Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes – Sofia ref.: 115797

Project Information

INNODIA

Grant agreement ID: 115797

DOI

10.3030/115797

Project closed

EC signature date 7 December 2015

Start date 1 November 2015

End date 31 October 2023

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 41 683 297,94

EU contribution

€ 17 630 000,00

Coordinated by

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (13)

Characterization of the role for post- translational modifications, alternative splicing and endoplasmic reticulum stress for β-cell recognition by the immune system

Migration

Discovery and pre-clinical validation of novel biomarkers of β-cell mass, dysfunction and death in human T1D

Migration

Relationships between immune response/regulation, genome, transcriptome, epigenome, proteome, metabolome and metagenome

Migration

A comprehensive pan-European research network for the study of the aetiology and prevention of T1D

Migration

Successful start-up of the project - Kick Off Meeting

Migration

EUnPOD functioning

Migration

Discovery and pre-clinical validation of biomarkers of immune activation and regulation in human T1D

Migration

Imaging tool for -cell inflammation/death

Migration

Development of novel approaches for in vivo β-cell imaging

Migration

Plan for access to the CTN by third parties

Migration

Modelling the role for T1D candidate genes in the beta-cell-immune system dialog, and using this information to develop novel approaches to prevent β-cell death in diabetes.

Migration

Novel models of the cross talk between human β-cells and the human system in vitro

Migration

Discovery analysis of novel biomarkers in β- cell-omics, immunomics, genomics, transcriptomics, proteomics, metabolomics and lipidomics

Migration

Websites, patent fillings, videos etc. (1)

Launch public website

Migration

Publications

Peer reviewed articles (248)

Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?

Author(s): Alexia Carré, Sarah J. Richardson, Etienne Larger, Roberto Mallone
Published in: Diabetologia, Issue 64/1, 2021, Page(s) 15-25, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-020-05298-y

Characterisation and clinical outcomes in children and adolescents with diabetes according to newly defined subgroups: a cohort study from the DPV registry

Author(s): Katharina Warncke, Alexander Eckert, Ezio Bonifacio, Peter Achenbach, Olga Kordonouri, Thomas Meissner, Ute Ohlenschläger, Walter Bonfig, Anette-G. Ziegler, Reinhard W. Holl
Published in: eClinicalMedicine, Issue 64, 2024, Page(s) 102208, ISSN 2589-5370
Publisher: London: The Lancet
DOI: 10.1016/j.eclinm.2023.102208

The SAgA of Antigen-Specific Immunotherapy for Type 1 Diabetes.

Author(s): Mallone R, You S.
Published in: Diabetes, Issue 70(6), 2021, Page(s) 1247-1249, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/dbi21-0011

Arresting or curing type 1 diabetes: an elusive goal, but closing the gap.

Author(s): Martens PJ, Gysemans C, Mathieu C.
Published in: The Journal of endocrinology, Issue 249(2), 2021, Page(s) T1-T11, ISSN 0022-0795
Publisher: Society for Endocrinology
DOI: 10.1530/joe-20-0552

Persistent coxsackievirus B1 infection triggers extensive changes in the transcriptome of human pancreatic ductal cells

Author(s): Buchacher T, Honkimaa A, Välikangas T, Lietzén N, Hirvonen MK, Laiho JE, Sioofy-Khojine AB, Eskelinen EL, Hyöty H, Elo LL, Lahesmaa R.
Published in: iScience, 2022, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2021.103653

The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults

Author(s): M. Loredana Marcovecchio, A. Emile J. Hendriks, Carl Delfin, Tadej Battelino, Thomas Danne, Mark L. Evans, Jesper Johannesen, Simranjeet Kaur, Mikael Knip, Lut Overbergh, Flemming Pociot, John A. Todd, Bart Van der Schueren, Linda S. Wicker, Mark Peakman, Chantal Mathieu, null null
Published in: Diabetologia, Issue 67, 2024, Page(s) 995-1008, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-024-06124-5

A single-cell human islet interactome atlas identifies disrupted autocrine and paracrine communications in type 2 diabetes.

Author(s): Bosi E, Marselli L, Suleiman M, Tesi M, De Luca C, Del Guerra S, Cnop M, Eizirik DL, Marchetti P.
Published in: NAR genomics and bioinformatics, Issue 4(4), 2022, Page(s) lqac084, ISSN 2631-9268
Publisher: [Oxford] : Oxford University Press, [2019]-
DOI: 10.1093/nargab/lqac084

Whole-Slide Image Analysis of Human Pancreas Samples to Elucidate the Immunopathogenesis of Type 1 Diabetes Using the QuPath Software.

Author(s): Apaolaza PS, Petropoulou PI, Rodriguez-Calvo T.
Published in: Frontiers in molecular biosciences., Issue 8:689799, 2021, ISSN 2296-889X
Publisher: Frontiers Media S.A.,
DOI: 10.3389/fmolb.2021.689799

The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes

Author(s): Huerta-Chagoya A, Schroeder P, Mandla R, Deutsch AJ, Zhu W, Petty L, Yi X, Cole JB, Udler MS, Dornbos P, Porneala B, DiCorpo D, Liu CT, Li JH, Szczerbiński L, Kaur V, Kim J, Lu Y, Martin A, Eizirik DL, Marchetti P, Marselli L, Chen L, Srinivasan S, Todd J, Flannick J, Gubitosi-Klug R, Levitsky L, Shah R, Kelsey M, Burke B, Dabelea DM, Divers J, Marcovina S, Stalbow L, Loos RJF, Darst BF, Kooperbe
Published in: Diabetologia, Issue 66(7), 2023, Page(s) 1273-1288, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-023-05912-9

Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes.

Author(s): Guyer P, Arribas-Layton D, Manganaro A, Speake C, Lord S, Eizirik DL, Kent SC, Mallone R, James EA.
Published in: Diabetes., Issue 72(1), 2022, Page(s) 85-96, ISSN 1939-327X
Publisher: [New York, American Diabetes Association]
DOI: 10.2337/db22-0191

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

Author(s): Décio L. Eizirik, Lorenzo Pasquali, Miriam Cnop
Published in: Nature Reviews Endocrinology, Issue 16/7, 2020, Page(s) 349-362, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-020-0355-7

Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes distinguishes markers of disease and C-peptide trajectory

Author(s): Moulder R, Välikangas T, Hirvonen MK, Suomi T, Brorsson CA, Lietzén N, Bruggraber SFA, Overbergh L, Dunger DB, Peakman M, Chmura PJ, Brunak S, Schulte AM, Mathieu C, Knip M, Elo LL, Lahesmaa R; INNODIA consortium
Published in: Diabetologia, Issue 66(11), 2023, Page(s) 1983-1996, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-023-05974-9

Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis

Author(s): Christian M. Cohrs, Julia K. Panzer, Denise M. Drotar, Stephen J. Enos, Nicole Kipke, Chunguang Chen, Robert Bozsak, Eyke Schöniger, Florian Ehehalt, Marius Distler, Ana Brennand, Stefan R. Bornstein, Jürgen Weitz, Michele Solimena, Stephan Speier
Published in: Cell Reports, Issue 31/1, 2020, Page(s) 107469, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.03.033

Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes

Author(s): Farooq Syed, Sarah A. Tersey, Jean-Valery Turatsinze, Jamie L. Felton, Nicole Jiyun Kang, Jennifer B. Nelson, Emily K. Sims, Mathieu Defrance, Martin Bizet, Francois Fuks, Miriam Cnop, Marco Bugliani, Piero Marchetti, Anette-Gabriele Ziegler, Ezio Bonifacio, Bobbie-Jo Webb-Robertson, Appakalai N. Balamurugan, Carmella Evans-Molina, Decio L. Eizirik, Kieren J. Mather, Silva Arslanian, Raghavendra G
Published in: Clinical Epigenetics, Issue 12/1, 2020, Page(s) 116, ISSN 1868-7075
Publisher: Springer Verlag
DOI: 10.1186/s13148-020-00906-5

YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress

Author(s): Elisa De Franco, Maria Lytrivi, Hazem Ibrahim, Hossam Montaser, Matthew N. Wakeling, Federica Fantuzzi, Kashyap Patel, Céline Demarez, Ying Cai, Mariana Igoillo-Esteve, Cristina Cosentino, Väinö Lithovius, Helena Vihinen, Eija Jokitalo, Thomas W. Laver, Matthew B. Johnson, Toshiaki Sawatani, Hadis Shakeri, Nathalie Pachera, Belma Haliloglu, Mehmet Nuri Ozbek, Edip Unal, Ruken Yıldırım, Tusha
Published in: Journal of Clinical Investigation, Issue 130/12, 2020, Page(s) 6338-6353, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci141455

Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes.

Author(s): Colli ML, Szymczak F, Eizirik DL.
Published in: Frontiers in endocrinology., 2020, Page(s) 11:568446, ISSN 1664-2392
Publisher: Frontiers Research Foundation
DOI: 10.3389/fendo.2020.568446

Area Deprivation and Regional Disparities in Treatment and Outcome Quality of 29,284 Pediatric Patients With Type 1 Diabetes in Germany: A Cross-sectional Multicenter DPV Analysis

Author(s): Marie Auzanneau, Stefanie Lanzinger, Barbara Bohn, Peter Kroschwald, Ursula Kuhnle-Krahl, Paul Martin Holterhus, Kerstin Placzek, Johannes Hamann, Rainer Bachran, Joachim Rosenbauer, Werner Maier
Published in: Diabetes Care, Issue 41/12, 2018, Page(s) 2517-2525, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dc18-0724

RedRibbon: A new rank-rank hypergeometric overlap for gene and transcript expression signatures

Author(s): Piron A, Szymczak F, Papadopoulou T, Alvelos MI, Defrance M, Lenaerts T, Eizirik DL, Cnop M
Published in: Life science alliance, Issue 7(2), 2023, Page(s) e202302203, ISSN 2575-1077
Publisher: Life Science Alliance, LLC
DOI: 10.26508/lsa.202302203

Proprotein convertase PCSK9 affects expression of key surface proteins in human pancreatic beta cells via intracellular and extracellular regulatory circuits.

Author(s): Saitoski K, Ryaboshapkina M, Hamza GM, Jarnuczak AF, Berthault C, Carlotti F, Armanet M, Sengupta K, Underwood CR, Andersson S, Guillas I, Le Goff W, Scharfmann R.
Published in: The Journal of biological chemistry., Issue 298, 2022, Page(s) 7, ISSN 1083-351X
Publisher: Baltimore, MD : American Society for Biochemistry and Molecular Biology
DOI: 10.1016/j.jbc.2022.102096

Fast Track Adaptation of Oncolytic Coxsackie B3 Virus to Resistant Colorectal Cancer Cells - a Method to Personalize Virotherapy

Author(s): Leslie Elsner, Lisanne Heimann, Anja Geisler, Babette Dieringer, Klaus-Peter Knoch, Luisa Hinze, Karin Klingel, Michel Solimena, Jens Kurreck, Henry Fechner
Published in: Biological Procedures Online, Issue 26, 2024, ISSN 1480-9222
Publisher: BioMed Central
DOI: 10.1186/s12575-024-00237-2

Preventing type 1 diabetes in childhood.

Author(s): Dayan CM, Besser REJ, Oram RA, Hagopian W, Vatish M, Bendor-Samuel O, Snape MD, Todd JA.
Published in: Science, Issue 373(6554), 2021, Page(s) 506-510, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abi4742

Endogenous mitochondrial double-stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells.

