Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes – Sofia ref.: 115797 | INNODIA | Progetto | Risultati | H2020 | CORDIS

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Characterization of the role for post- translational modifications, alternative splicing and endoplasmic reticulum stress for β-cell recognition by the immune system

Migration

Discovery and pre-clinical validation of novel biomarkers of β-cell mass, dysfunction and death in human T1D

Migration

Relationships between immune response/regulation, genome, transcriptome, epigenome, proteome, metabolome and metagenome

Migration

A comprehensive pan-European research network for the study of the aetiology and prevention of T1D

Migration

Successful start-up of the project - Kick Off Meeting

Migration

EUnPOD functioning

Migration

Discovery and pre-clinical validation of biomarkers of immune activation and regulation in human T1D

Migration

Imaging tool for -cell inflammation/death

Migration

Development of novel approaches for in vivo β-cell imaging

Migration

Plan for access to the CTN by third parties

Migration

Modelling the role for T1D candidate genes in the beta-cell-immune system dialog, and using this information to develop novel approaches to prevent β-cell death in diabetes.

Migration

Novel models of the cross talk between human β-cells and the human system in vitro

Migration

Discovery analysis of novel biomarkers in β- cell-omics, immunomics, genomics, transcriptomics, proteomics, metabolomics and lipidomics

Migration

Launch public website

Migration

Pubblicazioni

Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?

Autori: Alexia Carré, Sarah J. Richardson, Etienne Larger, Roberto Mallone
Pubblicato in: Diabetologia, Numero 64/1, 2021, Pagina/e 15-25, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-020-05298-y

Characterisation and clinical outcomes in children and adolescents with diabetes according to newly defined subgroups: a cohort study from the DPV registry

Autori: Katharina Warncke, Alexander Eckert, Ezio Bonifacio, Peter Achenbach, Olga Kordonouri, Thomas Meissner, Ute Ohlenschläger, Walter Bonfig, Anette-G. Ziegler, Reinhard W. Holl
Pubblicato in: eClinicalMedicine, Numero 64, 2024, Pagina/e 102208, ISSN 2589-5370
Editore: London: The Lancet
DOI: 10.1016/j.eclinm.2023.102208

The SAgA of Antigen-Specific Immunotherapy for Type 1 Diabetes.

Autori: Mallone R, You S.
Pubblicato in: Diabetes, Numero 70(6), 2021, Pagina/e 1247-1249, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/dbi21-0011

Arresting or curing type 1 diabetes: an elusive goal, but closing the gap.

Autori: Martens PJ, Gysemans C, Mathieu C.
Pubblicato in: The Journal of endocrinology, Numero 249(2), 2021, Pagina/e T1-T11, ISSN 0022-0795
Editore: Society for Endocrinology
DOI: 10.1530/joe-20-0552

Persistent coxsackievirus B1 infection triggers extensive changes in the transcriptome of human pancreatic ductal cells

Autori: Buchacher T, Honkimaa A, Välikangas T, Lietzén N, Hirvonen MK, Laiho JE, Sioofy-Khojine AB, Eskelinen EL, Hyöty H, Elo LL, Lahesmaa R.
Pubblicato in: iScience, 2022, ISSN 2589-0042
Editore: Cell Press
DOI: 10.1016/j.isci.2021.103653

The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults

Autori: M. Loredana Marcovecchio, A. Emile J. Hendriks, Carl Delfin, Tadej Battelino, Thomas Danne, Mark L. Evans, Jesper Johannesen, Simranjeet Kaur, Mikael Knip, Lut Overbergh, Flemming Pociot, John A. Todd, Bart Van der Schueren, Linda S. Wicker, Mark Peakman, Chantal Mathieu, null null
Pubblicato in: Diabetologia, Numero 67, 2024, Pagina/e 995-1008, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-024-06124-5

A single-cell human islet interactome atlas identifies disrupted autocrine and paracrine communications in type 2 diabetes.

Autori: Bosi E, Marselli L, Suleiman M, Tesi M, De Luca C, Del Guerra S, Cnop M, Eizirik DL, Marchetti P.
Pubblicato in: NAR genomics and bioinformatics, Numero 4(4), 2022, Pagina/e lqac084, ISSN 2631-9268
Editore: [Oxford] : Oxford University Press, [2019]-
DOI: 10.1093/nargab/lqac084

Whole-Slide Image Analysis of Human Pancreas Samples to Elucidate the Immunopathogenesis of Type 1 Diabetes Using the QuPath Software.

Autori: Apaolaza PS, Petropoulou PI, Rodriguez-Calvo T.
Pubblicato in: Frontiers in molecular biosciences., Numero 8:689799, 2021, ISSN 2296-889X
Editore: Frontiers Media S.A.,
DOI: 10.3389/fmolb.2021.689799

The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes

Autori: Huerta-Chagoya A, Schroeder P, Mandla R, Deutsch AJ, Zhu W, Petty L, Yi X, Cole JB, Udler MS, Dornbos P, Porneala B, DiCorpo D, Liu CT, Li JH, Szczerbiński L, Kaur V, Kim J, Lu Y, Martin A, Eizirik DL, Marchetti P, Marselli L, Chen L, Srinivasan S, Todd J, Flannick J, Gubitosi-Klug R, Levitsky L, Shah R, Kelsey M, Burke B, Dabelea DM, Divers J, Marcovina S, Stalbow L, Loos RJF, Darst BF, Kooperbe
Pubblicato in: Diabetologia, Numero 66(7), 2023, Pagina/e 1273-1288, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-023-05912-9

Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes.

Autori: Guyer P, Arribas-Layton D, Manganaro A, Speake C, Lord S, Eizirik DL, Kent SC, Mallone R, James EA.
Pubblicato in: Diabetes., Numero 72(1), 2022, Pagina/e 85-96, ISSN 1939-327X
Editore: [New York, American Diabetes Association]
DOI: 10.2337/db22-0191

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

Autori: Décio L. Eizirik, Lorenzo Pasquali, Miriam Cnop
Pubblicato in: Nature Reviews Endocrinology, Numero 16/7, 2020, Pagina/e 349-362, ISSN 1759-5029
Editore: Nature Publishing Group
DOI: 10.1038/s41574-020-0355-7

Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes distinguishes markers of disease and C-peptide trajectory

Autori: Moulder R, Välikangas T, Hirvonen MK, Suomi T, Brorsson CA, Lietzén N, Bruggraber SFA, Overbergh L, Dunger DB, Peakman M, Chmura PJ, Brunak S, Schulte AM, Mathieu C, Knip M, Elo LL, Lahesmaa R; INNODIA consortium
Pubblicato in: Diabetologia, Numero 66(11), 2023, Pagina/e 1983-1996, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-023-05974-9

Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis

Autori: Christian M. Cohrs, Julia K. Panzer, Denise M. Drotar, Stephen J. Enos, Nicole Kipke, Chunguang Chen, Robert Bozsak, Eyke Schöniger, Florian Ehehalt, Marius Distler, Ana Brennand, Stefan R. Bornstein, Jürgen Weitz, Michele Solimena, Stephan Speier
Pubblicato in: Cell Reports, Numero 31/1, 2020, Pagina/e 107469, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.03.033

Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes

Autori: Farooq Syed, Sarah A. Tersey, Jean-Valery Turatsinze, Jamie L. Felton, Nicole Jiyun Kang, Jennifer B. Nelson, Emily K. Sims, Mathieu Defrance, Martin Bizet, Francois Fuks, Miriam Cnop, Marco Bugliani, Piero Marchetti, Anette-Gabriele Ziegler, Ezio Bonifacio, Bobbie-Jo Webb-Robertson, Appakalai N. Balamurugan, Carmella Evans-Molina, Decio L. Eizirik, Kieren J. Mather, Silva Arslanian, Raghavendra G
Pubblicato in: Clinical Epigenetics, Numero 12/1, 2020, Pagina/e 116, ISSN 1868-7075
Editore: Springer Verlag
DOI: 10.1186/s13148-020-00906-5

YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress

Autori: Elisa De Franco, Maria Lytrivi, Hazem Ibrahim, Hossam Montaser, Matthew N. Wakeling, Federica Fantuzzi, Kashyap Patel, Céline Demarez, Ying Cai, Mariana Igoillo-Esteve, Cristina Cosentino, Väinö Lithovius, Helena Vihinen, Eija Jokitalo, Thomas W. Laver, Matthew B. Johnson, Toshiaki Sawatani, Hadis Shakeri, Nathalie Pachera, Belma Haliloglu, Mehmet Nuri Ozbek, Edip Unal, Ruken Yıldırım, Tusha
Pubblicato in: Journal of Clinical Investigation, Numero 130/12, 2020, Pagina/e 6338-6353, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci141455

Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes.

