Big Data 4 Better Hearts - Sofia ref.: 116074 | BigData Heart | Progetto | Risultati | H2020 | CORDIS

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Report on regional differences in the predictors and consequences of HF and AF

Migration

Open access catalogue detailing the available datasets and associated variables in the consortium

Migration

Standard Sets and Additional metrics for HF, AF and ACS

Migration

Report on findings of the omics enriched pilot studies

Migration

Minutes of annual meetings

Also due 25, 37, 49

Final Version of the Data Management Plan

Migration

Report defining requirements for meaningful patient and public involvement in Big Data health research

Migration

Report on basic model for datasharing and -access, data mapping, curating and analysis within the consortium

Migration

Impact of COVID-19 pandemic on cardiovascular disease management and outcomes

Task 5.3: Impact of COVID-19 pandemic on cardiovascular disease management and outcomes

Annual reports, including an Ethic Report of the external Ethics Advisor

Also due 24, 36, 48, 60

Expert group consensus statements on universal definition of HF and AF

Migration

Report on novel therapeutic targets with recommendations for drug development

Migration

Report on sample assays, QC and delivery of results from enrichment measures

Migration

Report specifying 3 new pilot studies demonstrating the scientific advance of omics enrichment

Migration

Exploitation plan and periodic updates

Also due 24,, 36, 48, 60

Final sustainability plan

To ensure commercialisation of deliverables, we will  also explore the need for  the supporting infrastructure, including investigations on how to deliver the results to the users, setting direction and ensuring compliance (Task 6.4).

Report of evaluation of enrichment strategies with recommendations

Migration

Communication and dissemination plan and periodic updates

Also due 12, 24, 36, 48, 60

Outreach plan, e.g. facilitate translation of results to improve patient outcomes

Migration

Report describing sustainable data sharing and -access model

Migration

Comprehensive and systematic literature review of contemporary data sources

Migration

Document detailing distinct project image, including logo and templates for presentations

Migration

Contact database (stakeholders and key project contacts)

Migration

Data management plan

Migration

Report on new disease definitions with recommendations

Migration

Manuscript of stakeholder consensus on new disease and outcome definitions

Migration

Detailed project plan, plus tracking tools, to be maintained throughout the life of the project

Migration

Project management plans

Migration

Report on the patient-centred outcomes with recommendation for wearables in trials

Migration

"Manuscripts for (a) machine learning-based extracted disease phenotypes and sub-phenotypes and new outcomes which have been technically validated; and (b) methodology for ""big data""-driven disease definitions"

Migration

Periodic reports on advice on legal, ethical and governance issues by the Governance Committee

Also due 24, 36, 48, 60

Minutes of kick-off

Migration

Report detailing basic structure of a governance framework for data-intensive health research

Migration

Manuscript of results of registry analyses

Migration

Final version of the remote monitoring platform, tested and rolled out to Android and iOS app stores

Migration

Collaborative website (intranet)

Migration

Final version and evaluation of OHDSI, the Common Data Model and developed disease phenotypes

Migration

First version of the remote monitoring platform, based on RADAR-CNS platform and deployed on Android and iOS, for capturing data for running studies in the consortium

Migration

Public website

Migration

First prototype of OHDSI data discovery and analysis platform with mapped data sources

Migration

Pubblicazioni

Evaluation and improvement of the National Early Warning Score (NEWS2) for COVID-19:a multi-hospital study

Autori: Ewan Carr, Rebecca Bendayan, Daniel Bean, Matt Stammers, Wenjuan Wang, Huayu Zhang, Thomas Searle, Zeljko Kraljevic, Anthony Shek, Hang T. T. Phan, Walter Muruet, Rishi K. Gupta, Anthony J. Shinton, Mike Wyatt, Ting Shi, Xin Zhang, Andrew Pickles, Daniel Stahl, Rosita Zakeri, Mahdad Noursadeghi, Kevin O’Gallagher, Matt Rogers, Amos Folarin, Andreas Karwath, Kristin E. Wickstrøm, Alvaro Köhn-Lu
Pubblicato in: BMC Medicine, 2021, ISSN 1741-7015
Editore: BioMed Central
DOI: 10.1186/s12916-020-01893-3

