éditeur: Washington, DC : American Association for the Advancement of Science
DOI: 10.1126/sciadv.abd7600

Noninvasive Monitoring of Glycemia-Induced Regulation of GLP-1R Expression in Murine and Human Islets of Langerhans.

Auteurs: Buitinga M, Cohrs CM, Eter WA, Claessens-Joosten L, Frielink C, Bos D, Sandker G, Brom M, Speier S, Gotthardt M.
Publié dans: Diabetes, Numéro 69(11), 2021, Page(s) 2246-2252, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/db20-0616

Pancreatic Alpha-Cells Contribute Together With Beta-Cells to CXCL10 Expression in Type 1 Diabetes.

Auteurs: Nigi L, Brusco N, Grieco GE, Licata G, Krogvold L, Marselli L, Gysemans C, Overbergh L, Marchetti P, Mathieu C, Dahl Jørgensen K, Sebastiani G, Dotta F.
Publié dans: Frontiers in Endocrinology, Numéro 11:630, 2020, ISSN 1664-2392
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fendo.2020.00630

Family Structure is Associated with Mental Health and Attention Deficit (Hyperactivity) Disorders in Adolescents with Type 1 Diabetes

Auteurs: Baechle C, Stahl-Pehe A, Castillo K, Holl RW, Rosenbauer J.
Publié dans: Experimental and Clinical Endocrinology and Diabetes, Numéro 130(9), 2022, Page(s) 604-613, ISSN 0947-7349
Éditeur: Johann Ambrosius Barth
DOI: 10.1055/a-1729-7972

The challenge of modulating β-cell autoimmunity in type 1 diabetes

Auteurs: Mark A Atkinson, Bart O Roep, Amanda Posgai, Daniel C S Wheeler, Mark Peakman
Publié dans: The Lancet Diabetes & Endocrinology, Numéro 7/1, 2019, Page(s) 52-64, ISSN 2213-8587
Éditeur: Elsevier BV
DOI: 10.1016/s2213-8587(18)30112-8

EndoC-βH5 cells are storable and ready-to-use human pancreatic beta cells with physiological insulin secretion

Auteurs: Blanchi B, Taurand M, Colace C, Thomaidou S, Audeoud C, Fantuzzi F, Sawatani T, Gheibi S, Sabadell-Basallote J, Boot FWJ, Chantier T, Piet A, Cavanihac C, Pilette M, Balguerie A, Olleik H, Carlotti F, Ejarque M, Fex M, Mulder H, Cnop M, Eizirik DL, Jouannot O, Gaffuri AL, Czernichow P, Zaldumbide A, Scharfmann R, Ravassard P
Publié dans: Molecular metabolism, Numéro 76, 2023, Page(s) 76:101772, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.1016/j.molmet.2023.101772

Editorial: Footprints of Immune Cells in the Type 1 Diabetic Pancreas.

Auteurs: Brusko TM, Mallone R, Rodriguez-Calvo T.
Publié dans: Frontiers in endocrinology., Numéro 12:767012, 2021, ISSN 1664-2392
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fendo.2021.767012

Preclinical evaluation of tyrosine kinase 2 inhibitors for human beta‐cell protection in type 1 diabetes

Auteurs: Alexandra Coomans de Brachène, Angela Castela, Anne Op de Beeck, Raghavendra G. Mirmira, Lorella Marselli, Piero Marchetti, Craig Masse, Wenyan Miao, Silvana Leit, Carmella Evans‐Molina, Decio L. Eizirik
Publié dans: Diabetes, Obesity and Metabolism, Numéro 2020-06, 2020, ISSN 1462-8902
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/dom.14104

Increased Expression of Viral Sensor MDA5 in Pancreatic Islets and in Hormone-Negative Endocrine Cells in Recent Onset Type 1 Diabetic Donors.

Auteurs: Nigi L, Brusco N, Grieco GE, Fignani D, Licata G, Formichi C, Aiello E, Marselli L, Marchetti P, Krogvold L, Jorgensen KD, Sebastiani G, Dotta F.
Publié dans: Frontiers in immunology., Numéro 13: 833141, 2022, ISSN 1664-3224
Éditeur: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2022.833141

Mapping T Cell Responses to Native and Neo-Islet Antigen Epitopes in at Risk and Type 1 Diabetes Subjects.

Auteurs: Arif S, Pujol-Autonell I, Kamra Y, Williams E, Yusuf N, Domingo-Vila C, Shahrabi Y, Pollock E, Khatri L, Peakman M, Tree T, Lorenc A.
Publié dans: Frontiers in immunology, Numéro 12:675746, 2021, ISSN 1664-3224
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.675746

Continuous Glucose Monitoring-Derived Data Report-Simply a Better Management Tool.

Auteurs: Battelino T, Bergenstal RM.
Publié dans: Diabetes Care, 2020, ISSN 0149-5992
Éditeur: American Diabetes Association
DOI: 10.2337/dci20-0032

The pancreatic β cell response to secretory demands and adaption to stress.

Auteurs: Kalwat MA, Scheuner D, Rodrigues Dos Santos K, Eizirik DL, Cobb MH.
Publié dans: Endocrinology, Numéro 162(11), 2021, Page(s) bqab173, ISSN 0013-7227
Éditeur: The Endocrine Society
DOI: 10.1210/endocr/bqab173

The role of the interferon/JAK-STAT axis in driving islet HLA-I hyperexpression in type 1 diabetes

Auteurs: Russell MA, Richardson SJ, Morgan NG
Publié dans: Frontiers in endocrinology, Numéro 14, 2023, Page(s) 1270325, ISSN 1664-2392
Éditeur: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fendo.2023.1270325

A Dual Systems Genetics Approach Identifies Common Genes, Networks, and Pathways for Type 1 and 2 Diabetes in Human Islets.

Auteurs: Kaur S, Mirza AH, Overgaard AJ, Pociot F, Størling J.
Publié dans: Frontiers in genetics., Numéro 12:630109, 2021, ISSN 1664-8021
Éditeur: Frontiers Media
DOI: 10.3389/fgene.2021.630109

Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells

Auteurs: Alexia Carré, Fatoumata Samassa, Zhicheng Zhou, Javier Perez-Hernandez, Christiana Lekka, Anthony Manganaro, Masaya Oshima, Hanqing Liao, Robert Parker, Annalisa Nicastri, Barbara Brandao, Maikel L. Colli, Decio L. Eizirik, Jahnavi Aluri, Deep Patel, Marcus Göransson, Orlando Burgos Morales, Amanda Anderson, Laurie Landry, Farah Kobaisi, Raphael Scharfmann, Lorella Marselli, Piero Marchetti, Syl
Publié dans: Nature Communications, Numéro 16, 2025, Page(s) 765, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-025-55908-9

Protocol to analyze circulating small non-coding RNAs by high-throughput RNA sequencing from human plasma samples.

Auteurs: Grieco GE, Sebastiani G, Fignani D, Brusco N, Nigi L, Formichi C, Licata G, Bruttini M, D'Aurizio R, Mathieu C, Gysemans C, Dotta F.
Publié dans: STAR protocols, Numéro 2(3), 2021, Page(s) 100606, ISSN 2666-1667
Éditeur: [Cambridge, MA] : Cell Press,
DOI: 10.1016/j.xpro.2021.100606

Tryptophan metabolism promotes immune evasion in human pancreatic β cells

Auteurs: Rachdi L, Zhou Z, Berthault C, Lourenço C, Fouque A, Domet T, Armanet M, You S, Peakman M, Mallone R, Scharfmann R.
Publié dans: EBioMedicine, Numéro 95, 2023, Page(s) 104740, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104740

Gene expression signature predicts rate of type 1 diabetes progression

Auteurs: Suomi T, Starskaia I, Kalim UU, Rasool O, Jaakkola MK, Grönroos T, Välikangas T, Brorsson C, Mazzoni G, Bruggraber S, Overbergh L, Dunger D, Peakman M, Chmura P, Brunak S, Schulte AM, Mathieu C, Knip M, Lahesmaa R, Elo LL; INNODIA Consortium
Publié dans: EBioMedicine, Numéro 92, 2023, Page(s) 92:104625, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104625

Nanoencapsulated human pancreatic islets for β-cell replacement in Type 1 diabetes

Auteurs: Silke Krol, Walter Baronti, Piero Marchetti
Publié dans: Nanomedicine, Numéro 15/18, 2020, Page(s) 1735-1738, ISSN 1743-5889
Éditeur: Future Medicine Ltd.
DOI: 10.2217/nnm-2020-0166

Reduced miR-184-3p expression protects pancreatic β-cells from lipotoxic and proinflammatory apoptosis in type 2 diabetes via CRTC1 upregulation.

Auteurs: Grieco GE, Brusco N, Fignani D, Nigi L, Formichi C, Licata G, Marselli L, Marchetti P, Salvini L, Tinti L, Po A, Ferretti E, Sebastiani G, Dotta F.
Publié dans: Cell death discovery., Numéro 8, 2022, Page(s) 340, ISSN 2058-7716
Éditeur: New York, NY] : Nature Publishing Group, [2015]
DOI: 10.1038/s41420-022-01142-x

INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes.

Auteurs: Dunger DB, Bruggraber SFA, Mander AP, Marcovecchio ML, Tree T, Chmura PJ, Knip M, Schulte AM, Mathieu C; INNODIA consortium.
Publié dans: Trials, Numéro 23, 2022, Page(s) 414, ISSN 1745-6215
Éditeur: BioMed Central
DOI: 10.1186/s13063-022-06259-z

Importance of beta cell mass for glycaemic control in people with type 1 diabetes.

Auteurs: Jansen TJP, Brom M, Boss M, Buitinga M, Tack CJ, van Meijel LA, de Galan BE, Gotthardt M.
Publié dans: Diabetologia, Numéro 1–9., 2022, ISSN 1432-0428
Éditeur: Berlin Springer Verlag
DOI: 10.1007/s00125-022-05830-2

Frequency and Characteristics of MODY 1 (HNF4A Mutation) and MODY 5 (HNF1B Mutation): Analysis From the DPV Database

Auteurs: Katharina Warncke, Sebastian Kummer, Klemens Raile, Jürgen Grulich-Henn, Joachim Woelfle, Elisabeth Steichen, Nicole Prinz, Reinhard W Holl
Publié dans: The Journal of Clinical Endocrinology & Metabolism, Numéro 104/3, 2018, Page(s) 845-855, ISSN 0021-972X
Éditeur: The Endocrine Society
DOI: 10.1210/jc.2018-01696

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.