Autori: Colli ML, Szymczak F, Eizirik DL.
Pubblicato in: Frontiers in endocrinology., 2020, Pagina/e 11:568446, ISSN 1664-2392
Editore: Frontiers Research Foundation
DOI: 10.3389/fendo.2020.568446

Area Deprivation and Regional Disparities in Treatment and Outcome Quality of 29,284 Pediatric Patients With Type 1 Diabetes in Germany: A Cross-sectional Multicenter DPV Analysis

Autori: Marie Auzanneau, Stefanie Lanzinger, Barbara Bohn, Peter Kroschwald, Ursula Kuhnle-Krahl, Paul Martin Holterhus, Kerstin Placzek, Johannes Hamann, Rainer Bachran, Joachim Rosenbauer, Werner Maier
Pubblicato in: Diabetes Care, Numero 41/12, 2018, Pagina/e 2517-2525, ISSN 0149-5992
Editore: American Diabetes Association
DOI: 10.2337/dc18-0724

RedRibbon: A new rank-rank hypergeometric overlap for gene and transcript expression signatures

Autori: Piron A, Szymczak F, Papadopoulou T, Alvelos MI, Defrance M, Lenaerts T, Eizirik DL, Cnop M
Pubblicato in: Life science alliance, Numero 7(2), 2023, Pagina/e e202302203, ISSN 2575-1077
Editore: Life Science Alliance, LLC
DOI: 10.26508/lsa.202302203

Proprotein convertase PCSK9 affects expression of key surface proteins in human pancreatic beta cells via intracellular and extracellular regulatory circuits.

Autori: Saitoski K, Ryaboshapkina M, Hamza GM, Jarnuczak AF, Berthault C, Carlotti F, Armanet M, Sengupta K, Underwood CR, Andersson S, Guillas I, Le Goff W, Scharfmann R.
Pubblicato in: The Journal of biological chemistry., Numero 298, 2022, Pagina/e 7, ISSN 1083-351X
Editore: Baltimore, MD : American Society for Biochemistry and Molecular Biology
DOI: 10.1016/j.jbc.2022.102096

Fast Track Adaptation of Oncolytic Coxsackie B3 Virus to Resistant Colorectal Cancer Cells - a Method to Personalize Virotherapy

Autori: Leslie Elsner, Lisanne Heimann, Anja Geisler, Babette Dieringer, Klaus-Peter Knoch, Luisa Hinze, Karin Klingel, Michel Solimena, Jens Kurreck, Henry Fechner
Pubblicato in: Biological Procedures Online, Numero 26, 2024, ISSN 1480-9222
Editore: BioMed Central
DOI: 10.1186/s12575-024-00237-2

Preventing type 1 diabetes in childhood.

Autori: Dayan CM, Besser REJ, Oram RA, Hagopian W, Vatish M, Bendor-Samuel O, Snape MD, Todd JA.
Pubblicato in: Science, Numero 373(6554), 2021, Pagina/e 506-510, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abi4742

Endogenous mitochondrial double-stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells.

Autori: Coomans de Brachène A, Castela A, Musuaya AE, Marselli L, Marchetti P, Eizirik DL.
Pubblicato in: Auto- immunity highlights., Numero 12(1), 2021, Pagina/e 6, ISSN 2038-0305
Editore: Springer Verlag Italia
DOI: 10.1186/s13317-021-00148-2

The Role of Beta Cell Recovery in Type 2 Diabetes Remission.

Autori: Suleiman M, Marselli L, Cnop M, Eizirik DL, De Luca C, Femia FR, Tesi M, Del Guerra S, Marchetti P.
Pubblicato in: International journal of molecular sciences., Numero 23(13), 2022, Pagina/e 7435, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23137435

Plasma Exosome-Enriched Extracellular Vesicles From Lactating Mothers With Type 1 Diabetes Contain Aberrant Levels of miRNAs During the Postpartum Period.

Autori: Frørup C, Mirza AH, Yarani R, Nielsen LB, Mathiesen ER, Damm P, Svare J, Engelbrekt C, Størling J, Johannesen J, Mortensen HB, Pociot F, Kaur S.
Pubblicato in: Frontiers in immunology., Numero 12:744509, 2021, ISSN 1664-3224
Editore: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.744509

The need and benefit of immune monitoring to define patient and disease heterogeneity, mechanisms of therapeutic action and efficacy of intervention therapy for precision medicine in type 1 diabetes

Autori: Bart O Roep
Pubblicato in: Frontiers in immunology, Numero 14, 2023, Pagina/e 14:1112858, ISSN 1664-3224
Editore: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2023.1112858

Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes?

Autori: Rodriguez-Calvo T, Christoffersson G, Bender C, von Herrath MG, Mallone R, Kent SC, James EA.
Pubblicato in: Frontiers in immunology, Numero 12:683091, 2021, ISSN 1664-3224
Editore: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.683091

The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events?

Autori: Mallone R, Halliez C, Rui J, Herold KC.
Pubblicato in: Diabetes, Numero 71(8), 2022, Pagina/e 1603-1610, ISSN 1939-327X
Editore: [New York, American Diabetes Association]
DOI: 10.2337/dbi21-0036

The Protective Action of Metformin against Pro-Inflammatory Cytokine-Induced Human Islet Cell Damage and the Mechanisms Involved.

Autori: Giusti L, Tesi M, Ciregia F, Marselli L, Zallocco L, Suleiman M, De Luca C, Del Guerra S, Zuccarini M, Trerotola M, Eizirik DL, Cnop M, Mazzoni MR, Marchetti P, Lucacchini A, Ronci M.
Pubblicato in: Cells, Numero 11(15), 2022, Pagina/e 2465, ISSN 2073-4409
Editore: Basel, Switzerland : MDPI
DOI: 10.3390/cells11152465

Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes.

Autori: Yang JHM, Ward-Hartstonge KA, Perry DJ, Blanchfield JL, Posgai AL, Wiedeman AE, Diggins K, Rahman A, Tree TIM, Brusko TM, Levings MK, James EA, Kent SC, Speake C, Homann D, Long SA; Immunology of Diabetes Society T-Cell Cytometry Group.
Pubblicato in: European journal of immunology., Numero 52(3), 2022, Pagina/e 372–388., ISSN 1521-4141
Editore: Weinheim, Verlag Chemie GmbH.
DOI: 10.1002/eji.202049067

A set of circulating microRNAs belonging to the 14q32 chromosome locus identifies two subgroups of individuals with recent-onset type 1 diabetes

Autori: Guido Sebastiani, Giuseppina Emanuela Grieco, Marco Bruttini, Stefano Auddino, Alessia Mori, Mattia Toniolli, Daniela Fignani, Giada Licata, Elena Aiello, Laura Nigi, Caterina Formichi, Juan Fernandez-Tajes, Alberto Pugliese, Carmella Evans-Molina, Lut Overbergh, Timothy Tree, Mark Peakman, Chantal Mathieu, Francesco Dotta
Pubblicato in: Cell Reports Medicine, Numero 5, 2024, Pagina/e 101591, ISSN 2666-3791
Editore: Cambridge, MA
DOI: 10.1016/j.xcrm.2024.101591

The extent and magnitude of islet T cell infiltration as powerful tools to define the progression to type 1 diabetes

Autori: Apaolaza PS, Balcacean D, Zapardiel-Gonzalo J, Rodriguez-Calvo T.
Pubblicato in: Diabetologia, Numero 66(6), 2023, Pagina/e 1129–1141, ISSN 1432-0428
Editore: Berlin Springer Verlag
DOI: 10.1007/s00125-023-05888-6

ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation

Autori: Szymczak F, Cohen-Fultheim R, Thomaidou S, de Brachène AC, Castela A, Colli M, Marchetti P, Levanon E, Eizirik D, Zaldumbide A.
Pubblicato in: Frontiers in endocrinology, Numero 13, 2022, Pagina/e 1058345, ISSN 1664-2392
Editore: [Lausanne : Frontiers Research Foundation]
DOI: 10.3389/fendo.2022.1058345

Characterization of diabetes following pancreatic surgery in patients with congenital hyperinsulinism

Autori: Alena Welters, Thomas Meissner, Jürgen Grulich-Henn, Elke Fröhlich-Reiterer, Katharina Warncke, Klaus Mohnike, Oliver Blankenstein, Ulrike Menzel, Nicolin Datz, Esther Bollow, Reinhard W. Holl
Pubblicato in: Orphanet Journal of Rare Diseases, Numero 13/1, 2018, ISSN 1750-1172
Editore: BioMed Central
DOI: 10.1186/s13023-018-0970-8

Validation of radiolabelled exendin for beta cell imaging by ex vivo autoradiography and immunohistochemistry of human pancreas

Autori: Theodorus J.P. Jansen, Sevilay Tokgöz, Mijke Buitinga, Sanne A.M. van Lith, Lieke Joosten, Cathelijne Frielink, Esther M. M. Smeets, Martijn W.J. Stommel, Marion B. van der Kolk, Bastiaan E. de Galan, Maarten Brom, Marti Boss, Martin Gotthardt
Pubblicato in: EJNMMI Research, Numero 14, 2024, Pagina/e 96, ISSN 2191-219X
Editore: Springer Berlin
DOI: 10.1186/s13550-024-01159-6

Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators

Autori: Perez-Hernandez J, Chiurchiu V, Perruche S, You S
Pubblicato in: Frontiers in immunology, Numero 12, 2021, Pagina/e 768133, ISSN 1664-3224
Editore: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.768133

Monitoring islet specific immune responses in type 1 diabetes clinical immunotherapy trials

Autori: Arif S, Domingo-Vila C, Pollock E, Christakou E, Williams E, Tree T.
Pubblicato in: Frontiers in immunology, Numero 14, 2023, Pagina/e 14:1183909, ISSN 1664-3224
Editore: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2023.1183909

Making Insulin and Staying Out of Autoimmune Trouble: The Beta-Cell Conundrum.