Author(s): Coomans de Brachène A, Castela A, Musuaya AE, Marselli L, Marchetti P, Eizirik DL.
Published in: Auto- immunity highlights., Issue 12(1), 2021, Page(s) 6, ISSN 2038-0305
Publisher: Springer Verlag Italia
DOI: 10.1186/s13317-021-00148-2

The Role of Beta Cell Recovery in Type 2 Diabetes Remission.

Author(s): Suleiman M, Marselli L, Cnop M, Eizirik DL, De Luca C, Femia FR, Tesi M, Del Guerra S, Marchetti P.
Published in: International journal of molecular sciences., Issue 23(13), 2022, Page(s) 7435, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23137435

Plasma Exosome-Enriched Extracellular Vesicles From Lactating Mothers With Type 1 Diabetes Contain Aberrant Levels of miRNAs During the Postpartum Period.

Author(s): Frørup C, Mirza AH, Yarani R, Nielsen LB, Mathiesen ER, Damm P, Svare J, Engelbrekt C, Størling J, Johannesen J, Mortensen HB, Pociot F, Kaur S.
Published in: Frontiers in immunology., Issue 12:744509, 2021, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.744509

The need and benefit of immune monitoring to define patient and disease heterogeneity, mechanisms of therapeutic action and efficacy of intervention therapy for precision medicine in type 1 diabetes

Author(s): Bart O Roep
Published in: Frontiers in immunology, Issue 14, 2023, Page(s) 14:1112858, ISSN 1664-3224
Publisher: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2023.1112858

Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes?

Author(s): Rodriguez-Calvo T, Christoffersson G, Bender C, von Herrath MG, Mallone R, Kent SC, James EA.
Published in: Frontiers in immunology, Issue 12:683091, 2021, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.683091

The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events?

Author(s): Mallone R, Halliez C, Rui J, Herold KC.
Published in: Diabetes, Issue 71(8), 2022, Page(s) 1603-1610, ISSN 1939-327X
Publisher: [New York, American Diabetes Association]
DOI: 10.2337/dbi21-0036

The Protective Action of Metformin against Pro-Inflammatory Cytokine-Induced Human Islet Cell Damage and the Mechanisms Involved.

Author(s): Giusti L, Tesi M, Ciregia F, Marselli L, Zallocco L, Suleiman M, De Luca C, Del Guerra S, Zuccarini M, Trerotola M, Eizirik DL, Cnop M, Mazzoni MR, Marchetti P, Lucacchini A, Ronci M.
Published in: Cells, Issue 11(15), 2022, Page(s) 2465, ISSN 2073-4409
Publisher: Basel, Switzerland : MDPI
DOI: 10.3390/cells11152465

Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes.

Author(s): Yang JHM, Ward-Hartstonge KA, Perry DJ, Blanchfield JL, Posgai AL, Wiedeman AE, Diggins K, Rahman A, Tree TIM, Brusko TM, Levings MK, James EA, Kent SC, Speake C, Homann D, Long SA; Immunology of Diabetes Society T-Cell Cytometry Group.
Published in: European journal of immunology., Issue 52(3), 2022, Page(s) 372–388., ISSN 1521-4141
Publisher: Weinheim, Verlag Chemie GmbH.
DOI: 10.1002/eji.202049067

A set of circulating microRNAs belonging to the 14q32 chromosome locus identifies two subgroups of individuals with recent-onset type 1 diabetes

Author(s): Guido Sebastiani, Giuseppina Emanuela Grieco, Marco Bruttini, Stefano Auddino, Alessia Mori, Mattia Toniolli, Daniela Fignani, Giada Licata, Elena Aiello, Laura Nigi, Caterina Formichi, Juan Fernandez-Tajes, Alberto Pugliese, Carmella Evans-Molina, Lut Overbergh, Timothy Tree, Mark Peakman, Chantal Mathieu, Francesco Dotta
Published in: Cell Reports Medicine, Issue 5, 2024, Page(s) 101591, ISSN 2666-3791
Publisher: Cambridge, MA
DOI: 10.1016/j.xcrm.2024.101591

The extent and magnitude of islet T cell infiltration as powerful tools to define the progression to type 1 diabetes

Author(s): Apaolaza PS, Balcacean D, Zapardiel-Gonzalo J, Rodriguez-Calvo T.
Published in: Diabetologia, Issue 66(6), 2023, Page(s) 1129–1141, ISSN 1432-0428
Publisher: Berlin Springer Verlag
DOI: 10.1007/s00125-023-05888-6

ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation

Author(s): Szymczak F, Cohen-Fultheim R, Thomaidou S, de Brachène AC, Castela A, Colli M, Marchetti P, Levanon E, Eizirik D, Zaldumbide A.
Published in: Frontiers in endocrinology, Issue 13, 2022, Page(s) 1058345, ISSN 1664-2392
Publisher: [Lausanne : Frontiers Research Foundation]
DOI: 10.3389/fendo.2022.1058345

Characterization of diabetes following pancreatic surgery in patients with congenital hyperinsulinism

Author(s): Alena Welters, Thomas Meissner, Jürgen Grulich-Henn, Elke Fröhlich-Reiterer, Katharina Warncke, Klaus Mohnike, Oliver Blankenstein, Ulrike Menzel, Nicolin Datz, Esther Bollow, Reinhard W. Holl
Published in: Orphanet Journal of Rare Diseases, Issue 13/1, 2018, ISSN 1750-1172
Publisher: BioMed Central
DOI: 10.1186/s13023-018-0970-8

Validation of radiolabelled exendin for beta cell imaging by ex vivo autoradiography and immunohistochemistry of human pancreas

Author(s): Theodorus J.P. Jansen, Sevilay Tokgöz, Mijke Buitinga, Sanne A.M. van Lith, Lieke Joosten, Cathelijne Frielink, Esther M. M. Smeets, Martijn W.J. Stommel, Marion B. van der Kolk, Bastiaan E. de Galan, Maarten Brom, Marti Boss, Martin Gotthardt
Published in: EJNMMI Research, Issue 14, 2024, Page(s) 96, ISSN 2191-219X
Publisher: Springer Berlin
DOI: 10.1186/s13550-024-01159-6

Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators

Author(s): Perez-Hernandez J, Chiurchiu V, Perruche S, You S
Published in: Frontiers in immunology, Issue 12, 2021, Page(s) 768133, ISSN 1664-3224
Publisher: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.768133

Monitoring islet specific immune responses in type 1 diabetes clinical immunotherapy trials

Author(s): Arif S, Domingo-Vila C, Pollock E, Christakou E, Williams E, Tree T.
Published in: Frontiers in immunology, Issue 14, 2023, Page(s) 14:1183909, ISSN 1664-3224
Publisher: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2023.1183909

Making Insulin and Staying Out of Autoimmune Trouble: The Beta-Cell Conundrum.

Author(s): Carré A, Mallone R.
Published in: Frontiers in immunology., Issue 12:639682, 2020, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.639682

The Impact of Pancreatic Head Resection on Blood Glucose Homeostasis in Patients with Chronic Pancreatitis.

Author(s): Hempel S, Oehme F, Ehehalt F, Solimena M, Kolbinger FR, Bogner A, Welsch T, Weitz J, Distler M.
Published in: Journal of Clinical Medicine, Issue 11(3), 2022, Page(s) 663, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm11030663

Comparing clinical characteristics of pediatric patients with pancreatic diabetes to patients with type 1 diabetes: A matched case‐control study

Author(s): Stefanie Lanzinger, Alena Welters, Angelika Thon, Katja Konrad, Thomas Kapellen, Jürgen Grulich‐Henn, Dirk Raddatz, Reinhard W. Holl
Published in: Pediatric Diabetes, Issue 20/7, 2019, Page(s) 955-963, ISSN 1399-543X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pedi.12894

Functional Impact of Risk Gene Variants on the Autoimmune Responses in Type 1 Diabetes.

Author(s): Gootjes C, Zwaginga JJ, Roep BO, Nikolic T.
Published in: Frontiers in immunology., Issue 13, 2022, Page(s) 886736, ISSN 1664-3224
Publisher: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2022.886736

Structure, interaction and nervous connectivity of beta cell primary cilia

Author(s): Andreas Müller, Nikolai Klena, Song Pang, Leticia Elizabeth Galicia Garcia, Oleksandra Topcheva, Solange Aurrecoechea Duran, Davud Sulaymankhil, Monika Seliskar, Hassan Mziaut, Eyke Schöniger, Daniela Friedland, Nicole Kipke, Susanne Kretschmar, Carla Münster, Jürgen Weitz, Marius Distler, Thomas Kurth, Deborah Schmidt, Harald F. Hess, C. Shan Xu, Gaia Pigino, Michele Solimena
Published in: Nature Communications, Issue 15, 2024, Page(s) 15(1):9168, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-53348-5

A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis.

Author(s): Alvelos MI, Szymczak F, Castela Â, Marín-Cañas S, de Souza BM, Gkantounas I, Colli M, Fantuzzi F, Cosentino C, Igoillo-Esteve M, Marselli L, Marchetti P, Cnop M, Eizirik DL.
Published in: Islwts, Issue 13(3-4), 2021, Page(s) 51-65, ISSN 1938-2014
Publisher: Landes Bioscience
DOI: 10.1080/19382014.2021.1948282

Aberrant expression of transglutaminase 2 in pancreas and thymus of NOD mice underscores the importance of deamidation in neoantigen generation.

Author(s): Callebaut A, Bruggeman Y, Zamit C, Sodré FMC, Irla M, Mathieu C, Buitinga M, Overbergh L.
Published in: Frontiers in endocrinology., Issue 13, 2022, Page(s) 908248, ISSN 1664-2392
Publisher: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fendo.2022.908248

Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Author(s): Balboa D, Barsby T, Lithovius V, Saarimäki-Vire J, Omar-Hmeadi M, Dyachok O, Montaser H, Lund PE, Yang M, Ibrahim H, Näätänen A, Chandra V, Vihinen H, Jokitalo E, Kvist J, Ustinov J, Nieminen AI, Kuuluvainen E, Hietakangas V, Katajisto P, Lau J, Carlsson PO, Barg S, Tengholm A, Otonkoski T.
Published in: Nature biotechnology., Issue 40(7), 2022, Page(s) 1042–1055, ISSN 1546-1696
Publisher: Nature Publishing Company
DOI: 10.1038/s41587-022-01219-z

Endoplasmic Reticulum-Mitochondria Crosstalk and Beta-Cell Destruction in Type 1 Diabetes.

Author(s): Vig S, Lambooij JM, Zaldumbide A, Guigas B.
Published in: Frontiers in immunology, Issue 12:669492, 2021, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.669492

Towards a Functional Cure for Diabetes Using Stem Cell-Derived Beta Cells: Are We There Yet?

Author(s): Bourgeois S, Sawatani T, Van Mulders A, De Leu N, Heremans Y, Heimberg H, Cnop M, Staels W.
Published in: Cells, Issue 10(1), 2021, Page(s) 191, ISSN 2073-4409
Publisher: Basel, Switzerland : MDPI
DOI: 10.3390/cells10010191

Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis.