Statistical integration of two omics datasets using GO2PLS

Autori: Zhujie Gu, Said el Bouhaddani, Jiayi Pei, Jeanine Houwing-Duistermaat & Hae-Won Uh
Pubblicato in: BMC Bioinformatics, 2021, ISSN 1471-2105
Editore: BioMed Central
DOI: 10.1186/s12859-021-03958-3

Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality:observational and Mendelian randomisation analyses

Autori: Eleni Sofianopoulou, Stephen K Kaptoge, Shoaib Afzal, Tao Jiang, Dipender Gill, Thomas E Gundersen, Thomas R Bolton, Elias Allara, Matthew G Arnold, Amy M Mason, Ryan Chung, Lisa A M Pennells, Fanchao Shi, Luanluan Sun, Peter Willeit, Nita G Forouhi, Claudia Langenberg, Stephen J Sharp, Salvatore Panico, Gunnar Engström, Olle Melander, Tammy Y N Tong, Aurora Perez-Cornago, Margareta Norberg, Inge
Pubblicato in: Lancet Diabetes Endocrinol, 2021, ISSN 2213-8587
Editore: Elsevier BV
DOI: 10.1016/s2213-8587(21)00263-1

Selenium and cancer risk: Wide-angled Mendelian randomization analysis

Autori: Shuai Yuan, Amy M. Mason, Paul Carter, Mathew Vithayathil, Siddhartha Kar, Stephen Burgess, Susanna C. Larsson
Pubblicato in: CANCER GENETICS AND EPIGENETICS, 2021, ISSN 0020-7136
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ijc.33902

Desiderata for the development of next-generation electronic health record phenotype libraries

Autori: Martin Chapman, Shahzad Mumtaz, Luke V Rasmussen, Andreas Karwath, Georgios V Gkoutos, Chuang Gao, Dan Thayer, Jennifer A Pacheco, Helen Parkinson, Rachel L Richesson, Emily Jefferson, Spiros Denaxas, Vasa Curcin
Pubblicato in: GigaScience, 2021, ISSN 2047-217X
Editore: Oxford Academic
DOI: 10.1093/gigascience/giab059

Rare and common genetic determinants of metabolic individuality and their effects on human health

Autori: Praveen Surendran, Isobel D. Stewart, Victoria P. W. Au Yeung, Maik Pietzner, Johannes Raffler, Maria A. Wörheide, Chen Li, Rebecca F. Smith, Laura B. L. Wittemans, Lorenzo Bomba, Cristina Menni, Jonas Zierer, Niccolò Rossi, Patricia A. Sheridan, Nicholas A. Watkins, Massimo Mangino, Pirro G. Hysi, Emanuele Di Angelantonio, Mario Falchi, Tim D. Spector, Nicole Soranzo, Gregory A. Michelotti, Wie
Pubblicato in: Nature Medicine, 2022, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-022-02046-0

Transforming clinical research by involving and empowering patients— the RATE-AF randomized trial

Autori: Karina V Bunting, Mary Stanbury, Otilia Tica, Dipak Kotecha
Pubblicato in: European Heart Journal, 2021, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehab098

Genetically Proxied Inhibition of Coagulation Factors and Risk of Cardiovascular Disease: A Mendelian Randomization Study

Autori: Shuai Yuan , Stephen Burgess , Mike Laffan , Amy M. Mason , Martin Dichgans , Dipender Gill and Susanna C. Larsson
Pubblicato in: Journal of the American Heart Association, 2021, ISSN 2047-9980
Editore: Wiley-Blackwell
DOI: 10.1161/jaha.120.019644

Generalizability of randomized controlled trials in heart failure with reduced ejection fraction

Autori: Yvonne Mei Fong Lim, Megan Molnar, Ilonca Vaartjes, Gianluigi Savarese, Marinus J C Eijkemans, Alicia Uijl, Eleni Vradi, Kiliana Suzart-Woischnik, Jasper J Brugts, Hans-Peter Brunner-La Rocca, Vanessa Blanc-Guillemaud, Fabrice Couvelard, Claire Baudier, Tomasz Dyszynski, Sandra Waechter, Lars H Lund, Arno W Hoes, Benoit Tyl, Folkert W Asselbergs, Christoph Gerlinger, Diederick E G
Pubblicato in: European Heart Journal, 2021, ISSN 2047-2404
Editore: Oxford University Press
DOI: 10.1093/ehjqcco/qcab070