Autori: Carré A, Mallone R.
Pubblicato in: Frontiers in immunology., Numero 12:639682, 2020, ISSN 1664-3224
Editore: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.639682

The Impact of Pancreatic Head Resection on Blood Glucose Homeostasis in Patients with Chronic Pancreatitis.

Autori: Hempel S, Oehme F, Ehehalt F, Solimena M, Kolbinger FR, Bogner A, Welsch T, Weitz J, Distler M.
Pubblicato in: Journal of Clinical Medicine, Numero 11(3), 2022, Pagina/e 663, ISSN 2077-0383
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm11030663

Comparing clinical characteristics of pediatric patients with pancreatic diabetes to patients with type 1 diabetes: A matched case‐control study

Autori: Stefanie Lanzinger, Alena Welters, Angelika Thon, Katja Konrad, Thomas Kapellen, Jürgen Grulich‐Henn, Dirk Raddatz, Reinhard W. Holl
Pubblicato in: Pediatric Diabetes, Numero 20/7, 2019, Pagina/e 955-963, ISSN 1399-543X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/pedi.12894

Functional Impact of Risk Gene Variants on the Autoimmune Responses in Type 1 Diabetes.

Autori: Gootjes C, Zwaginga JJ, Roep BO, Nikolic T.
Pubblicato in: Frontiers in immunology., Numero 13, 2022, Pagina/e 886736, ISSN 1664-3224
Editore: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2022.886736

Structure, interaction and nervous connectivity of beta cell primary cilia

Autori: Andreas Müller, Nikolai Klena, Song Pang, Leticia Elizabeth Galicia Garcia, Oleksandra Topcheva, Solange Aurrecoechea Duran, Davud Sulaymankhil, Monika Seliskar, Hassan Mziaut, Eyke Schöniger, Daniela Friedland, Nicole Kipke, Susanne Kretschmar, Carla Münster, Jürgen Weitz, Marius Distler, Thomas Kurth, Deborah Schmidt, Harald F. Hess, C. Shan Xu, Gaia Pigino, Michele Solimena
Pubblicato in: Nature Communications, Numero 15, 2024, Pagina/e 15(1):9168, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-53348-5

A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis.

Autori: Alvelos MI, Szymczak F, Castela Â, Marín-Cañas S, de Souza BM, Gkantounas I, Colli M, Fantuzzi F, Cosentino C, Igoillo-Esteve M, Marselli L, Marchetti P, Cnop M, Eizirik DL.
Pubblicato in: Islwts, Numero 13(3-4), 2021, Pagina/e 51-65, ISSN 1938-2014
Editore: Landes Bioscience
DOI: 10.1080/19382014.2021.1948282

Aberrant expression of transglutaminase 2 in pancreas and thymus of NOD mice underscores the importance of deamidation in neoantigen generation.

Autori: Callebaut A, Bruggeman Y, Zamit C, Sodré FMC, Irla M, Mathieu C, Buitinga M, Overbergh L.
Pubblicato in: Frontiers in endocrinology., Numero 13, 2022, Pagina/e 908248, ISSN 1664-2392
Editore: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fendo.2022.908248

Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Autori: Balboa D, Barsby T, Lithovius V, Saarimäki-Vire J, Omar-Hmeadi M, Dyachok O, Montaser H, Lund PE, Yang M, Ibrahim H, Näätänen A, Chandra V, Vihinen H, Jokitalo E, Kvist J, Ustinov J, Nieminen AI, Kuuluvainen E, Hietakangas V, Katajisto P, Lau J, Carlsson PO, Barg S, Tengholm A, Otonkoski T.
Pubblicato in: Nature biotechnology., Numero 40(7), 2022, Pagina/e 1042–1055, ISSN 1546-1696
Editore: Nature Publishing Company
DOI: 10.1038/s41587-022-01219-z

Endoplasmic Reticulum-Mitochondria Crosstalk and Beta-Cell Destruction in Type 1 Diabetes.

Autori: Vig S, Lambooij JM, Zaldumbide A, Guigas B.
Pubblicato in: Frontiers in immunology, Numero 12:669492, 2021, ISSN 1664-3224
Editore: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.669492

Towards a Functional Cure for Diabetes Using Stem Cell-Derived Beta Cells: Are We There Yet?

Autori: Bourgeois S, Sawatani T, Van Mulders A, De Leu N, Heremans Y, Heimberg H, Cnop M, Staels W.
Pubblicato in: Cells, Numero 10(1), 2021, Pagina/e 191, ISSN 2073-4409
Editore: Basel, Switzerland : MDPI
DOI: 10.3390/cells10010191

Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis.

Autori: Tesi M, Bugliani M, Ferri G, Suleiman M, De Luca C, Bosi E, Masini M, De Tata V, Gysemans C, Cardarelli F, Cnop M, Eizirik DL, Marchetti P, Marselli L.
Pubblicato in: Biomolecules, Numero 11(2), 2021, Pagina/e 320, ISSN 2218-273X
Editore: Basel, Switzerland : MDPI
DOI: 10.3390/biom11020320

Self-antigens, benign autoimmunity and type 1 diabetes: a beta-cell and T-cell perspective.

Autori: Samassa F, Mallone R.
Pubblicato in: Current opinion in endocrinology, diabetes, and obesity., Numero 29(4), 2022, Pagina/e 370-378, ISSN 1752-2978
Editore: London : Lippincott, Williams & Wilkins, 2007-
DOI: 10.1097/med.0000000000000735

Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances

Autori: Simi Ahmed, Karen Cerosaletti, Eddie James, S. Alice Long, Stuart Mannering, Cate Speake, Maki Nakayama, Timothy Tree, Bart O. Roep, Kevan C. Herold, Todd M. Brusko
Pubblicato in: Diabetes, Numero 68/7, 2019, Pagina/e 1366-1379, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db19-0119

The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells.

Autori: Alvelos MI, Brüggemann M, Sutandy FR, Juan-Mateu J, Colli ML, Busch A, Lopes M, Castela Â, Aartsma-Rus A, König J, Zarnack K, Eizirik DL.
Pubblicato in: Life science alliance, Numero 4(3), 2020, Pagina/e e202000825, ISSN 2575-1077
Editore: Life Science Alliance, LLC,
DOI: 10.26508/lsa.202000825

Immunoregulated insulitis and slow-progressing type 1 diabetes after duodenopancreatectomy.

Autori: Faucher P, Beuvon F, Fignani D, Sebastiani G, Afonso G, Zhou Z, Dousset B, Boitard C, Dotta F, Mallone R, Larger E.
Pubblicato in: Diabetologia, Numero 64(12), 2021, Pagina/e 2731-2740, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-021-05563-8

Why does the immune system destroy pancreatic β-cells but not α-cells in type 1 diabetes?

Autori: Eizirik DL, Szymczak F, Mallone R.
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Gut microbiome shifts in people with type 1 diabetes are associated with glycaemic control: an INNODIA study

Autori: Tommi Vatanen, Carine de Beaufort, M. Loredana Marcovecchio, Lut Overbergh, Soren Brunak, Mark Peakman, Chantal Mathieu, Mikael Knip, null null
Pubblicato in: Diabetologia, Numero 67, 2024, Pagina/e 1930-1942, ISSN 0012-186X
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Pleconaril and ribavirin in new-onset type 1 diabetes: a phase 2 randomized trial

Autori: Krogvold L, Mynarek IM, Ponzi E, Mørk FB, Hessel TW, Roald T, Lindblom N, Westman J, Barker P, Hyöty H, Ludvigsson J, Hanssen KF, Johannesen J, Dahl-Jørgensen K
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Peptides Derived From Insulin Granule Proteins are Targeted by CD8+ T Cells Across MHC Class I Restrictions in Humans and NOD Mice.

Autori: Azoury ME, Tarayrah M, Afonso G, Pais A, Colli ML, Maillard C, Lavaud C, Alexandre-Heymann L, Gonzalez-Duque S, Verdier Y, Vinh J, Pinto S, Buus S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Eizirik DL, You S, Mallone R.
Pubblicato in: Diabetes, Numero 69(12), 2020, Pagina/e 2678-2690, ISSN 0012-1797
Editore: American Diabetes Association
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Oral Fc-Coupled Preproinsulin Achieves Systemic and Thymic Delivery Through the Neonatal Fc Receptor and Partially Delays Autoimmune Diabetes.