Author(s): Tesi M, Bugliani M, Ferri G, Suleiman M, De Luca C, Bosi E, Masini M, De Tata V, Gysemans C, Cardarelli F, Cnop M, Eizirik DL, Marchetti P, Marselli L.
Published in: Biomolecules, Issue 11(2), 2021, Page(s) 320, ISSN 2218-273X
Publisher: Basel, Switzerland : MDPI
DOI: 10.3390/biom11020320

Self-antigens, benign autoimmunity and type 1 diabetes: a beta-cell and T-cell perspective.

Author(s): Samassa F, Mallone R.
Published in: Current opinion in endocrinology, diabetes, and obesity., Issue 29(4), 2022, Page(s) 370-378, ISSN 1752-2978
Publisher: London : Lippincott, Williams & Wilkins, 2007-
DOI: 10.1097/med.0000000000000735

Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances

Author(s): Simi Ahmed, Karen Cerosaletti, Eddie James, S. Alice Long, Stuart Mannering, Cate Speake, Maki Nakayama, Timothy Tree, Bart O. Roep, Kevan C. Herold, Todd M. Brusko
Published in: Diabetes, Issue 68/7, 2019, Page(s) 1366-1379, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db19-0119

The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells.

Author(s): Alvelos MI, Brüggemann M, Sutandy FR, Juan-Mateu J, Colli ML, Busch A, Lopes M, Castela Â, Aartsma-Rus A, König J, Zarnack K, Eizirik DL.
Published in: Life science alliance, Issue 4(3), 2020, Page(s) e202000825, ISSN 2575-1077
Publisher: Life Science Alliance, LLC,
DOI: 10.26508/lsa.202000825

Immunoregulated insulitis and slow-progressing type 1 diabetes after duodenopancreatectomy.

Author(s): Faucher P, Beuvon F, Fignani D, Sebastiani G, Afonso G, Zhou Z, Dousset B, Boitard C, Dotta F, Mallone R, Larger E.
Published in: Diabetologia, Issue 64(12), 2021, Page(s) 2731-2740, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-021-05563-8

Why does the immune system destroy pancreatic β-cells but not α-cells in type 1 diabetes?

Author(s): Eizirik DL, Szymczak F, Mallone R.
Published in: Nature reviews. Endocrinology, Issue 19(7), 2023, Page(s) 425-434, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-023-00826-3

Concise Review: Human Pluripotent Stem Cells for the Modeling of Pancreatic β-Cell Pathology

Author(s): Diego Balboa, Jonna Saarimäki-Vire, Timo Otonkoski
Published in: STEM CELLS, Issue 37/1, 2019, Page(s) 33-41, ISSN 1066-5099
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SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas Microvasculature

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Antigen-based immune modulation therapy for type 1 diabetes: the era of precision medicine

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Inhibition of the type 1 diabetes candidate gene PTPN2 aggravates TNF-α-induced human beta cell dysfunction and death

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Pancreatic Islet Cells Response to IFNγ Relies on Their Spatial Location within an Islet

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Lipidomic Abnormalities During the Pathogenesis of Type 1 Diabetes: a Quantitative Review

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Glucose treatment of human pancreatic β-cells enhances translation of mRNAs involved in energetics and insulin secretion.

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Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells.

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Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention

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Angiotensin I-converting enzyme type 2 expression is increased in pancreatic islets of type 2 diabetic donors

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Interferons are key cytokines acting on pancreatic islets in type 1 diabetes

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100 Years of Insulin: Lifesaver, immune target, and potential remedy for prevention

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Personalized Immunotherapies for Type 1 Diabetes: Who, What, When, and How?

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Published in: Diabetes, Issue 69(11), 2021, Page(s) 2246-2252, ISSN 0012-1797
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Pancreatic Alpha-Cells Contribute Together With Beta-Cells to CXCL10 Expression in Type 1 Diabetes.

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Family Structure is Associated with Mental Health and Attention Deficit (Hyperactivity) Disorders in Adolescents with Type 1 Diabetes

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Published in: Experimental and Clinical Endocrinology and Diabetes, Issue 130(9), 2022, Page(s) 604-613, ISSN 0947-7349
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The challenge of modulating β-cell autoimmunity in type 1 diabetes

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EndoC-βH5 cells are storable and ready-to-use human pancreatic beta cells with physiological insulin secretion

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Editorial: Footprints of Immune Cells in the Type 1 Diabetic Pancreas.

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Preclinical evaluation of tyrosine kinase 2 inhibitors for human beta‐cell protection in type 1 diabetes

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Increased Expression of Viral Sensor MDA5 in Pancreatic Islets and in Hormone-Negative Endocrine Cells in Recent Onset Type 1 Diabetic Donors.

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Mapping T Cell Responses to Native and Neo-Islet Antigen Epitopes in at Risk and Type 1 Diabetes Subjects.

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The role of the interferon/JAK-STAT axis in driving islet HLA-I hyperexpression in type 1 diabetes

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Publisher: Lausanne : Frontiers Research Foundation
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A Dual Systems Genetics Approach Identifies Common Genes, Networks, and Pathways for Type 1 and 2 Diabetes in Human Islets.

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Tryptophan metabolism promotes immune evasion in human pancreatic β cells

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Nanoencapsulated human pancreatic islets for β-cell replacement in Type 1 diabetes

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Reduced miR-184-3p expression protects pancreatic β-cells from lipotoxic and proinflammatory apoptosis in type 2 diabetes via CRTC1 upregulation.

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Peptides Derived From Insulin Granule Proteins are Targeted by CD8+ T Cells Across MHC Class I Restrictions in Humans and NOD Mice.

Author(s): Azoury ME, Tarayrah M, Afonso G, Pais A, Colli ML, Maillard C, Lavaud C, Alexandre-Heymann L, Gonzalez-Duque S, Verdier Y, Vinh J, Pinto S, Buus S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Eizirik DL, You S, Mallone R.
Published in: Diabetes, Issue 69(12), 2020, Page(s) 2678-2690, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db20-0013

Oral Fc-Coupled Preproinsulin Achieves Systemic and Thymic Delivery Through the Neonatal Fc Receptor and Partially Delays Autoimmune Diabetes.

Author(s): Corcos N, Culina S, Deligne C, Lavaud C, You S, Mallone R.
Published in: Frontiers in immunology, 2021, Page(s) 12:616215, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.616215

T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal

Author(s): Eddie A. James, Roberto Mallone, Sally C. Kent, Teresa P. DiLorenzo
Published in: Diabetes, Issue 69/7, 2020, Page(s) 1311-1335, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/dbi19-0022

MiR‐375‐mediated suppression of engineered coxsackievirus B3 in pancreatic cells

Author(s): Markian Pryshliak, Ahmet Hazini, Klaus Knoch, Babette Dieringer, Beatrice Tolksdorf, Michele Solimena, Jens Kurreck, Sandra Pinkert, Henry Fechner
Published in: FEBS Letters, Issue 594/4, 2020, Page(s) 763-775, ISSN 0014-5793
Publisher: Elsevier BV
DOI: 10.1002/1873-3468.13647

MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells

Author(s): Fabio Arturo Grieco, Guido Sebastiani, Jonas Juan-Mateu, Olatz Villate, Laura Marroqui, Laurence Ladrière, Ksenya Tugay, Romano Regazzi, Marco Bugliani, Piero Marchetti, Francesco Dotta, Décio L. Eizirik
Published in: Diabetes, Issue 66/1, 2016, Page(s) 100-112, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db16-0592

Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF)

Author(s): Daniel A. Cunha, Monia Cito, Fabio Arturo Grieco, Cristina Cosentino, Tatiana Danilova, Laurence Ladrière, Maria Lindahl, Andrii Domanskyi, Marco Bugliani, Piero Marchetti, Décio L. Eizirik, Miriam Cnop
Published in: Journal of Biological Chemistry, Issue 292/36, 2017, Page(s) 14977-14988, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M116.769877

New insights into non-conventional epitopes as T cell targets: The missing link for breaking immune tolerance in autoimmune disease?

Author(s): James Harbige, Martin Eichmann, Mark Peakman
Published in: Journal of Autoimmunity, Issue 84, 2017, Page(s) 12-20, ISSN 0896-8411
Publisher: Academic Press
DOI: 10.1016/j.jaut.2017.08.001

MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells

Author(s): Kira Meyerovich, Natalia M. Violato, Makiko Fukaya, Violette Dirix, Nathalie Pachera, Lorella Marselli, Piero Marchetti, Andreas Strasser, Decio L. Eizirik, Alessandra K. Cardozo
Published in: Diabetes, Issue 66/9, 2017, Page(s) 2446-2458, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db16-1252

Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes

Author(s): Laura Marroqui, Reinaldo S. Dos Santos, Anne Op de beeck, Alexandra Coomans de Brachène, Lorella Marselli, Piero Marchetti, Decio L. Eizirik
Published in: Diabetologia, Issue 60/4, 2017, Page(s) 656-667, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-016-4201-3

Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis

Author(s): Reinaldo S Dos Santos, Laura Marroqui, Fabio A Grieco, Lorella Marselli, Mara Suleiman, Stefan R Henz, Piero Marchetti, Rasmus Wernersson, Decio L Eizirik
Published in: Endocrinology, Issue 158/8, 2017, Page(s) 2503-2521, ISSN 0013-7227
Publisher: The Endocrine Society
DOI: 10.1210/en.2017-00104

Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes

Author(s): Lorraine Yeo, Alyssa Woodwyk, Sanjana Sood, Anna Lorenc, Martin Eichmann, Irma Pujol-Autonell, Rosella Melchiotti, Ania Skowera, Efthymios Fidanis, Garry M. Dolton, Katie Tungatt, Andrew K. Sewell, Susanne Heck, Alka Saxena, Craig A. Beam, Mark Peakman
Published in: Journal of Clinical Investigation, Issue 128/8, 2018, Page(s) 3460-3474, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/JCI120555

Characterization and non-parametric modeling of the developing serum proteome during infancy and early childhood

Author(s): Niina Lietzén, Lu Cheng, Robert Moulder, Heli Siljander, Essi Laajala, Taina Härkönen, Aleksandr Peet, Aki Vehtari, Vallo Tillmann, Mikael Knip, Harri Lähdesmäki, Riitta Lahesmaa
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-24019-5

Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes

Author(s): Mijke Buitinga, Aïsha Callebaut, Fernanda Marques Câmara Sodré, Inne Crèvecoeur, Gabriele Blahnik-Fagan, Mei-Ling Yang, Marco Bugliani, David Arribas-Layton, Meghan Marré, Dana P. Cook, Etienne Waelkens, Roberto Mallone, Jon D. Piganelli, Piero Marchetti, Mark J. Mamula, Rita Derua, Eddie A. James, Chantal Mathieu, Lut Overbergh
Published in: Diabetes, Issue 67/11, 2018, Page(s) 2337-2348, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db18-0295

Immunological biomarkers for the development and progression of type 1 diabetes

Author(s): Chantal Mathieu, Riitta Lahesmaa, Ezio Bonifacio, Peter Achenbach, Timothy Tree
Published in: Diabetologia, Issue 61/11, 2018, Page(s) 2252-2258, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-018-4726-8

When one becomes many-Alternative splicing in β-cell function and failure

Author(s): Maria Inês Alvelos, Jonàs Juan-Mateu, Maikel Luis Colli, Jean-Valéry Turatsinze, Décio L. Eizirik
Published in: Diabetes, Obesity and Metabolism, Issue 20, 2018, Page(s) 77-87, ISSN 1462-8902
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/dom.13388

