The effect of intracoronary reinfusion of bone marrow-derived mononuclear cells (BM-MNC) on all-cause mortality in acute myocardial infarction

Project Information

BAMI

Grant agreement ID: 278967

Project closed

Start date 1 November 2011

End date 31 October 2017

Funded under

• Specific Programme "Cooperation": Health

Total cost € 7 842 161,40

EU contribution € 5 993 083,00

Coordinated by

QUEEN MARY UNIVERSITY OF LONDON
United Kingdom

Objective

Although the long term prognosis of patients suffering acute myocardial infarction (AMI) has improved since the introduction of reperfusion therapies and primary angioplasty, the 1 year mortality of patients with AMI and resultant left ventricular systolic dysfunction (LVSD) is still as high as 13%. A major reason for the high morbidity and mortality is that the heart has an inadequate regenerative response to the myocardial necrosis sustained following AMI; cell death from the ischaemic damage can lead to progressive ventricular dilation and dysfunction through the processes of vascular remodelling. Despite the use of full conventional treatment, including ACE inhibitors, beta-blockers, aldosterone inhibitors and diuretics, yearly mortality rates of patients with post-infarction heart failure are still in the range of 13 % and rehospitalisation for worsening of heart failure occurs at a yearly rate of 6–8%.

Clinical data now exists supporting the concept that autologous bone marrow derived cells can restore cardiac function following AMI. We plan to advance this research in the BAMI project and will:
• Develop a standardised method of bone marrow cell collection
• Develop a standardised method of optimising reparative potential of bone marrow derived cells
• Standardise bone marrow preparation procedure so that it can be universally applied
• Standardise method of bone marrow cell delivery post AMI
• Conduct the first large scale all-cause mortality clinical trial to test if the product and delivery method mentioned above can lead to a 25% reduction in mortality end-point at 2 years

Our project will establish the therapeutic value of this approach to stem cell therapy. Success will demonstrate that transcoronary infusion of bone marrow-derived progenitor cells is safe and will reduce the mortality rate by 25% and reduce the rehospitalisation rate by 15%.

Fields of science

• social sciences › sociology › demography › mortality
• medical and health sciences › clinical medicine › cardiology
• medical and health sciences › medical biotechnology › cells technologies

Programme(s)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Topic(s)

• HEALTH.2011.1.4-1 - Regenerative medicine clinical trials
• HEALTH.2011.1.4-2 - Tools, technologies and devices for application in regenerative medicine

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

QUEEN MARY UNIVERSITY OF LONDON

Administrative Contact

Dylbere Koteci (Mrs.)

• EU contribution: € 1 979 853,55
• Address: 327 MILE END ROAD ; E1 4NS London ; United Kingdom
• Region: London › Inner London — East › Tower Hamlets
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

Participants (21)

ASSISTANCE PUBLIQUE HOPITAUX DE PARIS

France

Administrative Contact

Christophe Misse (Mr.)

• EU contribution: € 19 842,43
• Address: 55 BOULEVARD DIDEROT ; 75012 Paris
• Region: Ile-de-France › Ile-de-France › Val-de-Marne
• Activity type: Research Organisations
• Total cost: No data

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

Administrative Contact

Tine Heylen (Ms.)

• EU contribution: € 476 995,20
• Address: OUDE MARKT 13 ; 3000 Leuven
• Region: Vlaams Gewest › Prov. Vlaams-Brabant › Arr. Leuven
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN

Participation ended

Germany

Administrative Contact

Mareike Schmitt (Ms.)

• EU contribution: No data
• Address: THEODOR W ADORNO PLATZ 1 ; 60323 Frankfurt Am Main
• Region: Hessen › Darmstadt › Frankfurt am Main, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

INSTITUT CATALA DE LA SALUT

Spain

Administrative Contact

Ramon Cosialls (Mr.)

• EU contribution: € 154 191,92
• Address: GRAN VIA DE LES CORTS CATALANES 587 ; 08007 Barcelona
• Region: Este › Cataluña › Barcelona
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Total cost: No data

EURAM LIMITED

Participation ended

United Kingdom

Administrative Contact

Andrew Banasik (Mr.)

• EU contribution: € 258 936,87
• Address: LUCY TOWER STREET TOWER HOUSE ; LN1 1XW Lincoln
• Region: East Midlands (England) › Lincolnshire › Lincolnshire
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Total cost: No data

UNIVERSITY COLLEGE LONDON

Administrative Contact

Greta Borg-Carbott (Ms.)

• EU contribution: € 21 384,89
• Address: GOWER STREET ; WC1E 6BT LONDON
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

T2CURE GMBH

Germany

Administrative Contact

Susanne Knigge (Ms.)