Auteurs: Battaglia M, Ahmed S, Anderson MS, Atkinson MA, Becker D, Bingley PJ, Bosi E, Brusko TM, DiMeglio LA, Evans-Molina C, Gitelman SE, Greenbaum CJ, Gottlieb PA, Herold KC, Hessner MJ, Knip M, Jacobsen L, Krischer JP, Long SA, Lundgren M, McKinney EF, Morgan NG, Oram RA, Pastinen T, Peters MC, Petrelli A, Qian X, Redondo MJ, Roep BO, Schatz D, Skibinski D, Peakman M.
Publié dans: Diabetes Care, Numéro 43(1), 2022, Page(s) 5-12, ISSN 0149-5992
Éditeur: American Diabetes Association
DOI: 10.2337/dc19-0880

A circular RNA generated from an intron of the insulin gene controls insulin secretion

Auteurs: Lisa Stoll, Adriana Rodríguez-Trejo, Claudiane Guay, Flora Brozzi, Mustafa Bilal Bayazit, Sonia Gattesco, Véronique Menoud, Jonathan Sobel, Ana Claudia Marques, Morten Trillingsgaard Venø, Jonathan Lou S. Esguerra, Mohammad Barghouth, Mara Suleiman, Lorella Marselli, Jørgen Kjems, Lena Eliasson, Erik Renström, Karim Bouzakri, Michel Pinget, Piero Marchetti, Romano Regazzi
Publié dans: Nature Communications, Numéro 11/1, 2020, Page(s) 11(1):5611, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-19381-w

IL-2-based approaches to Treg enhancement

Auteurs: Harris F, Berdugo YA, Tree T.
Publié dans: Clinical and experimental immunology, Numéro 211(2), 2023, Page(s) 149–163, ISSN 0009-9104
Éditeur: Blackwell Publishing Inc.
DOI: 10.1093/cei/uxac105

3D FIB-SEM reconstruction of microtubule-organelle interaction in whole primary mouse beta cells.

Auteurs: Müller A, Schmidt D, Xu CS, Pang S, D'Costa JV, Kretschmar S, Münster C, Kurth T, Jug F, Weigert M, Hess HF, Solimena M.
Publié dans: The Journal of cell biology., Numéro 220(2), 2021, Page(s) e202010039, ISSN 0021-9525
Éditeur: Rockefeller University Press
DOI: 10.1083/jcb.202010039

Klf6 protects β-cells against insulin resistance-induced dedifferentiation

Auteurs: Christopher Dumayne, David Tarussio, Ana Rodriguez Sanchez-Archidona, Alexandre Picard, Davide Basco, Xavier Pascal Berney, Mark Ibberson, Bernard Thorens
Publié dans: Molecular Metabolism, Numéro 35, 2020, Page(s) 100958, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.02.001

Mast Cells and the Pancreas in Human Type 1 and Type 2 Diabetes.

Auteurs: Masini M, Suleiman M, Novelli M, Marselli L, Marchetti P, De Tata V.
Publié dans: Cells, Numéro 10(8), 2021, Page(s) 1875, ISSN 2073-4409
Éditeur: Basel, Switzerland : MDPI
DOI: 10.3390/cells10081875

Temporal regulation of interferon signalling in human EndoC-βH1 cells.

Auteurs: Dhayal S, Leslie KA, Baity M, Akhbari P, Richardson SJ, Russell MA, Morgan NG.
Publié dans: Journal of molecular endocrinology., Numéro 69(2), 2022, Page(s) 299–313, ISSN 1479-6813
Éditeur: Bristol, U.K. : Journal of Endocrinology, Ltd., c1988-
DOI: 10.1530/jme-21-0224

Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis

Auteurs: Anoop Arunagiri, Maroof Alam, Leena Haataja, Hassan Draz, Bashiyer Alasad, Praveen Samy, Nadeed Sadique, Yue Tong, Ying Cai, Hadis Shakeri, Federica Fantuzzi, Hazem Ibrahim, Insook Jang, Vaibhav Sidarala, Scott A. Soleimanpour, Leslie S. Satin, Timo Otonkoski, Miriam Cnop, Pamela Itkin‐Ansari, Randal J. Kaufman, Ming Liu, Peter Arvan
Publié dans: Protein Science, Numéro 33, 2024, Page(s) e4949, ISSN 0961-8368
Éditeur: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.4949

Cell Type-Selective Expression of Circular RNAs in Human Pancreatic Islets

Auteurs: Simranjeet Kaur, Aashiq Mirza, Flemming Pociot
Publié dans: Non-Coding RNA, Numéro 4/4, 2018, Page(s) 38, ISSN 2311-553X
Éditeur: MDPI
DOI: 10.3390/ncrna4040038

Beta Cell Imaging—From Pre-Clinical Validation to First in Man Testing

Auteurs: Stephane Demine, Michael L. Schulte, Paul R. Territo, Decio L. Eizirik
Publié dans: International Journal of Molecular Sciences, Numéro 21/19, 2020, Page(s) 7274, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21197274

A genetic screen identifies Crat as a regulator of pancreatic beta-cell insulin secretion

Auteurs: Dassine Berdous, Xavier Berney, Ana Rodriguez Sanchez-Archidona, Maxime Jan, Clara Roujeau, Isabel C. Lopez-Mejia, Randall Mynatt, Bernard Thorens
Publié dans: Molecular Metabolism, Numéro 37, 2020, Page(s) 100993, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.100993

Gut microbiome shifts in people with type 1 diabetes are associated with glycaemic control: an INNODIA study

Auteurs: Tommi Vatanen, Carine de Beaufort, M. Loredana Marcovecchio, Lut Overbergh, Soren Brunak, Mark Peakman, Chantal Mathieu, Mikael Knip, null null
Publié dans: Diabetologia, Numéro 67, 2024, Page(s) 1930-1942, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-024-06192-7

Pleconaril and ribavirin in new-onset type 1 diabetes: a phase 2 randomized trial

Auteurs: Krogvold L, Mynarek IM, Ponzi E, Mørk FB, Hessel TW, Roald T, Lindblom N, Westman J, Barker P, Hyöty H, Ludvigsson J, Hanssen KF, Johannesen J, Dahl-Jørgensen K
Publié dans: Nature medicine, Numéro 29(11), 2023, Page(s) 2902-2908, ISSN 1078-8956
Éditeur: Nature Publishing Group
DOI: 10.1038/s41591-023-02576-1

Peptides Derived From Insulin Granule Proteins are Targeted by CD8+ T Cells Across MHC Class I Restrictions in Humans and NOD Mice.

Auteurs: Azoury ME, Tarayrah M, Afonso G, Pais A, Colli ML, Maillard C, Lavaud C, Alexandre-Heymann L, Gonzalez-Duque S, Verdier Y, Vinh J, Pinto S, Buus S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Eizirik DL, You S, Mallone R.
Publié dans: Diabetes, Numéro 69(12), 2020, Page(s) 2678-2690, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/db20-0013

Oral Fc-Coupled Preproinsulin Achieves Systemic and Thymic Delivery Through the Neonatal Fc Receptor and Partially Delays Autoimmune Diabetes.

Auteurs: Corcos N, Culina S, Deligne C, Lavaud C, You S, Mallone R.
Publié dans: Frontiers in immunology, 2021, Page(s) 12:616215, ISSN 1664-3224
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.616215

T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal

Auteurs: Eddie A. James, Roberto Mallone, Sally C. Kent, Teresa P. DiLorenzo
Publié dans: Diabetes, Numéro 69/7, 2020, Page(s) 1311-1335, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/dbi19-0022

MiR‐375‐mediated suppression of engineered coxsackievirus B3 in pancreatic cells

Auteurs: Markian Pryshliak, Ahmet Hazini, Klaus Knoch, Babette Dieringer, Beatrice Tolksdorf, Michele Solimena, Jens Kurreck, Sandra Pinkert, Henry Fechner
Publié dans: FEBS Letters, Numéro 594/4, 2020, Page(s) 763-775, ISSN 0014-5793
Éditeur: Elsevier BV
DOI: 10.1002/1873-3468.13647

MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells

Auteurs: Fabio Arturo Grieco, Guido Sebastiani, Jonas Juan-Mateu, Olatz Villate, Laura Marroqui, Laurence Ladrière, Ksenya Tugay, Romano Regazzi, Marco Bugliani, Piero Marchetti, Francesco Dotta, Décio L. Eizirik
Publié dans: Diabetes, Numéro 66/1, 2016, Page(s) 100-112, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/db16-0592

Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF)

Auteurs: Daniel A. Cunha, Monia Cito, Fabio Arturo Grieco, Cristina Cosentino, Tatiana Danilova, Laurence Ladrière, Maria Lindahl, Andrii Domanskyi, Marco Bugliani, Piero Marchetti, Décio L. Eizirik, Miriam Cnop
Publié dans: Journal of Biological Chemistry, Numéro 292/36, 2017, Page(s) 14977-14988, ISSN 0021-9258
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M116.769877

New insights into non-conventional epitopes as T cell targets: The missing link for breaking immune tolerance in autoimmune disease?