Biomarkers of islet beta cell stress and death in type 1 diabetes

Author(s): Emily K. Sims, Carmella Evans-Molina, Sarah A. Tersey, Decio L. Eizirik, Raghavendra G. Mirmira
Published in: Diabetologia, Issue 61/11, 2018, Page(s) 2259-2265, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-018-4712-1

Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa

Author(s): Stéphane Demine, Alexander Balhuizen, Vinciane Debaille, Lieke Joosten, Maïté Fereau, Satya Chilla, Isabelle Millard, Raphaël Scharfmann, Dominique Egrise, Serge Goldman, Piero Marchetti, Martin Gotthardt, Sophie Laurent, Carmen Burtea, Decio Eizirik
Published in: Molecules, Issue 23/9, 2018, Page(s) 2100, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23092100

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction

Author(s): Maikel L. Colli, Jessica L.E. Hill, Laura Marroquí, Jessica Chaffey, Reinaldo S. Dos Santos, Pia Leete, Alexandra Coomans de Brachène, Flavia M.M. Paula, Anne Op de Beeck, Angela Castela, Lorella Marselli, Lars Krogvold, Knut Dahl-Jorgensen, Piero Marchetti, Noel G. Morgan, Sarah J. Richardson, Décio L. Eizirik
Published in: EBioMedicine, Issue 36, 2018, Page(s) 367-375, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2018.09.040

SRp55 Regulates a Splicing Network That Controls Human Pancreatic β-Cell Function and Survival

Author(s): Jonàs Juan-Mateu, Maria Inês Alvelos, Jean-Valéry Turatsinze, Olatz Villate, Esther Lizarraga-Mollinedo, Fabio Arturo Grieco, Laura Marroquí, Marco Bugliani, Piero Marchetti, Décio L. Eizirik
Published in: Diabetes, Issue 67/3, 2018, Page(s) 423-436, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db17-0736

IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells

Author(s): Alexandra Coomans de Brachène, Reinaldo S. Dos Santos, Laura Marroqui, Maikel L. Colli, Lorella Marselli, Raghavendra G. Mirmira, Piero Marchetti, Decio L. Eizirik
Published in: Diabetologia, Issue 61/3, 2018, Page(s) 636-640, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-017-4536-4

Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis

Author(s): Flavia M. M. Paula, Nayara C. Leite, Patricia C. Borck, Ricardo Freitas-Dias, Miriam Cnop, Mara P. T. Chacon-Mikahil, Claudia R. Cavaglieri, Piero Marchetti, Antonio C. Boschero, Claudio C. Zoppi, Decio L. Eizirik
Published in: The FASEB Journal, Issue 32/3, 2018, Page(s) 1524-1536, ISSN 0892-6638
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201700710R

A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells

Author(s): Alexander Balhuizen, Sam Massa, Iris Mathijs, Jean-Valery Turatsinze, Jens De Vos, Stéphane Demine, Catarina Xavier, Olatz Villate, Isabelle Millard, Dominique Egrise, Carmen Capito, Raphaël Scharfmann, Pieter In’t Veld, Piero Marchetti, Serge Muyldermans, Serge Goldman, Tony Lahoutte, Luc Bouwens, Decio L. Eizirik, Nick Devoogdt
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-15417-2

Frequent Monitoring of C-Peptide Levels in Newly Diagnosed Type 1 Subjects Using Dried Blood Spots Collected at Home

Author(s): Ruben H Willemsen, Keith Burling, Peter Barker, Fran Ackland, Renuka P Dias, Julie Edge, Anne Smith, John Todd, Boryana Lopez, Adrian P Mander, Catherine Guy, David B Dunger
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue 103/9, 2018, Page(s) 3350-3358, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/jc.2018-00500

Europe has to step up its efforts to produce innovative and safe diabetes technology

Author(s): Miriam Cnop, Tomasz Klupa, Nikolaos Tentolouris, Anna Novials, Rémy Burcelin, Mischa van Eimeren
Published in: Diabetologia, Issue 60/12, 2017, Page(s) 2532-2533, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-017-4455-4

MicroRNAs

Author(s): Francesco Dotta, Giuliana Ventriglia, Isaac V. Snowhite, Alberto Pugliese
Published in: Current Opinion in Endocrinology & Diabetes and Obesity, Issue 25/4, 2018, Page(s) 237-245, ISSN 1752-296X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MED.0000000000000420

Islet-reactive CD8 + T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

Author(s): Slobodan Culina, Ana Ines Lalanne, Georgia Afonso, Karen Cerosaletti, Sheena Pinto, Guido Sebastiani, Klaudia Kuranda, Laura Nigi, Anne Eugster, Thomas Østerbye, Alicia Maugein, James E. McLaren, Kristin Ladell, Etienne Larger, Jean-Paul Beressi, Anna Lissina, Victor Appay, Howard W. Davidson, Søren Buus, David A. Price, Matthias Kuhn, Ezio Bonifacio, Manuela Battaglia, Sophie Caillat-Zucman, Fr
Published in: Science Immunology, Issue 3/20, 2018, Page(s) eaao4013, ISSN 2470-9468
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciimmunol.aao4013

Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

Author(s): Sergio Gonzalez-Duque, Marie Eliane Azoury, Maikel L. Colli, Georgia Afonso, Jean-Valery Turatsinze, Laura Nigi, Ana Ines Lalanne, Guido Sebastiani, Alexia Carré, Sheena Pinto, Slobodan Culina, Noémie Corcos, Marco Bugliani, Piero Marchetti, Mathieu Armanet, Marc Diedisheim, Bruno Kyewski, Lars M. Steinmetz, Søren Buus, Sylvaine You, Daniele Dubois-Laforgue, Etienne Larger, Jean-Paul Beressi, G
Published in: Cell Metabolism, Issue 28/6, 2018, Page(s) 946-960.e6, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2018.07.007

The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms

Author(s): Pia Leete, Roberto Mallone, Sarah J. Richardson, Jay M. Sosenko, Maria J. Redondo, Carmella Evans-Molina
Published in: Current Diabetes Reports, Issue 18/11, 2018, ISSN 1534-4827
Publisher: Current Science Inc.
DOI: 10.1007/s11892-018-1083-4

Virus-like infection induces human β cell dedifferentiation

Author(s): Masaya Oshima, Klaus-Peter Knoch, Marc Diedisheim, Antje Petzold, Pierre Cattan, Marco Bugliani, Piero Marchetti, Pratik Choudhary, Guo-Cai Huang, Stefan R. Bornstein, Michele Solimena, Olivier Albagli-Curiel, Raphael Scharfmann
Published in: JCI Insight, Issue 3/3, 2018, ISSN 2379-3708
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.97732

Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource

Author(s): Piero Marchetti, Mara Suleiman, Lorella Marselli
Published in: Diabetologia, Issue 61/4, 2018, Page(s) 770-774, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-018-4546-x

MANF protects human pancreatic beta cells against stress-induced cell death

Author(s): Elina Hakonen, Vikash Chandra, Christopher L. Fogarty, Nancy Yiu-Lin Yu, Jarkko Ustinov, Shintaro Katayama, Emilia Galli, Tatiana Danilova, Päivi Lindholm, Aki Vartiainen, Elisabet Einarsdottir, Kaarel Krjutškov, Juha Kere, Mart Saarma, Maria Lindahl, Timo Otonkoski
Published in: Diabetologia, Issue 61/10, 2018, Page(s) 2202-2214, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-018-4687-y

Novel minor HLA DR associated antigens in type 1 diabetes

Author(s): Denise Müller, Tanja Telieps, Anne Eugster, Christina Weinzierl, Manja Jolink, Anette-Gabriele Ziegler, Ezio Bonifacio
Published in: Clinical Immunology, Issue 194, 2018, Page(s) 87-91, ISSN 1521-6616
Publisher: Academic Press
DOI: 10.1016/j.clim.2018.07.001

The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ Genotype

Author(s): Christina Reinauer, Joachim Rosenbauer, Christina Bächle, Christian Herder, Michael Roden, Sian Ellard, Elisa De Franco, Beate Karges, Reinhard Holl, Jürgen Enczmann, Thomas Meissner
Published in: Genes, Issue 8/5, 2017, Page(s) 146, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes8050146

DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway

Author(s): Reinaldo S. Dos Santos, Laura Marroqui, Teresa Velayos, Ane Olazagoitia-Garmendia, Amaia Jauregi-Miguel, Ainara Castellanos-Rubio, Decio L. Eizirik, Luis Castaño, Izortze Santin
Published in: Diabetologia, 2018, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-018-4782-0

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

Author(s): Diego Balboa, Jonna Saarimäki-Vire, Daniel Borshagovski, Mantas Survila, Päivi Lindholm, Emilia Galli, Solja Eurola, Jarkko Ustinov, Heli Grym, Hanna Huopio, Juha Partanen, Kirmo Wartiovaara, Timo Otonkoski
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.38519

Understanding type 1 diabetes through proteomics

Author(s): Inne Crèvecoeur, Saurabh Vig, Chantal Mathieu, Lut Overbergh
Published in: Expert Review of Proteomics, Issue 14/7, 2017, Page(s) 571-580, ISSN 1478-9450
Publisher: Future Drugs Ltd.
DOI: 10.1080/14789450.2017.1345633

Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells

Author(s): Saurabh Vig, Mijke Buitinga, Dieter Rondas, Inne Crèvecoeur, Marc van Zandvoort, Etienne Waelkens, Decio L. Eizirik, Conny Gysemans, Pieter Baatsen, Chantal Mathieu, Lut Overbergh
Published in: Cell Death & Disease, Issue 10/4, 2019, Page(s) 309, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-019-1518-0

Translating Mechanism of Regulatory Action of Tolerogenic Dendritic Cells to Monitoring Endpoints in Clinical Trials

Author(s): Jessica S. Suwandi, Tatjana Nikolic, Bart O. Roep
Published in: Frontiers in Immunology, Issue 8, 2017, Page(s) 1598, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2017.01598

Fostering improved human islet research: a European perspective

Author(s): Piero Marchetti, Anke M. Schulte, Lorella Marselli, Eyke Schoniger, Marco Bugliani, Werner Kramer, Lut Overbergh, Susanne Ullrich, Anna L. Gloyn, Mark Ibberson, Guy Rutter, Philippe Froguel, Leif Groop, Mark I. McCarthy, Francesco Dotta, Raphael Scharfmann, Christophe Magnan, Decio L. Eizirik, Chantal Mathieu, Miriam Cnop, Bernard Thorens, Michele Solimena
Published in: Diabetologia, Issue 62/8, 2019, Page(s) 1514-1516, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-019-4911-4

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes

Author(s): Amna Khamis, Mickaël Canouil, Afshan Siddiq, Hutokshi Crouch, Mario Falchi, Manon von Bulow, Florian Ehehalt, Lorella Marselli, Marius Distler, Daniela Richter, Jürgen Weitz, Krister Bokvist, Ioannis Xenarios, Bernard Thorens, Anke M. Schulte, Mark Ibberson, Amelie Bonnefond, Piero Marchetti, Michele Solimena, Philippe Froguel
Published in: Molecular Metabolism, Issue 24, 2019, Page(s) 98-107, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.03.004

DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes

Author(s): Marco Bugliani, Farooq Syed, Flavia M.M. Paula, Bilal A. Omar, Mara Suleiman, Sandra Mossuto, Francesca Grano, Francesco Cardarelli, Ugo Boggi, Fabio Vistoli, Franco Filipponi, Paolo De Simone, Lorella Marselli, Vincenzo De Tata, Bo Ahren, Decio L. Eizirik, Piero Marchetti
Published in: Molecular and Cellular Endocrinology, Issue 473, 2018, Page(s) 186-193, ISSN 0303-7207
Publisher: Elsevier BV
DOI: 10.1016/j.mce.2018.01.019

Longitudinal Trajectories of Metabolic Control From Childhood to Young Adulthood in Type 1 Diabetes From a Large German/Austrian Registry: A Group-Based Modeling Approach

Author(s): Anke Schwandt, Julia M. Hermann, Joachim Rosenbauer, Claudia Boettcher, Désirée Dunstheimer, Jürgen Grulich-Henn, Oliver Kuss, Birgit Rami-Merhar, Christian Vogel, Reinhard W. Holl
Published in: Diabetes Care, Issue 40/3, 2017, Page(s) 309-316, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dc16-1625

Polycystic Ovary Syndrome (PCOS) in Juvenile and Adult Type 1 Diabetes in a German/Austrian Cohort

Author(s): Christina Reinauer, Esther Bollow, Elke Fröhlich-Reiterer, Katharina Laubner, Dominik Bergis, Christof Schöfl, Hans-Peter Kempe, Michael Hummel, Pia Hennes, Katja Gollisch, Holger Haberland, Nicolin Datz, Thomas Meissner, Reinhard Holl
Published in: Experimental and Clinical Endocrinology & Diabetes, Issue 125/10, 2017, Page(s) 661-668, ISSN 0947-7349
Publisher: Johann Ambrosius Barth
DOI: 10.1055/s-0043-104701

Quantitative Proteomics Reveals the Dynamic Protein Landscape during Initiation of Human Th17 Cell Polarization

Author(s): Subhash K. Tripathi, Tommi Välikangas, Ankitha Shetty, Mohd Moin Khan, Robert Moulder, Santosh D. Bhosale, Elina Komsi, Verna Salo, Rafael Sales De Albuquerque, Omid Rasool, Sanjeev Galande, Laura L. Elo, Riitta Lahesmaa
Published in: iScience, Issue 11, 2019, Page(s) 334-355, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2018.12.020

Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells

Author(s): Maikel L. Colli, Flavia M. Paula, Lorella Marselli, Piero Marchetti, Merja Roivainen, Decio L. Eizirik, Anne Op de beeck
Published in: Journal of Innate Immunity, Issue 11/4, 2019, Page(s) 375-390, ISSN 1662-811X
Publisher: Karger AG
DOI: 10.1159/000496034

Succinylated Gelatin Improves the Theranostic Potential of Radiolabeled Exendin-4 in Insulinoma Patients

Author(s): Mijke Buitinga, Tom Jansen, Inge van der Kroon, Wietske Woliner-van der Weg, Marti Boss, Marcel Janssen, Erik Aarntzen, Martin Béhé, Damian Wild, Eric Visser, Maarten Brom, Martin Gotthardt
Published in: Journal of Nuclear Medicine, Issue 60/6, 2019, Page(s) 812-816, ISSN 0161-5505
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.118.219980

Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells

Author(s): Niina Lietzén, Karoliina Hirvonen, Anni Honkimaa, Tanja Buchacher, Jutta E. Laiho, Sami Oikarinen, Magdalena A. Mazur, Malin Flodström-Tullberg, Eric Dufour, Amir-Babak Sioofy-Khojine, Heikki Hyöty, Riitta Lahesmaa
Published in: iScience, Issue 19, 2019, Page(s) 340-357, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2019.07.040

ICA512 RESP18 homology domain is a protein-condensing factor and insulin fibrillation inhibitor

Author(s): Pamela L. Toledo, Juha M. Torkko, Andreas Müller, Carolin Wegbrod, Anke Sönmez, Michele Solimena, Mario R. Ermácora
Published in: Journal of Biological Chemistry, Issue 294/21, 2019, Page(s) 8564-8576, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.007607

Continuous glucose monitoring and glycemic control among youth with type 1 diabetes: International comparison from the T1D Exchange and DPV Initiative

Author(s): Daniel J. DeSalvo, Kellee M. Miller, Julia M. Hermann, David M. Maahs, Sabine E. Hofer, Mark A. Clements, Eggert Lilienthal, Jennifer L. Sherr, Martin Tauschmann, Reinhard W. Holl
Published in: Pediatric Diabetes, Issue 19/7, 2018, Page(s) 1271-1275, ISSN 1399-543X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pedi.12711

The supply chain of human pancreatic β cell lines

Author(s): Raphael Scharfmann, Willem Staels, Olivier Albagli
Published in: Journal of Clinical Investigation, Issue 129/9, 2019, Page(s) 3511-3520, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci129484

The microRNAs miR-211-5p and miR-204-5p modulate ER stress in human beta cells

Author(s): Fabio Arturo Grieco, Andrea Alex Schiavo, Flora Brozzi, Jonas Juan-Mateu, Marco Bugliani, Piero Marchetti, Décio Eizirik
Published in: Journal of Molecular Endocrinology, 2019, ISSN 0952-5041
Publisher: Society for Endocrinology
DOI: 10.1530/jme-19-0066

Mixed‐meal tolerance test to assess residual beta‐cell secretion: Beyond the area‐under‐curve of plasma C‐peptide concentration

Author(s): Yue Ruan, Ruben H. Willemsen, Malgorzata E. Wilinska, Martin Tauschmann, David B. Dunger, Roman Hovorka
Published in: Pediatric Diabetes, Issue 20/3, 2019, Page(s) 282-285, ISSN 1399-543X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pedi.12816

MicroRNAs as Regulators of Insulin Signaling: Research Updates and Potential Therapeutic Perspectives in Type 2 Diabetes

Author(s): Laura Nigi, Giuseppina Grieco, Giuliana Ventriglia, Noemi Brusco, Francesca Mancarella, Caterina Formichi, Francesco Dotta, Guido Sebastiani
Published in: International Journal of Molecular Sciences, Issue 19/12, 2018, Page(s) 3705, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19123705

Oral contraception in adolescents with type 1 diabetes and its association with cardiovascular risk factors. A multicenter DPV study on 24 011 patients from Germany, Austria or Luxembourg

Author(s): Barbara Bohn, Kirsten Mönkemöller, Dörte Hilgard, Axel Dost, Karl Otfried Schwab, Eggert Lilienthal, Elke Hammer, Kathrin Hake, Maria Fritsch, Bettina Gohlke, Carine de Beaufort, Reinhard W Holl
Published in: Pediatric Diabetes, Issue 19/5, 2018, Page(s) 937-944, ISSN 1399-543X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pedi.12656

Genome editing of human pancreatic beta cell models: problems, possibilities and outlook

Author(s): Diego Balboa, Rashmi B. Prasad, Leif Groop, Timo Otonkoski
Published in: Diabetologia, Issue 62/8, 2019, Page(s) 1329-1336, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-019-4908-z

Risk factors for decline in renal function among young adults with type 1 diabetes

Author(s): Anke Schwandt, Dominik Bergis, Michael Denkinger, Katja S.C. Gollisch, Dirk Sandig, Harald Stingl, Stefan Zimny, Reinhard W. Holl
Published in: Journal of Diabetes and its Complications, Issue 32/10, 2018, Page(s) 940-946, ISSN 1056-8727
Publisher: Elsevier BV
DOI: 10.1016/j.jdiacomp.2018.07.007

Trajectories of Body Mass Index from Childhood to Young Adulthood among Patients with Type 1 Diabetes—A Longitudinal Group-Based Modeling Approach Based on the DPV Registry

Author(s): Nicole Prinz, Anke Schwandt, Marianne Becker, Christian Denzer, Monika Flury, Maria Fritsch, Angela Galler, Andreas Lemmer, Matthias Papsch, Thomas Reinehr, Joachim Rosenbauer, Reinhard W. Holl
Published in: The Journal of Pediatrics, Issue 201, 2018, Page(s) 78-85.e4, ISSN 0022-3476
Publisher: Mosby Inc.
DOI: 10.1016/j.jpeds.2018.05.014

Ultra-high resolution MALDI-FTICR-MSI analysis of intact proteins in mouse and human pancreas tissue

Author(s): Isabella Piga, Bram Heijs, Simone Nicolardi, Laura Giusti, Lorella Marselli, Piero Marchetti, Maria Rosa Mazzoni, Antonio Lucacchini, Liam A. McDonnell
Published in: International Journal of Mass Spectrometry, Issue 437, 2019, Page(s) 10-16, ISSN 1387-3806
Publisher: Elsevier BV
DOI: 10.1016/j.ijms.2017.11.001

Impact of long-term air pollution exposure on metabolic control in children and adolescents with type 1 diabetes: results from the DPV registry

Author(s): Stefanie Lanzinger, Joachim Rosenbauer, Dorothea Sugiri, Tamara Schikowski, Birgit Treiber, Daniela Klee, Wolfgang Rathmann, Reinhard W. Holl
Published in: Diabetologia, Issue 61/6, 2018, Page(s) 1354-1361, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-018-4580-8

Center Size and Glycemic Control: An International Study With 504 Centers From Seven Countries

Author(s): Niels H. Birkebaek, Julia M. Hermann, Lena Hanberger, Dimitrios Charalampopoulos, Reinhard W. Holl, Torild Skrivarhaug, Karin Aakesson, Justin T. Warner, Ann K. Drivvoll, Ann-Marie Svensson, Terence Stephenson, Sabine E. Hofer, Siri Fredheim, Siv J. Kummernes, Rakesh Amin, Birgit Rami-Merhar, Anders Johansen, Thomas M. Kapellen, Doerte Hilgard, Knut Dahl-Jørgensen, Elke Froehlich-Reiterer, Maria
Published in: Diabetes Care, Issue 42/3, 2019, Page(s) e37-e39, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dc18-1253

CRISPR/Cas9 guided genome and epigenome engineering and its therapeutic applications in immune mediated diseases

Author(s): Desh Deepak Singh, R. David Hawkins, Riitta Lahesmaa, Subhash K. Tripathi
Published in: Seminars in Cell & Developmental Biology, 2019, ISSN 1084-9521
Publisher: Academic Press
DOI: 10.1016/j.semcdb.2019.05.007

Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation

Author(s): Johan Henriksson, Xi Chen, Tomás Gomes, Ubaid Ullah, Kerstin B. Meyer, Ricardo Miragaia, Graham Duddy, Jhuma Pramanik, Kosuke Yusa, Riitta Lahesmaa, Sarah A. Teichmann
Published in: Cell, Issue 176/4, 2019, Page(s) 882-896.e18, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.11.044

The role of proteomics in assessing beta-cell dysfunction and death in type 1 diabetes

Author(s): Ernesto S. Nakayasu, Wei-Jun Qian, Carmella Evans-Molina, Raghavendra G. Mirmira, Decio L. Eizirik, Thomas O. Metz
Published in: Expert Review of Proteomics, Issue 16/7, 2019, Page(s) 569-582, ISSN 1478-9450
Publisher: Future Drugs Ltd.
DOI: 10.1080/14789450.2019.1634548