Autori: Corcos N, Culina S, Deligne C, Lavaud C, You S, Mallone R.
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Editore: Frontiers Research Foundation
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T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal

Autori: Eddie A. James, Roberto Mallone, Sally C. Kent, Teresa P. DiLorenzo
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Editore: American Diabetes Association
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MiR‐375‐mediated suppression of engineered coxsackievirus B3 in pancreatic cells

Autori: Markian Pryshliak, Ahmet Hazini, Klaus Knoch, Babette Dieringer, Beatrice Tolksdorf, Michele Solimena, Jens Kurreck, Sandra Pinkert, Henry Fechner
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Editore: Elsevier BV
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MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells

Autori: Fabio Arturo Grieco, Guido Sebastiani, Jonas Juan-Mateu, Olatz Villate, Laura Marroqui, Laurence Ladrière, Ksenya Tugay, Romano Regazzi, Marco Bugliani, Piero Marchetti, Francesco Dotta, Décio L. Eizirik
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Editore: American Diabetes Association
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Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF)

Autori: Daniel A. Cunha, Monia Cito, Fabio Arturo Grieco, Cristina Cosentino, Tatiana Danilova, Laurence Ladrière, Maria Lindahl, Andrii Domanskyi, Marco Bugliani, Piero Marchetti, Décio L. Eizirik, Miriam Cnop
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New insights into non-conventional epitopes as T cell targets: The missing link for breaking immune tolerance in autoimmune disease?

Autori: James Harbige, Martin Eichmann, Mark Peakman
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Editore: Academic Press
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MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells

Autori: Kira Meyerovich, Natalia M. Violato, Makiko Fukaya, Violette Dirix, Nathalie Pachera, Lorella Marselli, Piero Marchetti, Andreas Strasser, Decio L. Eizirik, Alessandra K. Cardozo
Pubblicato in: Diabetes, Numero 66/9, 2017, Pagina/e 2446-2458, ISSN 0012-1797
Editore: American Diabetes Association
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Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes

Autori: Laura Marroqui, Reinaldo S. Dos Santos, Anne Op de beeck, Alexandra Coomans de Brachène, Lorella Marselli, Piero Marchetti, Decio L. Eizirik
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Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis

Autori: Reinaldo S Dos Santos, Laura Marroqui, Fabio A Grieco, Lorella Marselli, Mara Suleiman, Stefan R Henz, Piero Marchetti, Rasmus Wernersson, Decio L Eizirik
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Editore: The Endocrine Society
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Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes

Autori: Lorraine Yeo, Alyssa Woodwyk, Sanjana Sood, Anna Lorenc, Martin Eichmann, Irma Pujol-Autonell, Rosella Melchiotti, Ania Skowera, Efthymios Fidanis, Garry M. Dolton, Katie Tungatt, Andrew K. Sewell, Susanne Heck, Alka Saxena, Craig A. Beam, Mark Peakman
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Editore: American Society for Clinical Investigation
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Characterization and non-parametric modeling of the developing serum proteome during infancy and early childhood

Autori: Niina Lietzén, Lu Cheng, Robert Moulder, Heli Siljander, Essi Laajala, Taina Härkönen, Aleksandr Peet, Aki Vehtari, Vallo Tillmann, Mikael Knip, Harri Lähdesmäki, Riitta Lahesmaa
Pubblicato in: Scientific Reports, Numero 8/1, 2018, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-018-24019-5

Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes

Autori: Mijke Buitinga, Aïsha Callebaut, Fernanda Marques Câmara Sodré, Inne Crèvecoeur, Gabriele Blahnik-Fagan, Mei-Ling Yang, Marco Bugliani, David Arribas-Layton, Meghan Marré, Dana P. Cook, Etienne Waelkens, Roberto Mallone, Jon D. Piganelli, Piero Marchetti, Mark J. Mamula, Rita Derua, Eddie A. James, Chantal Mathieu, Lut Overbergh
Pubblicato in: Diabetes, Numero 67/11, 2018, Pagina/e 2337-2348, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db18-0295

Immunological biomarkers for the development and progression of type 1 diabetes

Autori: Chantal Mathieu, Riitta Lahesmaa, Ezio Bonifacio, Peter Achenbach, Timothy Tree
Pubblicato in: Diabetologia, Numero 61/11, 2018, Pagina/e 2252-2258, ISSN 0012-186X
Editore: Springer Verlag
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When one becomes many-Alternative splicing in β-cell function and failure

Autori: Maria Inês Alvelos, Jonàs Juan-Mateu, Maikel Luis Colli, Jean-Valéry Turatsinze, Décio L. Eizirik
Pubblicato in: Diabetes, Obesity and Metabolism, Numero 20, 2018, Pagina/e 77-87, ISSN 1462-8902
Editore: Blackwell Publishing Inc.
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Biomarkers of islet beta cell stress and death in type 1 diabetes

Autori: Emily K. Sims, Carmella Evans-Molina, Sarah A. Tersey, Decio L. Eizirik, Raghavendra G. Mirmira
Pubblicato in: Diabetologia, Numero 61/11, 2018, Pagina/e 2259-2265, ISSN 0012-186X
Editore: Springer Verlag
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Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa

Autori: Stéphane Demine, Alexander Balhuizen, Vinciane Debaille, Lieke Joosten, Maïté Fereau, Satya Chilla, Isabelle Millard, Raphaël Scharfmann, Dominique Egrise, Serge Goldman, Piero Marchetti, Martin Gotthardt, Sophie Laurent, Carmen Burtea, Decio Eizirik
Pubblicato in: Molecules, Numero 23/9, 2018, Pagina/e 2100, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
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PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction

Autori: Maikel L. Colli, Jessica L.E. Hill, Laura Marroquí, Jessica Chaffey, Reinaldo S. Dos Santos, Pia Leete, Alexandra Coomans de Brachène, Flavia M.M. Paula, Anne Op de Beeck, Angela Castela, Lorella Marselli, Lars Krogvold, Knut Dahl-Jorgensen, Piero Marchetti, Noel G. Morgan, Sarah J. Richardson, Décio L. Eizirik
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Editore: Elsevier BV
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SRp55 Regulates a Splicing Network That Controls Human Pancreatic β-Cell Function and Survival

Autori: Jonàs Juan-Mateu, Maria Inês Alvelos, Jean-Valéry Turatsinze, Olatz Villate, Esther Lizarraga-Mollinedo, Fabio Arturo Grieco, Laura Marroquí, Marco Bugliani, Piero Marchetti, Décio L. Eizirik
Pubblicato in: Diabetes, Numero 67/3, 2018, Pagina/e 423-436, ISSN 0012-1797
Editore: American Diabetes Association
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IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells

Autori: Alexandra Coomans de Brachène, Reinaldo S. Dos Santos, Laura Marroqui, Maikel L. Colli, Lorella Marselli, Raghavendra G. Mirmira, Piero Marchetti, Decio L. Eizirik
Pubblicato in: Diabetologia, Numero 61/3, 2018, Pagina/e 636-640, ISSN 0012-186X
Editore: Springer Verlag
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Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis

Autori: Flavia M. M. Paula, Nayara C. Leite, Patricia C. Borck, Ricardo Freitas-Dias, Miriam Cnop, Mara P. T. Chacon-Mikahil, Claudia R. Cavaglieri, Piero Marchetti, Antonio C. Boschero, Claudio C. Zoppi, Decio L. Eizirik
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Editore: Federation of American Societies for Experimental Biology
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A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells

Autori: Alexander Balhuizen, Sam Massa, Iris Mathijs, Jean-Valery Turatsinze, Jens De Vos, Stéphane Demine, Catarina Xavier, Olatz Villate, Isabelle Millard, Dominique Egrise, Carmen Capito, Raphaël Scharfmann, Pieter In’t Veld, Piero Marchetti, Serge Muyldermans, Serge Goldman, Tony Lahoutte, Luc Bouwens, Decio L. Eizirik, Nick Devoogdt
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
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Frequent Monitoring of C-Peptide Levels in Newly Diagnosed Type 1 Subjects Using Dried Blood Spots Collected at Home

Autori: Ruben H Willemsen, Keith Burling, Peter Barker, Fran Ackland, Renuka P Dias, Julie Edge, Anne Smith, John Todd, Boryana Lopez, Adrian P Mander, Catherine Guy, David B Dunger
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Editore: The Endocrine Society
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Europe has to step up its efforts to produce innovative and safe diabetes technology

Autori: Miriam Cnop, Tomasz Klupa, Nikolaos Tentolouris, Anna Novials, Rémy Burcelin, Mischa van Eimeren
Pubblicato in: Diabetologia, Numero 60/12, 2017, Pagina/e 2532-2533, ISSN 0012-186X
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MicroRNAs