Auteurs: James Harbige, Martin Eichmann, Mark Peakman
Publié dans: Journal of Autoimmunity, Numéro 84, 2017, Page(s) 12-20, ISSN 0896-8411
Éditeur: Academic Press
DOI: 10.1016/j.jaut.2017.08.001

MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells

Auteurs: Kira Meyerovich, Natalia M. Violato, Makiko Fukaya, Violette Dirix, Nathalie Pachera, Lorella Marselli, Piero Marchetti, Andreas Strasser, Decio L. Eizirik, Alessandra K. Cardozo
Publié dans: Diabetes, Numéro 66/9, 2017, Page(s) 2446-2458, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/db16-1252

Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes

Auteurs: Laura Marroqui, Reinaldo S. Dos Santos, Anne Op de beeck, Alexandra Coomans de Brachène, Lorella Marselli, Piero Marchetti, Decio L. Eizirik
Publié dans: Diabetologia, Numéro 60/4, 2017, Page(s) 656-667, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-016-4201-3

Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis

Auteurs: Reinaldo S Dos Santos, Laura Marroqui, Fabio A Grieco, Lorella Marselli, Mara Suleiman, Stefan R Henz, Piero Marchetti, Rasmus Wernersson, Decio L Eizirik
Publié dans: Endocrinology, Numéro 158/8, 2017, Page(s) 2503-2521, ISSN 0013-7227
Éditeur: The Endocrine Society
DOI: 10.1210/en.2017-00104

Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes

Auteurs: Lorraine Yeo, Alyssa Woodwyk, Sanjana Sood, Anna Lorenc, Martin Eichmann, Irma Pujol-Autonell, Rosella Melchiotti, Ania Skowera, Efthymios Fidanis, Garry M. Dolton, Katie Tungatt, Andrew K. Sewell, Susanne Heck, Alka Saxena, Craig A. Beam, Mark Peakman
Publié dans: Journal of Clinical Investigation, Numéro 128/8, 2018, Page(s) 3460-3474, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/JCI120555

Characterization and non-parametric modeling of the developing serum proteome during infancy and early childhood

Auteurs: Niina Lietzén, Lu Cheng, Robert Moulder, Heli Siljander, Essi Laajala, Taina Härkönen, Aleksandr Peet, Aki Vehtari, Vallo Tillmann, Mikael Knip, Harri Lähdesmäki, Riitta Lahesmaa
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-24019-5

Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes

Auteurs: Mijke Buitinga, Aïsha Callebaut, Fernanda Marques Câmara Sodré, Inne Crèvecoeur, Gabriele Blahnik-Fagan, Mei-Ling Yang, Marco Bugliani, David Arribas-Layton, Meghan Marré, Dana P. Cook, Etienne Waelkens, Roberto Mallone, Jon D. Piganelli, Piero Marchetti, Mark J. Mamula, Rita Derua, Eddie A. James, Chantal Mathieu, Lut Overbergh
Publié dans: Diabetes, Numéro 67/11, 2018, Page(s) 2337-2348, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/db18-0295

Immunological biomarkers for the development and progression of type 1 diabetes

Auteurs: Chantal Mathieu, Riitta Lahesmaa, Ezio Bonifacio, Peter Achenbach, Timothy Tree
Publié dans: Diabetologia, Numéro 61/11, 2018, Page(s) 2252-2258, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-018-4726-8

When one becomes many-Alternative splicing in β-cell function and failure

Auteurs: Maria Inês Alvelos, Jonàs Juan-Mateu, Maikel Luis Colli, Jean-Valéry Turatsinze, Décio L. Eizirik
Publié dans: Diabetes, Obesity and Metabolism, Numéro 20, 2018, Page(s) 77-87, ISSN 1462-8902
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/dom.13388

Biomarkers of islet beta cell stress and death in type 1 diabetes

Auteurs: Emily K. Sims, Carmella Evans-Molina, Sarah A. Tersey, Decio L. Eizirik, Raghavendra G. Mirmira
Publié dans: Diabetologia, Numéro 61/11, 2018, Page(s) 2259-2265, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-018-4712-1

Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa

Auteurs: Stéphane Demine, Alexander Balhuizen, Vinciane Debaille, Lieke Joosten, Maïté Fereau, Satya Chilla, Isabelle Millard, Raphaël Scharfmann, Dominique Egrise, Serge Goldman, Piero Marchetti, Martin Gotthardt, Sophie Laurent, Carmen Burtea, Decio Eizirik
Publié dans: Molecules, Numéro 23/9, 2018, Page(s) 2100, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23092100

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction

Auteurs: Maikel L. Colli, Jessica L.E. Hill, Laura Marroquí, Jessica Chaffey, Reinaldo S. Dos Santos, Pia Leete, Alexandra Coomans de Brachène, Flavia M.M. Paula, Anne Op de Beeck, Angela Castela, Lorella Marselli, Lars Krogvold, Knut Dahl-Jorgensen, Piero Marchetti, Noel G. Morgan, Sarah J. Richardson, Décio L. Eizirik
Publié dans: EBioMedicine, Numéro 36, 2018, Page(s) 367-375, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2018.09.040

SRp55 Regulates a Splicing Network That Controls Human Pancreatic β-Cell Function and Survival

Auteurs: Jonàs Juan-Mateu, Maria Inês Alvelos, Jean-Valéry Turatsinze, Olatz Villate, Esther Lizarraga-Mollinedo, Fabio Arturo Grieco, Laura Marroquí, Marco Bugliani, Piero Marchetti, Décio L. Eizirik
Publié dans: Diabetes, Numéro 67/3, 2018, Page(s) 423-436, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/db17-0736

IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells

Auteurs: Alexandra Coomans de Brachène, Reinaldo S. Dos Santos, Laura Marroqui, Maikel L. Colli, Lorella Marselli, Raghavendra G. Mirmira, Piero Marchetti, Decio L. Eizirik
Publié dans: Diabetologia, Numéro 61/3, 2018, Page(s) 636-640, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-017-4536-4

Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis

Auteurs: Flavia M. M. Paula, Nayara C. Leite, Patricia C. Borck, Ricardo Freitas-Dias, Miriam Cnop, Mara P. T. Chacon-Mikahil, Claudia R. Cavaglieri, Piero Marchetti, Antonio C. Boschero, Claudio C. Zoppi, Decio L. Eizirik
Publié dans: The FASEB Journal, Numéro 32/3, 2018, Page(s) 1524-1536, ISSN 0892-6638
Éditeur: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201700710R

A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells

Auteurs: Alexander Balhuizen, Sam Massa, Iris Mathijs, Jean-Valery Turatsinze, Jens De Vos, Stéphane Demine, Catarina Xavier, Olatz Villate, Isabelle Millard, Dominique Egrise, Carmen Capito, Raphaël Scharfmann, Pieter In’t Veld, Piero Marchetti, Serge Muyldermans, Serge Goldman, Tony Lahoutte, Luc Bouwens, Decio L. Eizirik, Nick Devoogdt
Publié dans: Scientific Reports, Numéro 7/1, 2017, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-017-15417-2

Frequent Monitoring of C-Peptide Levels in Newly Diagnosed Type 1 Subjects Using Dried Blood Spots Collected at Home

Auteurs: Ruben H Willemsen, Keith Burling, Peter Barker, Fran Ackland, Renuka P Dias, Julie Edge, Anne Smith, John Todd, Boryana Lopez, Adrian P Mander, Catherine Guy, David B Dunger
Publié dans: The Journal of Clinical Endocrinology & Metabolism, Numéro 103/9, 2018, Page(s) 3350-3358, ISSN 0021-972X
Éditeur: The Endocrine Society
DOI: 10.1210/jc.2018-00500

Europe has to step up its efforts to produce innovative and safe diabetes technology

Auteurs: Miriam Cnop, Tomasz Klupa, Nikolaos Tentolouris, Anna Novials, Rémy Burcelin, Mischa van Eimeren
Publié dans: Diabetologia, Numéro 60/12, 2017, Page(s) 2532-2533, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-017-4455-4

MicroRNAs

Auteurs: Francesco Dotta, Giuliana Ventriglia, Isaac V. Snowhite, Alberto Pugliese
Publié dans: Current Opinion in Endocrinology & Diabetes and Obesity, Numéro 25/4, 2018, Page(s) 237-245, ISSN 1752-296X
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MED.0000000000000420

Islet-reactive CD8 + T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

Auteurs: Slobodan Culina, Ana Ines Lalanne, Georgia Afonso, Karen Cerosaletti, Sheena Pinto, Guido Sebastiani, Klaudia Kuranda, Laura Nigi, Anne Eugster, Thomas Østerbye, Alicia Maugein, James E. McLaren, Kristin Ladell, Etienne Larger, Jean-Paul Beressi, Anna Lissina, Victor Appay, Howard W. Davidson, Søren Buus, David A. Price, Matthias Kuhn, Ezio Bonifacio, Manuela Battaglia, Sophie Caillat-Zucman, Fr
Publié dans: Science Immunology, Numéro 3/20, 2018, Page(s) eaao4013, ISSN 2470-9468
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/sciimmunol.aao4013

Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

Auteurs: Sergio Gonzalez-Duque, Marie Eliane Azoury, Maikel L. Colli, Georgia Afonso, Jean-Valery Turatsinze, Laura Nigi, Ana Ines Lalanne, Guido Sebastiani, Alexia Carré, Sheena Pinto, Slobodan Culina, Noémie Corcos, Marco Bugliani, Piero Marchetti, Mathieu Armanet, Marc Diedisheim, Bruno Kyewski, Lars M. Steinmetz, Søren Buus, Sylvaine You, Daniele Dubois-Laforgue, Etienne Larger, Jean-Paul Beressi, G
Publié dans: Cell Metabolism, Numéro 28/6, 2018, Page(s) 946-960.e6, ISSN 1550-4131
Éditeur: Cell Press
DOI: 10.1016/j.cmet.2018.07.007

The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms

Auteurs: Pia Leete, Roberto Mallone, Sarah J. Richardson, Jay M. Sosenko, Maria J. Redondo, Carmella Evans-Molina
Publié dans: Current Diabetes Reports, Numéro 18/11, 2018, ISSN 1534-4827
Éditeur: Current Science Inc.
DOI: 10.1007/s11892-018-1083-4

Virus-like infection induces human β cell dedifferentiation

Auteurs: Masaya Oshima, Klaus-Peter Knoch, Marc Diedisheim, Antje Petzold, Pierre Cattan, Marco Bugliani, Piero Marchetti, Pratik Choudhary, Guo-Cai Huang, Stefan R. Bornstein, Michele Solimena, Olivier Albagli-Curiel, Raphael Scharfmann
Publié dans: JCI Insight, Numéro 3/3, 2018, ISSN 2379-3708
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.97732

Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource

Auteurs: Piero Marchetti, Mara Suleiman, Lorella Marselli
Publié dans: Diabetologia, Numéro 61/4, 2018, Page(s) 770-774, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-018-4546-x

MANF protects human pancreatic beta cells against stress-induced cell death

Auteurs: Elina Hakonen, Vikash Chandra, Christopher L. Fogarty, Nancy Yiu-Lin Yu, Jarkko Ustinov, Shintaro Katayama, Emilia Galli, Tatiana Danilova, Päivi Lindholm, Aki Vartiainen, Elisabet Einarsdottir, Kaarel Krjutškov, Juha Kere, Mart Saarma, Maria Lindahl, Timo Otonkoski
Publié dans: Diabetologia, Numéro 61/10, 2018, Page(s) 2202-2214, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-018-4687-y