The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes

Author(s): Mireia Ramos-Rodríguez, Helena Raurell-Vila, Maikel L. Colli, Maria Inês Alvelos, Marc Subirana-Granés, Jonàs Juan-Mateu, Richard Norris, Jean-Valery Turatsinze, Ernesto S. Nakayasu, Bobbie-Jo M. Webb-Robertson, Jamie R. J. Inshaw, Piero Marchetti, Lorenzo Piemonti, Manel Esteller, John A. Todd, Thomas O. Metz, Décio L. Eizirik, Lorenzo Pasquali
Published in: Nature Genetics, Issue 51/11, 2019, Page(s) 1588-1595, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-019-0524-6

miR-409-3p is reduced in plasma and islet immune infiltrates of NOD diabetic mice and is differentially expressed in people with type 1 diabetes

Author(s): Giuliana Ventriglia, Francesca Mancarella, Guido Sebastiani, Dana P. Cook, Roberto Mallone, Chantal Mathieu, Conny Gysemans, Francesco Dotta
Published in: Diabetologia, 2019, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-019-05026-1

Proinsulin peptide promotes autoimmune diabetes in a novel HLA-DR3-DQ2-transgenic murine model of spontaneous disease

Author(s): Johan Verhagen, Norkhairin Yusuf, Emma L. Smith, Emily M. Whettlock, Kerina Naran, Sefina Arif, Mark Peakman
Published in: Diabetologia, Issue 62/12, 2019, Page(s) 2252-2261, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-019-04994-8

Breast Milk-Derived Extracellular Vesicles Enriched in Exosomes From Mothers With Type 1 Diabetes Contain Aberrant Levels of microRNAs

Author(s): Aashiq H. Mirza, Simranjeet Kaur, Lotte B. Nielsen, Joachim Størling, Reza Yarani, Martin Roursgaard, Elisabeth R. Mathiesen, Peter Damm, Jens Svare, Henrik B. Mortensen, Flemming Pociot
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: Frontiers Editorial Office
DOI: 10.3389/fimmu.2019.02543

Association of Glycemic Control and Cell Stress With Telomere Attrition in Type 1 Diabetes

Author(s): Tine Tesovnik, Jernej Kovac, Tinka Hovnik, Klemen Dovc, Nataša Bratina, Tadej Battelino, Katarina Trebušak Podkrajšek
Published in: JAMA Pediatrics, Issue 172/9, 2018, Page(s) 879, ISSN 2168-6203
Publisher: American Medical Association
DOI: 10.1001/jamapediatrics.2018.1175

Phenotypic Analysis of Human Lymph Nodes in Subjects With New-Onset Type 1 Diabetes and Healthy Individuals by Flow Cytometry

Author(s): Jennie H. M. Yang, Leena Khatri, Marius Mickunas, Evangelia Williams, Danijela Tatovic, Mohammad Alhadj Ali, Philippa Young, Penelope Moyle, Vishal Sahni, Ryan Wang, Rejbinder Kaur, Gillian M. Tannahill, Andrew R. Beaton, Danielle M. Gerlag, Caroline O. S. Savage, Antonella Napolitano Rosen, Frank Waldron-Lynch, Colin M. Dayan, Timothy I. M. Tree
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: Frontiers Editorial Office
DOI: 10.3389/fimmu.2019.02547

Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells

Author(s): Stéphane Demine, Andrea Alex Schiavo, Sandra Marín-Cañas, Piero Marchetti, Miriam Cnop, Decio L. Eizirik
Published in: Stem Cell Research & Therapy, Issue 11/1, 2020, ISSN 1757-6512
Publisher: BioMed Central
DOI: 10.1186/s13287-019-1523-3

From immunohistological to anatomical alterations of human pancreas in type 1 diabetes: New concepts on the stage

Author(s): Laura Nigi, Carla Maccora, Francesco Dotta, Guido Sebastiani
Published in: Diabetes/Metabolism Research and Reviews, 2019, ISSN 1520-7552
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/dmrr.3264

Targeting microRNAs as a Therapeutic Strategy to Reduce Oxidative Stress in Diabetes

Author(s): Giuseppina Emanuela Grieco, Noemi Brusco, Giada Licata, Laura Nigi, Caterina Formichi, Francesco Dotta, Guido Sebastiani
Published in: International Journal of Molecular Sciences, Issue 20/24, 2019, Page(s) 6358, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20246358

Capturing residual beta cell function in type 1 diabetes

Author(s): Pociot F
Published in: Diabetologia, Issue 2019 Jan;62(1), 2019, Page(s) 28-32, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-018-4768-y

PET-based dosimetry of [68Ga]Ga-NODAGA-exendin-4 in humans, a tracer for beta cell imaging

Author(s): Boss M, Buitinga M, Jansen TJ, Brom M, Visser EP, Gotthardt M
Published in: The Journal of Nuclear Medicine, Issue 2020 Jan; 61(1), 2019, Page(s) 112–116, ISSN 0161-5505
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.119.228627

Circulating β cell-specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes

Author(s): Yeo L, Pujol-Autonell I, Baptista R, Eichmann M, Kronenberg-Versteeg D, Heck S, Dolton G, Sewell AK, Härkönen T, Mikk ML, Toppari J, Veijola R, Knip M, Ilonen J, Peakman M
Published in: Clinical and Experimental Immunology, Issue 2019 Oct 29, 2019, ISSN 0009-9104
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cei.13391

Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity

Author(s): Masaya Oshima, Séverine Pechberty, Lara Bellini, Sven O. Göpel, Mélanie Campana, Claude Rouch, Julien Dairou, Cristina Cosentino, Federica Fantuzzi, Sanna Toivonen, Piero Marchetti, Christophe Magnan, Miriam Cnop, Hervé Le Stunff, Raphaël Scharfmann
Published in: Diabetologia, Issue 63/2, 2020, Page(s) 395-409, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-019-05046-x

In vitro beta-cell killing models using immune cells and human pluripotent stem cell-derived islets: Challenges and opportunities

Author(s): Halliez C, Ibrahim H, Otonkoski T, Mallone R.
Published in: Frontiers in endocrinology, Issue 13, 2023, Page(s) 13:1076683, ISSN 1664-2392
Publisher: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fendo.2022.1076683

Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice.

Author(s): Fernanda M. C. Sodré, Samal Bissenova, Ylke Bruggeman, Ronak Tilvawala, Dana P. Cook, Claire Berthault, Santanu Mondal, Aïsha Callebaut, Sylvaine You, Raphael Scharfmann, Roberto Mallone, Paul R. Thompson, Chantal Mathieu, Mijke Buitinga, Lut Overbergh
Published in: Diabetes, 2020, Page(s) db200421, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db20-0421

First-in-human, double-blind, randomized phase 1b study of peptide immunotherapy IMCY-0098 in new-onset type 1 diabetes

Author(s): Van Rampelbergh J, Achenbach P, Leslie RD, Ali MA, Dayan C, Keymeulen B, Owen KR, Kindermans M, Parmentier F, Carlier V, Ahangarani RR, Gebruers E, Bovy N, Vanderelst L, Van Mechelen M, Vandepapelière P, Boitard C.
Published in: BMC medicine, Issue 21(1), 2023, Page(s) 190, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-023-02900-z

Purification of pancreatic endocrine subsets reveals increased iron metabolism in beta-cells

Author(s): Berthault C, Staels W, Scharfmann R.
Published in: Molecular Metabolism, Issue 2020 Aug 4:101060, 2020, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101060

Long-RNA sequencing and ribosome profiling of inflamed beta-cells reveal an extensive translatome landscape.

Author(s): Thomaidou S, Slieker RC, van der Slik AR, Boom J, Mulder F, Munoz-Garcia A, 't Hart LM, Koeleman B, Carlotti F, Hoeben RC, Roep BO, Mei H, Zaldumbide A.
Published in: Diabetes, Issue 70(10), 2021, Page(s) 2299-2312, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db20-1122

Distinguishing activated T regulatory cell and T conventional cells by single-cell technologies.

Author(s): Reinhardt J, Sharma V, Stavridou A, Lindner A, Reinhardt S, Petzold A, Lesche M, Rost F, Bonifacio E, Eugster A.
Published in: Immunology, Issue 166(1), 2022, Page(s) 121-137, ISSN 1365-2567
Publisher: Oxford : Blackwell Scientific Publications
DOI: 10.1111/imm.13460

ER stress promotes mitochondrial DNA mediated type-1 interferon response in beta-cells and interleukin-8 driven neutrophil chemotaxis.

Author(s): Vig S, Lambooij JM, Dekkers MC, Otto F, Carlotti F, Guigas B, Zaldumbide A.
Published in: Frontiers in endocrinology., Issue 13, 2022, Page(s) 991632, ISSN 1664-2392
Publisher: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fendo.2022.991632

Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?

Author(s): Roberto Mallone, Decio L. Eizirik
Published in: Diabetologia, Issue 63/10, 2020, Page(s) 1999-2006, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-020-05176-7

Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes affirms markers of disease

Author(s): Robert Moulder, M. Karoliina Hirvonen, Tommi Välikangas, Tomi Suomi, Lut Overbergh, Mark Peakman, Søren Brunak, Chantal Mathieu, Mikael Knip, Laura L. Elo, Riitta Lahesmaa, null null
Published in: Diabetologia, 2025, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-025-06394-7

A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes

Author(s): Marwaha AK, Chow S, Pesenacker AM, Cook L, Sun A, Long SA, Yang JHM, Ward-Hartstonge KA, Williams E, Domingo-Vila C, Halani K, Harris KM, Tree TIM, Levings MK, Elliott T, Tan R, Dutz JP.
Published in: Immunotherapy Advances, 2021, Page(s) 2(1), ISSN 2732-4303
Publisher: Oxford University Press
DOI: 10.1093/immadv/ltab022

The Transatlantic HbA1c gap : differences in glycaemic control across the lifespan between people included in the US T1D Exchange Registry and those included in the German/Austrian DPV registry

Author(s): Hermann, Julia M.; Miller, K. M.; Hofer, S. E.; Clements, M. A.; Karges, Wolfram; Foster, N. C.; Fröhlich-Reiterer, E.; Rickels, M. R.; Rosenbauer, J.; DeSalvo, D. J.; Holl, R. W.; Maahs, D. M.
Published in: Diabetic medicine (2019). doi:10.1111/dme.14148, Issue 1, 2020, ISSN 1464-5491
Publisher: Wiley
DOI: 10.18154/RWTH-2020-01942

CD4+ T Cells From Individuals With Type 1 Diabetes Respond to a Novel Class of Deamidated Peptides Formed in Pancreatic Islets

Author(s): Aïsha Callebaut, Perrin Guyer, Rita Derua, Mijke Buitinga, Anthony Manganaro, Xiaoyan Yi, Fernanda Marques Câmara Sodré, Saurabh Vig, Mara Suleiman, Piero Marchetti, Decio L. Eizirik, Sally C. Kent, Chantal Mathieu, Eddie A. James, Lut Overbergh
Published in: Diabetes, Issue 73, 2024, Page(s) 728-742, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db23-0588

Clinical care advice for monitoring of islet autoantibody positive individuals with presymptomatic type 1 diabetes

Author(s): A. Emile J. Hendriks, M. Loredana Marcovecchio, Rachel E. J. Besser, Ezio Bonifacio, Kristina Casteels, Helena Elding Larsson, Gita Gemulla, Markus Lundgren, Olga Kordonouri, Roberto Mallone, Flemming Pociot, Agnieszka Szypowska, Jorma Toppari, Thekla von dem Berge, Anette G. Ziegler, Chantal Mathieu, Peter Achenbach, null null
Published in: Diabetes/Metabolism Research and Reviews, Issue 40, 2024, Page(s) e3777, ISSN 1520-7552
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/dmrr.3777

Glycemic variability - the danger of a physiologically stable metric.