Autori: Francesco Dotta, Giuliana Ventriglia, Isaac V. Snowhite, Alberto Pugliese
Pubblicato in: Current Opinion in Endocrinology & Diabetes and Obesity, Numero 25/4, 2018, Pagina/e 237-245, ISSN 1752-296X
Editore: Lippincott Williams & Wilkins Ltd.
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Islet-reactive CD8 + T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

Autori: Slobodan Culina, Ana Ines Lalanne, Georgia Afonso, Karen Cerosaletti, Sheena Pinto, Guido Sebastiani, Klaudia Kuranda, Laura Nigi, Anne Eugster, Thomas Østerbye, Alicia Maugein, James E. McLaren, Kristin Ladell, Etienne Larger, Jean-Paul Beressi, Anna Lissina, Victor Appay, Howard W. Davidson, Søren Buus, David A. Price, Matthias Kuhn, Ezio Bonifacio, Manuela Battaglia, Sophie Caillat-Zucman, Fr
Pubblicato in: Science Immunology, Numero 3/20, 2018, Pagina/e eaao4013, ISSN 2470-9468
Editore: American Association for the Advancement of Science
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Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

Autori: Sergio Gonzalez-Duque, Marie Eliane Azoury, Maikel L. Colli, Georgia Afonso, Jean-Valery Turatsinze, Laura Nigi, Ana Ines Lalanne, Guido Sebastiani, Alexia Carré, Sheena Pinto, Slobodan Culina, Noémie Corcos, Marco Bugliani, Piero Marchetti, Mathieu Armanet, Marc Diedisheim, Bruno Kyewski, Lars M. Steinmetz, Søren Buus, Sylvaine You, Daniele Dubois-Laforgue, Etienne Larger, Jean-Paul Beressi, G
Pubblicato in: Cell Metabolism, Numero 28/6, 2018, Pagina/e 946-960.e6, ISSN 1550-4131
Editore: Cell Press
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The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms

Autori: Pia Leete, Roberto Mallone, Sarah J. Richardson, Jay M. Sosenko, Maria J. Redondo, Carmella Evans-Molina
Pubblicato in: Current Diabetes Reports, Numero 18/11, 2018, ISSN 1534-4827
Editore: Current Science Inc.
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Virus-like infection induces human β cell dedifferentiation

Autori: Masaya Oshima, Klaus-Peter Knoch, Marc Diedisheim, Antje Petzold, Pierre Cattan, Marco Bugliani, Piero Marchetti, Pratik Choudhary, Guo-Cai Huang, Stefan R. Bornstein, Michele Solimena, Olivier Albagli-Curiel, Raphael Scharfmann
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Editore: American Society for Clinical Investigation
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Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource

Autori: Piero Marchetti, Mara Suleiman, Lorella Marselli
Pubblicato in: Diabetologia, Numero 61/4, 2018, Pagina/e 770-774, ISSN 0012-186X
Editore: Springer Verlag
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MANF protects human pancreatic beta cells against stress-induced cell death

Autori: Elina Hakonen, Vikash Chandra, Christopher L. Fogarty, Nancy Yiu-Lin Yu, Jarkko Ustinov, Shintaro Katayama, Emilia Galli, Tatiana Danilova, Päivi Lindholm, Aki Vartiainen, Elisabet Einarsdottir, Kaarel Krjutškov, Juha Kere, Mart Saarma, Maria Lindahl, Timo Otonkoski
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Editore: Springer Verlag
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Novel minor HLA DR associated antigens in type 1 diabetes

Autori: Denise Müller, Tanja Telieps, Anne Eugster, Christina Weinzierl, Manja Jolink, Anette-Gabriele Ziegler, Ezio Bonifacio
Pubblicato in: Clinical Immunology, Numero 194, 2018, Pagina/e 87-91, ISSN 1521-6616
Editore: Academic Press
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The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ Genotype

Autori: Christina Reinauer, Joachim Rosenbauer, Christina Bächle, Christian Herder, Michael Roden, Sian Ellard, Elisa De Franco, Beate Karges, Reinhard Holl, Jürgen Enczmann, Thomas Meissner
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Editore: Multidisciplinary Digital Publishing Institute (MDPI)
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DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway

Autori: Reinaldo S. Dos Santos, Laura Marroqui, Teresa Velayos, Ane Olazagoitia-Garmendia, Amaia Jauregi-Miguel, Ainara Castellanos-Rubio, Decio L. Eizirik, Luis Castaño, Izortze Santin
Pubblicato in: Diabetologia, 2018, ISSN 0012-186X
Editore: Springer Verlag
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Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

Autori: Diego Balboa, Jonna Saarimäki-Vire, Daniel Borshagovski, Mantas Survila, Päivi Lindholm, Emilia Galli, Solja Eurola, Jarkko Ustinov, Heli Grym, Hanna Huopio, Juha Partanen, Kirmo Wartiovaara, Timo Otonkoski
Pubblicato in: eLife, Numero 7, 2018, ISSN 2050-084X
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Understanding type 1 diabetes through proteomics

Autori: Inne Crèvecoeur, Saurabh Vig, Chantal Mathieu, Lut Overbergh
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Editore: Future Drugs Ltd.
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Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells

Autori: Saurabh Vig, Mijke Buitinga, Dieter Rondas, Inne Crèvecoeur, Marc van Zandvoort, Etienne Waelkens, Decio L. Eizirik, Conny Gysemans, Pieter Baatsen, Chantal Mathieu, Lut Overbergh
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Editore: Nature Publishing Group
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Translating Mechanism of Regulatory Action of Tolerogenic Dendritic Cells to Monitoring Endpoints in Clinical Trials

Autori: Jessica S. Suwandi, Tatjana Nikolic, Bart O. Roep
Pubblicato in: Frontiers in Immunology, Numero 8, 2017, Pagina/e 1598, ISSN 1664-3224
Editore: Frontiers Media
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Fostering improved human islet research: a European perspective

Autori: Piero Marchetti, Anke M. Schulte, Lorella Marselli, Eyke Schoniger, Marco Bugliani, Werner Kramer, Lut Overbergh, Susanne Ullrich, Anna L. Gloyn, Mark Ibberson, Guy Rutter, Philippe Froguel, Leif Groop, Mark I. McCarthy, Francesco Dotta, Raphael Scharfmann, Christophe Magnan, Decio L. Eizirik, Chantal Mathieu, Miriam Cnop, Bernard Thorens, Michele Solimena
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Editore: Springer Verlag
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Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes

Autori: Amna Khamis, Mickaël Canouil, Afshan Siddiq, Hutokshi Crouch, Mario Falchi, Manon von Bulow, Florian Ehehalt, Lorella Marselli, Marius Distler, Daniela Richter, Jürgen Weitz, Krister Bokvist, Ioannis Xenarios, Bernard Thorens, Anke M. Schulte, Mark Ibberson, Amelie Bonnefond, Piero Marchetti, Michele Solimena, Philippe Froguel
Pubblicato in: Molecular Metabolism, Numero 24, 2019, Pagina/e 98-107, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.03.004

DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes

Autori: Marco Bugliani, Farooq Syed, Flavia M.M. Paula, Bilal A. Omar, Mara Suleiman, Sandra Mossuto, Francesca Grano, Francesco Cardarelli, Ugo Boggi, Fabio Vistoli, Franco Filipponi, Paolo De Simone, Lorella Marselli, Vincenzo De Tata, Bo Ahren, Decio L. Eizirik, Piero Marchetti
Pubblicato in: Molecular and Cellular Endocrinology, Numero 473, 2018, Pagina/e 186-193, ISSN 0303-7207
Editore: Elsevier BV
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Longitudinal Trajectories of Metabolic Control From Childhood to Young Adulthood in Type 1 Diabetes From a Large German/Austrian Registry: A Group-Based Modeling Approach

Autori: Anke Schwandt, Julia M. Hermann, Joachim Rosenbauer, Claudia Boettcher, Désirée Dunstheimer, Jürgen Grulich-Henn, Oliver Kuss, Birgit Rami-Merhar, Christian Vogel, Reinhard W. Holl
Pubblicato in: Diabetes Care, Numero 40/3, 2017, Pagina/e 309-316, ISSN 0149-5992
Editore: American Diabetes Association
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Polycystic Ovary Syndrome (PCOS) in Juvenile and Adult Type 1 Diabetes in a German/Austrian Cohort

Autori: Christina Reinauer, Esther Bollow, Elke Fröhlich-Reiterer, Katharina Laubner, Dominik Bergis, Christof Schöfl, Hans-Peter Kempe, Michael Hummel, Pia Hennes, Katja Gollisch, Holger Haberland, Nicolin Datz, Thomas Meissner, Reinhard Holl
Pubblicato in: Experimental and Clinical Endocrinology & Diabetes, Numero 125/10, 2017, Pagina/e 661-668, ISSN 0947-7349
Editore: Johann Ambrosius Barth
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Quantitative Proteomics Reveals the Dynamic Protein Landscape during Initiation of Human Th17 Cell Polarization