Novel minor HLA DR associated antigens in type 1 diabetes

Auteurs: Denise Müller, Tanja Telieps, Anne Eugster, Christina Weinzierl, Manja Jolink, Anette-Gabriele Ziegler, Ezio Bonifacio
Publié dans: Clinical Immunology, Numéro 194, 2018, Page(s) 87-91, ISSN 1521-6616
Éditeur: Academic Press
DOI: 10.1016/j.clim.2018.07.001

The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ Genotype

Auteurs: Christina Reinauer, Joachim Rosenbauer, Christina Bächle, Christian Herder, Michael Roden, Sian Ellard, Elisa De Franco, Beate Karges, Reinhard Holl, Jürgen Enczmann, Thomas Meissner
Publié dans: Genes, Numéro 8/5, 2017, Page(s) 146, ISSN 2073-4425
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes8050146

DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway

Auteurs: Reinaldo S. Dos Santos, Laura Marroqui, Teresa Velayos, Ane Olazagoitia-Garmendia, Amaia Jauregi-Miguel, Ainara Castellanos-Rubio, Decio L. Eizirik, Luis Castaño, Izortze Santin
Publié dans: Diabetologia, 2018, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-018-4782-0

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

Auteurs: Diego Balboa, Jonna Saarimäki-Vire, Daniel Borshagovski, Mantas Survila, Päivi Lindholm, Emilia Galli, Solja Eurola, Jarkko Ustinov, Heli Grym, Hanna Huopio, Juha Partanen, Kirmo Wartiovaara, Timo Otonkoski
Publié dans: eLife, Numéro 7, 2018, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.38519

Understanding type 1 diabetes through proteomics

Auteurs: Inne Crèvecoeur, Saurabh Vig, Chantal Mathieu, Lut Overbergh
Publié dans: Expert Review of Proteomics, Numéro 14/7, 2017, Page(s) 571-580, ISSN 1478-9450
Éditeur: Future Drugs Ltd.
DOI: 10.1080/14789450.2017.1345633

Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells

Auteurs: Saurabh Vig, Mijke Buitinga, Dieter Rondas, Inne Crèvecoeur, Marc van Zandvoort, Etienne Waelkens, Decio L. Eizirik, Conny Gysemans, Pieter Baatsen, Chantal Mathieu, Lut Overbergh
Publié dans: Cell Death & Disease, Numéro 10/4, 2019, Page(s) 309, ISSN 2041-4889
Éditeur: Nature Publishing Group
DOI: 10.1038/s41419-019-1518-0

Translating Mechanism of Regulatory Action of Tolerogenic Dendritic Cells to Monitoring Endpoints in Clinical Trials

Auteurs: Jessica S. Suwandi, Tatjana Nikolic, Bart O. Roep
Publié dans: Frontiers in Immunology, Numéro 8, 2017, Page(s) 1598, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2017.01598

Fostering improved human islet research: a European perspective

Auteurs: Piero Marchetti, Anke M. Schulte, Lorella Marselli, Eyke Schoniger, Marco Bugliani, Werner Kramer, Lut Overbergh, Susanne Ullrich, Anna L. Gloyn, Mark Ibberson, Guy Rutter, Philippe Froguel, Leif Groop, Mark I. McCarthy, Francesco Dotta, Raphael Scharfmann, Christophe Magnan, Decio L. Eizirik, Chantal Mathieu, Miriam Cnop, Bernard Thorens, Michele Solimena
Publié dans: Diabetologia, Numéro 62/8, 2019, Page(s) 1514-1516, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-019-4911-4

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes

Auteurs: Amna Khamis, Mickaël Canouil, Afshan Siddiq, Hutokshi Crouch, Mario Falchi, Manon von Bulow, Florian Ehehalt, Lorella Marselli, Marius Distler, Daniela Richter, Jürgen Weitz, Krister Bokvist, Ioannis Xenarios, Bernard Thorens, Anke M. Schulte, Mark Ibberson, Amelie Bonnefond, Piero Marchetti, Michele Solimena, Philippe Froguel
Publié dans: Molecular Metabolism, Numéro 24, 2019, Page(s) 98-107, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.03.004

DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes

Auteurs: Marco Bugliani, Farooq Syed, Flavia M.M. Paula, Bilal A. Omar, Mara Suleiman, Sandra Mossuto, Francesca Grano, Francesco Cardarelli, Ugo Boggi, Fabio Vistoli, Franco Filipponi, Paolo De Simone, Lorella Marselli, Vincenzo De Tata, Bo Ahren, Decio L. Eizirik, Piero Marchetti
Publié dans: Molecular and Cellular Endocrinology, Numéro 473, 2018, Page(s) 186-193, ISSN 0303-7207
Éditeur: Elsevier BV
DOI: 10.1016/j.mce.2018.01.019

Longitudinal Trajectories of Metabolic Control From Childhood to Young Adulthood in Type 1 Diabetes From a Large German/Austrian Registry: A Group-Based Modeling Approach

Auteurs: Anke Schwandt, Julia M. Hermann, Joachim Rosenbauer, Claudia Boettcher, Désirée Dunstheimer, Jürgen Grulich-Henn, Oliver Kuss, Birgit Rami-Merhar, Christian Vogel, Reinhard W. Holl
Publié dans: Diabetes Care, Numéro 40/3, 2017, Page(s) 309-316, ISSN 0149-5992
Éditeur: American Diabetes Association
DOI: 10.2337/dc16-1625

Polycystic Ovary Syndrome (PCOS) in Juvenile and Adult Type 1 Diabetes in a German/Austrian Cohort

Auteurs: Christina Reinauer, Esther Bollow, Elke Fröhlich-Reiterer, Katharina Laubner, Dominik Bergis, Christof Schöfl, Hans-Peter Kempe, Michael Hummel, Pia Hennes, Katja Gollisch, Holger Haberland, Nicolin Datz, Thomas Meissner, Reinhard Holl
Publié dans: Experimental and Clinical Endocrinology & Diabetes, Numéro 125/10, 2017, Page(s) 661-668, ISSN 0947-7349
Éditeur: Johann Ambrosius Barth
DOI: 10.1055/s-0043-104701

Quantitative Proteomics Reveals the Dynamic Protein Landscape during Initiation of Human Th17 Cell Polarization

Auteurs: Subhash K. Tripathi, Tommi Välikangas, Ankitha Shetty, Mohd Moin Khan, Robert Moulder, Santosh D. Bhosale, Elina Komsi, Verna Salo, Rafael Sales De Albuquerque, Omid Rasool, Sanjeev Galande, Laura L. Elo, Riitta Lahesmaa
Publié dans: iScience, Numéro 11, 2019, Page(s) 334-355, ISSN 2589-0042
Éditeur: Elsevier
DOI: 10.1016/j.isci.2018.12.020

Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells

Auteurs: Maikel L. Colli, Flavia M. Paula, Lorella Marselli, Piero Marchetti, Merja Roivainen, Decio L. Eizirik, Anne Op de beeck
Publié dans: Journal of Innate Immunity, Numéro 11/4, 2019, Page(s) 375-390, ISSN 1662-811X
Éditeur: Karger AG
DOI: 10.1159/000496034

Succinylated Gelatin Improves the Theranostic Potential of Radiolabeled Exendin-4 in Insulinoma Patients

Auteurs: Mijke Buitinga, Tom Jansen, Inge van der Kroon, Wietske Woliner-van der Weg, Marti Boss, Marcel Janssen, Erik Aarntzen, Martin Béhé, Damian Wild, Eric Visser, Maarten Brom, Martin Gotthardt
Publié dans: Journal of Nuclear Medicine, Numéro 60/6, 2019, Page(s) 812-816, ISSN 0161-5505
Éditeur: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.118.219980

Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells

Auteurs: Niina Lietzén, Karoliina Hirvonen, Anni Honkimaa, Tanja Buchacher, Jutta E. Laiho, Sami Oikarinen, Magdalena A. Mazur, Malin Flodström-Tullberg, Eric Dufour, Amir-Babak Sioofy-Khojine, Heikki Hyöty, Riitta Lahesmaa
Publié dans: iScience, Numéro 19, 2019, Page(s) 340-357, ISSN 2589-0042
Éditeur: Elsevier
DOI: 10.1016/j.isci.2019.07.040

ICA512 RESP18 homology domain is a protein-condensing factor and insulin fibrillation inhibitor

Auteurs: Pamela L. Toledo, Juha M. Torkko, Andreas Müller, Carolin Wegbrod, Anke Sönmez, Michele Solimena, Mario R. Ermácora
Publié dans: Journal of Biological Chemistry, Numéro 294/21, 2019, Page(s) 8564-8576, ISSN 0021-9258
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.007607

Continuous glucose monitoring and glycemic control among youth with type 1 diabetes: International comparison from the T1D Exchange and DPV Initiative

Auteurs: Daniel J. DeSalvo, Kellee M. Miller, Julia M. Hermann, David M. Maahs, Sabine E. Hofer, Mark A. Clements, Eggert Lilienthal, Jennifer L. Sherr, Martin Tauschmann, Reinhard W. Holl
Publié dans: Pediatric Diabetes, Numéro 19/7, 2018, Page(s) 1271-1275, ISSN 1399-543X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/pedi.12711

The supply chain of human pancreatic β cell lines

Auteurs: Raphael Scharfmann, Willem Staels, Olivier Albagli
Publié dans: Journal of Clinical Investigation, Numéro 129/9, 2019, Page(s) 3511-3520, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci129484

The microRNAs miR-211-5p and miR-204-5p modulate ER stress in human beta cells

Auteurs: Fabio Arturo Grieco, Andrea Alex Schiavo, Flora Brozzi, Jonas Juan-Mateu, Marco Bugliani, Piero Marchetti, Décio Eizirik
Publié dans: Journal of Molecular Endocrinology, 2019, ISSN 0952-5041
Éditeur: Society for Endocrinology
DOI: 10.1530/jme-19-0066

Mixed‐meal tolerance test to assess residual beta‐cell secretion: Beyond the area‐under‐curve of plasma C‐peptide concentration

Auteurs: Yue Ruan, Ruben H. Willemsen, Malgorzata E. Wilinska, Martin Tauschmann, David B. Dunger, Roman Hovorka
Publié dans: Pediatric Diabetes, Numéro 20/3, 2019, Page(s) 282-285, ISSN 1399-543X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/pedi.12816

MicroRNAs as Regulators of Insulin Signaling: Research Updates and Potential Therapeutic Perspectives in Type 2 Diabetes