Genetically personalised organ-specific metabolic models in health and disease

Autori: Carles Foguet, Yu Xu, Scott C. Ritchie, Samuel A. Lambert, Elodie Persyn, Artika P. Nath, Emma E. Davenport, David J. Roberts, Dirk S. Paul, Emanuele Di Angelantonio, John Danesh, Adam S. Butterworth, Christopher Yau & Michael Inouye
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-35017-7

Supervised Analysis for Phenotype Identification: The Case of Heart Failure Ejection Fraction Class

Autori: Cristina Lopez, Jose Luis Holgado, Raquel Cortes, Inma Sauri, Antonio Fernandez, Jose Miguel Calderon, Julio Nuñez and Josep Redon
Pubblicato in: Bioengineering, 2021, ISSN 2306-5354
Editore: MDPI AG
DOI: 10.3390/bioengineering8060085

Diagnosis and treatment for hyperuricemia and gout: a systematic review of clinical practice guidelines and consensus statements

Autori: Qianrui Li, Xiaodan Li, Jing Wang, Hongdie Liu, Joey Sum-Wing Kwong, Hao Chen, Ling Li, Sheng-Chia Chung, Anoop Shah, Yaolong Chen, Zhenmei An, Xin Sun, Harry Hemingway, Haoming Tian, Sheyu Li
Pubblicato in: BMJ Open., 2019, ISSN 2044-6055
Editore: BMJ Publishing Group
DOI: 10.1136/bmjopen-2018-026677

Sleep duration and risk of overall and 22 site‐specific cancers: A Mendelian randomization study

Autori: Olga E. Titova, Karl Michaëlsson, Mathew Vithayathil, Amy M. Mason, Siddhartha Kar, Stephen Burgess, Susanna C. Larsson
Pubblicato in: International Journal of Cancer, Numero 148/4, 2021, Pagina/e 914-920, ISSN 0020-7136
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ijc.33286

Assessing the feasibility of a web-based outcome measurement system in child and adolescent mental health services – myHealthE a randomised controlled feasibility pilot study

Autori: Anna C. Morris, Zina Ibrahim, Margaret Heslin, Omer S. Moghraby, Argyris Stringaris, Ian M. Grant, Lukasz Zalewski, Megan Pritchard, Robert Stewart, Matthew Hotopf, Andrew Pickles, Richard J. B. Dobson, Emily Simonoff, Johnny Downs
Pubblicato in: Child and Adolescent Mental Health, 2022, ISSN 1475-357X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/camh.12571

Acute kidney injury in heart failure: a population study

Autori: Jose Luis Holgado, Cristina Lopez, Antonio Fernandez, Inmaculada Sauri, Ruth Uso, Jose Luis Trillo, Sara Vela, Julio Nuñez, Josep Redon, Adrian Ruiz
Pubblicato in: ESC Heart Failure, Numero 7/2, 2020, Pagina/e 415-422, ISSN 2055-5822
Editore: Wiley Online Library
DOI: 10.1002/ehf2.12595

Artificial intelligence to enhance clinical value across the spectrum of cardiovascular healthcare

Autori: Simrat K Gill, Andreas Karwath, Hae-Won Uh, Victor Roth Cardoso, Zhujie Gu, Andrey Barsky, Luke Slater, Animesh Acharjee, Jinming Duan, Lorenzo Dall'Olio, Said el Bouhaddani, Saisakul Chernbumroong, Mary Stanbury, Sandra Haynes, Folkert W Asselbergs, Diederick E Grobbee, Marinus J C Eijkemans, Georgios V Gkoutos, Dipak Kotecha, BigData@Heart Consortium and the cardAIc group
Pubblicato in: European Heart Journal, 2023, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehac758

The genomics of heart failure: design and rationale of the HERMES consortium

Autori: R. Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, Daniel I. Swerdlow, Anders Mälarstig, Charlotte Andersson, Niek Verweij, Michael V. Holmes, Johan Ärnlöv, Per Svensson, Harry Hemingway, Neneh Sallah, Peter Almgren, Krishna G. Aragam, Geraldine Asselin, Joshua D. Backman, Mary L. Biggs, Heather L. Bloom, Eric Boersma, Jeffrey Brandimarto, Michael R. Brown, Hans-Peter Bru
Pubblicato in: ESC Heart Failure, 2021, ISSN 2055-5822
Editore: John Wiley & Sons
DOI: 10.1002/ehf2.13517

Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition

Autori: Johannes Kettunen, Michael V Holmes, Elias Allara, Olga Anufrieva, Pauli Ohukainen, Clare Oliver-Williams, Qin Wang, Therese Tillin, Alun D Hughes, Mika Kähönen, Terho Lehtimäki, Jorma Viikari, Olli T Raitakari, Veikko Salomaa, Marjo-Riitta Järvelin, Markus Perola, George Davey Smith, Nish Chaturvedi, John Danesh, Emanuele Di Angelantonio, Adam S Butterworth, Mika Ala-Korpela
Pubblicato in: PLOS BIOLOGY, 2019, ISSN 1544-9173
Editore: Public Library of Science
DOI: 10.1371/journal.pbio.3000572

A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis

Autori: Steven Bell, Andreas S. Rigas, Magnus K. Magnusson, Egil Ferkingstad, Elias Allara, Gyda Bjornsdottir, Anna Ramond, Erik Sørensen, Gisli H. Halldorsson, Dirk S. Paul, Kristoffer S. Burgdorf, Hannes P. Eggertsson, Joanna M. M. Howson, Lise W. Thørner, Snaedis Kristmundsdottir, William J. Astle, Christian Erikstrup, Jon K. Sigurdsson, Dragana Vuckovic, Khoa M. Dinh, Vinicius Tragante, Praveen Sure
Pubblicato in: communications biology, 2021, ISSN 2399-3642
Editore: Nature Research
DOI: 10.1038/s42003-020-01575-z

Estimating the Population Benefits of Blood Pressure Lowering: A Wide‐Angled Mendelian Randomization Study in UK Biobank

Autori: Hannah Higgins , Amy M. Mason , Susanna C. Larsson , Dipender Gill , Claudia Langenberg and Stephen Burgess
Pubblicato in: Journal of the American Heart Association, 2021, ISSN 2047-9980
Editore: Wiley-Blackwell
DOI: 10.1161/jaha.121.021098

Association between renin–angiotensin–aldosterone system inhibitor use and COVID‐19 hospitalization and death: a 1.4 million patient nationwide registry analysis

Autori: Gianluigi Savarese, Lina Benson, Johan Sundström, Lars H. Lund
Pubblicato in: European Journal of Heart Failure, Numero 23/3, 2021, Pagina/e 476-485, ISSN 1388-9842
Editore: Elsevier BV
DOI: 10.1002/ejhf.2060

An agenda-setting paper on data sharing platforms: euCanSHare workshop

Autori: Thijs Devriendt; Clemens Ammann; Folkert W. Asselberghs; Alexander Bernier; Rodrigo Costas; Matthias G. Friedrich; Josep Lluís Gelpí; Josep Lluís Gelpí; Marjo-Riitta Järvelin; Kari Kuulasmaa; Karim Lekadir; Michaela Th. Mayrhofer; Vaclav Papez; Gerard Pasterkamp; Steffen E. Petersen; Carsten Oliver Schmidt; Jeanette Schulz-Menger; Jeanette Schulz-Menger; Stefan Söderberg; Mahsa Shabani; Giov
Pubblicato in: Open Research Europe, Numero 38, 2021, ISSN 0265-9247
Editore: John Wiley & Sons Inc.
DOI: 10.12688/openreseurope.13860.1

Accurate detection of atrial fibrillation using a smartphone remains uncertain: a systematic review and meta-analysis

Autori: Gill, S ; Sartini, C ; Uh, H.W ; Ghoreishi, N ; Cardoso, V ; Bunting, K.V ; Gkoutos, G ; Suzart-Woischnik, K ; Asselbergs, F.W ; Eijkemans, M.J.C ; Kotecha, D
Pubblicato in: European Heart Journal, 2020, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/ehjci/ehaa946.3505

Prediction of vascular aging based on smartphone acquired PPG signals

Autori: Lorenzo Dall’Olio, Nico Curti, Daniel Remondini, Yosef Safi Harb, Folkert W. Asselbergs, Gastone Castellani, Hae-Won Uh
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-76816-6

Clinical characteristics, causes and predictors of outcomes in patients with in-hospital cardiac arrest: results from the SURVIVE-ARREST study