Autori: Subhash K. Tripathi, Tommi Välikangas, Ankitha Shetty, Mohd Moin Khan, Robert Moulder, Santosh D. Bhosale, Elina Komsi, Verna Salo, Rafael Sales De Albuquerque, Omid Rasool, Sanjeev Galande, Laura L. Elo, Riitta Lahesmaa
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Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells

Autori: Maikel L. Colli, Flavia M. Paula, Lorella Marselli, Piero Marchetti, Merja Roivainen, Decio L. Eizirik, Anne Op de beeck
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Succinylated Gelatin Improves the Theranostic Potential of Radiolabeled Exendin-4 in Insulinoma Patients

Autori: Mijke Buitinga, Tom Jansen, Inge van der Kroon, Wietske Woliner-van der Weg, Marti Boss, Marcel Janssen, Erik Aarntzen, Martin Béhé, Damian Wild, Eric Visser, Maarten Brom, Martin Gotthardt
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Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells

Autori: Niina Lietzén, Karoliina Hirvonen, Anni Honkimaa, Tanja Buchacher, Jutta E. Laiho, Sami Oikarinen, Magdalena A. Mazur, Malin Flodström-Tullberg, Eric Dufour, Amir-Babak Sioofy-Khojine, Heikki Hyöty, Riitta Lahesmaa
Pubblicato in: iScience, Numero 19, 2019, Pagina/e 340-357, ISSN 2589-0042
Editore: Elsevier
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ICA512 RESP18 homology domain is a protein-condensing factor and insulin fibrillation inhibitor

Autori: Pamela L. Toledo, Juha M. Torkko, Andreas Müller, Carolin Wegbrod, Anke Sönmez, Michele Solimena, Mario R. Ermácora
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Continuous glucose monitoring and glycemic control among youth with type 1 diabetes: International comparison from the T1D Exchange and DPV Initiative

Autori: Daniel J. DeSalvo, Kellee M. Miller, Julia M. Hermann, David M. Maahs, Sabine E. Hofer, Mark A. Clements, Eggert Lilienthal, Jennifer L. Sherr, Martin Tauschmann, Reinhard W. Holl
Pubblicato in: Pediatric Diabetes, Numero 19/7, 2018, Pagina/e 1271-1275, ISSN 1399-543X
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The supply chain of human pancreatic β cell lines

Autori: Raphael Scharfmann, Willem Staels, Olivier Albagli
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Editore: American Society for Clinical Investigation
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The microRNAs miR-211-5p and miR-204-5p modulate ER stress in human beta cells

Autori: Fabio Arturo Grieco, Andrea Alex Schiavo, Flora Brozzi, Jonas Juan-Mateu, Marco Bugliani, Piero Marchetti, Décio Eizirik
Pubblicato in: Journal of Molecular Endocrinology, 2019, ISSN 0952-5041
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Mixed‐meal tolerance test to assess residual beta‐cell secretion: Beyond the area‐under‐curve of plasma C‐peptide concentration

Autori: Yue Ruan, Ruben H. Willemsen, Malgorzata E. Wilinska, Martin Tauschmann, David B. Dunger, Roman Hovorka
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MicroRNAs as Regulators of Insulin Signaling: Research Updates and Potential Therapeutic Perspectives in Type 2 Diabetes

Autori: Laura Nigi, Giuseppina Grieco, Giuliana Ventriglia, Noemi Brusco, Francesca Mancarella, Caterina Formichi, Francesco Dotta, Guido Sebastiani
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Oral contraception in adolescents with type 1 diabetes and its association with cardiovascular risk factors. A multicenter DPV study on 24 011 patients from Germany, Austria or Luxembourg

Autori: Barbara Bohn, Kirsten Mönkemöller, Dörte Hilgard, Axel Dost, Karl Otfried Schwab, Eggert Lilienthal, Elke Hammer, Kathrin Hake, Maria Fritsch, Bettina Gohlke, Carine de Beaufort, Reinhard W Holl
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Genome editing of human pancreatic beta cell models: problems, possibilities and outlook

Autori: Diego Balboa, Rashmi B. Prasad, Leif Groop, Timo Otonkoski
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Risk factors for decline in renal function among young adults with type 1 diabetes

Autori: Anke Schwandt, Dominik Bergis, Michael Denkinger, Katja S.C. Gollisch, Dirk Sandig, Harald Stingl, Stefan Zimny, Reinhard W. Holl
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Trajectories of Body Mass Index from Childhood to Young Adulthood among Patients with Type 1 Diabetes—A Longitudinal Group-Based Modeling Approach Based on the DPV Registry

Autori: Nicole Prinz, Anke Schwandt, Marianne Becker, Christian Denzer, Monika Flury, Maria Fritsch, Angela Galler, Andreas Lemmer, Matthias Papsch, Thomas Reinehr, Joachim Rosenbauer, Reinhard W. Holl
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Ultra-high resolution MALDI-FTICR-MSI analysis of intact proteins in mouse and human pancreas tissue

Autori: Isabella Piga, Bram Heijs, Simone Nicolardi, Laura Giusti, Lorella Marselli, Piero Marchetti, Maria Rosa Mazzoni, Antonio Lucacchini, Liam A. McDonnell
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Impact of long-term air pollution exposure on metabolic control in children and adolescents with type 1 diabetes: results from the DPV registry

Autori: Stefanie Lanzinger, Joachim Rosenbauer, Dorothea Sugiri, Tamara Schikowski, Birgit Treiber, Daniela Klee, Wolfgang Rathmann, Reinhard W. Holl
Pubblicato in: Diabetologia, Numero 61/6, 2018, Pagina/e 1354-1361, ISSN 0012-186X
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Center Size and Glycemic Control: An International Study With 504 Centers From Seven Countries

Autori: Niels H. Birkebaek, Julia M. Hermann, Lena Hanberger, Dimitrios Charalampopoulos, Reinhard W. Holl, Torild Skrivarhaug, Karin Aakesson, Justin T. Warner, Ann K. Drivvoll, Ann-Marie Svensson, Terence Stephenson, Sabine E. Hofer, Siri Fredheim, Siv J. Kummernes, Rakesh Amin, Birgit Rami-Merhar, Anders Johansen, Thomas M. Kapellen, Doerte Hilgard, Knut Dahl-Jørgensen, Elke Froehlich-Reiterer, Maria
Pubblicato in: Diabetes Care, Numero 42/3, 2019, Pagina/e e37-e39, ISSN 0149-5992
Editore: American Diabetes Association
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CRISPR/Cas9 guided genome and epigenome engineering and its therapeutic applications in immune mediated diseases

Autori: Desh Deepak Singh, R. David Hawkins, Riitta Lahesmaa, Subhash K. Tripathi
Pubblicato in: Seminars in Cell & Developmental Biology, 2019, ISSN 1084-9521
Editore: Academic Press
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Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation

Autori: Johan Henriksson, Xi Chen, Tomás Gomes, Ubaid Ullah, Kerstin B. Meyer, Ricardo Miragaia, Graham Duddy, Jhuma Pramanik, Kosuke Yusa, Riitta Lahesmaa, Sarah A. Teichmann
Pubblicato in: Cell, Numero 176/4, 2019, Pagina/e 882-896.e18, ISSN 0092-8674
Editore: Cell Press
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The role of proteomics in assessing beta-cell dysfunction and death in type 1 diabetes

Autori: Ernesto S. Nakayasu, Wei-Jun Qian, Carmella Evans-Molina, Raghavendra G. Mirmira, Decio L. Eizirik, Thomas O. Metz
Pubblicato in: Expert Review of Proteomics, Numero 16/7, 2019, Pagina/e 569-582, ISSN 1478-9450
Editore: Future Drugs Ltd.
DOI: 10.1080/14789450.2019.1634548

The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes

Autori: Mireia Ramos-Rodríguez, Helena Raurell-Vila, Maikel L. Colli, Maria Inês Alvelos, Marc Subirana-Granés, Jonàs Juan-Mateu, Richard Norris, Jean-Valery Turatsinze, Ernesto S. Nakayasu, Bobbie-Jo M. Webb-Robertson, Jamie R. J. Inshaw, Piero Marchetti, Lorenzo Piemonti, Manel Esteller, John A. Todd, Thomas O. Metz, Décio L. Eizirik, Lorenzo Pasquali
Pubblicato in: Nature Genetics, Numero 51/11, 2019, Pagina/e 1588-1595, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-019-0524-6

miR-409-3p is reduced in plasma and islet immune infiltrates of NOD diabetic mice and is differentially expressed in people with type 1 diabetes

Autori: Giuliana Ventriglia, Francesca Mancarella, Guido Sebastiani, Dana P. Cook, Roberto Mallone, Chantal Mathieu, Conny Gysemans, Francesco Dotta
Pubblicato in: Diabetologia, 2019, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-019-05026-1

Proinsulin peptide promotes autoimmune diabetes in a novel HLA-DR3-DQ2-transgenic murine model of spontaneous disease

Autori: Johan Verhagen, Norkhairin Yusuf, Emma L. Smith, Emily M. Whettlock, Kerina Naran, Sefina Arif, Mark Peakman
Pubblicato in: Diabetologia, Numero 62/12, 2019, Pagina/e 2252-2261, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-019-04994-8