Auteurs: Laura Nigi, Giuseppina Grieco, Giuliana Ventriglia, Noemi Brusco, Francesca Mancarella, Caterina Formichi, Francesco Dotta, Guido Sebastiani
Publié dans: International Journal of Molecular Sciences, Numéro 19/12, 2018, Page(s) 3705, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19123705

Oral contraception in adolescents with type 1 diabetes and its association with cardiovascular risk factors. A multicenter DPV study on 24 011 patients from Germany, Austria or Luxembourg

Auteurs: Barbara Bohn, Kirsten Mönkemöller, Dörte Hilgard, Axel Dost, Karl Otfried Schwab, Eggert Lilienthal, Elke Hammer, Kathrin Hake, Maria Fritsch, Bettina Gohlke, Carine de Beaufort, Reinhard W Holl
Publié dans: Pediatric Diabetes, Numéro 19/5, 2018, Page(s) 937-944, ISSN 1399-543X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/pedi.12656

Genome editing of human pancreatic beta cell models: problems, possibilities and outlook

Auteurs: Diego Balboa, Rashmi B. Prasad, Leif Groop, Timo Otonkoski
Publié dans: Diabetologia, Numéro 62/8, 2019, Page(s) 1329-1336, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-019-4908-z

Risk factors for decline in renal function among young adults with type 1 diabetes

Auteurs: Anke Schwandt, Dominik Bergis, Michael Denkinger, Katja S.C. Gollisch, Dirk Sandig, Harald Stingl, Stefan Zimny, Reinhard W. Holl
Publié dans: Journal of Diabetes and its Complications, Numéro 32/10, 2018, Page(s) 940-946, ISSN 1056-8727
Éditeur: Elsevier BV
DOI: 10.1016/j.jdiacomp.2018.07.007

Trajectories of Body Mass Index from Childhood to Young Adulthood among Patients with Type 1 Diabetes—A Longitudinal Group-Based Modeling Approach Based on the DPV Registry

Auteurs: Nicole Prinz, Anke Schwandt, Marianne Becker, Christian Denzer, Monika Flury, Maria Fritsch, Angela Galler, Andreas Lemmer, Matthias Papsch, Thomas Reinehr, Joachim Rosenbauer, Reinhard W. Holl
Publié dans: The Journal of Pediatrics, Numéro 201, 2018, Page(s) 78-85.e4, ISSN 0022-3476
Éditeur: Mosby Inc.
DOI: 10.1016/j.jpeds.2018.05.014

Ultra-high resolution MALDI-FTICR-MSI analysis of intact proteins in mouse and human pancreas tissue

Auteurs: Isabella Piga, Bram Heijs, Simone Nicolardi, Laura Giusti, Lorella Marselli, Piero Marchetti, Maria Rosa Mazzoni, Antonio Lucacchini, Liam A. McDonnell
Publié dans: International Journal of Mass Spectrometry, Numéro 437, 2019, Page(s) 10-16, ISSN 1387-3806
Éditeur: Elsevier BV
DOI: 10.1016/j.ijms.2017.11.001

Impact of long-term air pollution exposure on metabolic control in children and adolescents with type 1 diabetes: results from the DPV registry

Auteurs: Stefanie Lanzinger, Joachim Rosenbauer, Dorothea Sugiri, Tamara Schikowski, Birgit Treiber, Daniela Klee, Wolfgang Rathmann, Reinhard W. Holl
Publié dans: Diabetologia, Numéro 61/6, 2018, Page(s) 1354-1361, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-018-4580-8

Center Size and Glycemic Control: An International Study With 504 Centers From Seven Countries

Auteurs: Niels H. Birkebaek, Julia M. Hermann, Lena Hanberger, Dimitrios Charalampopoulos, Reinhard W. Holl, Torild Skrivarhaug, Karin Aakesson, Justin T. Warner, Ann K. Drivvoll, Ann-Marie Svensson, Terence Stephenson, Sabine E. Hofer, Siri Fredheim, Siv J. Kummernes, Rakesh Amin, Birgit Rami-Merhar, Anders Johansen, Thomas M. Kapellen, Doerte Hilgard, Knut Dahl-Jørgensen, Elke Froehlich-Reiterer, Maria
Publié dans: Diabetes Care, Numéro 42/3, 2019, Page(s) e37-e39, ISSN 0149-5992
Éditeur: American Diabetes Association
DOI: 10.2337/dc18-1253

CRISPR/Cas9 guided genome and epigenome engineering and its therapeutic applications in immune mediated diseases

Auteurs: Desh Deepak Singh, R. David Hawkins, Riitta Lahesmaa, Subhash K. Tripathi
Publié dans: Seminars in Cell & Developmental Biology, 2019, ISSN 1084-9521
Éditeur: Academic Press
DOI: 10.1016/j.semcdb.2019.05.007

Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation

Auteurs: Johan Henriksson, Xi Chen, Tomás Gomes, Ubaid Ullah, Kerstin B. Meyer, Ricardo Miragaia, Graham Duddy, Jhuma Pramanik, Kosuke Yusa, Riitta Lahesmaa, Sarah A. Teichmann
Publié dans: Cell, Numéro 176/4, 2019, Page(s) 882-896.e18, ISSN 0092-8674
Éditeur: Cell Press
DOI: 10.1016/j.cell.2018.11.044

The role of proteomics in assessing beta-cell dysfunction and death in type 1 diabetes

Auteurs: Ernesto S. Nakayasu, Wei-Jun Qian, Carmella Evans-Molina, Raghavendra G. Mirmira, Decio L. Eizirik, Thomas O. Metz
Publié dans: Expert Review of Proteomics, Numéro 16/7, 2019, Page(s) 569-582, ISSN 1478-9450
Éditeur: Future Drugs Ltd.
DOI: 10.1080/14789450.2019.1634548

The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes

Auteurs: Mireia Ramos-Rodríguez, Helena Raurell-Vila, Maikel L. Colli, Maria Inês Alvelos, Marc Subirana-Granés, Jonàs Juan-Mateu, Richard Norris, Jean-Valery Turatsinze, Ernesto S. Nakayasu, Bobbie-Jo M. Webb-Robertson, Jamie R. J. Inshaw, Piero Marchetti, Lorenzo Piemonti, Manel Esteller, John A. Todd, Thomas O. Metz, Décio L. Eizirik, Lorenzo Pasquali
Publié dans: Nature Genetics, Numéro 51/11, 2019, Page(s) 1588-1595, ISSN 1061-4036
Éditeur: Nature Publishing Group
DOI: 10.1038/s41588-019-0524-6

miR-409-3p is reduced in plasma and islet immune infiltrates of NOD diabetic mice and is differentially expressed in people with type 1 diabetes

Auteurs: Giuliana Ventriglia, Francesca Mancarella, Guido Sebastiani, Dana P. Cook, Roberto Mallone, Chantal Mathieu, Conny Gysemans, Francesco Dotta
Publié dans: Diabetologia, 2019, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-019-05026-1

Proinsulin peptide promotes autoimmune diabetes in a novel HLA-DR3-DQ2-transgenic murine model of spontaneous disease

Auteurs: Johan Verhagen, Norkhairin Yusuf, Emma L. Smith, Emily M. Whettlock, Kerina Naran, Sefina Arif, Mark Peakman
Publié dans: Diabetologia, Numéro 62/12, 2019, Page(s) 2252-2261, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-019-04994-8

Breast Milk-Derived Extracellular Vesicles Enriched in Exosomes From Mothers With Type 1 Diabetes Contain Aberrant Levels of microRNAs

Auteurs: Aashiq H. Mirza, Simranjeet Kaur, Lotte B. Nielsen, Joachim Størling, Reza Yarani, Martin Roursgaard, Elisabeth R. Mathiesen, Peter Damm, Jens Svare, Henrik B. Mortensen, Flemming Pociot
Publié dans: Frontiers in Immunology, Numéro 10, 2019, ISSN 1664-3224
Éditeur: Frontiers Editorial Office
DOI: 10.3389/fimmu.2019.02543

Association of Glycemic Control and Cell Stress With Telomere Attrition in Type 1 Diabetes

Auteurs: Tine Tesovnik, Jernej Kovac, Tinka Hovnik, Klemen Dovc, Nataša Bratina, Tadej Battelino, Katarina Trebušak Podkrajšek
Publié dans: JAMA Pediatrics, Numéro 172/9, 2018, Page(s) 879, ISSN 2168-6203
Éditeur: American Medical Association
DOI: 10.1001/jamapediatrics.2018.1175

Phenotypic Analysis of Human Lymph Nodes in Subjects With New-Onset Type 1 Diabetes and Healthy Individuals by Flow Cytometry

Auteurs: Jennie H. M. Yang, Leena Khatri, Marius Mickunas, Evangelia Williams, Danijela Tatovic, Mohammad Alhadj Ali, Philippa Young, Penelope Moyle, Vishal Sahni, Ryan Wang, Rejbinder Kaur, Gillian M. Tannahill, Andrew R. Beaton, Danielle M. Gerlag, Caroline O. S. Savage, Antonella Napolitano Rosen, Frank Waldron-Lynch, Colin M. Dayan, Timothy I. M. Tree
Publié dans: Frontiers in Immunology, Numéro 10, 2019, ISSN 1664-3224
Éditeur: Frontiers Editorial Office
DOI: 10.3389/fimmu.2019.02547

Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells

Auteurs: Stéphane Demine, Andrea Alex Schiavo, Sandra Marín-Cañas, Piero Marchetti, Miriam Cnop, Decio L. Eizirik
Publié dans: Stem Cell Research & Therapy, Numéro 11/1, 2020, ISSN 1757-6512
Éditeur: BioMed Central
DOI: 10.1186/s13287-019-1523-3

From immunohistological to anatomical alterations of human pancreas in type 1 diabetes: New concepts on the stage

Auteurs: Laura Nigi, Carla Maccora, Francesco Dotta, Guido Sebastiani
Publié dans: Diabetes/Metabolism Research and Reviews, 2019, ISSN 1520-7552
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/dmrr.3264

Targeting microRNAs as a Therapeutic Strategy to Reduce Oxidative Stress in Diabetes

Auteurs: Giuseppina Emanuela Grieco, Noemi Brusco, Giada Licata, Laura Nigi, Caterina Formichi, Francesco Dotta, Guido Sebastiani
Publié dans: International Journal of Molecular Sciences, Numéro 20/24, 2019, Page(s) 6358, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20246358