Author(s): Battelino T, Dovč K.
Published in: The Journal of clinical endocrinology and metabolism., Issue 105(10), 2020, Page(s) e3815–e3817, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/clinem/dgaa486

β-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Posttranscriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1

Author(s): Sofia Thomaidou, Maria J.L. Kracht, Arno van der Slik, Sandra Laban, Eelco J. de Koning, Francoise Carlotti, Rob C. Hoeben, Bart O. Roep, Arnaud Zaldumbide
Published in: Diabetes, Issue 69/4, 2020, Page(s) 670-680, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db19-0984

From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes.

Author(s): Eizirik DL, Szymczak F, Alvelos MI, Martin F.
Published in: Diabetes, Issue 70(9), 2021, Page(s) 1915-1925, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/dbi20-0046

Neoepitopes in Type 1 Diabetes: Etiological Insights, Biomarkers and Therapeutic Targets.

Author(s): Rodriguez-Calvo T, Johnson JD, Overbergh L, Dunne JL.
Published in: Frontiers in immunology, 2021, Page(s) 12:667989, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.667989

Defining a cure for type 1 diabetes: a call to action.

Author(s): Roep BO, Montero E, van Tienhoven R, Atkinson MA, Schatz DA, Mathieu C.
Published in: The lancet. Diabetes & endocrinology, Issue (9), 2021, Page(s) 553-555, ISSN 2213-8587
Publisher: Elsevier BV
DOI: 10.1016/s2213-8587(21)00181-9

Prognostic transcriptome classes of duodenopancreatic neuroendocrine tumors.

Author(s): Diedisheim M, Dermine S, Jouinot A, Septier A, Gaujoux S, Dousset B, Cadiot G, Larger E, Bertherat J, Scharfmann R, Terris B, Coriat R, Assié G.
Published in: Endocrine-Related Cancer, Issue 28(8), 2021, Page(s) 563-571, ISSN 1351-0088
Publisher: Society for Endocrinology
DOI: 10.1530/erc-21-0051

Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses

Author(s): Vecchio F, Carré A, Korenkov D, Zhou Z, Apaolaza P, Tuomela S, Burgos-Morales O, Snowhite I, Perez-Hernandez J, Brandao B, Afonso G, Halliez C, Kaddis J, Kent SC, Nakayama M, Richardson SJ, Vinh J, Verdier Y, Laiho J, Scharfmann R, Solimena M, Marinicova Z, Bismuth E, Lucidarme N, Sanchez J, Bustamante C, Gomez P, Buus S; nPOD-Virus Working Group; You S, Pugliese A, Hyoty H, Rodriguez-Calvo T, Fl
Published in: The lancet. Diabetes & endocrinology, Issue 11(9), 2023, Page(s) 657-666, ISSN 2213-8587
Publisher: Elsevier BV
DOI: 10.1101/2023.08.19.553954

Citrullination and PAD Enzyme Biology in Type 1 Diabetes - Regulators of Inflammation, Autoimmunity, and Pathology.

Author(s): Yang ML, Sodré FMC, Mamula MJ, Overbergh L.
Published in: Frontiers in immunology, Issue 12:678953, 2021, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.678953

A nanobody-based nuclear imaging tracer targeting dipeptidyl peptidase 6 to determine the mass of human beta cell grafts in mice

Author(s): Stéphane Demine, Rita Garcia Ribeiro, Julien Thevenet, Lorella Marselli, Piero Marchetti, François Pattou, Julie Kerr-Conte, Nick Devoogdt, Decio L. Eizirik
Published in: Diabetologia, Issue 63/4, 2020, Page(s) 825-836, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-019-05068-5

International benchmarking in type 1 diabetes: Large difference in childhood HbA1c between 8 high-income countries but similar rise during adolescence-A quality registry study.

Author(s): Anderzén J, Hermann JM, Samuelsson U, Charalampopoulos D, Svensson J, Skrivarhaug T, Fröhlich-Reiterer E, Maahs DM, Akesson K, Kapellen T, Fritsch M, Birkebaek NH, Drivvoll AK, Miller K, Stephenson T, Hofer SE, Fredheim S, Kummernes SJ, Foster N, Amin R, Hilgard D, Rami-Merhar B, Dahl-Jørgensen K, Clements M, Hanas R, Holl RW, Warner JT.
Published in: Pediatric diabetes., Issue 21(4), 2020, Page(s) 621-627, ISSN 1399-5448
Publisher: Copenhagen : Munksgaard
DOI: 10.1111/pedi.13014

Monitoring beta cell survival after intrahepatic islet transplantation using dynamic exendin PET imaging: a proof-of-concept study in individuals with type 1 diabetes

Author(s): Jansen TJP, Buitinga M, Boss M, Nijhoff MF, Brom M, de Galan BE, van der Graaf M, van Koeverden S, Vantyghem MC, Beron A, Pattou F, Engelse MA, Velikyan I, Eriksson O, de Koning EJP, Gotthardt M
Published in: Diabetes, Issue 72(7), 2023, Page(s) 898-907, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db22-0884

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes.

Author(s): Marselli L, Piron A, Suleiman M, Colli ML, Yi X, Khamis A, Carrat GR, Rutter GA, Bugliani M, Giusti L, Ronci M, Ibberson M, Turatsinze JV, Boggi U, De Simone P, De Tata V, Lopes M, Nasteska D, De Luca C, Tesi M, Bosi E, Singh P, Campani D, Schulte AM, Solimena M, Hecht P, Rady B, Bakaj I, Pocai A, Norquay L, Thorens B, Canouil M, Froguel P, Eizirik DL, Cnop M, Marchetti P.
Published in: Cell reports., Issue 33(9), 2020, Page(s) 108466, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108466

NET Proteome in Established Type 1 Diabetes Is Enriched in Metabolic Proteins

Author(s): Bissenova S, Ellis D, Callebaut A, Eelen G, Derua R, Buitinga M, Mathieu C, Gysemans C, Overbergh L
Published in: Cells, Issue 12(9), 2023, Page(s) 1319, ISSN 2073-4409
Publisher: Basel, Switzerland : MDPI
DOI: 10.3390/cells12091319

Study protocol: Minimum effective low dose: anti-human thymocyte globulin (MELD-ATG): phase II, dose ranging, efficacy study of antithymocyte globulin (ATG) within 6 weeks of diagnosis of type 1 diabetes.

Author(s): Wilhelm-Benartzi CS, Miller SE, Bruggraber S, Picton D, Wilson M, Gatley K, Chhabra A, Marcovecchio ML, Hendriks AEJ, Morobé H, Chmura PJ, Bond S, Aschemeier-Fuchs B, Knip M, Tree T, Overbergh L, Pall J, Arnaud O, Haller MJ, Nitsche A, Schulte AM, Mathieu C, Mander A, Dunger D.
Published in: BMJ Open, Issue 11(12), 2021, Page(s) e053669, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2021-053669

In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo.

Author(s): Fantuzzi F, Toivonen S, Schiavo AA, Chae H, Tariq M, Sawatani T, Pachera N, Cai Y, Vinci C, Virgilio E, Ladriere L, Suleiman M, Marchetti P, Jonas JC, Gilon P, Eizirik DL, Igoillo-Esteve M, Cnop M.
Published in: Frontiers in cell and developmental biology., Issue 10, 2022, Page(s) 967765, ISSN 2296-634X
Publisher: Lausanne : Frontiers Media S.A., [2013]-
DOI: 10.3389/fcell.2022.967765

Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways.

Author(s): Bosi E, Marchetti P, Rutter GA, Eizirik DL.
Published in: iScience, Issue 25(10), 2022, Page(s) 105056, ISSN 2589-0042
Publisher: [Cambridge, MA] : Cell Press, [2018]-
DOI: 10.1016/j.isci.2022.105056

Investigating the effect of verapamil on preservation of beta-cell function in adults with newly diagnosed type 1 diabetes mellitus (Ver-A-T1D): protocol for a randomised, double-blind, placebo-controlled, parallel-group, multicentre trial

Author(s): Julie Wych, Martina Brunner, Rachel Stenson, Piotr Jaroslaw Chmura, Thomas Danne, Adrian Paul Mander, Chantal Mathieu, Colin Dayan, Thomas R Pieber
Published in: BMJ Open, Issue 14, 2024, Page(s) e091597, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2024-091597

Extracellular Vesicles in Immune System Regulation and Type 1 Diabetes: Cell-to-Cell Communication Mediators, Disease Biomarkers, and Promising Therapeutic Tools.

Author(s): Grieco GE, Fignani D, Formichi C, Nigi L, Licata G, Maccora C, Brusco N, Sebastiani G, Dotta F.
Published in: Frontiers in immunology., Issue 12:682948, 2021, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.682948

Revisiting the role of inflammation in the loss of pancreatic β-cells in T1DM

Author(s): Decio L. Eizirik, Maikel L. Colli
Published in: Nature Reviews Endocrinology, Issue 16/11, 2020, Page(s) 611-612, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-020-00409-6

Costimulation Blockade Disrupts CD4+ T Cell Memory Pathways and Uncouples Their Link to Decline in β-Cell Function in Type 1 Diabetes.

Author(s): Eichmann M, Baptista R, Ellis RJ, Heck S, Peakman M, Beam CA.
Published in: Journal of Immunology, Issue 204(12), 2020, Page(s) 3129-3138, ISSN 0022-1767
Publisher: American Association of Immunologists
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Targeting B-cell subsets in type 1 diabetes: possible routes to therapy?

Author(s): Noel G. Morgan
Published in: eBioMedicine, Issue 113, 2025, Page(s) 105610, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2025.105610

Heterogeneity and endotypes in type 1 diabetes mellitus

Author(s): Redondo MJ, Morgan NG
Published in: Nature reviews. Endocrinology, Issue 19(9), 2023, Page(s) 542-554, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-023-00853-0

The role of Interleukin-32 in autoimmunity.

Author(s): de Albuquerque R, Komsi E, Starskaia I, Ullah U, Lahesmaa R.
Published in: Scandinavian journal of immunology., Issue 93(2), 2021, Page(s) e13012, ISSN 0300-9475
Publisher: Blackwell Publishing Inc.
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Exendin-4 analogs in insulinoma theranostics

Author(s): Tom.J.P. Jansen, Sanne.A.M. van Lith, Marti Boss, Maarten Brom, Lieke Joosten, Martin Béhé, Mijke Buitinga, Martin Gotthardt
Published in: Journal of Labelled Compounds and Radiopharmaceuticals, Issue 62/10, 2019, Page(s) 656-672, ISSN 0362-4803
Publisher: John Wiley & Sons Inc.
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Emerging Concepts and Success Stories in Type 1 Diabetes Research: A Road Map for a Bright Future

Author(s): Roberto Mallone, Emily Sims, Peter Achenbach, Chantal Mathieu, Alberto Pugliese, Mark Atkinson, Sanjoy Dutta, Carmella Evans-Molina, David Klatzmann, Anne Koralova, S. Alice Long, Lut Overbergh, Teresa Rodriguez-Calvo, Anette-Gabriele Ziegler, Sylvaine You
Published in: Diabetes, Issue 74, 2024, Page(s) 12-21, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db24-0439

A classification and regression tree analysis identifies subgroups of childhood type 1 diabetes.