Breast Milk-Derived Extracellular Vesicles Enriched in Exosomes From Mothers With Type 1 Diabetes Contain Aberrant Levels of microRNAs

Autori: Aashiq H. Mirza, Simranjeet Kaur, Lotte B. Nielsen, Joachim Størling, Reza Yarani, Martin Roursgaard, Elisabeth R. Mathiesen, Peter Damm, Jens Svare, Henrik B. Mortensen, Flemming Pociot
Pubblicato in: Frontiers in Immunology, Numero 10, 2019, ISSN 1664-3224
Editore: Frontiers Editorial Office
DOI: 10.3389/fimmu.2019.02543

Association of Glycemic Control and Cell Stress With Telomere Attrition in Type 1 Diabetes

Autori: Tine Tesovnik, Jernej Kovac, Tinka Hovnik, Klemen Dovc, Nataša Bratina, Tadej Battelino, Katarina Trebušak Podkrajšek
Pubblicato in: JAMA Pediatrics, Numero 172/9, 2018, Pagina/e 879, ISSN 2168-6203
Editore: American Medical Association
DOI: 10.1001/jamapediatrics.2018.1175

Phenotypic Analysis of Human Lymph Nodes in Subjects With New-Onset Type 1 Diabetes and Healthy Individuals by Flow Cytometry

Autori: Jennie H. M. Yang, Leena Khatri, Marius Mickunas, Evangelia Williams, Danijela Tatovic, Mohammad Alhadj Ali, Philippa Young, Penelope Moyle, Vishal Sahni, Ryan Wang, Rejbinder Kaur, Gillian M. Tannahill, Andrew R. Beaton, Danielle M. Gerlag, Caroline O. S. Savage, Antonella Napolitano Rosen, Frank Waldron-Lynch, Colin M. Dayan, Timothy I. M. Tree
Pubblicato in: Frontiers in Immunology, Numero 10, 2019, ISSN 1664-3224
Editore: Frontiers Editorial Office
DOI: 10.3389/fimmu.2019.02547

Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells

Autori: Stéphane Demine, Andrea Alex Schiavo, Sandra Marín-Cañas, Piero Marchetti, Miriam Cnop, Decio L. Eizirik
Pubblicato in: Stem Cell Research & Therapy, Numero 11/1, 2020, ISSN 1757-6512
Editore: BioMed Central
DOI: 10.1186/s13287-019-1523-3

From immunohistological to anatomical alterations of human pancreas in type 1 diabetes: New concepts on the stage

Autori: Laura Nigi, Carla Maccora, Francesco Dotta, Guido Sebastiani
Pubblicato in: Diabetes/Metabolism Research and Reviews, 2019, ISSN 1520-7552
Editore: John Wiley & Sons Inc.
DOI: 10.1002/dmrr.3264

Targeting microRNAs as a Therapeutic Strategy to Reduce Oxidative Stress in Diabetes

Autori: Giuseppina Emanuela Grieco, Noemi Brusco, Giada Licata, Laura Nigi, Caterina Formichi, Francesco Dotta, Guido Sebastiani
Pubblicato in: International Journal of Molecular Sciences, Numero 20/24, 2019, Pagina/e 6358, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
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Capturing residual beta cell function in type 1 diabetes

Autori: Pociot F
Pubblicato in: Diabetologia, Numero 2019 Jan;62(1), 2019, Pagina/e 28-32, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-018-4768-y

PET-based dosimetry of [68Ga]Ga-NODAGA-exendin-4 in humans, a tracer for beta cell imaging

Autori: Boss M, Buitinga M, Jansen TJ, Brom M, Visser EP, Gotthardt M
Pubblicato in: The Journal of Nuclear Medicine, Numero 2020 Jan; 61(1), 2019, Pagina/e 112–116, ISSN 0161-5505
Editore: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.119.228627

Circulating β cell-specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes

Autori: Yeo L, Pujol-Autonell I, Baptista R, Eichmann M, Kronenberg-Versteeg D, Heck S, Dolton G, Sewell AK, Härkönen T, Mikk ML, Toppari J, Veijola R, Knip M, Ilonen J, Peakman M
Pubblicato in: Clinical and Experimental Immunology, Numero 2019 Oct 29, 2019, ISSN 0009-9104
Editore: Blackwell Publishing Inc.
DOI: 10.1111/cei.13391

Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity

Autori: Masaya Oshima, Séverine Pechberty, Lara Bellini, Sven O. Göpel, Mélanie Campana, Claude Rouch, Julien Dairou, Cristina Cosentino, Federica Fantuzzi, Sanna Toivonen, Piero Marchetti, Christophe Magnan, Miriam Cnop, Hervé Le Stunff, Raphaël Scharfmann
Pubblicato in: Diabetologia, Numero 63/2, 2020, Pagina/e 395-409, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-019-05046-x

In vitro beta-cell killing models using immune cells and human pluripotent stem cell-derived islets: Challenges and opportunities

Autori: Halliez C, Ibrahim H, Otonkoski T, Mallone R.
Pubblicato in: Frontiers in endocrinology, Numero 13, 2023, Pagina/e 13:1076683, ISSN 1664-2392
Editore: Lausanne : Frontiers Research Foundation
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Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice.

Autori: Fernanda M. C. Sodré, Samal Bissenova, Ylke Bruggeman, Ronak Tilvawala, Dana P. Cook, Claire Berthault, Santanu Mondal, Aïsha Callebaut, Sylvaine You, Raphael Scharfmann, Roberto Mallone, Paul R. Thompson, Chantal Mathieu, Mijke Buitinga, Lut Overbergh
Pubblicato in: Diabetes, 2020, Pagina/e db200421, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db20-0421

First-in-human, double-blind, randomized phase 1b study of peptide immunotherapy IMCY-0098 in new-onset type 1 diabetes

Autori: Van Rampelbergh J, Achenbach P, Leslie RD, Ali MA, Dayan C, Keymeulen B, Owen KR, Kindermans M, Parmentier F, Carlier V, Ahangarani RR, Gebruers E, Bovy N, Vanderelst L, Van Mechelen M, Vandepapelière P, Boitard C.
Pubblicato in: BMC medicine, Numero 21(1), 2023, Pagina/e 190, ISSN 1741-7015
Editore: BioMed Central
DOI: 10.1186/s12916-023-02900-z

Purification of pancreatic endocrine subsets reveals increased iron metabolism in beta-cells

Autori: Berthault C, Staels W, Scharfmann R.
Pubblicato in: Molecular Metabolism, Numero 2020 Aug 4:101060, 2020, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101060

Long-RNA sequencing and ribosome profiling of inflamed beta-cells reveal an extensive translatome landscape.

Autori: Thomaidou S, Slieker RC, van der Slik AR, Boom J, Mulder F, Munoz-Garcia A, 't Hart LM, Koeleman B, Carlotti F, Hoeben RC, Roep BO, Mei H, Zaldumbide A.
Pubblicato in: Diabetes, Numero 70(10), 2021, Pagina/e 2299-2312, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db20-1122

Distinguishing activated T regulatory cell and T conventional cells by single-cell technologies.

Autori: Reinhardt J, Sharma V, Stavridou A, Lindner A, Reinhardt S, Petzold A, Lesche M, Rost F, Bonifacio E, Eugster A.
Pubblicato in: Immunology, Numero 166(1), 2022, Pagina/e 121-137, ISSN 1365-2567
Editore: Oxford : Blackwell Scientific Publications
DOI: 10.1111/imm.13460

ER stress promotes mitochondrial DNA mediated type-1 interferon response in beta-cells and interleukin-8 driven neutrophil chemotaxis.

Autori: Vig S, Lambooij JM, Dekkers MC, Otto F, Carlotti F, Guigas B, Zaldumbide A.
Pubblicato in: Frontiers in endocrinology., Numero 13, 2022, Pagina/e 991632, ISSN 1664-2392
Editore: Lausanne : Frontiers Research Foundation
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Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?