Capturing residual beta cell function in type 1 diabetes

Auteurs: Pociot F
Publié dans: Diabetologia, Numéro 2019 Jan;62(1), 2019, Page(s) 28-32, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-018-4768-y

PET-based dosimetry of [68Ga]Ga-NODAGA-exendin-4 in humans, a tracer for beta cell imaging

Auteurs: Boss M, Buitinga M, Jansen TJ, Brom M, Visser EP, Gotthardt M
Publié dans: The Journal of Nuclear Medicine, Numéro 2020 Jan; 61(1), 2019, Page(s) 112–116, ISSN 0161-5505
Éditeur: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.119.228627

Circulating β cell-specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes

Auteurs: Yeo L, Pujol-Autonell I, Baptista R, Eichmann M, Kronenberg-Versteeg D, Heck S, Dolton G, Sewell AK, Härkönen T, Mikk ML, Toppari J, Veijola R, Knip M, Ilonen J, Peakman M
Publié dans: Clinical and Experimental Immunology, Numéro 2019 Oct 29, 2019, ISSN 0009-9104
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/cei.13391

Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity

Auteurs: Masaya Oshima, Séverine Pechberty, Lara Bellini, Sven O. Göpel, Mélanie Campana, Claude Rouch, Julien Dairou, Cristina Cosentino, Federica Fantuzzi, Sanna Toivonen, Piero Marchetti, Christophe Magnan, Miriam Cnop, Hervé Le Stunff, Raphaël Scharfmann
Publié dans: Diabetologia, Numéro 63/2, 2020, Page(s) 395-409, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-019-05046-x

In vitro beta-cell killing models using immune cells and human pluripotent stem cell-derived islets: Challenges and opportunities

Auteurs: Halliez C, Ibrahim H, Otonkoski T, Mallone R.
Publié dans: Frontiers in endocrinology, Numéro 13, 2023, Page(s) 13:1076683, ISSN 1664-2392
Éditeur: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fendo.2022.1076683

Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice.

Auteurs: Fernanda M. C. Sodré, Samal Bissenova, Ylke Bruggeman, Ronak Tilvawala, Dana P. Cook, Claire Berthault, Santanu Mondal, Aïsha Callebaut, Sylvaine You, Raphael Scharfmann, Roberto Mallone, Paul R. Thompson, Chantal Mathieu, Mijke Buitinga, Lut Overbergh
Publié dans: Diabetes, 2020, Page(s) db200421, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/db20-0421

First-in-human, double-blind, randomized phase 1b study of peptide immunotherapy IMCY-0098 in new-onset type 1 diabetes

Auteurs: Van Rampelbergh J, Achenbach P, Leslie RD, Ali MA, Dayan C, Keymeulen B, Owen KR, Kindermans M, Parmentier F, Carlier V, Ahangarani RR, Gebruers E, Bovy N, Vanderelst L, Van Mechelen M, Vandepapelière P, Boitard C.
Publié dans: BMC medicine, Numéro 21(1), 2023, Page(s) 190, ISSN 1741-7015
Éditeur: BioMed Central
DOI: 10.1186/s12916-023-02900-z

Purification of pancreatic endocrine subsets reveals increased iron metabolism in beta-cells

Auteurs: Berthault C, Staels W, Scharfmann R.
Publié dans: Molecular Metabolism, Numéro 2020 Aug 4:101060, 2020, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101060

Long-RNA sequencing and ribosome profiling of inflamed beta-cells reveal an extensive translatome landscape.

Auteurs: Thomaidou S, Slieker RC, van der Slik AR, Boom J, Mulder F, Munoz-Garcia A, 't Hart LM, Koeleman B, Carlotti F, Hoeben RC, Roep BO, Mei H, Zaldumbide A.
Publié dans: Diabetes, Numéro 70(10), 2021, Page(s) 2299-2312, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/db20-1122

Distinguishing activated T regulatory cell and T conventional cells by single-cell technologies.

Auteurs: Reinhardt J, Sharma V, Stavridou A, Lindner A, Reinhardt S, Petzold A, Lesche M, Rost F, Bonifacio E, Eugster A.
Publié dans: Immunology, Numéro 166(1), 2022, Page(s) 121-137, ISSN 1365-2567
Éditeur: Oxford : Blackwell Scientific Publications
DOI: 10.1111/imm.13460

ER stress promotes mitochondrial DNA mediated type-1 interferon response in beta-cells and interleukin-8 driven neutrophil chemotaxis.

Auteurs: Vig S, Lambooij JM, Dekkers MC, Otto F, Carlotti F, Guigas B, Zaldumbide A.
Publié dans: Frontiers in endocrinology., Numéro 13, 2022, Page(s) 991632, ISSN 1664-2392
Éditeur: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fendo.2022.991632

Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?

Auteurs: Roberto Mallone, Decio L. Eizirik
Publié dans: Diabetologia, Numéro 63/10, 2020, Page(s) 1999-2006, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-020-05176-7

Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes affirms markers of disease

Auteurs: Robert Moulder, M. Karoliina Hirvonen, Tommi Välikangas, Tomi Suomi, Lut Overbergh, Mark Peakman, Søren Brunak, Chantal Mathieu, Mikael Knip, Laura L. Elo, Riitta Lahesmaa, null null
Publié dans: Diabetologia, 2025, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-025-06394-7

A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes

Auteurs: Marwaha AK, Chow S, Pesenacker AM, Cook L, Sun A, Long SA, Yang JHM, Ward-Hartstonge KA, Williams E, Domingo-Vila C, Halani K, Harris KM, Tree TIM, Levings MK, Elliott T, Tan R, Dutz JP.
Publié dans: Immunotherapy Advances, 2021, Page(s) 2(1), ISSN 2732-4303
Éditeur: Oxford University Press
DOI: 10.1093/immadv/ltab022

The Transatlantic HbA1c gap : differences in glycaemic control across the lifespan between people included in the US T1D Exchange Registry and those included in the German/Austrian DPV registry

Auteurs: Hermann, Julia M.; Miller, K. M.; Hofer, S. E.; Clements, M. A.; Karges, Wolfram; Foster, N. C.; Fröhlich-Reiterer, E.; Rickels, M. R.; Rosenbauer, J.; DeSalvo, D. J.; Holl, R. W.; Maahs, D. M.
Publié dans: Diabetic medicine (2019). doi:10.1111/dme.14148, Numéro 1, 2020, ISSN 1464-5491
Éditeur: Wiley
DOI: 10.18154/RWTH-2020-01942

CD4+ T Cells From Individuals With Type 1 Diabetes Respond to a Novel Class of Deamidated Peptides Formed in Pancreatic Islets

Auteurs: Aïsha Callebaut, Perrin Guyer, Rita Derua, Mijke Buitinga, Anthony Manganaro, Xiaoyan Yi, Fernanda Marques Câmara Sodré, Saurabh Vig, Mara Suleiman, Piero Marchetti, Decio L. Eizirik, Sally C. Kent, Chantal Mathieu, Eddie A. James, Lut Overbergh
Publié dans: Diabetes, Numéro 73, 2024, Page(s) 728-742, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/db23-0588

Clinical care advice for monitoring of islet autoantibody positive individuals with presymptomatic type 1 diabetes

Auteurs: A. Emile J. Hendriks, M. Loredana Marcovecchio, Rachel E. J. Besser, Ezio Bonifacio, Kristina Casteels, Helena Elding Larsson, Gita Gemulla, Markus Lundgren, Olga Kordonouri, Roberto Mallone, Flemming Pociot, Agnieszka Szypowska, Jorma Toppari, Thekla von dem Berge, Anette G. Ziegler, Chantal Mathieu, Peter Achenbach, null null
Publié dans: Diabetes/Metabolism Research and Reviews, Numéro 40, 2024, Page(s) e3777, ISSN 1520-7552
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/dmrr.3777

Glycemic variability - the danger of a physiologically stable metric.

Auteurs: Battelino T, Dovč K.
Publié dans: The Journal of clinical endocrinology and metabolism., Numéro 105(10), 2020, Page(s) e3815–e3817, ISSN 0021-972X
Éditeur: The Endocrine Society
DOI: 10.1210/clinem/dgaa486

β-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Posttranscriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1

Auteurs: Sofia Thomaidou, Maria J.L. Kracht, Arno van der Slik, Sandra Laban, Eelco J. de Koning, Francoise Carlotti, Rob C. Hoeben, Bart O. Roep, Arnaud Zaldumbide
Publié dans: Diabetes, Numéro 69/4, 2020, Page(s) 670-680, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/db19-0984

From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes.

Auteurs: Eizirik DL, Szymczak F, Alvelos MI, Martin F.
Publié dans: Diabetes, Numéro 70(9), 2021, Page(s) 1915-1925, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/dbi20-0046

Neoepitopes in Type 1 Diabetes: Etiological Insights, Biomarkers and Therapeutic Targets.

Auteurs: Rodriguez-Calvo T, Johnson JD, Overbergh L, Dunne JL.
Publié dans: Frontiers in immunology, 2021, Page(s) 12:667989, ISSN 1664-3224
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.667989

Defining a cure for type 1 diabetes: a call to action.

Auteurs: Roep BO, Montero E, van Tienhoven R, Atkinson MA, Schatz DA, Mathieu C.
Publié dans: The lancet. Diabetes & endocrinology, Numéro (9), 2021, Page(s) 553-555, ISSN 2213-8587
Éditeur: Elsevier BV
DOI: 10.1016/s2213-8587(21)00181-9

Prognostic transcriptome classes of duodenopancreatic neuroendocrine tumors.

Auteurs: Diedisheim M, Dermine S, Jouinot A, Septier A, Gaujoux S, Dousset B, Cadiot G, Larger E, Bertherat J, Scharfmann R, Terris B, Coriat R, Assié G.
Publié dans: Endocrine-Related Cancer, Numéro 28(8), 2021, Page(s) 563-571, ISSN 1351-0088
Éditeur: Society for Endocrinology
DOI: 10.1530/erc-21-0051

Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses

Auteurs: Vecchio F, Carré A, Korenkov D, Zhou Z, Apaolaza P, Tuomela S, Burgos-Morales O, Snowhite I, Perez-Hernandez J, Brandao B, Afonso G, Halliez C, Kaddis J, Kent SC, Nakayama M, Richardson SJ, Vinh J, Verdier Y, Laiho J, Scharfmann R, Solimena M, Marinicova Z, Bismuth E, Lucidarme N, Sanchez J, Bustamante C, Gomez P, Buus S; nPOD-Virus Working Group; You S, Pugliese A, Hyoty H, Rodriguez-Calvo T, Fl
Publié dans: The lancet. Diabetes & endocrinology, Numéro 11(9), 2023, Page(s) 657-666, ISSN 2213-8587
Éditeur: Elsevier BV
DOI: 10.1101/2023.08.19.553954

Citrullination and PAD Enzyme Biology in Type 1 Diabetes - Regulators of Inflammation, Autoimmunity, and Pathology.