Autori: Laura Erika Maria Hannen, Betül Toprak, Jessica Weimann, Bahara Mahmoodi, Nina Fluschnik, Benedikt Schrage, Kevin Roedl, Gerold Söffker, Stefan Kluge, Malte Issleib, Stefan Blankenberg, Paulus Kirchhof, Peter Clemmensen, Christoph Sinning, Elvin Zengin-Sahm & Peter Moritz Becher
Pubblicato in: Clinical Research in Cardiology, 2022, ISSN 1861-0692
Editore: D. Steinkopff-Verlag
DOI: 10.1007/s00392-022-02084-1

ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study

Autori: Dipender Gill , Marios Arvanitis , Paul Carter , Ana I. Hernández Cordero , Brian Jo , Ville Karhunen , Susanna C. Larsson , Xuan Li , Sam M. Lockhart , Amy Mason , Evanthia Pashos , Ashis Saha , Vanessa Y. Tan , Verena Zuber , Yohan Bossé , Sarah Fahle , Ke Hao , Tao Jiang , Philippe Joubert , Alan C. Lunt† , Willem Hendrik Ouwehand , David J. Roberts , Wim Timens , Maarten van den Berge , Ni
Pubblicato in: Royal Society Open Science, 2020, ISSN 2054-5703
Editore: Royal Society
DOI: 10.1098/rsos.200958

Patient profile and outcomes associated with follow-up in specialty vs. primary care in heart failure

Autori: Felix Lindberg, Lars H. Lund, Lina Benson, Benedikt Schrage, Magnus Edner, Ulf Dahlström, Cecilia Linde, Giuseppe Rosano, Gianluigi Savarese
Pubblicato in: ESC Heart Failure, 2022, Pagina/e 822-833, ISSN 2055-5822
Editore: Wiley
DOI: 10.1002/ehf2.13848

Patients’ and Publics’ Preferences for Data-Intensive Health Research Governance: Survey Study

Autori: Sam H A Muller, Ghislaine J M W van Thiel, Marilena Vrana, Menno Mostert, Johannes J M van Delden
Pubblicato in: JMIR Human Factors, 2022, ISSN 2292-9495
Editore: JMIR Publications Inc.
DOI: 10.2196/36797

Aortic root dimensions as a correlate for aortic regurgitation’s severity

Autori: Jan-Per Wenzel, Elina Petersen, Julius Nikorowitsch, Jessica Müller, Tilo Kölbel, Hermann Reichenspurner, Stefan Blankenberg & Evaldas Girdauskas
Pubblicato in: The International Journal of Cardiovascular Imaging, 2021, ISSN 1875-8312
Editore: Springer Netherlands
DOI: 10.1007/s10554-021-02337-6

Estimating excess 1-year mortality associated with the COVID-19 pandemic according to underlying conditions and age: a population-based cohort study

Autori: Amitava Banerjee, Laura Pasea, Steve Harris, Arturo Gonzalez-Izquierdo, Ana Torralbo, Laura Shallcross, Mahdad Noursadeghi, Deenan Pillay, Neil Sebire, Chris Holmes, Christina Pagel, Wai Keong Wong, Claudia Langenberg, Bryan Williams, Spiros Denaxas, Harry Hemingway
Pubblicato in: Lancet, 2020, Pagina/e 1715-1725, ISSN 0140-6736
Editore: The Lancet Publishing Group
DOI: 10.1016/s0140-6736(20)30854-0

A population-based study of 92 clinically recognized risk factors for heart failure: co-occurrence, prognosis and preventive potential

Autori: Amitava Banerjee, Laura Pasea, Sheng-Chia Chung, Kenan Direk, Folkert Asselbergs, Diederick E. Grobbee, Dipak Kotecha, Stefan D. Anker, Tomasz Dyszynski, Benoît Tyl, Spiros Denaxas, R. Thomas Lumbers, Harry Hemingway
Pubblicato in: European Heart Journal of Heart Failure, 2021, ISSN 1388-9842
Editore: Elsevier BV
DOI: 10.1002/ejhf.2417

Excess deaths in people with cardiovascular diseases during the COVID-19 pandemic