• EU contribution: € 163 955,23
• Address: KENNEDYALLEE 93 ; 60596 FRANKFURT AM MAIN
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Total cost: No data

CARDIOVASCULAR RESEARCH CENTER AALST VZW

Belgium

Administrative Contact

Jozef Bartunek (Dr.)

• EU contribution: € 111 275,00
• Address: MOORSELBAAN 164 ; 9300 Aalst
• Region: Vlaams Gewest › Prov. Oost-Vlaanderen › Arr. Aalst
• Activity type: Research Organisations
• Total cost: No data

MEDIZINISCHE HOCHSCHULE HANNOVER

Germany

Administrative Contact

Frank Dittrich (Mr.)

• EU contribution: € 22 464,12
• Address: Carl-Neuberg-Strasse 1 ; 30625 Hannover
• Region: Niedersachsen › Hannover › Region Hannover
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

FAKULTNI NEMOCNICE BRNO

Czechia

Administrative Contact

Iveta Mareschova (Ms.)

• EU contribution: € 151 882,63
• Address: JIHLAVSKA 20 ; 625 00 Brno
• Region: Česko › Jihovýchod › Jihomoravský kraj
• Activity type: Research Organisations
• Total cost: No data

REGION HOVEDSTADEN

Denmark

Administrative Contact

Jens Kastrup (Prof.)

• EU contribution: € 136 776,16
• Address: KONGENS VAENGE 2 ; 3400 Hillerod
• Region: Danmark › Hovedstaden › Nordsjælland
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Total cost: No data

UNIVERSITA CATTOLICA DEL SACRO CUORE

Italy

Administrative Contact

Filippo Leone (Mr.)

• EU contribution: € 205 270,04
• Address: LARGO GEMELLI 1 ; 20123 Milano
• Region: Nord-Ovest › Lombardia › Milano
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

KING'S COLLEGE HOSPITAL NHS FOUNDATION TRUST

United Kingdom

Administrative Contact

Kathryn Huggins (Ms.)

• EU contribution: € 138 265,49
• Address: DENMARK HILL ; SE5 9RS London
• Region: London › Inner London — East › Lambeth
• Activity type: Research Organisations
• Total cost: No data

SLASKI UNIWERSYTET MEDYCZNY W KATOWICACH

Participation ended

Poland

Administrative Contact

Barbara Jarzebska (Ms.)

• EU contribution: € 2 699,53
• Address: UL. PONIATOWSKIEGO 15 ; 40 055 Katowice
• Region: Makroregion południowy › Śląskie › Katowicki
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

UNIVERSITAET ROSTOCK

Participation ended

Germany

Administrative Contact

Gustav Steinhoff (Prof.)

• EU contribution: No data
• Address: UNIVERSITATSPLATZ 1 ; 18055 Rostock
• Region: Mecklenburg-Vorpommern › Mecklenburg-Vorpommern › Rostock, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

CELYAD

Belgium

Administrative Contact

Patrick Jeanmart (Mr.)

• EU contribution: € 185 836,88
• Address: RUE EDOUARD BELIN 12 ; 1435 MONT SAINT GUIBERT
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Total cost: No data

ITA-SUOMEN YLIOPISTO

Finland

Administrative Contact

Tiina Reinikainen (Ms.)

• EU contribution: € 113 136,90
• Address: YLIOPISTONRANTA 8 ; 70211 KUOPIO
• Region: Manner-Suomi › Pohjois- ja Itä-Suomi › Pohjois-Savo
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

OSLO UNIVERSITETSSYKEHUS HF

Participation ended

Norway

Administrative Contact

Ketil Lunde (Prof.)

• EU contribution: No data
• Address: KIRKEVEIEN 166 TARNBYGGET ; 0450 Oslo
• Region: Norge › Oslo og Viken › Oslo
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

SERVICIO MADRILENO DE SALUD

Spain

Administrative Contact

Thierry Bardinet (Mr.)

• EU contribution: € 540 710,60
• Address: Paseo De la Castellana, 280 ; 28046 MADRID
• Region: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Total cost: No data

THE UNIVERSITY OF EXETER

United Kingdom

Administrative Contact

Gaynor Hughes (Ms.)

• EU contribution: € 165 701,20
• Address: THE QUEEN'S DRIVE NORTHCOTE HOUSE ; EX4 4QJ Exeter
• Region: South West (England) › Devon › Devon CC
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

KLINIKUM DER JOHANN WOLFGANG VON GOETHE UNIVERSITAET

Germany

Administrative Contact

Kseniya Polozheyeva (Ms.)

• EU contribution: € 1 143 904,36
• Address: THEODOR STERN KAI 7 ; 60596 Frankfurt Am Main
• Region: Hessen › Darmstadt › Frankfurt am Main, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data