Auteurs: Yang ML, Sodré FMC, Mamula MJ, Overbergh L.
Publié dans: Frontiers in immunology, Numéro 12:678953, 2021, ISSN 1664-3224
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.678953

A nanobody-based nuclear imaging tracer targeting dipeptidyl peptidase 6 to determine the mass of human beta cell grafts in mice

Auteurs: Stéphane Demine, Rita Garcia Ribeiro, Julien Thevenet, Lorella Marselli, Piero Marchetti, François Pattou, Julie Kerr-Conte, Nick Devoogdt, Decio L. Eizirik
Publié dans: Diabetologia, Numéro 63/4, 2020, Page(s) 825-836, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-019-05068-5

International benchmarking in type 1 diabetes: Large difference in childhood HbA1c between 8 high-income countries but similar rise during adolescence-A quality registry study.

Auteurs: Anderzén J, Hermann JM, Samuelsson U, Charalampopoulos D, Svensson J, Skrivarhaug T, Fröhlich-Reiterer E, Maahs DM, Akesson K, Kapellen T, Fritsch M, Birkebaek NH, Drivvoll AK, Miller K, Stephenson T, Hofer SE, Fredheim S, Kummernes SJ, Foster N, Amin R, Hilgard D, Rami-Merhar B, Dahl-Jørgensen K, Clements M, Hanas R, Holl RW, Warner JT.
Publié dans: Pediatric diabetes., Numéro 21(4), 2020, Page(s) 621-627, ISSN 1399-5448
Éditeur: Copenhagen : Munksgaard
DOI: 10.1111/pedi.13014

Monitoring beta cell survival after intrahepatic islet transplantation using dynamic exendin PET imaging: a proof-of-concept study in individuals with type 1 diabetes

Auteurs: Jansen TJP, Buitinga M, Boss M, Nijhoff MF, Brom M, de Galan BE, van der Graaf M, van Koeverden S, Vantyghem MC, Beron A, Pattou F, Engelse MA, Velikyan I, Eriksson O, de Koning EJP, Gotthardt M
Publié dans: Diabetes, Numéro 72(7), 2023, Page(s) 898-907, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/db22-0884

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes.

Auteurs: Marselli L, Piron A, Suleiman M, Colli ML, Yi X, Khamis A, Carrat GR, Rutter GA, Bugliani M, Giusti L, Ronci M, Ibberson M, Turatsinze JV, Boggi U, De Simone P, De Tata V, Lopes M, Nasteska D, De Luca C, Tesi M, Bosi E, Singh P, Campani D, Schulte AM, Solimena M, Hecht P, Rady B, Bakaj I, Pocai A, Norquay L, Thorens B, Canouil M, Froguel P, Eizirik DL, Cnop M, Marchetti P.
Publié dans: Cell reports., Numéro 33(9), 2020, Page(s) 108466, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2020.108466

NET Proteome in Established Type 1 Diabetes Is Enriched in Metabolic Proteins

Auteurs: Bissenova S, Ellis D, Callebaut A, Eelen G, Derua R, Buitinga M, Mathieu C, Gysemans C, Overbergh L
Publié dans: Cells, Numéro 12(9), 2023, Page(s) 1319, ISSN 2073-4409
Éditeur: Basel, Switzerland : MDPI
DOI: 10.3390/cells12091319

Study protocol: Minimum effective low dose: anti-human thymocyte globulin (MELD-ATG): phase II, dose ranging, efficacy study of antithymocyte globulin (ATG) within 6 weeks of diagnosis of type 1 diabetes.

Auteurs: Wilhelm-Benartzi CS, Miller SE, Bruggraber S, Picton D, Wilson M, Gatley K, Chhabra A, Marcovecchio ML, Hendriks AEJ, Morobé H, Chmura PJ, Bond S, Aschemeier-Fuchs B, Knip M, Tree T, Overbergh L, Pall J, Arnaud O, Haller MJ, Nitsche A, Schulte AM, Mathieu C, Mander A, Dunger D.
Publié dans: BMJ Open, Numéro 11(12), 2021, Page(s) e053669, ISSN 2044-6055
Éditeur: BMJ Publishing Group
DOI: 10.1136/bmjopen-2021-053669

In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo.

Auteurs: Fantuzzi F, Toivonen S, Schiavo AA, Chae H, Tariq M, Sawatani T, Pachera N, Cai Y, Vinci C, Virgilio E, Ladriere L, Suleiman M, Marchetti P, Jonas JC, Gilon P, Eizirik DL, Igoillo-Esteve M, Cnop M.
Publié dans: Frontiers in cell and developmental biology., Numéro 10, 2022, Page(s) 967765, ISSN 2296-634X
Éditeur: Lausanne : Frontiers Media S.A., [2013]-
DOI: 10.3389/fcell.2022.967765

Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways.

Auteurs: Bosi E, Marchetti P, Rutter GA, Eizirik DL.
Publié dans: iScience, Numéro 25(10), 2022, Page(s) 105056, ISSN 2589-0042
Éditeur: [Cambridge, MA] : Cell Press, [2018]-
DOI: 10.1016/j.isci.2022.105056

Investigating the effect of verapamil on preservation of beta-cell function in adults with newly diagnosed type 1 diabetes mellitus (Ver-A-T1D): protocol for a randomised, double-blind, placebo-controlled, parallel-group, multicentre trial

Auteurs: Julie Wych, Martina Brunner, Rachel Stenson, Piotr Jaroslaw Chmura, Thomas Danne, Adrian Paul Mander, Chantal Mathieu, Colin Dayan, Thomas R Pieber
Publié dans: BMJ Open, Numéro 14, 2024, Page(s) e091597, ISSN 2044-6055
Éditeur: BMJ Publishing Group
DOI: 10.1136/bmjopen-2024-091597

Extracellular Vesicles in Immune System Regulation and Type 1 Diabetes: Cell-to-Cell Communication Mediators, Disease Biomarkers, and Promising Therapeutic Tools.

Auteurs: Grieco GE, Fignani D, Formichi C, Nigi L, Licata G, Maccora C, Brusco N, Sebastiani G, Dotta F.
Publié dans: Frontiers in immunology., Numéro 12:682948, 2021, ISSN 1664-3224
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.682948

Revisiting the role of inflammation in the loss of pancreatic β-cells in T1DM

Auteurs: Decio L. Eizirik, Maikel L. Colli
Publié dans: Nature Reviews Endocrinology, Numéro 16/11, 2020, Page(s) 611-612, ISSN 1759-5029
Éditeur: Nature Publishing Group
DOI: 10.1038/s41574-020-00409-6

Costimulation Blockade Disrupts CD4+ T Cell Memory Pathways and Uncouples Their Link to Decline in β-Cell Function in Type 1 Diabetes.

Auteurs: Eichmann M, Baptista R, Ellis RJ, Heck S, Peakman M, Beam CA.
Publié dans: Journal of Immunology, Numéro 204(12), 2020, Page(s) 3129-3138, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.1901439

Targeting B-cell subsets in type 1 diabetes: possible routes to therapy?

Auteurs: Noel G. Morgan
Publié dans: eBioMedicine, Numéro 113, 2025, Page(s) 105610, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2025.105610

Heterogeneity and endotypes in type 1 diabetes mellitus

Auteurs: Redondo MJ, Morgan NG
Publié dans: Nature reviews. Endocrinology, Numéro 19(9), 2023, Page(s) 542-554, ISSN 1759-5029
Éditeur: Nature Publishing Group
DOI: 10.1038/s41574-023-00853-0

The role of Interleukin-32 in autoimmunity.

Auteurs: de Albuquerque R, Komsi E, Starskaia I, Ullah U, Lahesmaa R.
Publié dans: Scandinavian journal of immunology., Numéro 93(2), 2021, Page(s) e13012, ISSN 0300-9475
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/sji.13012

Exendin-4 analogs in insulinoma theranostics

Auteurs: Tom.J.P. Jansen, Sanne.A.M. van Lith, Marti Boss, Maarten Brom, Lieke Joosten, Martin Béhé, Mijke Buitinga, Martin Gotthardt
Publié dans: Journal of Labelled Compounds and Radiopharmaceuticals, Numéro 62/10, 2019, Page(s) 656-672, ISSN 0362-4803
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/jlcr.3750

Emerging Concepts and Success Stories in Type 1 Diabetes Research: A Road Map for a Bright Future

Auteurs: Roberto Mallone, Emily Sims, Peter Achenbach, Chantal Mathieu, Alberto Pugliese, Mark Atkinson, Sanjoy Dutta, Carmella Evans-Molina, David Klatzmann, Anne Koralova, S. Alice Long, Lut Overbergh, Teresa Rodriguez-Calvo, Anette-Gabriele Ziegler, Sylvaine You
Publié dans: Diabetes, Numéro 74, 2024, Page(s) 12-21, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/db24-0439

A classification and regression tree analysis identifies subgroups of childhood type 1 diabetes.