Autori: Amitava Banerjee, Suliang Chen, Laura Pasea, Alvina G Lai, Michail Katsoulis, Spiros Denaxas, Vahe Nafilyan, Bryan Williams, Wai Keong Wong, Ameet Bakhai, Kamlesh Khunti, Deenan Pillay, Mahdad Noursadeghi, Honghan Wu, Nilesh Pareek, Daniel Bromage, Theresa A McDonagh, Jonathan Byrne, James T H Teo, Ajay M Shah, Ben Humberstone, Liang V Tang, Anoop S V Shah, Andrea Rubboli, Yutao Guo, Yu Hu, Cathie
Pubblicato in: European Journal of Preventive Cardiology, 2021, ISSN 2047-4881
Editore: Oxford University Press (OUP)
DOI: 10.1093/eurjpc/zwaa155

Transforming and evaluating the UK Biobank to the OMOP Common Data Model for COVID-19 research and beyond

Autori: Vaclav Papez, Maxim Moinat, Erica A Voss, Sofia Bazakou, Anne Van Winzum, Alessia Peviani, Stefan Payralbe, Elena Garcia Lara, Michael Kallfelz, Folkert W Asselbergs, Daniel Prieto-Alhambra, Richard J B Dobson, Spiros Denaxas
Pubblicato in: Journal of the American Medical Informatics Association, 2023, ISSN 1527-974X
Editore: Zenodo
DOI: 10.1093/jamia/ocac203

Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation

Autori: Jasmeet S. Reyat, Winnie Chua, Victor R. Cardoso, Anika Witten, Peter M. Kastner, S. Nashitha Kabir, Moritz F. Sinner, Robin Wesselink, Andrew P. Holmes, Davor Pavlovic, Monika Stoll, Stefan Kaeaeb, Georgios Gkoutos, Joris R. de Groot, Paulus Kirchhof, Larissa Fabritz
Pubblicato in: JCI INSIGHT, 2020, ISSN 2379-3708
Editore: American Society for Clinical investigation
DOI: 10.1172/jci.insight.139179

Predictors of primary prevention implantable cardioverter-defibrillator use in heart failure with reduced ejection fraction: impact of the predicted risk of sudden cardiac death and all-cause mortality

Autori: Benedikt Schrage, Lars H. Lund, Lina Benson, Ulf Dahlström, Ramin Shadman, Cecilia Linde, Frieder Braunschweig, Wayne C. Levy, Gianluigi Savarese
Pubblicato in: European Journal of Heart Failure, 2022, ISSN 1388-9842
Editore: Elsevier BV
DOI: 10.1002/ejhf.2530

CODE-EHR best-practice framework for the use of structured electronic health-care records in clinical research

Autori: Dipak Kotecha, Folkert W Asselbergs, Stephan Achenbach, Stefan D Anker, Dan Atar, Colin Baigent, Amitava Banerjee, Birgit Beger, Gunnar Brobert, Barbara Casadei, Cinzia Ceccarelli, Martin R Cowie, Filippo Crea, Maureen Cronin, Spiros Denaxas, Andrea Derix, Donna Fitzsimons, Martin Fredriksson, Chris P Gale, Georgios V Gkoutos, Wim Goettsch, Harry Hemingway, Martin Ingvar, Adrian Jonas, Robert Kazm
Pubblicato in: The Lancet, 2022, ISSN 2589-7500
Editore: Elsevier
DOI: 10.1016/s2589-7500(22)00151-0

Natural language processing for disease phenotyping in UK primary care records for research: a pilot study in myocardial infarction and death

Autori: Anoop D. Shah, Emily Bailey, Tim Williams, Spiros Denaxas, Richard Dobson, Harry Hemingway
Pubblicato in: Journal of Biomedical Semantics, 2019, ISSN 2041-1480
Editore: BMC
DOI: 10.1186/s13326-019-0214-4

Identification and Mapping Real-World Data Sources for Heart Failure, Acute Coronary Syndrome, and Atrial Fibrillation

Autori: Studer R.a · Sartini C.b · Suzart-Woischnik K.b · Agrawal R.c · Natani H.c · Gill S.K.d · Wirta S.B.a · Asselbergs F.W.e,f · Dobson R.e · Denaxas S.e · Kotecha D.d,f,g
Pubblicato in: Cardiology, 2021, ISSN 0735-1097
Editore: Elsevier BV
DOI: 10.1159/000520674

Machine learning: a long way from implementation in cardiovascular disease

Autori: Suliang Chen, Amitava Banerjee
Pubblicato in: Heart, Numero 106/5, 2020, Pagina/e 318-320, ISSN 1355-6037
Editore: BMJ Publishing Group
DOI: 10.1136/heartjnl-2019-316030