Autori: Roberto Mallone, Decio L. Eizirik
Pubblicato in: Diabetologia, Numero 63/10, 2020, Pagina/e 1999-2006, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-020-05176-7

Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes affirms markers of disease

Autori: Robert Moulder, M. Karoliina Hirvonen, Tommi Välikangas, Tomi Suomi, Lut Overbergh, Mark Peakman, Søren Brunak, Chantal Mathieu, Mikael Knip, Laura L. Elo, Riitta Lahesmaa, null null
Pubblicato in: Diabetologia, 2025, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-025-06394-7

A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes

Autori: Marwaha AK, Chow S, Pesenacker AM, Cook L, Sun A, Long SA, Yang JHM, Ward-Hartstonge KA, Williams E, Domingo-Vila C, Halani K, Harris KM, Tree TIM, Levings MK, Elliott T, Tan R, Dutz JP.
Pubblicato in: Immunotherapy Advances, 2021, Pagina/e 2(1), ISSN 2732-4303
Editore: Oxford University Press
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The Transatlantic HbA1c gap : differences in glycaemic control across the lifespan between people included in the US T1D Exchange Registry and those included in the German/Austrian DPV registry

Autori: Hermann, Julia M.; Miller, K. M.; Hofer, S. E.; Clements, M. A.; Karges, Wolfram; Foster, N. C.; Fröhlich-Reiterer, E.; Rickels, M. R.; Rosenbauer, J.; DeSalvo, D. J.; Holl, R. W.; Maahs, D. M.
Pubblicato in: Diabetic medicine (2019). doi:10.1111/dme.14148, Numero 1, 2020, ISSN 1464-5491
Editore: Wiley
DOI: 10.18154/RWTH-2020-01942

CD4+ T Cells From Individuals With Type 1 Diabetes Respond to a Novel Class of Deamidated Peptides Formed in Pancreatic Islets

Autori: Aïsha Callebaut, Perrin Guyer, Rita Derua, Mijke Buitinga, Anthony Manganaro, Xiaoyan Yi, Fernanda Marques Câmara Sodré, Saurabh Vig, Mara Suleiman, Piero Marchetti, Decio L. Eizirik, Sally C. Kent, Chantal Mathieu, Eddie A. James, Lut Overbergh
Pubblicato in: Diabetes, Numero 73, 2024, Pagina/e 728-742, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db23-0588

Clinical care advice for monitoring of islet autoantibody positive individuals with presymptomatic type 1 diabetes

Autori: A. Emile J. Hendriks, M. Loredana Marcovecchio, Rachel E. J. Besser, Ezio Bonifacio, Kristina Casteels, Helena Elding Larsson, Gita Gemulla, Markus Lundgren, Olga Kordonouri, Roberto Mallone, Flemming Pociot, Agnieszka Szypowska, Jorma Toppari, Thekla von dem Berge, Anette G. Ziegler, Chantal Mathieu, Peter Achenbach, null null
Pubblicato in: Diabetes/Metabolism Research and Reviews, Numero 40, 2024, Pagina/e e3777, ISSN 1520-7552
Editore: John Wiley & Sons Inc.
DOI: 10.1002/dmrr.3777

Glycemic variability - the danger of a physiologically stable metric.

Autori: Battelino T, Dovč K.
Pubblicato in: The Journal of clinical endocrinology and metabolism., Numero 105(10), 2020, Pagina/e e3815–e3817, ISSN 0021-972X
Editore: The Endocrine Society
DOI: 10.1210/clinem/dgaa486

β-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Posttranscriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1

Autori: Sofia Thomaidou, Maria J.L. Kracht, Arno van der Slik, Sandra Laban, Eelco J. de Koning, Francoise Carlotti, Rob C. Hoeben, Bart O. Roep, Arnaud Zaldumbide
Pubblicato in: Diabetes, Numero 69/4, 2020, Pagina/e 670-680, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db19-0984

From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes.

Autori: Eizirik DL, Szymczak F, Alvelos MI, Martin F.
Pubblicato in: Diabetes, Numero 70(9), 2021, Pagina/e 1915-1925, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/dbi20-0046

Neoepitopes in Type 1 Diabetes: Etiological Insights, Biomarkers and Therapeutic Targets.

Autori: Rodriguez-Calvo T, Johnson JD, Overbergh L, Dunne JL.
Pubblicato in: Frontiers in immunology, 2021, Pagina/e 12:667989, ISSN 1664-3224
Editore: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.667989

Defining a cure for type 1 diabetes: a call to action.

Autori: Roep BO, Montero E, van Tienhoven R, Atkinson MA, Schatz DA, Mathieu C.
Pubblicato in: The lancet. Diabetes & endocrinology, Numero (9), 2021, Pagina/e 553-555, ISSN 2213-8587
Editore: Elsevier BV
DOI: 10.1016/s2213-8587(21)00181-9

Prognostic transcriptome classes of duodenopancreatic neuroendocrine tumors.

Autori: Diedisheim M, Dermine S, Jouinot A, Septier A, Gaujoux S, Dousset B, Cadiot G, Larger E, Bertherat J, Scharfmann R, Terris B, Coriat R, Assié G.
Pubblicato in: Endocrine-Related Cancer, Numero 28(8), 2021, Pagina/e 563-571, ISSN 1351-0088
Editore: Society for Endocrinology
DOI: 10.1530/erc-21-0051

Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses

Autori: Vecchio F, Carré A, Korenkov D, Zhou Z, Apaolaza P, Tuomela S, Burgos-Morales O, Snowhite I, Perez-Hernandez J, Brandao B, Afonso G, Halliez C, Kaddis J, Kent SC, Nakayama M, Richardson SJ, Vinh J, Verdier Y, Laiho J, Scharfmann R, Solimena M, Marinicova Z, Bismuth E, Lucidarme N, Sanchez J, Bustamante C, Gomez P, Buus S; nPOD-Virus Working Group; You S, Pugliese A, Hyoty H, Rodriguez-Calvo T, Fl
Pubblicato in: The lancet. Diabetes & endocrinology, Numero 11(9), 2023, Pagina/e 657-666, ISSN 2213-8587
Editore: Elsevier BV
DOI: 10.1101/2023.08.19.553954

Citrullination and PAD Enzyme Biology in Type 1 Diabetes - Regulators of Inflammation, Autoimmunity, and Pathology.

Autori: Yang ML, Sodré FMC, Mamula MJ, Overbergh L.
Pubblicato in: Frontiers in immunology, Numero 12:678953, 2021, ISSN 1664-3224
Editore: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.678953

A nanobody-based nuclear imaging tracer targeting dipeptidyl peptidase 6 to determine the mass of human beta cell grafts in mice

Autori: Stéphane Demine, Rita Garcia Ribeiro, Julien Thevenet, Lorella Marselli, Piero Marchetti, François Pattou, Julie Kerr-Conte, Nick Devoogdt, Decio L. Eizirik
Pubblicato in: Diabetologia, Numero 63/4, 2020, Pagina/e 825-836, ISSN 0012-186X
Editore: Springer Verlag
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International benchmarking in type 1 diabetes: Large difference in childhood HbA1c between 8 high-income countries but similar rise during adolescence-A quality registry study.

Autori: Anderzén J, Hermann JM, Samuelsson U, Charalampopoulos D, Svensson J, Skrivarhaug T, Fröhlich-Reiterer E, Maahs DM, Akesson K, Kapellen T, Fritsch M, Birkebaek NH, Drivvoll AK, Miller K, Stephenson T, Hofer SE, Fredheim S, Kummernes SJ, Foster N, Amin R, Hilgard D, Rami-Merhar B, Dahl-Jørgensen K, Clements M, Hanas R, Holl RW, Warner JT.
Pubblicato in: Pediatric diabetes., Numero 21(4), 2020, Pagina/e 621-627, ISSN 1399-5448
Editore: Copenhagen : Munksgaard
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Monitoring beta cell survival after intrahepatic islet transplantation using dynamic exendin PET imaging: a proof-of-concept study in individuals with type 1 diabetes

Autori: Jansen TJP, Buitinga M, Boss M, Nijhoff MF, Brom M, de Galan BE, van der Graaf M, van Koeverden S, Vantyghem MC, Beron A, Pattou F, Engelse MA, Velikyan I, Eriksson O, de Koning EJP, Gotthardt M
Pubblicato in: Diabetes, Numero 72(7), 2023, Pagina/e 898-907, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db22-0884

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes.

Autori: Marselli L, Piron A, Suleiman M, Colli ML, Yi X, Khamis A, Carrat GR, Rutter GA, Bugliani M, Giusti L, Ronci M, Ibberson M, Turatsinze JV, Boggi U, De Simone P, De Tata V, Lopes M, Nasteska D, De Luca C, Tesi M, Bosi E, Singh P, Campani D, Schulte AM, Solimena M, Hecht P, Rady B, Bakaj I, Pocai A, Norquay L, Thorens B, Canouil M, Froguel P, Eizirik DL, Cnop M, Marchetti P.
Pubblicato in: Cell reports., Numero 33(9), 2020, Pagina/e 108466, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.108466

NET Proteome in Established Type 1 Diabetes Is Enriched in Metabolic Proteins

Autori: Bissenova S, Ellis D, Callebaut A, Eelen G, Derua R, Buitinga M, Mathieu C, Gysemans C, Overbergh L
Pubblicato in: Cells, Numero 12(9), 2023, Pagina/e 1319, ISSN 2073-4409
Editore: Basel, Switzerland : MDPI
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Study protocol: Minimum effective low dose: anti-human thymocyte globulin (MELD-ATG): phase II, dose ranging, efficacy study of antithymocyte globulin (ATG) within 6 weeks of diagnosis of type 1 diabetes.

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Oral vaccination with Fc-coupled preproinsulin for Type 1 Diabetes prevention

Autori: Corcos, Noémie
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Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes – Sofia ref.: 115797

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