Author(s): Achenbach P, Hippich M, Zapardiel-Gonzalo J, Karges B, Holl RW, Petrera A, Bonifacio E, Ziegler AG; DiMelli Study group and DPV Study group.
Published in: EBioMedicine., Issue 82, 2022, Page(s) 104118, ISSN 2352-3964
Publisher: Elsevier BV
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Multi‐omics analysis reveals drivers of loss of <i>β</i>‐cell function after newly diagnosed autoimmune type 1 diabetes: An INNODIA multicenter study

Author(s): Jose Juan Almagro Armenteros, Caroline Brorsson, Christian Holm Johansen, Karina Banasik, Gianluca Mazzoni, Robert Moulder, Karoliina Hirvonen, Tomi Suomi, Omid Rasool, Sylvaine F. A. Bruggraber, M. Loredana Marcovecchio, Emile Hendricks, Naba Al‐Sari, Ismo Mattila, Cristina Legido‐Quigley, Tommi Suvitaival, Piotr J. Chmura, Mikael Knip, Anke M. Schulte, Jeong Heon Lee, Guido Sebastiani, Giuse
Published in: Diabetes/Metabolism Research and Reviews, Issue 40, 2024, Page(s) e3833, ISSN 1520-7552
Publisher: John Wiley & Sons Inc.
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Mining the transcriptome of target tissues of autoimmune and degenerative pancreatic β-cell and brain diseases to discover therapies

Author(s): Yi X, Marmontel de Souza B, Sawatani T, Szymczak F, Marselli L, Marchetti P, Cnop M, Eizirik DL.
Published in: iScience, Issue 25(11), 2022, Page(s) 105376, ISSN 2589-0042
Publisher: [Cambridge, MA] : Cell Press, [2018]-
DOI: 10.1016/j.isci.2022.105376

Comparative characteristics of older people with type 1 diabetes treated with continuous subcutaneous insulin infusion or insulin injection therapy: data from the German/Austrian DPV registry

Author(s): J. Grammes, E. Küstner, A. Dapp, M. Hummel, J.‐C. Kämmer, T. Kubiak, I. Schütz‐Fuhrmann, S. Zimny, E. Bollow, R.W. Holl
Published in: Diabetic Medicine, Issue 37/5, 2020, Page(s) 856-862, ISSN 0742-3071
Publisher: Blackwell Publishing Inc.
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The Landscape of microRNAs in βCell: Between Phenotype Maintenance and Protection.

Author(s): Grieco GE, Brusco N, Licata G, Fignani D, Formichi C, Nigi L, Sebastiani G, Dotta F.
Published in: International journal of molecular sciences., Issue 22(2), 2021, Page(s) 803, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020803

Identification of Deamidated Peptides in Cytokine-Exposed MIN6 Cells through LC-MS/MS Using a Shortened Digestion Time and Inspection of MS2 Spectra.

Author(s): Callebaut A, Derua R, Vig S, Delong T, Mathieu C, Overbergh L.
Published in: Journal of Proteome Research, Issue 20(2), 2021, Page(s) 1405-1414, ISSN 1535-3893
Publisher: American Chemical Society
DOI: 10.1021/acs.jproteome.0c00801

Extracellular Vesicles Derived Human-miRNAs Modulate the Immune System in Type 1 Diabetes

Author(s): Tine Tesovnik, Jernej Kovač, Katka Pohar, Samo Hudoklin, Klemen Dovč, Nataša Bratina, Katarina Trebušak Podkrajšek, Maruša Debeljak, Peter Veranič, Emanuele Bosi, Lorenzo Piemonti, Alojz Ihan, Tadej Battelino
Published in: Frontiers in Cell and Developmental Biology, Issue 8, 2020, Page(s) 202, ISSN 2296-634X
Publisher: Frontiers Media
DOI: 10.3389/fcell.2020.00202

A direct look at the dysfunction and pathology of the β cells in human type 2 diabetes

Author(s): Piero Marchetti, Mara Suleiman, Carmela De Luca, Walter Baronti, Emanuele Bosi, Marta Tesi, Lorella Marselli
Published in: Seminars in Cell & Developmental Biology, Issue 103, 2020, Page(s) 83-93, ISSN 1084-9521
Publisher: Academic Press
DOI: 10.1016/j.semcdb.2020.04.005

CD8+ T cells variably recognize native versus citrullinated GRP78 epitopes in type 1 diabetes

Author(s): Azoury ME, Samassa F, Buitinga M, Nigi L, Brusco N, Callebaut A, Giraud M, Irla M, Lalanne AI, Carre A, Afonso G, Zhou Z, Brandao B, Colli ML, Sebastiani G, Dotta F, Nakayma M, Eizirik DL, You S, Pinto S, Mamula MJ, Verdier Y, Vinh J, Buus S, Mathieu C, Overgergh Lut, Mallone R
Published in: Diabetes, Issue 70(12), 2021, Page(s) 2879-2891, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db21-0259

Early Detection of Peripheral Blood Cell Signature in Children Developing β-Cell Autoimmunity at a Young Age

Author(s): Henna Kallionpää, Juhi Somani, Soile Tuomela, Ubaid Ullah, Rafael de Albuquerque, Tapio Lönnberg, Elina Komsi, Heli Siljander, Jarno Honkanen, Taina Härkönen, Aleksandr Peet, Vallo Tillmann, Vikash Chandra, Mahesh Kumar Anagandula, Gun Frisk, Timo Otonkoski, Omid Rasool, Riikka Lund, Harri Lähdesmäki, Mikael Knip, Riitta Lahesmaa
Published in: Diabetes, Issue 68/10, 2019, Page(s) 2024-2034, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db19-0287

High-Throughput Analysis of Neutrophil Extracellular Trap Levels in Subtypes of People with Type 1 Diabetes

Author(s): Bissenova S, Buitinga M, Boesch M, Korf H, Casteels K, Teunkens A, Mathieu C, Gysemans C.
Published in: Biology, Issue 12(6), 2023, Page(s) 882, ISSN 2079-7737
Publisher: MDPI
DOI: 10.3390/biology12060882

Exercise as a non-pharmacological intervention to protect pancreatic beta cells in individuals with type 1 and type 2 diabetes.

Author(s): Coomans de Brachène A, Scoubeau C, Musuaya AE, Costa-Junior JM, Castela A, Carpentier J, Faoro V, Klass M, Cnop M, Eizirik DL.
Published in: Diabetologia, Issue 1-11, 2022, ISSN 1432-0428
Publisher: Berlin Springer Verlag
DOI: 10.1007/s00125-022-05837-9

The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α.

Author(s): Chandra V, Ibrahim H, Halliez C, Prasad RB, Vecchio F, Dwivedi OP, Kvist J, Balboa D, Saarimäki-Vire J, Montaser H, Barsby T, Lithovius V, Artner I, Gopalakrishnan S, Groop L, Mallone R, Eizirik DL, Otonkoski T.
Published in: Nature communications, Issue 13, 2022, Page(s) 6363, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34069-z

Psychological care in children and adolescents with type 1 diabetes in a real‐world setting and associations with metabolic control

Author(s): Angela Galler, Dörte Hilgard, Esther Bollow, Thomas Hermann, Nicole Kretschmer, Berthold Maier, Kirsten Mönkemöller, Ralf Schiel, Reinhard W. Holl
Published in: Pediatric Diabetes, Issue 2020 Sep;21(6), 2020, Page(s) 1050-1058, ISSN 1399-543X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pedi.13065

Single-cell imaging of α and β cell metabolic response to glucose in living human Langerhans islets.

Author(s): Azzarello F, Pesce L, De Lorenzi V, Ferri G, Tesi M, Del Guerra S, Marchetti P, Cardarelli F.
Published in: Communications biology., Issue 5, 2022, Page(s) 1232, ISSN 2399-3642
Publisher: London, United Kingdom : Nature Publishing Group UK, [2018]-
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Regulated expression and function of the GABAB receptor in human pancreatic beta cell line and islets

Author(s): Latif Rachdi, Alicia Maugein, Severine Pechberty, Mathieu Armanet, Juliette Hamroune, Philippe Ravassard, Stefano Marullo, Olivier Albagli, Raphael Scharfmann
Published in: Scientific Reports, Issue 10/1, 2020, Page(s) 13469, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-69758-6

Quantitative analysis of islet prohormone convertase 1/3 expression in human pancreas donors with diabetes

Author(s): Paola S. Apaolaza, Yi-Chun Chen, Kavi Grewal, Yannik Lurz, Severin Boulassel, C. Bruce Verchere, Teresa Rodriguez-Calvo
Published in: Diabetologia, Issue 67, 2024, Page(s) 2771-2785, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-024-06275-5

Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes.

Author(s): Bosi E, Marselli L, De Luca C, Suleiman M, Tesi M, Ibberson M, Eizirik DL, Cnop M, Marchetti P.
Published in: NAR genomics and bioinformatics., Issue 2(4), 2020, Page(s) lqaa097, ISSN 2631-9268
Publisher: Oxford University Press
DOI: 10.1093/nargab/lqaa097

The making of insulin in health and disease

Author(s): Jovana Vasiljević, Juha M. Torkko, Klaus-Peter Knoch, Michele Solimena
Published in: Diabetologia, Issue 63/10, 2020, Page(s) 1981-1989, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-020-05192-7

Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells.

Author(s): Szymczak F, Alvelos MI, Marín-Cañas S, Castela Â, Demine S, Colli ML, Op de Beeck A, Thomaidou S, Marselli L, Zaldumbide A, Marchetti P, Eizirik DL.
Published in: Science advances., Issue 8(37), 2022, Page(s) eabn5732, ISSN 2375-2548
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Targeting citrullination in autoimmunity: insights learned from preclinical mouse models.

Author(s): Bruggeman Y, Sodré FMC, Buitinga M, Mathieu C, Overbergh L, Kracht MJL.
Published in: Expert opinion on therapeutic targets., Issue 25(4), 2021, Page(s) 269-281, ISSN 1472-8222
Publisher: Ashley Publications Ltd.
DOI: 10.1080/14728222.2021.1918104

Presence of immunogenic alternatively spliced insulin gene product in human pancreatic delta cells

Author(s): van Tienhoven R, Kracht MJL, van der Slik AR, Thomaidou S, Wolters AHG, Giepmans BNG, Riojas JPR, Nelson MS, Carlotti F, de Koning EJP, Hoeben RC, Zaldumbide A, Roep BO
Published in: Diabetologia, Issue 66(5), 2023, Page(s) 884-896, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-023-05882-y

A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes.

Author(s): Luce S, Guinoiseau S, Gadault A, Letourneur F, Nitschke P, Bras M, Vidaud M, Charneau P, Larger E, Colli ML, Eizirik DL, Lemonnier F, Boitard C.
Published in: Frontiers in immunology., Issue 12:748679, 2021, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.748679

Thesis and dissertations (1)

Oral vaccination with Fc-coupled preproinsulin for Type 1 Diabetes prevention

Author(s): Corcos, Noémie
Published in: Issue 4, 2023
Publisher: Université Paris Cité