Transthoracic echocardiographic reference values of the aortic root: results from the Hamburg City Health Study

Autori: Jan-Per Wenzel, Elina Petersen, Julius Nikorowitsch, Juliana Senftinger, Christoph Sinning, Matthias Theissen, Johannes Petersen, Hermann Reichenspurner & Evaldas Girdauskas
Pubblicato in: The International Journal of Cardiovascular Imaging, 2021, ISSN 1875-8312
Editore: Springer Netherlands
DOI: 10.1007/s10554-021-02354-5

Genetic liability to insomnia in relation to cardiovascular diseases: a Mendelian randomisation study

Autori: Shuai Yuan, Amy M. Mason, Stephen Burgess & Susanna C. Larsson
Pubblicato in: European Journal of Epidemiology, 2021, ISSN 0393-2990
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10654-021-00737-5

Estimating the Effect of Reduced Attendance at Emergency Departments for Suspected Cardiac Conditions on Cardiac Mortality During the COVID-19 Pandemic

Autori: Michail Katsoulis , Manuel Gomes , Alvina G. Lai , Albert Henry , Spiros Denaxas , Pagona Lagiou , Vahe Nafilyan , Ben Humberstone , Amitava Banerjee , Harry Hemingway and R. Thomas Lumbers
Pubblicato in: Circulation: Cardiovascular Quality and Outcomes, 2021, ISSN 1941-7713
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circoutcomes.120.007085

Post-mortem examination of high mortality in patients with heart failure and atrial fibrillation

Autori: Otilia Țica, Ovidiu Țica, Karina V. Bunting, Joseph deBono, Georgios V. Gkoutos, Mircea I. Popescu & Dipak Kotecha
Pubblicato in: BMC Medicine, 2022, ISSN 1741-7015
Editore: BioMed Central
DOI: 10.1186/s12916-022-02533-8

Association between dosing and combination use of medications and outcomes in heart failure with reduced ejection fraction: data from the Swedish Heart Failure Registry

Autori: Domenico D'Amario, Daniele Rodolico, Giuseppe M.C. Rosano, Ulf Dahlström, Filippo Crea, Lars H. Lund, Gianluigi Savarese
Pubblicato in: European Journal of Heart Failure, 2022, ISSN 1388-9842
Editore: Elsevier BV
DOI: 10.1002/ejhf.2477

Million Migrants study of healthcare and mortality outcomes in non-EU migrants and refugees to England: Analysis protocol for a linked population-based cohort study of 1.5 million migrants

Autori: Rachel Burns, Neha Pathak, Ines Campos-Matos, Dominik Zenner, Srinivasa Vittal Katikireddi, Morris C. Muzyamba, J. Jaime Miranda, Ruth Gilbert, Harry Rutter, Lucy Jones, Elizabeth J. Williamson, Andrew C. Hayward, Liam Smeeth, Ibrahim Abubakar, Harry Hemingway, Robert W. Aldridge
Pubblicato in: Wellcome Open Research, 2019, ISSN 2398-502X
Editore: F1000Research
DOI: 10.12688/wellcomeopenres.15007.1

Pre-existing cardiovascular disease rather than cardiovascular risk factors drives mortality in COVID-19

Autori: Kevin O’Gallagher, Anthony Shek, Daniel M. Bean, Rebecca Bendayan, Alexandros Papachristidis, James T. H. Teo, Richard J. B. Dobson, Ajay M. Shah, Rosita Zakeri
Pubblicato in: BMC Cardiovascular Disorders, 2021, ISSN 1471-2261
Editore: BioMed Central
DOI: 10.1186/s12872-021-02137-9

Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study

Autori: Shuai Yuan, Paul Carter, Amy M. Mason, Stephen Burgess and Susanna C. Larsson
Pubblicato in: Nutrients, 2021, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13072218

CODE-EHR best practice framework for the use of structured electronic healthcare records in clinical research

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Cabins, castles, and constant hearts: rhythm control therapy in patients with atrial fibrillation

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A semi-supervised approach for rapidly creating clinical biomarker phenotypes in the UK Biobank using different primary care EHR and clinical terminology systems

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Diastolic dysfunction in individuals with and without heart failure with preserved ejection fraction

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COVID-19 infection and attributable mortality in UK care homes: Cohort study using active surveillance and electronic records (March-June 2020)

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Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19

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Fit for the future: empowering clinical trials with digital technology

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Morning chronotype and digestive tract cancers: Mendelian randomization study

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Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study

Autori: Shuai Yuan, Amy M. Mason, Paul Carter, Stephen Burgess & Susanna C. Larsson
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Effects of tumour necrosis factor on cardiovascular disease and cancer: A two-sample Mendelian randomization study

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Machine learning for subtype definition and risk prediction in heart failure, acute coronary syndromes and atrial fibrillation: systematic review of validity and clinical utility

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Heart rate in patients with atrial fibrillation and heart failure with preserved ejection fraction: a prognosticator like in sinus rhythm?