Auteurs: Achenbach P, Hippich M, Zapardiel-Gonzalo J, Karges B, Holl RW, Petrera A, Bonifacio E, Ziegler AG; DiMelli Study group and DPV Study group.
Publié dans: EBioMedicine., Numéro 82, 2022, Page(s) 104118, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2022.104118

Multi‐omics analysis reveals drivers of loss of <i>β</i>‐cell function after newly diagnosed autoimmune type 1 diabetes: An INNODIA multicenter study

Auteurs: Jose Juan Almagro Armenteros, Caroline Brorsson, Christian Holm Johansen, Karina Banasik, Gianluca Mazzoni, Robert Moulder, Karoliina Hirvonen, Tomi Suomi, Omid Rasool, Sylvaine F. A. Bruggraber, M. Loredana Marcovecchio, Emile Hendricks, Naba Al‐Sari, Ismo Mattila, Cristina Legido‐Quigley, Tommi Suvitaival, Piotr J. Chmura, Mikael Knip, Anke M. Schulte, Jeong Heon Lee, Guido Sebastiani, Giuse
Publié dans: Diabetes/Metabolism Research and Reviews, Numéro 40, 2024, Page(s) e3833, ISSN 1520-7552
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/dmrr.3833

Mining the transcriptome of target tissues of autoimmune and degenerative pancreatic β-cell and brain diseases to discover therapies

Auteurs: Yi X, Marmontel de Souza B, Sawatani T, Szymczak F, Marselli L, Marchetti P, Cnop M, Eizirik DL.
Publié dans: iScience, Numéro 25(11), 2022, Page(s) 105376, ISSN 2589-0042
Éditeur: [Cambridge, MA] : Cell Press, [2018]-
DOI: 10.1016/j.isci.2022.105376

Comparative characteristics of older people with type 1 diabetes treated with continuous subcutaneous insulin infusion or insulin injection therapy: data from the German/Austrian DPV registry

Auteurs: J. Grammes, E. Küstner, A. Dapp, M. Hummel, J.‐C. Kämmer, T. Kubiak, I. Schütz‐Fuhrmann, S. Zimny, E. Bollow, R.W. Holl
Publié dans: Diabetic Medicine, Numéro 37/5, 2020, Page(s) 856-862, ISSN 0742-3071
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/dme.14218

The Landscape of microRNAs in βCell: Between Phenotype Maintenance and Protection.

Auteurs: Grieco GE, Brusco N, Licata G, Fignani D, Formichi C, Nigi L, Sebastiani G, Dotta F.
Publié dans: International journal of molecular sciences., Numéro 22(2), 2021, Page(s) 803, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020803

Identification of Deamidated Peptides in Cytokine-Exposed MIN6 Cells through LC-MS/MS Using a Shortened Digestion Time and Inspection of MS2 Spectra.

Auteurs: Callebaut A, Derua R, Vig S, Delong T, Mathieu C, Overbergh L.
Publié dans: Journal of Proteome Research, Numéro 20(2), 2021, Page(s) 1405-1414, ISSN 1535-3893
Éditeur: American Chemical Society
DOI: 10.1021/acs.jproteome.0c00801

Extracellular Vesicles Derived Human-miRNAs Modulate the Immune System in Type 1 Diabetes

Auteurs: Tine Tesovnik, Jernej Kovač, Katka Pohar, Samo Hudoklin, Klemen Dovč, Nataša Bratina, Katarina Trebušak Podkrajšek, Maruša Debeljak, Peter Veranič, Emanuele Bosi, Lorenzo Piemonti, Alojz Ihan, Tadej Battelino
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 8, 2020, Page(s) 202, ISSN 2296-634X
Éditeur: Frontiers Media
DOI: 10.3389/fcell.2020.00202

A direct look at the dysfunction and pathology of the β cells in human type 2 diabetes

Auteurs: Piero Marchetti, Mara Suleiman, Carmela De Luca, Walter Baronti, Emanuele Bosi, Marta Tesi, Lorella Marselli
Publié dans: Seminars in Cell & Developmental Biology, Numéro 103, 2020, Page(s) 83-93, ISSN 1084-9521
Éditeur: Academic Press
DOI: 10.1016/j.semcdb.2020.04.005

CD8+ T cells variably recognize native versus citrullinated GRP78 epitopes in type 1 diabetes

Auteurs: Azoury ME, Samassa F, Buitinga M, Nigi L, Brusco N, Callebaut A, Giraud M, Irla M, Lalanne AI, Carre A, Afonso G, Zhou Z, Brandao B, Colli ML, Sebastiani G, Dotta F, Nakayma M, Eizirik DL, You S, Pinto S, Mamula MJ, Verdier Y, Vinh J, Buus S, Mathieu C, Overgergh Lut, Mallone R
Publié dans: Diabetes, Numéro 70(12), 2021, Page(s) 2879-2891, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/db21-0259

Early Detection of Peripheral Blood Cell Signature in Children Developing β-Cell Autoimmunity at a Young Age

Auteurs: Henna Kallionpää, Juhi Somani, Soile Tuomela, Ubaid Ullah, Rafael de Albuquerque, Tapio Lönnberg, Elina Komsi, Heli Siljander, Jarno Honkanen, Taina Härkönen, Aleksandr Peet, Vallo Tillmann, Vikash Chandra, Mahesh Kumar Anagandula, Gun Frisk, Timo Otonkoski, Omid Rasool, Riikka Lund, Harri Lähdesmäki, Mikael Knip, Riitta Lahesmaa
Publié dans: Diabetes, Numéro 68/10, 2019, Page(s) 2024-2034, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/db19-0287

High-Throughput Analysis of Neutrophil Extracellular Trap Levels in Subtypes of People with Type 1 Diabetes

Auteurs: Bissenova S, Buitinga M, Boesch M, Korf H, Casteels K, Teunkens A, Mathieu C, Gysemans C.
Publié dans: Biology, Numéro 12(6), 2023, Page(s) 882, ISSN 2079-7737
Éditeur: MDPI
DOI: 10.3390/biology12060882

Exercise as a non-pharmacological intervention to protect pancreatic beta cells in individuals with type 1 and type 2 diabetes.

Auteurs: Coomans de Brachène A, Scoubeau C, Musuaya AE, Costa-Junior JM, Castela A, Carpentier J, Faoro V, Klass M, Cnop M, Eizirik DL.
Publié dans: Diabetologia, Numéro 1-11, 2022, ISSN 1432-0428
Éditeur: Berlin Springer Verlag
DOI: 10.1007/s00125-022-05837-9

The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α.

Auteurs: Chandra V, Ibrahim H, Halliez C, Prasad RB, Vecchio F, Dwivedi OP, Kvist J, Balboa D, Saarimäki-Vire J, Montaser H, Barsby T, Lithovius V, Artner I, Gopalakrishnan S, Groop L, Mallone R, Eizirik DL, Otonkoski T.
Publié dans: Nature communications, Numéro 13, 2022, Page(s) 6363, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-34069-z

Psychological care in children and adolescents with type 1 diabetes in a real‐world setting and associations with metabolic control

Auteurs: Angela Galler, Dörte Hilgard, Esther Bollow, Thomas Hermann, Nicole Kretschmer, Berthold Maier, Kirsten Mönkemöller, Ralf Schiel, Reinhard W. Holl
Publié dans: Pediatric Diabetes, Numéro 2020 Sep;21(6), 2020, Page(s) 1050-1058, ISSN 1399-543X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/pedi.13065

Single-cell imaging of α and β cell metabolic response to glucose in living human Langerhans islets.

Auteurs: Azzarello F, Pesce L, De Lorenzi V, Ferri G, Tesi M, Del Guerra S, Marchetti P, Cardarelli F.
Publié dans: Communications biology., Numéro 5, 2022, Page(s) 1232, ISSN 2399-3642
Éditeur: London, United Kingdom : Nature Publishing Group UK, [2018]-
DOI: 10.1038/s42003-022-04215-w

Regulated expression and function of the GABAB receptor in human pancreatic beta cell line and islets

Auteurs: Latif Rachdi, Alicia Maugein, Severine Pechberty, Mathieu Armanet, Juliette Hamroune, Philippe Ravassard, Stefano Marullo, Olivier Albagli, Raphael Scharfmann
Publié dans: Scientific Reports, Numéro 10/1, 2020, Page(s) 13469, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-69758-6

Quantitative analysis of islet prohormone convertase 1/3 expression in human pancreas donors with diabetes

Auteurs: Paola S. Apaolaza, Yi-Chun Chen, Kavi Grewal, Yannik Lurz, Severin Boulassel, C. Bruce Verchere, Teresa Rodriguez-Calvo
Publié dans: Diabetologia, Numéro 67, 2024, Page(s) 2771-2785, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-024-06275-5

Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes.

Auteurs: Bosi E, Marselli L, De Luca C, Suleiman M, Tesi M, Ibberson M, Eizirik DL, Cnop M, Marchetti P.
Publié dans: NAR genomics and bioinformatics., Numéro 2(4), 2020, Page(s) lqaa097, ISSN 2631-9268
Éditeur: Oxford University Press
DOI: 10.1093/nargab/lqaa097

The making of insulin in health and disease

Auteurs: Jovana Vasiljević, Juha M. Torkko, Klaus-Peter Knoch, Michele Solimena
Publié dans: Diabetologia, Numéro 63/10, 2020, Page(s) 1981-1989, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-020-05192-7

Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells.

Auteurs: Szymczak F, Alvelos MI, Marín-Cañas S, Castela Â, Demine S, Colli ML, Op de Beeck A, Thomaidou S, Marselli L, Zaldumbide A, Marchetti P, Eizirik DL.
Publié dans: Science advances., Numéro 8(37), 2022, Page(s) eabn5732, ISSN 2375-2548
Éditeur: Washington, DC : American Association for the Advancement of Science, [2015]-
DOI: 10.1126/sciadv.abn5732

Targeting citrullination in autoimmunity: insights learned from preclinical mouse models.

Auteurs: Bruggeman Y, Sodré FMC, Buitinga M, Mathieu C, Overbergh L, Kracht MJL.
Publié dans: Expert opinion on therapeutic targets., Numéro 25(4), 2021, Page(s) 269-281, ISSN 1472-8222
Éditeur: Ashley Publications Ltd.
DOI: 10.1080/14728222.2021.1918104

Presence of immunogenic alternatively spliced insulin gene product in human pancreatic delta cells

Auteurs: van Tienhoven R, Kracht MJL, van der Slik AR, Thomaidou S, Wolters AHG, Giepmans BNG, Riojas JPR, Nelson MS, Carlotti F, de Koning EJP, Hoeben RC, Zaldumbide A, Roep BO
Publié dans: Diabetologia, Numéro 66(5), 2023, Page(s) 884-896, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-023-05882-y

A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes.

Auteurs: Luce S, Guinoiseau S, Gadault A, Letourneur F, Nitschke P, Bras M, Vidaud M, Charneau P, Larger E, Colli ML, Eizirik DL, Lemonnier F, Boitard C.
Publié dans: Frontiers in immunology., Numéro 12:748679, 2021, ISSN 1664-3224
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.748679

Oral vaccination with Fc-coupled preproinsulin for Type 1 Diabetes prevention

Auteurs: Corcos, Noémie
Publié dans: Numéro 4, 2023
Éditeur: Université Paris Cité

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Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes – Sofia ref.: 115797

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