Objective
Osteoporosis, currently diagnosed by measuring bone mineral density (BMD) using dual-energy X.-ray absorptiometry, is the most common metabolic bone disease in Europe. It results in highly increased fracture risk, which is not optimally predicted by BMD. Bisphosphonates are used for medical treatment of osteoporosis. They have an advantageous impact on bone microarchitecture, but long term treatment can lead to deterioration of bone structural integrity and increased fracture risk, despite high BMD. Several factors related to bone quality. i.e. bone architecture, geometry, turnover and mineralization and accumulation of microfractures contribute significantly to fracture risk. Development of new coherent methods for evaluating bone quality is necessary to improve diagnostics, and to monitor treatments and assessment of fracture risk. The aims are to 1) improve the understanding of bone quality in health and disease, 2) diagnose more effectively early osteoporosis and 3) predict more accurately fracture risk. Specifically, we assess the effects of aging, osteoporosis, and long term bisphosphonate treatment on structural, compositional and mechanical properties of trabecular bone from human cadavers. MicroCT is used to analyze trabecular microarchitecture and spatial BMD. Cellular events and bone remodeling processes are analyzed histomorphometrically. Microscopic and spectroscopic methods are used to study composition of organic and non-organic components. Also, novel backscattered ultrasound methods are used for trabecular bone diagnostics and to assess their feasibility for clinical practice. Interrelationships between bone characteristics will be addressed using statistical and modeling techniques. The techniques will provide quantitative information on bone quality, not previously possible. University of Kuopio provides excellent facilities to carry out this study, including well-known bone researchers (profs Jurvelin and Kröger), who will act as supervisors.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences mathematics pure mathematics geometry
- natural sciences physical sciences acoustics ultrasound
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-1-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
70211 KUOPIO
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.