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Big Data in Cardiovascular Disease

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Big data from electronic health records for early and late translational cardiovascular research: challenges and potential

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From lipid locus to drug target through human genomics

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Responsible data sharing in international health research: a systematic review of principles and norms

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Risk factors for incident heart failure in age- and sex-specific strata: a population-based cohort using linked electronic health records

Autori: Alicia Uijl, Stefan Koudstaal, Kenan Direk, Spiros Denaxas, Rolf H. H. Groenwold, Amitava Banerjee, Arno W. Hoes, Harry Hemingway, Folkert W. Asselbergs
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An electronic health records cohort study on heart failure following myocardial infarction in England: incidence and predictors

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UK phenomics platform for developing and validating electronic health record phenotypes: CALIBER

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Bleeding in cardiac patients prescribed antithrombotic drugs: electronic health record phenotyping algorithms, incidence, trends and prognosis

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Subtypes of atrial fibrillation with concomitant valvular heart disease derived from electronic health records: phenotypes, population prevalence, trends and prognosis

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Semantic computational analysis of anticoagulation use in atrial fibrillation from real world data

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Genetic determinants of lipids and cardiovascular disease outcomes: a wide-angled Mendelian randomization investigation

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Responsible data sharing in a big data-driven translational research platform: lessons learned

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Association between beta‐blocker use and mortality/morbidity in older patients with heart failure with reduced ejection fraction. A propensity score‐matched analysis from the Swedish Heart Failure Registry

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Patients’ and public views and attitudes towards the sharing of health data for research: a narrative review of the empirical evidence

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Association Between Use of Primary-Prevention Implantable Cardioverter-Defibrillators and Mortality in Patients With Heart Failure

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Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

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Comorbidities and cause-specific outcomes in heart failure across the ejection fraction spectrum: A blueprint for clinical trial design

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Impact of Acute Hemoglobin Falls in Heart Failure Patients: A Population Study

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A registry‐based algorithm to predict ejection fraction in patients with heart failure

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Genetic drug target validation using Mendelian randomisation

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Genetically predicted circulating vitamin C in relation to cardiovascular disease

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Genetically predicted circulating B vitamins in relation to digestive system cancers

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The social licence for data-intensive health research: towards co-creation, public value and trust

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Assessing the protective role of allergic disease in gastrointestinal tract cancers using Mendelian randomization analysis

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Integrative Bioinformatics Approaches for Identification of Drug Targets in Hypertension

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Metformin use and cardiovascular outcomes after acute myocardial infarction in patients with type 2 diabetes: a cohort study

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Familial atrial fibrillation mutation M1875T-SCN5A increases early sodium current and dampens the effect of flecainide

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Metabolic Traits and Stroke Risk in Individuals of African Ancestry: Mendelian Randomization Analysis

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Smartphone detection of atrial fibrillation using photoplethysmography: a systematic review and meta-analysis

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Quantification of fibroblast growth factor 23 and N-terminal pro-B-type natriuretic peptide to identify patients with atrial fibrillation using a high-throughput platform: A validation study.

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Long COVID: mechanisms, risk factors and recovery

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Identification of distinct phenotypic clusters in heart failure with preserved ejection fraction

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Redefining β-blocker response in heart failure patients with sinus rhythm and atrial fibrillation: a machine learning cluster analysis

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Anticoagulation, therapy of concomitant conditions, and early rhythm control therapy: a detailed analysis of treatment patterns in the EAST - AFNET 4 trial

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Genetically proxied milk consumption and risk of colorectal, bladder, breast, and prostate cancer: a two-sample Mendelian randomization study

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Pubblicato in: BMC Medicine, 2020, ISSN 1741-7015
Editore: BioMed Central
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